• Title/Summary/Keyword: AR-23

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Effects of Alismatis Rhizoma Pharmacopuncture at BL23 on Cisplatin-Induced Acute Renal Failure in Rats (신수(BL23) 택사약침이 Cisplatin으로 유발된 급성신부전 백서에 미치는 영향)

  • Kim, Myung Sik;Kim, Jae Hong;Youn, Dae Hwan;Jeong, Hyun Woo;Cho, Myoung Rae
    • Korean Journal of Acupuncture
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    • v.36 no.1
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    • pp.63-73
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    • 2019
  • Objectives : This study was designed to investigate the effects of Alismatis Rhizoma (AR) pharmacopuncture at BL23 on acute renal failure induced by cisplatin. Methods : The Sprague-Dawley rats were divided into Normal group (no injection of cisplatin and no treatment), Control group (cisplatin injection without treatment), Acu group (needling at BL23 after cisplatin injection), AR-PA1 group (treated with $0.3571mg/kg/20{\mu}l$ of AR pharmacopuncture at BL23 after cisplatin injection), and AR-PA2 group (treated with $1.7855mg/kg/20{\mu}l$ of AR pharmacopuncture at BL23 after cisplatin injection). Each treatment was given once daily for 8 days. Changes in body weight, kidney weight, tumor necrosis factor-alpha ($TNF-{\alpha}$), interleukin-6 (IL-6), Cu-Zn superoxide dismutase (Cu-Zn SOD), glutathione peroxidase (GPx), serum blood urea nitrogen (serum BUN), and serum creatinine were observed. Results : Body weight was significantly increased in AR-PA1 on $4^{th}$ and $6^{th}$ days and AR-PA2 on $2^{nd}$ day. $TNF-{\alpha}$ was significantly decreased in Acu, AR-PA1 and AR-PA2 groups. Cu-Zn SOD was significantly increased in AR-PA2 group. GPx was significantly increased in AR-PA1 and AR-PA2 groups. But kidney weight, IL-6, serum BUN and serum creatinine were not significantly changed in any groups compared to control group. Conclusions : In acute renal failure induced by cisplatin, AR pharmacopuncture has a mitigating effect on the inflammatory reaction related to the increase of $TNF-{\alpha}$ in the kidney tissue and a protective effect on the oxidative stress of the kidney tissue. However it is unlikely to restore the glomerular function or inhibit the renal swelling.

Comparison of Atmospheric River Detection Algorithms in East Asia (동아시아 대기의 강 탐지 알고리즘 비교)

  • Gyuri Kim;Seung-Yoon Back;Yeeun Kwon;Seok-Woo Son
    • Atmosphere
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    • v.33 no.4
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    • pp.399-411
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    • 2023
  • This study compares the three detection algorithms of East Asian summer atmospheric rivers (ARs). The algorithms developed by Guan and Waliser (GW15), Park et al. (P21), and Tian et al. (T23) are particularly compared in terms of the AR frequency, the number of AR events, and the AR duration for the period of 2016-2020. All three algorithms show similar spatio-temporal distributions of AR frequency, centered along the edge of the North Pacific high. The maximum AR frequency gradually shifts northward in early summer as the edge of the North Pacific High expands, and retreats in late summer. However, the detailed pattern and the maximum value differ among the algorithms. When the AR frequency is decomposed into the number of AR events and the AR duration, the AR frequencies detected by GW15 and P21 are equally explained by both factors. However, the number of AR events primarily determine the AR frequency in T23. This difference occurs as T23 utilizes the machine learning algorithm applied to moisture field while GW15 and P21 apply the threshold value to moisture transport field. When evaluating AR-related precipitation, the ARs detected by P21 show the closest relationship with total precipitation in East Asia by up to 60%. These results indicate that AR detection in the East Asian summer is sensitive to the choice of the detection algorithm and can be optimized for the target region.

Study on the application of VR/AR technology to the future ROK Army Synthetic Battlespace Training System (미래 육군합성전장훈련체계에 VR/AR 기술 적용방안 연구)

  • Jong-Hoon Lee;Junwook Park
    • Convergence Security Journal
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    • v.23 no.5
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    • pp.189-197
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    • 2023
  • The Republic of Korea Army (ROK Army) is currently developing the Army Synthetic Battle Training System (ASBTS) by 2026 and will use it to advance division-level LVC integrated training. This study proposes a way to improve the effectiveness and efficiency of training by applying VR/AR technology to the ASBTS. To this end, we analyzed cases of VR/AR technology use in the defense field in advanced countries and the ROK military. As a result, we confirmed that the effectiveness and efficiency of training can be improved when the training system is converted to an immersive system. Accordingly, we selected and presented defense training subjects to be applied to VR/AR technology, considered the development direction for applying VR/AR technology to the ASBTS, and proposed a way to apply VR/AR technology to the ASBTS.

RV-23, a Melittin-Related Peptide with Cell-Selective Antibacterial Activity and High Hemocompatibility

  • Zhang, Shi-Kun;Ma, Qian;Li, Su-Bo;Gao, Hong-Wei;Tan, Ying-Xia;Gong, Feng;Ji, Shou-Ping
    • Journal of Microbiology and Biotechnology
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    • v.26 no.6
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    • pp.1046-1056
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    • 2016
  • RV-23 is a melittin-related antibacterial peptide (MRP) with lower cytotoxicity than either melittin or AR-23, another MRP. The aim of this study was to explore the mechanism of RV-23's antibacterial selectivity and its hemocompatibility. The results showed that all the peptides exhibited lytic activity against Staphylococcus aureus and Escherichia coli, with RV-23 showing the highest potency. Moreover, RV-23 had lower cytotoxicity than melittin or AR-23 at their minimal inhibitory concentration. In addition, CD experiments showed that melittin, RV-23, and AR-23 all had a typical α-helical structure, and RV-23 had the lowest α-helix content. The structural information showed that RV-23 has the lowest hydrophobicity and highest hydrophobic moment. Because hydrophobicity and α-helix content are believed to correlate with hemolysis, the results indicate that the selective lytic activity against bacteria of RV-23 may be due to its low hydrophobicity and α-helicity, which lead to low cytotoxicity without affecting antibacterial activity. Furthermore, RV-23 did not affect the structure and function of blood components such as red blood cells, platelets, albumin, and the blood coagulation system. In conclusion, RV-23 is a cell-selective antibacterial peptide with high hemocompatibility due to its unique structure.

Estimation of Net Community Production Based on O2/Ar Measurements (O2/Ar 관측에 기반한 순군집생산량 추정 연구 동향)

  • HAHM, DOSHIK;LEE, INHEE
    • The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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    • v.23 no.1
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    • pp.49-62
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    • 2018
  • Net community production (NCP), defined as the difference between net primary production and respiration of heterotrophs, has been used as a measure of oceanic biological carbon pump. This paper summarizes the theoretical background and experimental methods for the estimation of NCP based on $O_2/Ar$ measurements ($O_2/Ar-NCP$). The high frequency measurements of $O_2/Ar-NCP$ (<1 min) is a significant enhancement over the conventional measures of biological pump, such as new production and export production. This paper also introduces some of important works as to the comparison between $O_2/Ar-NCP$ and other measures of biological pump, the distributions of $O_2/Ar-NCP$ in the oceans, and the correlation of $O_2/Ar-NCP$ with various oceanic parameters, including community structures.

Implementation of a Robust Speaker Recognition System in Noisy Environment Using AR HMM with Duration-term (지속시간항을 갖는 AR HMM을 이용한 잡음환경에서의 강인 화자인식 시스템 구현)

  • 이기용;임재열
    • The Journal of the Acoustical Society of Korea
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    • v.20 no.6
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    • pp.26-33
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    • 2001
  • Though speaker recognition based on conventional AR HMM shows good performance, its lack of modeling the environmental noise makes its performance degraded in case of practical noisy environment. In this paper, a robust speaker recognition system based on AR HMM is proposed, where noise is considered in the observation signal model for practical noisy environment and duration-term is considered to increase performance. Experimental results, using the digits database from 100 speakers (77 males and 23 females) under white noise and car noise, show improved performance.

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Analysis on the Characteristic of Current Waveform and Welding for SM45C Using FCAW According to Gas Mixture Ratio (FCAW를 이용한 SM45C의 혼합가스비율에 따른 전류파형 및 용접특성 연구)

  • Lee, JongHun;Lim, ByungChul;Park, SangHeup
    • Journal of the Korean Society of Manufacturing Technology Engineers
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    • v.23 no.6
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    • pp.618-623
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    • 2014
  • This study, analyzed the waveform and mechanical properties of flux cored arc Welding on SM45C. $CO_2$ 10% + Ar 90% shows the lowest standard deviation and shunt ratio at which the arc was most stable. $CO_2$ 10% + Ar 90% is equal to $CO_2$ 20% + Ar 80%. therefore, $CO_2$ 20% + Ar 80% is the best of mixture gases. The hardness test result for the gas mixture ratio of $CO_2$ 10% + Ar 90% was HV 249.7 which is the highest measured value. According to tensile test results, the tensile strength increased with increasing Ar in the mixture gas. This was because of the inertness of the argon, which does not combine with other elements, causing $CO_2$ to combine with pearlite and ferrite and decreasing the maximum tensile strength. Microstructural examination results show that with increasing Ar, ferrite generation decreases while the mild microstructure increases which influences the hardness.

A Study on the Azimuth Direction Extrapolation for SAR Image Using ω-κ Algorithm (ω-κ 알고리즘을 이용한 SAR 영상의 방위각 방향 외삽 기법 연구)

  • Park, Se-Hoon;Choi, In-Sik;Cho, Byung-Lae
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.23 no.8
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    • pp.1014-1017
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    • 2012
  • In this paper, we introduce a method which enhances the azimuth resolution to obtain the high-resolution SAR image. We used ${\omega}-k$ algorithm to obtain the SAR image and extrapolation using auto-regressive(AR) method to enhance the azimuth resolution in the 2-D frequency domain. The AR method is a linear prediction model-based extrapolation technique. In the result, we showed the performance comparison with respect to the target range and the prediction order of Burg algorithm which is one of AR method.

Vibrational Structure and Predissociation of Ar-CO2 by CO2 Symmetric Stretching Mode Coupled with Ar Motion

  • Jung, Jae-Hoon;Sun, Ho-Sung
    • Bulletin of the Korean Chemical Society
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    • v.23 no.2
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    • pp.245-252
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    • 2002
  • The computationally simple quantum mechanical method (VSCF-DWB-IOS) has been applied to studying the Ar-$CO_2$ vibrational predissociation phenomenon. The new methodology utilizes the vibrational self-consistent field method to determine the vibrational structure of the van der Waals complex, the distorted-wave Born approximation for dissociating process, and the infinite-order sudden approximation for the continuum dissociating product of $CO_2$. The dissociation due to the coupling of the symmetric stretching vibrational motion of $CO_2$ with the motion of the Ar van der Waals mode has been extensively investigated. The lifetimes of transient excited vibrational states, linewidths of absorption peak, and the rotational state distributions of the product, $CO_2$ have been computed. It has been found that the lifetime of the Ar-$CO_2$ in excited vibrational state is very long compared with that of triatomic van der Waals complexes and the product $CO_2$ carries a major portion of dissociation energy as a rotational energy.

A Study of the Etched ZnO Thin Films Surface by Reactive Ion in the Cl2/BCl3/Ar Plasma (Cl2/BCl3/Ar 플라즈마에서 반응성 이온들에 의해 식각된 ZnO 박막 표면 연구)

  • Woo, Jong-Chang;Kim, Chang-Il
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.23 no.10
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    • pp.747-751
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    • 2010
  • In the study, the characteristics of the etched Zinc oxide (ZnO) thin films surface, the etch rate of ZnO thin film in $Cl_2/BCl_3/Ar$ plasma was investigated. The maximum ZnO etch rate of 53 nm/min was obtained for $Cl_2/BCl_3/Ar$=3:16:4 sccm gas mixture. According to the x-ray diffraction (XRD) and atomic force microscopy (AFM), the etched ZnO thin film was investigated to the chemical reaction of the ZnO surface in $Cl_2/BCl_3/Ar$ plasma. The field emission auger electron spectroscopy (FE-AES) analysis showed an elemental analysis from the etched surfaces. According to the etching time, the ZnO thin film of etched was obtained to The AES depth-profile analysis. We used to atomic force microscopy to determine the roughness of the surface. So, the root mean square of ZnO thin film was 17.02 in $Cl_2/BCl_3/Ar$ plasma. Based on these data, the ion-assisted chemical reaction was proposed as the main etch mechanism for the plasmas.