• 한국국방경영분석학회지
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• 제35권2호
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• pp.63-76
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• 2009

IT와 과학 기술의 비약적인 발전으로 미래전의 양상도 바뀌고 있으며 이에 따라 효과적인 군수지원의 중요성이 부각되고 있다. 본 연구에서는 최근 부각되고 있는 통합 물류창고 중 자동창고를 중심으로 S/R machine의 운영문제를 Travel Time에 기반을 둔 수리적 분석과 AutoMod를 이용한 시뮬레이션으로 수리적 분석의 타당성을 검증하였다. 이에 따라 자동창고의 S/R machine의 개선된 정주위치 고려와 재고회전 빈도에 따른 운용성능을 분석할 수 있었다.

• Clinical and Experimental Pediatrics
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• 제54권8호
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• pp.335-339
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• 2011

Purpose: Hyperhomocysteinemia is known as a risk factor for atherosclerosis. Preclinical arteriosclerosis is noted and premature atherosclerosis is known to be accelerated in Kawasaki disease (KD) patients. Genetic polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene result in elevated plasma homocysteine concentrations and are known to be associated with the development of coronary artery disease. Our hypothesis is that single nucleotide polymorphisms (SNPs) of the MTHFR gene are related to the development of KD and coronary artery lesions (CALs). Methods: For this study, we selected 3 candidate single nucleotide polymorphisms (SNPs) (rs2274976, rs1801131, and rs1801133) of MTHFR. These SNPs are located on chromosome 1p36.3. We included 101 KD patients and 306 healthy adults as controls in this study. CALs were seen in 38 patients. Genotypes of the selected SNPs were determined by direct sequencing and analyzed with SNPAlyze. Results: The genetic distribution and allelic frequency of the 3 MTHFR SNPs (rs2274976, rs1801131, and rs1801133) were not significantly different in patients with KD compared to the control group (P=0.71, 0.17, and 0.96, respectively). There was no difference in the genetic distribution of the MTHFR SNPs between the normal control group and the CAL group (P=0.43, 0.39, 0.52 respectively). Conclusion: The genetic distribution of the MTHFR SNPs (rs2274976, rs1801131, and rs1801133) was not different in the KD group compared to the control group. In addition, the genetic distribution of these SNPs was not different in the CAL group compared to the control group in the Korean population.

• 대한전자공학회논문지SD
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• 제45권2호
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• pp.101-111
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• 2008

본 논문은 40Gb/s급 광통신 시스템에서 사용되는 고속 리드-솔로몬(RS) 복호기의 하드웨어 면적을 줄인 새로운 구조를 소개하고 RS 복호기 기반의 고속 FEC구조를 제안한다. 특히 높은 데이터처리율과 적은 하드웨어 복잡도를 가지고 있는 차수 연산 블록이 제거된 pDCME 알고리즘 구조를 소개한다. 제안된 16채널 RS FEC구조는 8개의 신드롬 계산 블록이 1개의 KES 블록을 공유하는 8 채널 RS FEC구조 2개로 구성되어 있다. 따라서 4개의 신드롬 계산 블록에 1개의 KES블록을 공유하는 기존의 16채널 3-병렬 FEC 구조와 비교하여 하드웨어 복잡도를 약 30%정도 줄일 수 있다. 제안된 FEC 구조는 1.8V의 공급전압과 $0.18-{\mu}m$ CMOS 기술을 사용하여 구현하였고 총 250K개의 게이트수와 5.1Gbit/s의 데이터 처리율을 가지고 400MHz의 클럭 주파수에서 동작함을 보여준다. 제안된 면적 효율적인 FEC 구조는 초고속 광통신뿐만 아니라 무선통신을 위한 차세대 FEC 구조 등에 바로 적용될 수 있을 것이다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.5929-5934
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• 2013

Background: Primary brain tumors constitute a small percent of all malignant cancers, but their etiology remains poorly understood. ${\beta}3$ integrin (ITGB3) has been recognized to play influential roles in angiogenesis, tumor growth and metastasis. Intercellular adhesion molecule-1 (ICAM-1) is a surface glycoprotein important for tumor invasion and angiogenesis. The aim of this study was to investigate whether specific genetic polymorphisms of ICAM-1 and ITGB3 could be associated with brain cancer development and progression in a Turkish population. Our study is the first to our knowledge to investigate the relationship between brain tumor risk and ICAM-1 and ${\beta}3$ integrin gene polymorphisms. Materials and Methods: The study covered 92 patients with primary brain tumors and 92 age-matched healthy control subjects. Evaluation of ${\beta}3$ integrin (Leu33Pro (rs5918)) and ICAM-1 (R241G (rs1799969) and K469E (rs5498)) gene polymorphisms was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: According to results of our research, the A allele of the ICAM-1 R241G gene polymorphism appeared to be a risk factor for primary brain tumors (p<0.001). Similarly, the frequency of the A mutant allele of ICAM-1 R241G was statistically significant in patients with brain tumors classified as glioma (p<0.001). When allele and genotype distributions of ICAM-1 K469E, ICAM-1 R241G and ${\beta}3$ integrin Leu33Pro gene polymorphisms were evaluated with age, sex, and smoking, there were no statistically significant differences. Haplotype analysis revealed that the frequencies of GAC (rs1799969-rs5498-rs5918) and GAT (rs1799969-rs5498-rs5918) haplotypes were significantly lower in patients as compared with controls (p=0.001; p=0.036 respectively). Conclusions: This study provides the first evidence that ICAM-1 R241G SNP significantly contributes to the risk of primary brain tumors in a Turkish population. In addition, our results suggest that ICAM-1 R241G in combination ICAM-1 K469E may have protective effects against the development of brain cancer.

• 환경영향평가
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• 제23권5호
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• pp.337-352
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• 2014

본 연구의 목적은 우리나라의 대표적 환경축제인 함평나비축제를 대상으로 환경축제가 지역주민의 충성도 제고라는 측면에서 지향해야 할 방향과 과제를 모색하는 것이다. 이에 지역주민을 대상으로 지역사회 애착도와 같은 축제의 외생적 요인과 축제의 경제 효과, 개최자와 지역주민 간의 의사소통, 그리고 지역주민의 축제 참여의사 같은 내생적 요인이 축제의 만족도 및 충성도에 미치는 영향과 경로를 구조 방정식모형을 통해 분석하였다. 분석 결과 애착도, 참여의사, 의사소통은 축제의 만족도에 정(+)의 영향을 미치고, 이 중 애착도는 충성도에도 정(+)의 영향을 미치며, 만족도는 충성도에 정(+)의 영향을 미칠 것이라는 본 연구의 가설은 유의수준 0.05에서 통계적으로 유의한 것으로 판명되었다. 다만 경제 효과는 연구가설과는 달리 만족도에 별다른 영향을 주지 않는 것으로 분석되었다. 한편 충성도에 미치는 총 영향력은 애착도, 의사소통, 참여의사 보다 만족도가 월등히 높은 것으로 나타났다. 그러므로 충성도 제고를 위해서는 원천적으로 애착도 제고, 의사소통 활성화, 참여의사 제고가 긴요하겠지만 이는 장기적으로 꾸준히 추진해야 할 과제일 것이며 단기적으로는 무엇보다도 만족도 제고에 노력하여야 한다.

• 한국산학기술학회논문지
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• 제11권7호
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• pp.2349-2357
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• 2010

본 논문은 물류 정보시스템과 관련된 자동입출고 시스템의 실행 및 최적화에 관한 것이다. 논문은 우선 문헌연구와 이에 따른 사례연구를 제시하고 있다. 사례연구에서는 기업의 프로세스를 분석한 다음 자동입출고 시스템의 실행 및 활용에 대해 조사하였다. 물류정보시스템은 글로벌 환경에서 경쟁력을 유지하기 위해 주요한 구성요소이며 사례연구에서의 기업은 효율적인 물리적 배분관리에 적용하였다. 자동입출고시스템은 저장공간을 극대화하고 생산성 증가, 정확성을 증가시키는 것으로 판명되고 특히 비좁은 통로와 높은 저장선반의 경우 효과적임을 보여주었다.

• 한국시뮬레이션학회논문지
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• 제32권4호
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• pp.11-18
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• 2023

본 연구는 자동차 공장의 혼류생산을 위한 자동창고시스템에서 저장과 반출 작업을 수행하는 트윈크레인 간 협업(Handshake) 위치 시뮬레이션 분석을 수행한다. Handshake 운영은 트윈크레인의 작업영역 구분을 통해 경로 간섭과 각 크레인의 이동 거리를 개선한다. 그러나 Handshake 위치로 구분된 작업영역 간 부품 이송을 위해 Handshake 위치에서 추가적인 부품 적재와 하역 작업이 발생한다. 그러므로 저장 및 반출 요청 응답시간을 개선하기 위한 효과적인 Handshake 위치 결정이 필요하다. 시뮬레이션 실험을 통해 최적 Handshake 위치를 결정하였으며 평균 입고 요청 응답시간이 87% 개선됨을 확인하였다.

• Preventive Nutrition and Food Science
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• 제3권4호
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• pp.303-308
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• 1998

Influence of amylose content on formation and characteristics of enzyme-resistant starch (RS) was investigated by scanning electron microscopy, X-ray diffractometry and differential scanning calorimetry. RS yield increased up to 36.1 % as the amylose content of corn starch increased. Starch granules of Amyulomaize V and Ⅶ were more rounded and smaller than those of regular corn ; some were elongated and had appendages. After autoclaving -cooling cycles, the granular structure disappeared and a continous spongy-like porous network was visible in regular corn starch ; the granular structure was stillevident in parts in Amylomaize V and Ⅶ starches. In all isolated RS residues , the porous structures were no longer visible and more compact formations predominated. While regular corn starch showed an A-type X-ray profile, Amylomaize V and Ⅶ starches exhibited a combination of B- and V-types. Regular corn starch lost most of its crystallinity during autoclaving , but the crystallinity was still left in Amylomaize starches as diffuse or poor B-types. All RS residues showed the presence of poor B-type regardless of amylose contents. Transition temperatures and enthalypy of native starches were a little higher in Amylomaize V and Ⅶ starches than those of regular corn starch . Regardless of amylose contents, all RS residues exhibited an endothermic transition over a similar temperature range (135 $^{\circ}C$~169$^{\circ}C$), with a mean peak temperature of ~154$^{\circ}C$, which is generally foud for retrograded amylose crystallities. Higher transition temperature, enthalypy, and RS yield of AMylomaize V and Ⅶ starches were related granular stability shown by the microscopic and crystallographic studies.

• Journal of Gastric Cancer
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• 제20권2호
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• pp.127-138
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• 2020

Purpose: Mucin 1 (MUC1) was identified as a gastric cancer (GC) susceptibility gene by genome-wide association studies in Asians and candidate gene studies in Europeans. This study aimed to investigate the association between the MUC1 rs4072037 polymorphism and GC in terms of the Lauren classification and long-term clinical outcomes. Materials and Methods: A total of 803 patients with GC and 816 unrelated healthy controls were enrolled in the study. The association between the MUC1 rs4072037 variant and GC histological types and clinical outcomes, including tumor recurrence and prognosis was investigated. Results: The major A allele of rs4072037 was associated with increased GC risk (P<0.05). In subtype analysis, the association was most significant for diffuse-type GC (P<0.05) and in a dominant model (P<0.05), whereas there was no association with intestinal-type GC (P>0.05). Cox proportional hazards analysis revealed the heterozygote AG rs4072037 allele as an independent risk factor influencing tumor recurrence and disease-related death in diffusetype GC (P<0.05). but not in intestinal-type GC (P>0.05). Conclusions: The exonic single nucleotide polymorphism rs4072037 in MUC1 was associated with diffuse-type GC and was an independent risk factor influencing tumor recurrence and disease-related death in diffuse-type GC.

• Asian Pacific Journal of Cancer Prevention
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• 제16권5호
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• pp.1939-1944
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• 2015

MicroRNA-27a (miR-27a) is deemed to be an oncogene that plays an important role in development of various cancers, and single nucleotide polymorphism (SNP) of miR-27a can influence the maturation or aberrant expression of hsa-miR27a, resulting in increased risk of cancer and poor prognosis for non-small cell lung cancer (NSCLC). This study aimed to assess the effects of rs895819 within miR-27a on susceptibility and prognosis of NSCLC patients in 560 clinical confirmed cases and 568 healthy check-up individuals. Adjusted odds/hazard ratios (ORs/HRs) and 95% confidential intervals (CIs) were calculated to evaluate the association between rs895819 and the risk and prognosis of NSCLC. The results showed that allele A and genotype GG of rs895819 were significantly associated with an increased risk of NSCLC (38.9% vs 30.8%, adjusted OR=1.26, 95%CI=1.23-1.29 for allele G vs A; 18.1% vs 11.7%, adjusted OR=1.67, 95%CI=1.59-1.75 for genotype GG vs AA). Moreover, positive associations were also observed in dominant and recessive models (53.7% vs 49.9%, adjusted OR=1.17, 95%CI=1.13-1.20 for GG/AG vs AA; 18.1% vs 11.7%, adjusted=1.65, 95%CI=1.58-1.73). However, no significant association was found between rs895819 and the prognosis of NSCLC in genotype, dominant and recessive models. These results suggested that miR-27a might be involved in NSCLC carcinogenesis, but not in progression of NSCLC. The allele G, genotype GG and allele G carrier (GG/AG vs AA) of rs895819 might be genetic susceptible factors for NSCLC. Further multi-central, large sample size and well-designed prospective studies as well as functional studies are warranted to verify our findings.