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http://dx.doi.org/10.3345/kjp.2011.54.8.335

Polymorphisms of methylenetetrahydrofolate reductase are not a risk factor for Kawasaki disease in the Korean population  

Yoon, Kyung-Lim (Department of Pediatrics, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine)
Ko, Jin-Hee (Department of Pediatrics, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine)
Shim, Kye-Shik (Department of Pediatrics, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine)
Han, Mi-Young (Department of Pediatrics, Kyung-Hee University Medical Center, Kyung Hee University School of Medicine)
Cha, Sung-Ho (Department of Pediatrics, Kyung-Hee University Medical Center, Kyung Hee University School of Medicine)
Kim, Su-Kang (Department of Clinical Pharmacology, Kyung Hee University School of Medicine)
Jung, Joo-Ho (Department of Clinical Pharmacology, Kyung Hee University School of Medicine)
Publication Information
Clinical and Experimental Pediatrics / v.54, no.8, 2011 , pp. 335-339 More about this Journal
Abstract
Purpose: Hyperhomocysteinemia is known as a risk factor for atherosclerosis. Preclinical arteriosclerosis is noted and premature atherosclerosis is known to be accelerated in Kawasaki disease (KD) patients. Genetic polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene result in elevated plasma homocysteine concentrations and are known to be associated with the development of coronary artery disease. Our hypothesis is that single nucleotide polymorphisms (SNPs) of the MTHFR gene are related to the development of KD and coronary artery lesions (CALs). Methods: For this study, we selected 3 candidate single nucleotide polymorphisms (SNPs) (rs2274976, rs1801131, and rs1801133) of MTHFR. These SNPs are located on chromosome 1p36.3. We included 101 KD patients and 306 healthy adults as controls in this study. CALs were seen in 38 patients. Genotypes of the selected SNPs were determined by direct sequencing and analyzed with SNPAlyze. Results: The genetic distribution and allelic frequency of the 3 MTHFR SNPs (rs2274976, rs1801131, and rs1801133) were not significantly different in patients with KD compared to the control group (P=0.71, 0.17, and 0.96, respectively). There was no difference in the genetic distribution of the MTHFR SNPs between the normal control group and the CAL group (P=0.43, 0.39, 0.52 respectively). Conclusion: The genetic distribution of the MTHFR SNPs (rs2274976, rs1801131, and rs1801133) was not different in the KD group compared to the control group. In addition, the genetic distribution of these SNPs was not different in the CAL group compared to the control group in the Korean population.
Keywords
Hyperhomocysteinemia; Coronary artery lesion; Kawasaki disease; Methylenetetrahydrofolate reductase; Polymorphism;
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