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Molecular targets of pepper as bioavailability enhancer

  • Gohil, Priyanshee;Mehta, Anita
    • Advances in Traditional Medicine
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    • v.9 no.4
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    • pp.269-276
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    • 2009
  • Black pepper (family Piperaceae), is called king of spices because it is one of the oldest spice and alone accounts for about 35% of the world's total spice trade. The pepper is used in Ayurvedic medicine for the treatment of various ailments particularly neurological, broncho-pulmonary and gastrointestinal disorders. Pepper has also been reported to have various pharmacological actions but recently, it is highlighted as a bioavailability enhancer. This results in higher plasma concentration of drugs, nutrients, ions and other xenobiotics, rendering them more bioavailable for physiological as well as pharmacological actions in the body. Numerous scientific studies reported that piperine; a main bioactive compound of pepper, is responsible for its bioavailability enhancing property. It's a well known fact that pepper enhances bioavailability by inhibition of microsomal enzyme system but other mechanisms are also responsible to acts as a bioavailability enhancer. The brief overview of the mechanism of action of pepper as well as its applications as bioavailability enhancer is given in the present article.

A Study on the Expression of Movement in Architectural Design in the Second Machine Age (제2기계시대 건축디자인에서의 운동의 표현에 관한 연구)

  • Kim, Won-Gaff
    • Korean Institute of Interior Design Journal
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    • v.15 no.6 s.59
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    • pp.101-110
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    • 2006
  • Many architects in the second machine age experiment on the movement in architectural design. They consider a movement as a flow of information and vector as well as the real motion. They express the movement in architectural design as nomad architecture, network city, rhizome, mutual transformation among building, environment and visitors, and form generation as the actualization of the virtual. It is partly the result of the philosophy of Deleuze and Bergson that a movement is just a duration as a difference of quality. It is because Deleuze explains that the realization of the virtual as a becoming is also the kind of movement. This study analyzes the method of expression of movement in architectural design in the second machine age. As a result, the movement in architectural design in the second machine age was expressed in two ways. One method is a territorialized movement that moves in the fixed trajectory and the other is a deterritorialized movement that moves in the random indeterminate trajectory.

A Regressional Study on the Relation between Marriage Variables and Fertility (결혼관련 요인의 출산력에 미치는 영향 연구)

  • 김성혜;김초강
    • Korean Journal of Health Education and Promotion
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    • v.8 no.1
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    • pp.87-97
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    • 1991
  • The purpose of this study is to identify the important marriage variables influencing fertilty. The data on which this study is based was selected from the survey data which was nation-widely collected from 2,824 married women in 1989 as the Korean. Family Function Study performed by the Korea Institute for Population and Health. The data was analyzed by the methods such as Cross Tabulation, Pearson's Correlation, and Multiple Regression. And the data analysis was processed by SPSS. The results are as follows. 1. There are differences in fertility according to the socioeconomic factor. The higher the educational level of a married woman is the lower the fertility level. And if the decision of marriage was made by herself, the fertility level is significantly low. As the duration of living in a large city is longer and the educational level of her husband is higher, the fertility level is low. 2. There are differences is fertility according to the demographic factor. As the first marriage age of her and her husband, the fertility level was low. And when a couple doesn't live with the husband's parents and the size of a family is small, the fertility level is low. 3. Finally the factors affecting fertility were analyzed by the Stepwised Multiple Regression. The result shows that as the educational level of a married woman is higher, she herself decides the marriage, the first marriage level of her is higher, the size of a family is small, her husband is higher, the fertility level is low.

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The Meaning of Practice in Theory (이론(理論, Theoria)에 있어서의 실기의 의미)

  • Kang, Tai-Sung
    • The Journal of Art Theory & Practice
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    • no.1
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    • pp.7-22
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    • 2003
  • What is 'Art Theory'? In the western sense, the term poses a vague ambiguity, and in the eastern, it is rather an abstract and metaphysical concept. As for etymology, theory is derived from theoria and theoria from theoros. It refers to an act of viewing or seeing, of course not in a metaphysical sense. Plato understood it as 'eide'. During the time of Plotinus, theoria encompassed gazing at every possible reality, and this gazing, that is theoria, is closely related to reality as aunit that theoriacan perceive. However, we tend to distinguish, as other scientists of dualism have done, studio art from theory since a pre-modern approach to art has been particularly tuned to studio practice, set apart from theory. Therefore, in studio classes, students are expected to learn the subject based on the foundational curriculum methods such as medium, genre, technique:, rather than bringing out their own interpretations and discussing theories. As a result, students have become artists, who are not able to understand their own art. Art professors who conduct class in studio are required to proceed with specific 'theories' as well as 'intellectual reflections'. In this respect, this thesis presents poiesis and an idea of 'acting out'. Although art history and aesthetic theory tend to view art as a finished product, actual art-making and related theories should not only be acknowledged as 'completion' (finition) but also be accompanied by theoretic interpretations of the act itself and process. Accordingly, it is to accept and appreciate art as finished result in view of current theory and aesthetics thus boils down to aisthesis. Likewise, poietics starts from a point where an artist is related to studio and examines the 'work process' that extends as far as to the exact end of work. Through the study of such relationship, it is possible that theory understands 'studio' and 'process', and an artist can grant an independent meaning to studio where s/he pours her/his heart out creating a work of art. Theory is a study on artistic discovery thus should be equipped with functions that can accommodate fortuity, imitation, thinking, culture, and surrounding.

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A Consideration of Hydrazine Syntheses (Hydrazine 合成의 一考察)

  • Lee, Hac-Ki
    • Journal of the Korean Chemical Society
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    • v.5 no.1
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    • pp.1-6
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    • 1961
  • It is important to study hydrazine because of the development of new uses for its derivatives. The Rasching method is the only satisfactory one for synthesizing hydrazine; it involves the oxidation of ammonia by sodium hypochlorite in the presence of some such catalyst as gelatin. Calcium hypochlorite was substituted for the sodium hypochlorite particularly in this work, applying agar-agar as catalyst. The results of the experiments are as follow: 1. The yield is proportional to the mole-ratio of ammonia to available chlorine in calcium hypochlorite and about 60% is obtained when the ratio is 20. 2. Agar-agar can be used as a catalyst and its proper concentration in the solution is 0.005%. 3. Proper concentration of available chlorine in the reaction solution is 0.23 mole/l. 4. The most effective condition for the reaction is a temperature of $60{\sim}65^{\circ}C.$ maintained for $20{\sim}25min$. 5. The reaction takes place equally well in either an open or closed container. 6. When calcium hypochlorite is applied in place of sodium hypochlorite, the yield of hydrazine is increased as much as 17%. 7. The yield of hydrazine is decreased by eliminating the suspension of $Ca(OH)_2$ which results from the use of calcium hypochlorite. 8. When $Ca(OH)_2$ is added to Rasching process, the yield of hydrazine is raised normally. 9. The fact that some metal ions, such as $Cu^{++},$ inhibit the formation of hydrazine was proved. 10. The suspension of $Ca(OH)_2$ acted as a remarkable adsorbent for $Cu^{++}$ like gelatin. The suspension of $Ca(OH)_2$ which results from the use of calcium hypochlorite acts as a catalyst, absorbing metal ions, to increase the yield of hydrazine. So I think that calcium hypochlorite is a more efficient oxidant than sodium hypochlorite in hydrazine syntheses.

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Proteins as the molecular markers of male fertility

  • Beeram, Eswari
    • The Korean Journal of Food & Health Convergence
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    • v.4 no.4
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    • pp.18-25
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    • 2018
  • Proteins play a key role in many functions such as metabolic activity, differentiation, as cargos and cell fate regulators. It is necessary to know about the markers involved in male fertility in order to develop remedies for the treatment of male infertility. But, the role of the proteins is not limited to particular function in the biological systems. Some of the proteins act as ion channels such as catsper and proteins like Nanos acts as a translational repressor in germ cells and expressed in prenatal period whose role in male fertility is uncertain. Rbm5 is a pre mRNA splicing factor necessary for sperm differentiation whose loss of function results deficit in sperm production. DEFB114 is a beta defensin family protein necessary for sperm motility in LPS challenged mice where as TEX 101 is a plasma membrane specific germ cell protein whose function is not clearly known u to now. Gpr56 is another adhesion protein whose null mutation leads to arrest of production of pups in rats. Amyloid precursor protein role in Alzheimer's disease is already known but it plays an important role in male fertility also but its function is uncertain and has to be considered while targeting APP during the treatment of Alzheimer's disease. The study on amyloid precursor protein in male fertility is a novel thing but requires further study in correlation to alzheimer's disease.

Drying Shrinkage of High-Volume Fly Ash Concrete (High-Volume 플라이애쉬 콘크리트의 건조수축특성)

  • 최석균;이광명;이진용
    • Proceedings of the Korea Concrete Institute Conference
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    • 1999.10a
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    • pp.195-198
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    • 1999
  • Fly ash is the most common artificial pozzolan, which is a material precipitated electrostatically from the exhaust gases of coal-fired power stations. Fly ash can be used as the supplementary material as well as the material for high performance concrete and hence, the development of high-volume fly ash concrete is imperative. In this study, the characteristics of drying shrinkage of high volume fly ash concrete is investigated. It is found from test results that as the replaced amount of fly ash in concrete is increased, drying shrinkage of concrete is reduced.

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The Impact of the Organizational Characteristics, IS Basis, IS Planning Capability and IS Quality on the CRM Performance (조직특성, IS 기반, IS 기획능력 및 IS 품질이 CRM 성과에 미치는 영향)

  • Lee, Seung-Myoung;Kim, Eun-Hong
    • Journal of Information Technology Services
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    • v.4 no.1
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    • pp.71-105
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    • 2005
  • The purpose of this study was to test various variables that affect CRM performance in order to evaluate CRM performance. The results of the proposed research hypotheses are as follows; First, the IS based factors perform more important roles on system and information quality compared to organizational factors. Second, the variables of IS and planning capability playa role as a parameter. Third, among organizational factors, non-structural factors such as degrees of acceptance of business transition, support of CEO, and customer-orientation perform more important roles on CRM. Fourth, IS based factors have bigger Impact on information quality than system quality. Fifth, it was proven that IS quality, proposed as a parameter and as a dependant variable, and CRM have significant relations.

A study on breakthrough characteristics of activated carbon fiber by development of sorbent tube (ACF 흡착관 개발을 위한 파괴특성에 관한 연구)

  • Won Jung-Il;Kim Ki-Hwan
    • Journal of environmental and Sanitary engineering
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    • v.20 no.1 s.55
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    • pp.40-54
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    • 2005
  • This dissertation aims to develop adsorption tubes for measuring organic solvents in the working environment, by comparing and analyzing breakthrough condition and adsorption capacity with ACF. 1. In breakthrough characteristics, the raising velocity of breakthrough curve is increasing according to assault concentration, but $50\%$ breakthrough time is decreasing. As breakthrough curve of calculated data using this agrees with the one of experimental data both of them can be used on determining sampling time of adsorption tubes. It is predicted by theoretical that $10\%$ breakthrough time is increasing in the case of increasing filled adsorbent amount. 2. $10\%$ breakthrough time is regularly decreasing as much as assault concentration is increasing. As a result, we can predict the life of adsorbent within the range of the low concentration, and adsorption amount that ACF can sample during $10\%$ breakthrough time is increasing as much as assault concentration is increasing.

An Immune System Modeling for Realization of Cooperative Strategies and Group Behavior in Collective Autonomous Mobile Robots (자율이동로봇군의 협조전략과 군행동의 실현을 위한 면역시스템의 모델링)

  • 이동욱;심귀보
    • Proceedings of the Korean Institute of Intelligent Systems Conference
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    • 1998.03a
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    • pp.127-130
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    • 1998
  • In this paper, we propose a method of cooperative control(T-cell modeling) and selection of group behavior strategy(B-cell modeling) based on immune system in distributed autonomous robotic system(DARS). Immune system is living body's self-protection and self-maintenance system. Thus these features can be applied to decision making of optimal swarm behavior in dynamically changing environment. For the purpose of applying immune system to DARS, a robot is regarded as a B cell, each environmental condition as an antigen, a behavior strategy as an antibody and control parameter as a T-call respectively. The executing process of proposed method is as follows. When the environmental condition changes, a robot selects an appropriate behavior strategy. And its behavior strategy is stimulated and suppressed by other robot using communication. Finally much stimulated strategy is adopted as a swarm behavior strategy. This control scheme is based of clonal selection and idiotopic network hypothesis. And it is used for decision making of optimal swarm strategy. By T-cell modeling, adaptation ability of robot is enhanced in dynamic environments.

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