• 대한족부족관절학회지
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• 제17권4호
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• pp.329-333
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• 2013

Controversies exist regarding the treatment options for the end-stage arthritic change in the lateral tarsometatarsal joints. Arthrodesis has been frequently performed, but has a disadvantage of sacrificing a mobile joint. Resection arthroplasty also gained its popularity, especially in the patients with Rheumatoid arthritis, but possible hypermobility can lead to deformity. We report a successful clinical outcome of a patient with Rheumatoid arthritis in the 4th, 5th tarsometatarsal joints treated with tendon interpositional arthroplasties.

• The Journal of Korean Physical Therapy
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• 제31권5호
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• pp.317-321
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• 2019

Purpose: To identify the effect of knee joint traction therapy on pain, physical function, and depression in patients with degenerative arthritis. Methods: In total, 30 patients with degenerative arthritis were randomly assigned to one of two groups: the experimental group, who underwent knee joint traction therapy, and the control group, who underwent general physical therapy (15 patients per group). Pain was measured using the visual analogue scale (VAS), physical function was measured using the Western ontario and McMaster universities osteoarthritis (WOMAC) index, and depression was measured using the Beck depression inventory (BDI). The VAS, WOMAC score, and BDI score were recorded before and after the 4-week treatment. Results: As a result of comparison within groups, the experimental and control group showed significant difference for VAS, WOMAC and BDI after the experiment (p<0.05). In comparison between the two groups, the experimental group in which knee joint traction was applied showed more significant change in VAS, WOMAC and BDI than the control group (p<0.05). Conclusion: This study showed that knee joint traction therapy was effective in improving pain, physical function, and depression in patients with degenerative arthritis.

• 근관절건강학회지
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• 제25권3호
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• pp.240-249
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• 2018

Purpose: This study was to identify the attributes, antecedents, their consequences, and empirical indicators of rehabilitation motivation in rheumatoid arthritis patients. Methods: Walker and Avant's method was used to analyze the concept. Articles published after 1990 were searched in Medline, CINAHL, NSDL, and RISS databases using "rehabilitation", "motivation" and their combination as keywords. Results: The attributes of rehabilitation motivation are: 1) certitude and trust toward rehabilitation treatment; 2) confidence in the rehabilitation process; 3) efforts and commitments to achieve health goals; 4) psychological needs to act toward health recovery. Its antecedents include: 1) rights of self-determination; 2) goal setting and goal-oriented attitude; 3) personal needs; 4) getting rewards; 5) social and family support; 6) professional behavior of healthcare providers; and 7) least risks or costs for actions taken. Conclusion: The study results could be used as a conceptual framework for developing tools to measure the motivation of rheumatoid arthritis patients.

• 대한족부족관절학회지
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• 제25권4호
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• pp.190-194
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• 2021

A bursa is an obstructive sac filled with synovial fluid and usually occurs in any area of the body exposed to friction. The bursa of the ankle is not a normal anatomical structure and is caused by repetitive trauma, constant friction, or inflammatory disease of the ankle. Bursitis can occur in any bursa in the human body; however it rarely progresses to septic arthritis. We report a rare case of septic ankle arthritis following intractable lateral malleolar bursitis successfully treated with negative-pressure wound therapy.

• IMMUNE NETWORK
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• 제16권1호
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• pp.44-51
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• 2016

Dendritic cells (DCs) are professional antigen presenting cells, and play an important role in the induction of antigen-specific adaptive immunity. However, some DC populations are involved in immune regulation and immune tolerance. These DC populations are believed to take part in the control of immune exaggeration and immune disorder, and maintain immune homeostasis in the body. Tolerogenic DCs (tolDCs) can be generated in vitro by genetic or pharmacological modification or by controlling the maturation stages of cytokine-derived DCs. These tolDCs have been investigated for the treatment of rheumatoid arthritis (RA) in experimental animal models. In the last decade, several in vitro and in vivo approaches have been translated into clinical trials. As of 2015, three tolDC trials for RA are on the list of ClinicalTrial.gov (www.clinicaltrials.gov). Other trials for RA are in progress and will be listed soon. In this review, we discuss the evolution of tolDC-based immunotherapy for RA and its limitations and future prospects.

• 대한근관절건강학회:학술대회논문집
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• 대한근관절건강학회 2003년도 제19회 추계 학술대회
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• pp.223-227
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• 2003

• 동의생리병리학회지
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• 제21권1호
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• pp.62-69
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• 2007

To evaluate effect of CYTG on inhibiting the occurrence of arthritis, we performed the experiments including production of inflammatory cytokine and immunoglobulin in collagen arthritis model. The results were obtained as fellows. CYTG group showed inhibitory effect on arthritis incidence than control group for four weeks. Arthritis index of CYTG group reduced compared with control group. In CYTG group, production of cytokines which show suppressive effect on inflammation(IL-2, COX-2) was increased and which promotes inflammation(IL-10) was decreases in spleen. In CYTG group, production of immunoglobulin (IgG-RF) was reduced compared with control, and rate of CD3+CD69+T cell is lower in lymph node and CD4+CD25+ T cell is higher in lymph node and spleen. And synovial infiltration in the knee were observed in the controls (PBS-treated mice), whereas CYTG-treated mice exhibited significantly reduced histologic evidence of destruction and inflammation. So, the histopathological scoring average of CYTG group was 2.5 compared with control group(CIA mice) 4.5. It was thought that our data express high effect via immune system specially through the controling the inflammatory cytokines and immunoglobulins. CYTG could be usefully applied for the prevention and treatment of RA, and also is expected to be clinically helpful on the treatment of RA through modification.

• IMMUNE NETWORK
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• 제11권5호
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• pp.299-306
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• 2011

Background: $CD4^+Fop3^+$ regulatory T cells (Tregs) are needed to maintain peripheral tolerance, but their role in the development of autoimmune arthritis is still debated. The present study was undertaken to investigate the mechanism by which Tregs influence autoimmune arthritis, using a mouse model entitled K/BxN. Methods: We generated Treg-deficient K/BxNsf mice by congenically crossing K/BxN mice with Foxp3 mutant scurfy mice. The arthritic symptoms of the mice were clinically and histopathologically examined. The proportions and activation of $CD4^+$ T cells and/or dendritic cells were assessed in the spleens, draining lymph nodes and synovial tissue of these mice. Results: K/BxNsf mice exhibited earlier onset and more aggressive progression of arthritis than their K/BxN littermates. In particular, bone destruction associated with the influx of numerous RANKL+ cells into synovia was very prominent. They also contained more memory phenotype $CD4^+$ T cells, more Th1 and Th2 cells, and fewer Th17 cells than their control counterparts. Plasmacytoid dendritic cells expressing high levels of CD86 and CD40 were elevated in the K/BxNsf synovia. Conclusion: We conclude that Tregs oppose the progression of arthritis by inhibiting the development of $RANKL^+$ cells, homeostatically proliferating $CD4^+$ T cells, Th1, Th2 and mature plasmacytoid dendritic cells, and by inhibiting their influx into joints.

• The Korean Journal of Physiology and Pharmacology
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• 제19권2호
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• pp.83-88
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• 2015

CD4+CD25+ regulatory T cells (CD4+CD25+ Tregs) have been shown to play a regulatory or suppressive role in the immune response and are possibly relevant to the pathogenesis of autoimmune diseases. In the present study, we attempted to investigate the frequency of CD4+CD25+ Tregs in peripheral blood (PB) of collagen-induced arthritis (CIA) rats during the development of arthritis, to determine whether their frequency is involved in the immunoregulation of this disease. The results showed that normal rats had similar frequencies of CD4+CD25+ Tregs in PB during the experiment time, expressed as a percentage of CD4+CD25+Foxp3+ T cells among the CD4+ T lymphocyte population. In contrast, the frequency of CD4+CD25+Foxp3+ T cells in CIA rats was found to change during the development of arthritis. In CIA rats, there is a significant negative correlation between the frequency of CD4+CD25+Foxp3+ T cells and paw swelling (r=-0.786, p< 0.01). The relationship between the frequency of CD4+CD25+Foxp3+ T and immune activation was not found in normal rats. During the time course, the frequency of CD4+CD25+Foxp3+ T was lower in CIA rats than in normal ones. The data suggest that the frequency of PB CD4+CD25+ Tregs may be a promising marker for arthritis activity.

• Journal of Acupuncture Research
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• 제20권6호
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• pp.13-26
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• 2003

Background and Objectives: Bee venom therapy is a new acupuncture theraphy using both acupuncture effect and a medical effect that the biochemical peculiar material affects body. The bee venom theraphy is efficacious of injecting region of disease and acupoint with extracting bee venom from bee and processing it. There have been more than 20 dissertations in Korea about bee venom and the bee venom research has actively been carrying done in other countries such as US, China, Russia, Northern Europe since 1980s. This paper is to understand the trend of arthritis and bee venom, and will be contributed to further bee venom study by analyzing local and international theses. Material and Method: This paper is reported by analyzing the dissertations regarding arthritis and bee venom of Korea and other countries and referencing PubMed. The reference terminology is as follows. bee venom, bee venom therapy, apitoxin, apitherapy, bee sting, bee sing therapy, arthritis, rheumatoid, rheumatic arthritis and so on. Results and Conclusions: The following result have been obtained. 1. Bee venom has an effect on both in vivio and in vitro of arthritisthis with suppressing inflammation, fever and pain. 2. Occasionally bee venom may induce either pain or inflammation. 3. Bee venom induces acute pain in healthy condition, while it suppresses inflammation and pain in regional inflammation state. 4. Bee venom may either induce or suppress pain and inflammation according to the used dosage.