• Journal of Chest Surgery
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• v.41 no.1
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• pp.106-109
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• 2008

Multiple coronary aneurysms are rare in adults. The cause may be atherosclerosis, congenital malformations, post-traumatic or post-syphilitic vascular lesions, connective tissue diseases like Marfan and Ehler-Danlos syndromes or Kawasaki disease, all of which cause weakening of the media. Surgical intervention is indicated to prevent rupture, embolization or compression symptoms. The successful management of multiple coronary artery. aneurysms, associated with previous rupture and arrhythmia, originating from proximal potions of ramus intermedius and left circumflex artery are reported.

• Science of Emotion and Sensibility
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• v.1 no.2
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• pp.13-22
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• 1998

The sense of touch has both objective and subjective characteristics. During hand evaluation of the fabrics. psycho physiological processes such as emotion and stimulation. On other site, the mode of touch (passive vs. active) is also capable to modulate somatosensory responses. I.e., suppress somatocensory perception during active electrocortical responses to passive and active touch of the textiles with different subjective emotional preference. The study was carried out on 36 female college students. Physiological signals were acquired by Grass and BIOPAC 100 systems with AcqKnowledge variables, namely heart rate (HR), respiratory sinus arrhythmia (RSA), pulse transit time (PTT), respiration rate (RSP) and skin conductance parameters (SCL, amplitude, risetime and number of SCRs) were analyzed for baseline and stimulation conditions. Analysis was manifested in a form of moderate HR acceleration. RSP increase, RSA decrease (lowered vagal tone), decreased PTT and increased electrodermal activity (increased SCL, several SCRs) that reflects general sympathetic activation. Parietal EEG effects (on contra-lateral side to stimulated hand)were featured by short-term alpha-blocking, slightly reduced theta, significantly increased delta and enhanced fast beta activity with few variations across stimuli. The main finding of the study was that most and least preferred textures exhibited significant differences in autonomic (HR, RSP, PTT, SCR, and at less extent in RSA and SCL) and electrocortical responses (delta, slow and fast alpha, fast beta relative power). These differences were recorded both in passive and active stimulation modes, thus demonstrating reproducibility of distinction between most and least emotionally preferred tactile stimuli, suggesting influence of psychological factors, such as emotional property of stimulus, on physiological outcome.

• Tuberculosis and Respiratory Diseases
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• v.59 no.4
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• pp.413-417
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• 2005

Amiodarone is widely used to control fatal arrhythmia. However, amiodarone therapy is associated with a relatively high incidence of pulmonary toxicity, up to 5 to 10%. Typical symptoms are nonspecific and often manifest as nonproductive cough, dyspnea and interstitial infiltrates in patients with acute pneumonitis or chronic fibrosis. However, hemoptysis is a very rare symptom of amiodarone pulmonary toxicity. We report a case of amiodarone pulmonary toxicity, who presented with hemoptysis and was successfully treated with the cessation of amiodarone, with review of the relevant literature.

• Journal of Haehwa Medicine
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• v.15 no.2
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• pp.135-148
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• 2006

Sophorae Radix (SFR) is known as a therapeutic drug that has been used in Oriental traditional medicine for the treatment of skin and mucosal ulcers, gastrointestinal hemorrhage, diarrhea, inflammation and arrhythmia. In the present study, we examined the effects of the aqueous extract of SFR on anti-inflammation, anti-allergic and anti-oxidant effect in various cell lines; they include mouse lung fibroblast cells (hFCs), human mast cells (HMC-1), human monocytic cells (THP-1), and RAW 264.7 cells. Treatment with SFR extract at a concentration of 250 ${\mu}g$/ml for 24h showed no significant decrease in the survival rate of the hFCs. SFR decreased the mRNA expression of IL-8, TNF-$\alpha$, and IL-6 in HMC-1 cells. SFR extract treatment significantly inhi-bited the protein expression of IL-6 and, IL-8 induced by mite in THP-1 cells and it also did MCP-1 expression. We examined the alternation of histamine release in HMC-1 cells for investigating anti-allergic effect of SFR. Histamine secretion decreased after the treatment with SFR. In addition, SFR extract treatment at a concentration of 10 ${\mu}g$/ml, 100 ${\mu}g$ /ml, and 200 ${\mu}g$/ml lowered the $\beta$-hexosaminidase to 10.3%, 21.7%, and 50.8%, respectively. IC50 of SFR extract in RBL-2H3 cells was 196.85 ${\mu}g$/ml. Both activity of NF-$\kappa$B promoter in RBL-2H3 cells significantly diminished after the dose-dependent treatment of SFR. Therefore, our results indicate that SFR has anti-inflammatory and it may be useful for treating allergic diseases such as atopic dermatitis.

• Journal of Biomedical Engineering Research
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• v.17 no.1
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• pp.121-128
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• 1996

This paper presents the ECG data compression method referred the adaptive fractal interpolation algorithm. In the previous piecewise fractal interpolation(PFI) algorithm, the size of range is fixed So, the reconstruction error of the PFI algorithm is nonuniformly distributed in the part of the original ECG signal. In order to improve this problem, the adaptive fractal interpolation(AEI) algorithm uses the variable range. If the predetermined tolerance was not satisfied, the range would be subdivided into two equal size blocks. large ranges are used for encoding the smooth waveform to yield high compression efficiency, and the smaller ranges are U for encoding rapidly varying parts of the signal to preserve the signal quality. The suggested algorithm was evaluated using MIT/BIH arrhythmia database. The AEI algorithm was found to yield a relatively low reconstruction error for a given compression ratio than the PFI algorithm. In applications where a PRD of about 7.13% was acceptable, the ASI algorithm yielded compression ratio as high as 10.51, without any entropy coding of the parameters of the fractal code.

• Journal of the Korean Institute of Intelligent Systems
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• v.21 no.5
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• pp.653-659
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• 2011

In general, electrocardiogram(ECG) signals are sampled with a frequency over 200Hz and stored for a long time. It is required to compress data efficiently for storing and transmitting them. In this paper, a method for compression of ECG data is proposed, using by Non Uniform B-spline approximation, which has been widely used to approximation theory of applied mathematics and geometric modeling. ECG signals are compressed and reconstructed using B-spline basis function which curve has local controllability and control a shape and curve in part. The proposed method selected additional knot with each step for minimizing reconstruction error and reduced time complexity. It is established that the proposed method using B-spline approximation has good compression ratio and reconstruct besides preserving all feature point of ECG signals, through the experimental results from MIT-BIH Arrhythmia database.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.5
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• pp.242-250
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• 2013

In this paper, R-wave detection algorithm using refractory period to reflect the depolarization and repolarization of the myocardial cells of the heart is proposed. The proposed algorithm detects R-peaks using the features of R-wave and variable refractory period. First, the proposed algorithm extracts candidate R-peaks that have a relatively high potential and calculates the refractory period based on the kurtosis and potential for candidate R-peaks. Next, R-peak is determined by morphological features of the R-wave within the refractory period. In addition, due to less computation in the proposed algorithm, real-time processing is possible. The algorithm is applied to all records of the MIT-BIH arrhythmia database and the obtained results show a competitive detection rate of over 99.7%.

• Journal of the Korean Institute of Intelligent Systems
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• v.20 no.5
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• pp.624-630
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• 2010

As electrocardiogram(ECG) signals are generally sampled with a frequency of over 200Hz, a method to compress diagnostic information without losing data is required to store and transmit them efficiently. In this paper, an ECG signal compression method, which uses feature points based on curvature, is proposed. The feature points of P, Q, R, S, T waves, which are critical components of the ECG signal, have large curvature values compared to other vertexes. Thus, these vertexes are extracted with the proposed method, which uses local extremum of curvatures. Furthermore, in order to minimize reconstruction errors of the ECG signal, extra vertexes are added according to the iterative vertex selection method. Through the experimental results on the ECG signals from MIT-BIH Arrhythmia database, it is concluded that the vertexes selected by the proposed method preserve all feature points of the ECG signals. In addition, they are more efficient than the AZTEC(Amplitude Zone Time Epoch Coding) method.

• The KIPS Transactions:PartD
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• v.19D no.1
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• pp.105-112
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• 2012

Most methods for detecting PVC and APC require the measurement of accurate QRS complex, P wave and T wave. In this study, we propose new algorithm for detecting PVC and APC without using complex parameter and algorithms. Proposed algorithm have wide applicability to abnormal waveform by personal distinction and difference as well as all sorts of normal waveform on ECG. To achieve this, we separate ECG signal into each unit patterns and made a standard unit pattern by just using unit patterns which have normal R-R internal. After that, we detect PVC and APC by using similarity analysis for pattern matching between standard unit pattern and each unit patterns.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.35 no.11
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• pp.1213-1217
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• 2011

Electric stimulators are used for various treatments, such as for pain relief and to improve rehabilitation in and out of the hospital. However, if the stimulation pulse affects the patient's heart, it can cause critical cardiac disorders such as arrhythmia or ventricular fibrillation. As a result, it must be ensured that the transmission length of the stimulation pulse does not exceed the proper range in the design of an electric stimulator. Furthermore, every anticipated risk factor must be monitored in in-vitro and in-vivo experiments. A new stimulator was designed to supply continuous 0.001 J stimulation pulses at a rate of 60 pulses per second. To evaluate the safety of the new electric stimulator and to measure its energy transfer and pulse transmission length, we built a conduction model that was filled with saline and measured the electric field at various positions in response to real stimulations. In an animal experiment with two pigs, heart disorders were induced by applying electric stimulation to tissues near the heart. These heart disorders were different from the result obtained with 9 V DC stimulation.