• Nutrition Research and Practice
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• 제10권4호
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• pp.377-384
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• 2016

BACKGROUND/OBJECTIVES: Resveratrol, a natural polyphenol, has multiple functions in cellular responses including apoptosis, survival, and differentiation. It also participates in the regulation of inflammatory response and oxidative stress. MicroRNA-Let-7A (miR-Let7A), known as a tumor suppressor miRNA, was recently reported to play a crucial role in both inflammation and apoptosis. Therefore, we examined involvement of miR-Let7A in the modulation of inflammation and cell survival/apoptosis regulated by resveratrol. MATERIALS/METHODS: mRNA expression of pro-/anti-inflammatory cytokines and sirtuin 1 (SIRT1), and protein expression of apoptosis signal-regulating kinase 1 (ASK1), p-ASK1, and caspase-3 and cleaved caspase-3 were measured, and cell viability and Hoechst/PI staining for apoptosis were observed in Lipopolysaccharide (LPS)-stimulated human THP-1 macrophages with the treatment of resveratrol and/or miR-Let7A overexpression. RESULTS: Pre-treatment with resveratrol ($25-200{\mu}M$) resulted in significant recovery of the reduced cell viabilities under LPS-induced inflammatory condition and in markedly increased expression of miR-Let7A in non-stimulated or LPS-stimulated cells. Increased mRNA levels of tumor necrosis $factor-{\alpha}$ and interleukin (IL)-6 induced by LPS were significantly attenuated, and decreased levels of IL-10 and brain-derived neurotrophic factor were significantly restored by resveratrol and miR-Let7A overexpression, respectively, or in combination. Decreased expression of IL-4 mRNA by LPS stimulation was also significantly increased by miR-Let7A overexpression co-treated with resveratrol. In addition, decreased SIRT1 mRNA levels, and increased p-ASK1 levels and PI-positive cells by LPS stimulation were significantly restored by resveratrol and miR-Let7A overexpression, respectively, or in combination. CONCLUSIONS: miR-Let7A may be involved in the inflammatory response and cell survival/apoptosis modulated by resveratrol in human THP-1 macrophages.

• KSBB Journal
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• 제14권3호
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• pp.351-357
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• 1999

A marine bacterium Bacillus cereus ASK202, agarase producing strain, was treated with some mutagenic agents, ultraviolte(UV), 1-methyl-3-nitro-1-nitrosoguanidine(NTG), and ethyl methane sulfonate(EMS), several times for the increasing of the agarase production After mutagen treatment, we isolated one mutant strain treated with NTG showed the highest stability and agarase productivity and named as Bacillus cereus ASK202-N3. This Bacillus cereus ASK202-N3 strain was well grown in the modified marine medium containing 0.5%(w/v) agar, 0.3%(w/v) yeast extract, and 5.0%(w/v) NaCl, and the optimal initial pH, temperature and culture time were 7.8, $25^{\circ}C$ and 32h, respectively. In the optimal culture conditions, the agarase production was increased to 5.3 fold(850units/L) compared to that of the wild type.

• 대한전자공학회논문지SD
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• 제45권11호
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• pp.44-49
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• 2008

ASK 100% RF 입력신호를 이용하는 13.56MHz RFID 태그를 위한 클럭 복원회로를 제안하였다. 제안한 클럭 복원회로는, 레지스터로 조절되는 DLL을 이용하여 입력 RF 신호의 크기가 0인 구간에서도 기준 클럭 신호를 사용하지 클럭을 생성하도록 설계되었다. 제안한 회로는 TSMC 0.18um 1P6M 공정을 사용하여 설계하였으며, 제안된 회로는 DLL의 위상 잠김 시간이 6.4usec 이하이며 공급전압이 3.3V에서 43uW를 소모한다.

• 한국정보통신학회논문지
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• 제5권4호
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• pp.692-698
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• 2001

해안국과 군대의 기지국에서는 기존의 SSB 와 VHF송수신기에 의한 무선통신은 아직도 매 우 유효하게 사용하고 있다. 해안국과 터미널간에 있어서 기존 SSB 와 VHF 송수신기에 의한 통신상대는 1:1 방식이다. 그러나 이 1:1의 방식을 1대 다수로 한다. 그러면 주파수를 아낄 수 있고, 또 해상에서 조난, 긴급, 안전통신 및 군용통신에서 효과적으로 할 수 있다. 이 논문은 기존의 SSB 나 VHF 통신장비에 ICS를 설치하였다. 이것은 하나의 단말기에서 여러 송수신장비와 통신을 할 수 있다. ICS에 의한 회선교환 방법은 PPT 신호와 음성신호가 변조된 ASK로 원격조정을 한다. ICS 는 회선교환기를 통하여 단말기와 송수신기의 접속을 수시로 변경할 수 있다. 이렇게 하기 위해서 ASK방식에 대한 정보전송, ICS의 시스템 개발 제어 알고리즘의 구현, 멀티프로세서의 시스템 개발, 전송방식, 모니터링을 연구하였다. 따라서 이 논문은 원격제어를 위한 무선통신장비의 회선교환 제어방식으로서 해상통신, 군용통신, 어업통신 등을 위한 무선국 통신장비의 개선에 기여도가 클 것으로 기대된다.

• 한국통신학회논문지
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• 제17권3호
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• pp.268-276
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• 1992

본 논문에서는 전파감측(감시 및 측정)이나 유니버셜 복조기의 개발을 위한 기초 연구로써, 미지의 디지털 변조 신호 식별에 대하여 논의한다. 제안한 식별 방법은 시간 영역의 파라미터를 이용하는 방안으로 먼저 포락선, 순시 주파수, 차위상 정보를 기본특징으로 추출한다. 추출된 기본특징은 식별을 위해 2개의 2차원 비선형 식별 공간으로 사상되며 입력 신호의 식별은 1차 선형식별함수를 이용해 이루어진다. 본 논문에서 제안한 방법의 타당성을 검증하기 위하여 가우스성 잡음 환경하에서 ASK-2, ASK-4, BPSK, QPSK, 8PSK, FSK, QAM 신호를 대상으로 특징추출과 식별과정을 모의실험한다.

• KSBB Journal
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• 제13권5호
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• pp.524-529
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• 1998

An agarase was partially purified from the culture broth of marine bacterium Bacillus cereus ASK202. Optimal pH and temperature of this agarase were found to be 7.0 and 40$^{\circ}C$, respectively. The maximum productivity of agarooligosaccharides was obtained from 0.3 %(w/v) agar by using of 1 unit agarase. As the results of TLC and HPLC analysis, these oilgosaccharides consisted of neoagarobiose, neoagarotetraose and neoagarohexaose. Under the optimal reaction conditions, 77.5 %(w/v) neoagarobiose and 6.2 %(w/v) neoagarotetraose were produced from agar and the conversion yield of total agarooligosaccharides was 83.7 %(w/v) after for 2 h reaction at 40$^{\circ}C$.

• 재무관리논총
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• 제2권1호
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• pp.127-144
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• 1995

Previous literature in financial economics documents the existence of a liquidity premium in expected returns, measured by the bid-ask spread. This study provides a more comprehensive test of the egect of liquidity on common stock returns by including trading volume as an additional liquidity measure. we find that trading volume is a relevant measure of liquidity, and affects expected returns even aher controlling for the effects of systematic risk, firm size, and the relative bid-ask spread. We also find that trading volume complements the bid-ask spread as a liquidity measure, and provides additional information about the liquidity premium. The liquidity effect emerges in non-January months as a volume effect, in addition to the spread effect in January documented by Eleswarapu and Reinganum(1993).

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2008년도 하계종합학술대회
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• pp.443-444
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• 2008

A double-balanced frequency up-converter using the Gilbert cell structure has been designed with the TSMC $0.18\;{\mu}m$ CMOS library. The frequency up-converter consists of a Mixer core and IF / LO balun. Frequency Up-converter exhibits a 3.4 dB conversion gain with a - 7.6 dBm $P_{1dB}$ for IF power of -10 dBm and LO power of 0 dBm inputs. It also exhibits 92.2 % modulation depth as a ASK modulator.

• 융합신호처리학회논문지
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• 제12권1호
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• pp.44-49
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• 2011

The need of data transmission in oceans and other underwater mediums are increasing day by day, so as the research. The underwater medium is very different from that of air. Propagation of electromagnetic wave in water or underground is very difficult because of the conductivity of the propagation materials. In this case, we usually use acoustic signals as ultrasonic but, they are not easy to transfer long distance with coherent method because of time varying multipaths, Doppler effects and attenuations. So, we use non-coherent methods such as FSK or ASK to communicate between long distances. But, as the propagation speed of acoustic wave is very slow, BW of the channel is narrow. It is very hard to guaranty the enough speed for the transmission of digital image data. In previous studies, we proposed this data communication protocol theoretically. In this paper, an underwater channel is modeled and this protocol is tested in this channel condition. The results show that the protocol is 4-6 times faster than ASK. Some relations and results are shown depending on the data length, channel length, bit rate etc.

• Transactions on Electrical and Electronic Materials
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• 제11권1호
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• pp.20-23
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• 2010

The analog front end (AFE) of a radio frequency identification transponder using the ISO 14443 type A standard with a 100% amplitude shift keying (ASK) modulation is proposed in this paper and verified by circuit simulations and measurements. This AFE circuit, using a 13.56 MHz carrier frequency, consists of a rectifier, a modulator, a demodulator, a regulator, a power on reset, and a dynamically enabled digital phase locked loop (DPLL). The DPLL, with a charge pump enable circuit, was used to recover the clock of a 100% modulated ASK signal during the pause period. A high voltage lateral double diffused metal-oxide semiconductor transistor was used to protect the rectifier and the clock recovery circuit from high voltages. The proposed AFE was fabricated using the $0.18\;{\mu}m$ standard CMOS process, with an AFE core size of $350\;{\mu}m\;{\times}\;230\;{\mu}m$. The measurement results show that the DPLL, using a demodulator output signal, generates a constant 1.695 MHz clock during the pause period of the 100% ASK signal.