• The Korean Journal of Physiology and Pharmacology
• /
• v.17 no.3
• /
• pp.189-195
• /
• 2013

Amyloid-${\beta}$ peptide ($A{\beta}$), generated by proteolytic cleavage of the amyloid precursor protein (APP), plays a pivotal role in the pathogenesis of Alzheimer's disease (AD). The key step in the generation of $A{\beta}$ is cleavage of APP by beta-site APP-cleaving enzyme 1 (BACE1). Levels of BACE1 are increased in vulnerable regions of the AD brain, but the underlying mechanism is unknown. In the present study, we reported the effects of ferrous ions at subtoxic concentrations on the mRNA levels of BACE1 and a-disintegrin-and-metalloproteinase 10 (ADAM10) in PC12 cells and the cell responses to ferrous ions. The cell survival in PC12 cells significantly decreased with 0 to 0.3 mM $FeCl_2$, with 0.6 mM $FeCl_2$ treatment resulting in significant reductions by about 75%. 4,6-diamidino-2-phenylindole (DAPI) staining showed that the nuclei appeared fragmented in 0.2 and 0.3 mM $FeCl_2$. APP-${\alpha}$-carboxyl terminal fragment (APP-${\alpha}$-CTF) associations with ADAM10 and APP-${\beta}$-CTF with BACE1 were increased. Levels of ADAM10 and BACE1 mRNA increased in response to the concentrations of 0.25 mM, respectively. In addition, p-ERK and p-Bad (S112, S155) expressions were increased, suggesting that APP-CTF formation is related to ADAM10/ BACE1 expression. Levels of Bcl-2 protein were increased, but significant changes were not observed in the expression of Bax. These data suggest that ion-induced enhanced expression of AMDA10/BACE1 could be one of the causes for APP-${\alpha}/{\beta}$-CTF activation.

• The Journal of the Convergence on Culture Technology
• /
• v.3 no.1
• /
• pp.35-41
• /
• 2017

Smart phone based IT support programs are faced with difficulties due to the following reasons first, long development period is required as separate developments are necessary respectively depending on the operating system of Smart phone second, it is also difficult to secure high development cost for the outsourcing of the development. It is a big problem for improving app developing productivity. Smart App Factory which is suggested in this thesis is the business strategy to surpass the Android market of Google and App Store of Apple within short period of time based on App productivity of Smart App Authoring Tool and to accomplish the materialization of App market which is in the 1st global position and all potential customers who need programs for their works regardless of budget, scope, complexity and scale will be implemented by unfolding unprecedented low price policy and global online marketing activities for App development.

• Journal of Veterinary Science
• /
• v.21 no.2
• /
• pp.20.1-20.13
• /
• 2020

Actinobacillus pleuropneumoniae (APP) causes a form of porcine pleuropneumonia that leads to significant economic losses in the swine industry worldwide. The apxIBD gene is responsible for the secretion of the ApxI and ApxII toxins and the pnp gene is responsible for the adaptation of bacteria to cold temperature and a virulence factor. The apxIBD and pnp genes were deleted successfully from APP serotype 1 and 5 by transconjugation and sucrose counter-selection. The APP1ΔapxIBDΔpnp and APP5ΔapxIBDΔpnp mutants lost hemolytic activity and could not secrete ApxI and ApxII toxins outside the bacteria because both mutants lost the ApxI- and ApxII-secreting proteins by deletion of the apxIBD gene. Besides, the growth of these mutants was defective at low temperatures resulting from the deletion of pnp. The APP1ΔapxIBDΔpnp and APP5ΔapxIBDΔpnp mutants were significantly attenuated compared with wild-type ones. However, mice vaccinated intraperitoneally with APP5ΔapxIBDΔpnp did not provide any protection when challenged with a 10-times 50% lethal dose of virulent homologous (APP5) and heterologous (APP1) bacterial strains, while mice vaccinated with APP1ΔapxIBDΔpnp offered 75% protection against a homologous challenge. The ΔapxIBDΔpnp mutants were significantly attenuated and gave different protection rate against homologous virulent wild-type APP challenging.

• Journal of Microbiology and Biotechnology
• /
• v.7 no.5
• /
• pp.329-332
• /
• 1997

Cell-free extracts of Streptomyces neyagawaensis SL-387 grown on a chemically defined medium supplemented with DL-3-amino-3-phenylpropionic acid (APP) produced N-acetyl-APP (Ac-APP) in the presence of APP and acetyl coenzyme A. The APP obtained by acid hydrolysis of the Ac-APP was D-configuration: $[\alpha]_D+6.5^{\circ}(H_2O)\;at\;20^{\circ}C$, optical purity 92% enantiomeric excesses (ee). These results suggest that an N-acetyltransferase exists in the cell-free extract as a novel enzyme with specificity for D-APP.

• Journal of Information Technology Applications and Management
• /
• v.21 no.4
• /
• pp.127-139
• /
• 2014

This study presents a logging method to trace the usage patterns of existing smartphone apps. The actual smartphone app itself, not a specially developed similar app with usage logging, would be used best for the experiment of observing the usage patterns. For this purpose, we used a method of injecting logging codes into existing smartphone app. Using this method, we conducted an experiment to trace usage patterns of a commercial IPTV app, and found that the method is very useful for acquiring detail usage log without influencing participants.

• International Journal of Advanced Culture Technology
• /
• v.8 no.3
• /
• pp.241-246
• /
• 2020

In this paper, we propose a user matching app based on hybrid app and a utilization plan to promote sports tourism in line with the growing trend of sports industry scale. The proposed app categorizes sports facilities across the country into regional, sports, private and public sports facilities to support reservations and matching. The proposed app applied a matching system in which matching scores were given according to the preference of events, places, and users by user net matching algorithm. Users can enjoy sports as a team or individual through the suggestion app even if they do not have any clubs or friends to which they belong. It can be used to improve tourism content services and establish tourism industry policies by analyzing data generated while using a user matching system.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2012.10a
• /
• pp.171-173
• /
• 2012

광범위한 스마트폰의 보급으로 인해 관련 APP 시장 또한 급격하게 증가하고 있다. 많은 APP이 개발되고 있지만 대부분 특정 분야에 집중되어 있으며 교육용 APP이 시장에서 차지하고 있는 비율은 극히 낮다. 시장 비율이 낮은 이유는 기존 출시된 대다수의 교육용 APP이 가지는 두 문제점 때문이다. 첫 번째는 동일 콘텐츠의 반복학습으로 인해 재사용 빈도가 많이 낮고 자기주도학습 능력을 이끌어 낼 수 없다는 점이며 두 번째는 문제 제공 및 정답 확인의 단순 구조로 되어 있어 사용자가 자신의 수준 및 취약 부분을 분석하기 힘들다는 점이다. 본 논문은 스마트폰 환경에서 앞서 언급한 두 가지 문제점을 해결하기 위해 시스템 구조 변경 없이 콘텐츠 변경이 가능하며 사용자의 수준을 파악할 수 있는 기능을 가진 사용자 맞춤 교육을 위한 교육용 앱 설계에 대하여 제안한다.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2012.10a
• /
• pp.357-358
• /
• 2012

현재 스마트폰 사용이 상용화되고 있는 시점에서 사용자들은 각 사용자에게 맞는 편리한 App(Application)을 제작 또는 다운받아 사용을 하고 있다. 현재 등록되어 있는 App.의 수는 50만이 넘는 추세이다. 이로 인해 사용자들은 보급되어있는 App.중 사용자 취향에 맞는 App을 다운받아 사용 하고 있다. 따라서 본 논문에서는 사용자들이 핸드폰으로 간단히 타자연습을 위한 목적으로 제작되었다. 제작된 App은 사용자들이 편리하게 타자연습을 하며, 사용자들이 타자연습에 지루함을 느낄 수 있기에 추가적으로 랭킹, 페이스북 친구에게 자신의 타자속도를 보여주는 기능을 가지고 있다.

• International Journal of Computer Science & Network Security
• /
• v.21 no.5
• /
• pp.217-221
• /
• 2021

Recent studies have indicated that mobile markets harbor applications (apps) that are either malicious or vulnerable, compromising millions of devices. Some studies indicate that 96% of companies' employees have used at least one malicious app. Some app stores do not employ security quality attributes regarding authorization, which is the function of specifying access rights to access control resources. However, well-defined access control policies can prevent mobile apps from being malicious. The problem is that those who oversee app market sites lack the mechanisms necessary to assess mobile app security. Because thousands of apps are constantly being added to or updated on mobile app market sites, these security testing mechanisms must be automated. This paper, therefore, introduces a new mechanism for testing mobile app security, using white-box testing in a way that is compatible with Bring Your Own Device (BYOD) working environments. This framework will benefit end-users, organizations that oversee app markets, and employers who implement the BYOD trend.

• Proceedings of the Korea Information Processing Society Conference
• /
• 2012.11a
• /
• pp.278-279
• /
• 2012

본 논문에선 개방형 모바일 클라우드 서비스를 위한 Home App과 Repository App을 OMC Home App 생성 마법사를 통해 쉽고 효율적이고 사용자 기호에 맞게 개발할 수 있는 Home App Template과 Repository App Template을 제안한다.