Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Suppressive Effect of CYTG on Collagen Induced Arthritis(CIA) in DBA1/J Mice

CYTG 처방이 콜라겐 유발 관절염 모델에 미치는 효과

  • Choi, Sung-Wook (Department of Physiology of Oriental Medicine, Daejeon University) ;
  • Kim, Yong-Chan (Department of Physiology of Oriental Medicine, Daejeon University) ;
  • Kim, Kyoung-Shin (Department of Physiology of Oriental Medicine, Daejeon University) ;
  • Kim, Byoung-Soo (Department of Physiology of Oriental Medicine, Daejeon University) ;
  • Lim, Jong-Soon (Institute of Traditional Medicine and Bioscience, Daejeon University) ;
  • Kang, Jung-Soo (Department of Physiology of Oriental Medicine, Daejeon University)
  • 최성욱 (대전대학교 한의과대학 생리학교실) ;
  • 김용찬 (대전대학교 한의과대학 생리학교실) ;
  • 김경신 (대전대학교 한의과대학 생리학교실) ;
  • 김병수 (대전대학교 한의과대학 생리학교실) ;
  • 임종순 (대전대학교 동서생명과학연구원) ;
  • 강정수 (대전대학교 한의과대학 생리학교실)
  • Published : 2007.02.25
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Abstract

To evaluate effect of CYTG on inhibiting the occurrence of arthritis, we performed the experiments including production of inflammatory cytokine and immunoglobulin in collagen arthritis model. The results were obtained as fellows. CYTG group showed inhibitory effect on arthritis incidence than control group for four weeks. Arthritis index of CYTG group reduced compared with control group. In CYTG group, production of cytokines which show suppressive effect on inflammation(IL-2, COX-2) was increased and which promotes inflammation(IL-10) was decreases in spleen. In CYTG group, production of immunoglobulin (IgG-RF) was reduced compared with control, and rate of CD3+CD69+T cell is lower in lymph node and CD4+CD25+ T cell is higher in lymph node and spleen. And synovial infiltration in the knee were observed in the controls (PBS-treated mice), whereas CYTG-treated mice exhibited significantly reduced histologic evidence of destruction and inflammation. So, the histopathological scoring average of CYTG group was 2.5 compared with control group(CIA mice) 4.5. It was thought that our data express high effect via immune system specially through the controling the inflammatory cytokines and immunoglobulins. CYTG could be usefully applied for the prevention and treatment of RA, and also is expected to be clinically helpful on the treatment of RA through modification.

Keywords

References

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