• Genomics & Informatics
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• 제9권2호
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• pp.64-68
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• 2011

Monomelic amyotrophy (MA), also known as Hirayama disease, occurs mainly in young men and manifests as weakness and wasting of the muscles of the distal upper limbs. Here, we sought to identify a genetic basis for MA. Given the predominance of MA in males, we focused on candidate neurological disease genes located on the X chromosome, selecting two X-linked candidate genes, androgen receptor (AR ) and ubiquitin-like modifier activating enzyme 1 (UBA1). Screening for genetic variants using patients' genomic DNA revealed three known genetic variants in the coding region of the AR gene: one nonsynonymous single-nucleotide polymorphism (SNP; rs78686797) encoding Leu57Gln, and two variants of polymorphic trinucleotide repeat segments that encode polyglutamine (CAG repeat; rs5902610) and polyglycine (GGC repeat; rs3138869) tracts. Notably, the Leu57Gln polymorphism was found in two patients with MA from 24 MA patients, whereas no variants were found in 142 healthy male controls. However, the numbers of CAG and GGC repeats in the AR gene were within the normal range. These data suggest that the Leu57Gln polymorphism encoded by the X-linked AR gene may contribute to the development of MA.

• 대한임베디드공학회논문지
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• 제10권5호
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• pp.281-296
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• 2015

This paper describes a novel disaster evacuation system using embedded systems such as smart devices for crisis and emergency management. In indoor environments deployed with the Bluetooth Low Energy(BLE) beacons, smart devices detect their indoor positions from beacon messages and interact with Map Server(MS) and Route Server(RS) in the Internet over the LTE and/or Wi-Fi functions. The MS and RS generate an optimal path to the nearest emergency exit based on a novel graph generation method for less route computation, called the Disaster Evacuation Graph(DEG), for each smart device. The DEG also enables efficient processing of some constraints in the computation of route, such as load balancing in situation of different capacities of paths or exits. All data interfaces among three system components, the MS, RS, smart devices, have been defined for modular implementation of our disaster evacuation system. Our experimental system has been deployed and tested in our building thoroughly and gives a good evidence that the modular design of the system and a novel approach to compute emergency route based on the DEG is competitive and viable.

• 항공우주기술
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• 제10권2호
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• pp.82-86
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• 2011

본 논문에서는 통신해양기상위성의 TM 안테나[2.290 GHz]에 의해 발생된 RF가 발사체 PROTON M/Breeze M long 패어링 안에서 형성되는 전기장의 세기를 예측한다. 위성이 TM을 내보내기 위해 의도적으로 방사하는 전기장의 세기는 PROTON M / BREEZE M 패어링의 특성을 고려함으로써 예측될수 있다. 다른 정지궤도 발사체는 PROTON의 패어링과 유사한 특성을 갖기 때문에, 예측된 결과가 다른 발사체에도 적용될 것이라 예상된다. 해석결과로써, 패어링내의 전기장의 세기는 위성 본체와는 전자파 적합성 요구사항을 만족하나, 발사체 PROTON M/Breeze M과는 전자파 적합성 요구사항을 만족하지 못한다.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2004년도 하계학술대회 논문집 Vol.5 No.1
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• pp.369-372
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• 2004

The characteristics of antimony implants are relatively well-known. Antimony has lower diffusion coefficient, shorter implantation range, and smaller scattering as compared with conventional dopants such as phosphorous and arsenic. It has been commonly used in the doping of buried layer in Bi-CMOS process. In this paper, characteristics and appropriate condition of monitoring in antimony implant beam tuning using $Sb_2O_3$ were investigated to get a reliable process. TW(Thema Wave) and Rs(Sheet Resistance) test were carried out to set up condition of monitoring for stable operation through the periodic inspection of instruction condition. The monitoring was progressed at the point that the slant of Rs varied significantly to investigate the variation of instruction accurately.

• Asian-Australasian Journal of Animal Sciences
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• 제11권5호
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• pp.586-596
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• 1998

The relevance and importance of buffalo production under coconut plantations in the North Westen Province of Sri Lanka was studied in three districts (Bingiriya, Pannala, Kuliyapitiya). The objective of the study was to collect baseline information on socioeconomic and cultural aspects of buffalo production, with a view to promote and disseminate new technologies. The survey technique used consisted of a formal survey using a structured questionnaire (71 households) and rapid appraisal (55 households). The results indicate the existence of a wide stratification of dariy farmers which ranged from skilled dairy operators with high levels of production and management of efficiency to marginal subsistence farmers with low levels of productivity. The most frequent family size of households ranged from 4-5 members (58%), and the average family size was 4.7. The actual average land ownership accounts to 2.4 ha of upland and 0.5 ha of lowland, but when their accessibility to common property resources are taken into account, the land availability was assessed at 13 ha and 0.7 ha of upland and lowland, respectively. The highest average monthly income (Rs. 13,590) was received by farmers with off-farm employment (primary) who are also engaged in livestock production (secondary), and livestock contributed 43% of the total income. Livestock farmers who practised integrated crop farming as a secondary source of income received a monthly income of Rs. 10,843, and those involved in crop production as the primary source received the lowest average income (Rs. 7,295). The survey revealed a high investment cost on concentrate feeds (47%) for milk production. However some farmers obtained higher milk yields (11 litres/cow/day) at lower ration costs, and this could be attributed to the entrepreneurship skills and management efficiency. The study area had a well developed market infrastructure for fresh milk, principally due to the existence of the Nestle's company and the Coconut Triangle Milk Union. On an average the producer collected Rs. 10 per litre of milk marketed.

• 원예과학기술지
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• 제31권3호
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• pp.299-307
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• 2013

A radish (Raphanus sativus L.) polygalacturonase-inhibiting protein (PGIP) gene was cloned and compared to the PGIP gene (BrPGIP2) from Chinese cabbage (Brassica rapa ssp. pekinensis) in order to gain more information on controlling a disease and improving produce quality. To clone the radish PGIP gene, primers were designed based on conserved sequences of two PGIP genes (BnPGIP1 and BnPGIP2) from rape (B. napus L. ssp. oleifera), Chinese cabbage and Arabidopsis thaliana. PCR cloning was performed with cDNA from the stigma of radish 'Daejinyeoreum' as a template to confirm DNA fragments which were about 600 base pair in size. Sequence analysis revealed 84.1% homology with BrPGIP2 and 70.1% with BnPGIP1. DNA walking was conducted to confirm the open reading frame of 972 bp, and the gene was named RsPGIP1. RsPGIP1 consisting with 323 amino acids (aa) has a high leucine content (54/323) and contains 10 leucine-rich repeat domains, as do most BrPGIPs of Chinese cabbage. The gene expression of RsPGIP1 was induced by abiotic stresses and methyl jasmonate. It showed enrichment in the stigma and the primary root than a leaf. Cloning RsPGIP1 will aid to further apply practices on postharvest quality maintenance and disease control of the root.

• 한국정보통신학회논문지
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• 제20권5호
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• pp.923-930
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• 2016

상 하수도, 해양플랜트 등 다양한 배관이 산업현장에 이용되고 있으며, 이러한 배관의 유지보수 작업은 필수적이다. 특히 산업현장에서 배관 유지보수 작업은 전문 인력이 배관 내 투입되어 작업이 진행되거나, 인력 투입이 불가능한 경우 와이어에 연결된 스크래퍼를 배관에 삽입하는 방식을 이용한다. 그러나 이 방식은 교통체증, 막대한 예산의 투입 등의 문제를 야기한다. 이런 문제점을 해결하기 위한 배관 청소 로봇의 연구, 개발이 진행되고 있다. 현재 배관청소 로봇은 작업 및 운용 상태를 실시간으로 확인할 수 없는 문제점이 있다. 본 논문에서는 배관 청소로봇의 운용, 배관 내부 및 청소 상태를 확인할 수 있도록 카메라로부터 촬영된 영상을 수집하며, 수집된 데이터는 RS-485 통신을 이용하여 모니터링 시스템에 전송하여 사용자가 실시간으로 상태를 확인할 수 있게 구성하였다.

• 한국정밀공학회지
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• 제33권10호
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• pp.821-828
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• 2016

Recently, the use of composite materials in the defense system has grown dramatically. The strength/weight and stiffness/weight ratios of composite structures are normally higher than of metals. Woven composites, especially, are increasingly considered for a variety of applications, because they offer good workability for complicated structures. HPW193/RS1222 is one of the most famous woven composites and has been used in many types of Korean military equipment, such as antenna pedestals and radar systems. In this study, we predicted the elastic modulus of HPW193/RS1222 using the principles of unidirectional composite stiffness predictions, such as ROM (Rule of Mixture), HSR (Hart Smith 10% Rule), CLA (Classical Laminate Analysis) and LAP (Laminate Analysis Program). We compared the dynamic characteristics with the experimental predictions and finite-element analysis (FEA). From our results we concluded that transversely isotropic materials are similar to isotropic materials when the shape of the composite structure is complicated.

• Journal of Pharmaceutical Investigation
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• 제37권3호
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• pp.193-196
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• 2007

This study aimed to evaluate and develop $Eudragit^{(R)}$-coated pellets based on the dissolution using the paddle method. As coating materials, two types of $Eudragit^{(R)}$ were applied to obtain either sustained release form or fast released form. The dissolution test was carried out in phosphate buffer solution (pH 6.5) at $37^{\circ}C$, 100 rpm. In order to develop a sustained release preparation containing felodipine, a comparative dissolution study was done using commercial product as a control. The dissolution at 30 min of felodipine from $Eudragit^{(R)}$ RS or RL-coated pellets were 0.96% and 99.65, respectively. The weight ratio of $Eudragit^{(R)}$ RL pellets to RS pellets altered the dissolution rate, but did not optimize the dissolution rate. However, the sustained dissolution of felodipine from pellets was optimized by varying the coating ratios of $Eudragit^{(R)}$ RS. It is suggested that the coating ratio of pellets is the main factor which controls dissolution rate. Taken together, $Eudragit^{(R)}$ RS 30D-coated pellets showed the most comparable dissolution rate pattern to commercial product, $Splendil^{(R)}$. This sustained release pellets for oral delivery system of felodipine was simply manufactured, and drug release behavior was highly reproducible.

• 응용통계연구
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• 제24권3호
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• pp.523-533
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• 2011

위험관리수단으로 시장위험을 정확하게 측정하는 방법 중의 하나로 VaR를 선호한다. 현실생활에서는 단일분포가 아닌 두 개 이상의 다변량분포에 대한 VaR를 추정해야 하는 경우가 많다. 이런 경우에는 VaR를 추정하기 위해 다변량분포를 고려해야 한다. 본 연구는 확률변수들의 종속적 구조를 파악하고 비정규성의 특성을 갖는 다변량 분포함수를 생성하기 위하여 Copula 함수를 사용한다. 여러 산업의 수익률분포에 적합한 Clayton, Gumbel, Frank Copula 함수가 포함된 Archimedean Copula 함수를 추정하여 다변량 수익률 분포함수를 결정하고 이에 대응하는 VaR를 유도한다. 국내의 두 산업체의 자료를 실증예제로 하여 세 종류의 Copula 함수의 모수를 추정하고 이에 대응하는 이변량 분포로부터 VaR와 각각의 주변 분포의 VaR를 구한다. 실제의 VaR를 기준으로 기존 방법으로 구한 VaR와 비교 분석하여 추정의 정확성을 토론한다.