• The Transactions of The Korean Institute of Electrical Engineers
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• v.58 no.7
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• pp.1418-1423
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• 2009

This paper describes the design and implementation of a System-on-a-Chip (SoC) for image processing applications to use in wearable/mobile products. The target Soc consists of LEON 2 core, AMBA/APB bus-systems and custom-designed controllers. A new FPGA-based prototyping platform is implemented and used for design and verification of the target SoC. To ensure that the implemented SoC satisfies the required performances, an image processing application is performed.

• Proceedings of the Korean Information Science Society Conference
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• 2004.04a
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• pp.919-921
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• 2004

최근 임베디드 시스템 설계에서 저전력 소모와 SoC가 주된 관심사가 되면서, ARM 프로세서와 AMBA 버스가 각광을 받고 있다. AMBA 버스가 고속 모듈에 대해서는 장점을 지니지만. 저속 모듈과의 인터페이스에는 많은 제약이 따른다. 따라서 속도가 서로 다른 이종 모듈간에 속도 보상을 위한 bridge 가 필요하다. 이러한 용도로 APB bridge가 표준으로 자리 매김하고 있지만, 속도가 고정되어 있기 때문에 융통성이 배제된다. 본 논문에서는 이러한 단정을 보완하기 위해, 구조가 간단하고 구현이 쉬운 ISA 방식의 bridge를 제안하여, 많은 주변장치들을 손쉽게 AHB Slave로 인터페이스 할 수 있게 만든다.

• Proceedings of the IEEK Conference
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• 2002.06b
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• pp.317-320
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• 2002

Recently, AMBA(Advanced Microcontroller Bus Architecture) is used as common system bus at embedded system. In this paper, we described test method of peripheral device which is connected to AMBA according to the bus interface defined by AMBA protocol We implemented one of the APB(Advanced Peripheral Bus) peipheral module, GPIO(General Purpose Input/output), and tested its functionality as il is connected to the AMBA system.

• The Korean Journal of Physiology and Pharmacology
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• v.20 no.2
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• pp.177-183
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• 2016

We fortuitously observed a human neutrophil intracellular free-calcium concentration ($[Ca^{2+}]_i$) increasing activity in the commercially available phosphodiesterase I (PDE I), which is actually dried crude venom of Crotalus atrox. As this activity was not observed with another commercially available pure PDE I, we tried to find out the causative molecule(s) present in 'crude' PDE, and identified Lys49-phospholipase A2 (Lys49-PLA2 or K49-PLA2), a catalytically inactive protein which belongs to the phospholipase A2 family, by activity-driven three HPLC (reverse phase, size exclusion, reverse phase) steps followed by SDS-PAGE and LC-MS/MS. K49-PLA2 induced $Ca^{2+}$ influx in human neutrophils without any cytotoxic effect. Two calcium channel inhibitors, 2-aminoetoxydiphenyl borate (2-APB) ($30{\mu}M$) and SKF-96365 ($20{\mu}M$) significantly inhibited K49-PLA2-induced $[Ca^{2+}]_i$ increase. These results suggest that K49-PLA2 modulates $[Ca^{2+}]_i$ in human neutrophils via 2-APB- and SKF-96365-sensitive calcium channels without causing membrane disruption.

• Journal of Pharmacopuncture
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• v.15 no.3
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• pp.31-38
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• 2012

Sophorae Radix (SR) plays a role in a number of physiologic and pharmacologic functions in many organs. Objective: The aim of this study was to clarify the potential role for transient receptor potential melastatin 7 (TRPM7) channels in SR-inhibited growth and survival of AGS and MCF-7 cells, the most common human gastric and breast adenocarcinoma cell lines. Methods: The AGS and the MCF-7 cells were treated with varying concentrations of SR. Analyses of the caspase-3 and - 9 activity, the mitochondrial depolarization and the poly (ADPribose) polymerase (PARP) cleavage were conducted to determine if AGS and MCF-7 cell death occured by apoptosis. TRPM7 channel blockers ($Gd^{3+}$ or 2-APB) and small interfering RNA (siRNA) were used in this study to confirm the role of TRPM7 channels. Furthermore, TRPM7 channels were overexpressed in human embryonic kidney (HEK) 293 cells to identify the role of TRPM7 channels in AGS and MCF-7 cell growth and survival. Results: The addition of SR to a culture medium inhibited AGS and MCF-7 cell growth and survival. Experimental results showed that the caspase-3 and -9 activity, the mitochondrial depolarization, and the degree of PARP cleavage was increased. TRPM7 channel blockade, either by $Gd^{3+}$ or 2-APB or by suppressing TRPM7 expression with small interfering RNA, blocked the SR-induced inhibition of cell growth and survival. Furthermore, TRPM7 channel overexpression in HEK 293 cells exacerbated SR-induced cell death. Conclusions: These findings indicate that SR inhibits the growth and survival of gastric and breast cancer cells due to a blockade of the TRPM7 channel activity. Therefore, TRPM7 channels may play an important role in the survival of patients with gastric and breast cancer.

• The Korean Journal of Physiology and Pharmacology
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• v.18 no.6
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• pp.503-508
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• 2014

Spontaneous myometrial contraction (SMC) in pregnant uterus is greatly related with gestational age and growing in frequency and amplitude toward the end of gestation to initiate labor. But, an accurate mechanism has not been elucidated. In human and rat uterus, all TRPCs except TRPC2 are expressed in pregnant myometrium and among them, TRPC4 are predominant throughout gestation, suggesting a possible role in regulation of SMC. Therefore, we investigated whether the TRP channel may be involved SMC evoked by mechanical stretch in pregnant myometrial strips of rat using isometric tension measurement and patch-clamp technique. In the present results, hypoosmotic cell swelling activated a potent outward rectifying current in G protein-dependent manner in rat pregnant myocyte. The current was significantly potentiated by $1{\mu}M$ lanthanides (a potent TRPC4/5 stimulator) and suppressed by $10{\mu}M$ 2-APB (TRPC4-7 inhibitor). In addition, in isometric tension experiment, SMC which was evoked by passive stretch was greatly potentiated by lanthanide ($1{\mu}M$) and suppressed by 2-APB ($10{\mu}M$), suggesting a possible involvement of TRPC4/5 channel in regulation of SMC in pregnant myometrium. These results provide a possible cellular mechanism for regulation of SMC during pregnancy and provide basic information for developing a new agent for treatment of premature labor.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.2
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• pp.343-350
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• 2016

A secure and effective on-chip bus for detecting and preventing malicious attacks by infected IPs is presented in this paper. Most system inter-connects (on-chip bus) are vulnerable to hardware Trojan (Malware) attack because all data and control signals are routed. A proposed secure bus with modifications in arbitration, address decoding, and wrapping for bus master and slaves is designed using the Advanced High-Performance and Advance Peripheral Bus (AHB and APB Bus). It is implemented with the concept that arbiter checks share of masters and manage infected masters and slaves in every transaction. The proposed hardware is designed with the Xilinx 14.7 ISE and verified using the HBE-SoC-IPD test board equipped with Virtex4 XC4VLX80 FPGA device. The design has a total gate count of 39K at an operating frequency of 313MHz using the $0.13{\mu}m$ TSMC process.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2015.10a
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• pp.885-888
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• 2015

A secure and effective on-chip bus for detecting and preventing malicious attacks by infected IPs is presented in this paper. Most system inter-connect (on-chip bus) are vulnerable to hardware Trojan (Malware) attack because all data and control signals are routed. A proposed secure bus with modifications in arbitration, address decoding, and wrapping for bus master and slaves is designed using the Advanced High-Performance and Advance Peripheral Bus (AHB and APB Bus). It is implemented with the concept that arbiter checks share of masters and manage infected masters and slaves in every transaction. The proposed hardware is designed with the Xilinx 14.7 ISE and verified using the HBE-SoC-IPD test board equipped with Virtex4 XC4VLX80 FPGA device. The design has a total gate count of 40K at an operating frequency of 250MHz using the $0.13{\mu}m$ TSMC process.

• Management & Information Systems Review
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• v.7
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• pp.93-111
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• 2001

In this article, we perform an international overview of accounting standards for tax effect accounting(or income taxes). Specially, we compare accounting standards for tax effect accounting of U.S. and International Accounting Standards. The principal component of U.S. accounting standards for tax effect accounting is as follow. Statement of Financial Accounting Standards No. 109, Accounting for Income Taxes (SFAS No. 109) represents the culmination of a multi-year process in which Financial Accounting Standards Board (FASB) reviewed and subsequently modified the requirements for accounting for income taxes. SFAS No. 109 requires an 'asset and liability' approach for the accounting for income taxes. That is, deferred income taxes are viewed as assets and liabilities of the firm, and deferred tax expenses id determined by the current-year change in the firm's deferred tax liabilities and assets. Previously, Accounting Principles Board Opinion No. 11, Accounting for Income Taxes (APB No. 11) required a 'deferral' approach to accounting for income taxes. The primary intent of the deferral approach was to match tax expense with corresponding revenues and expenses for the year in which the revenues and expenses were recognized in the financial statement. Unlike the SFAS No. 109, APB No. 11 did not require firms to adjust deferred tax balances for subsequent events such as changes in tax rates or laws. And, the principal deference between SFAS No. 109 and the previous statement on accounting for income taxes, SFAS No. 96, is that SFAS No. 109 requires firms to recognize deferred tax assets for the tax benefits of tax credit or operating loss carryforwards, no matter how likely the firm was to realize these benefits, and this was one of the reasons for its demise.

• Molecules and Cells
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• v.42 no.3
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• pp.252-261
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• 2019

The omega-3 fatty acid docosahexaenoic acid (DHA) is known to induce apoptosis and cell cycle arrest via the induction of reactive oxygen species (ROS) production and endoplasmic reticulum (ER) stress in many types of cancers. However, the roles of DHA in drug-resistant cancer cells have not been elucidated. In this study, we investigated the effects of DHA in cisplatin-resistant gastric cancer SNU-601/cis2 cells. DHA was found to induce ROS-dependent apoptosis in these cells. The inositol 1,4,5-triphosphate receptor ($IP_3R$) blocker 2-aminoethyl diphenylboninate (2-APB) reduced DHA-induced ROS production, consequently reducing apoptosis. We also found that G-protein-coupled receptor 120 (GPR120), a receptor of long-chain fatty acids, is expressed in SNU-601/cis2 cells, and the knockdown of GPR120 using specific shRNAs alleviated DHA-mediated ROS production and apoptosis. GPR120 knockdown reduced the expression of ER stress response genes, similar to the case for the pre-treatment of the cells with N-acetyl-L-cysteine (NAC), an ROS scavenger, or 2-APB. Indeed, the knockdown of C/EBP homologous protein (CHOP), a transcription factor that functions under ER stress conditions, markedly reduced DHA-mediated apoptosis, indicating that CHOP plays an essential role in the anti-cancer activity of DHA. These results suggest that GPR120 mediates DHA-induced apoptosis by regulating $IP_3R$, ROS, and ER stress levels in cisplatin-resistant cancer cells, and that GPR120 is an effective chemotherapeutic target for cisplatin resistance.