• The Korean Journal of Physiology and Pharmacology
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• v.2 no.6
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• pp.671-676
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• 1998

In the present study, we first examined whether the changes in the DNA binding activities of the transcription factors, cAMP response element binding protein (CREB) and activator protein-1 (AP-1) mediate the long-term effects of morphine in differentiated SH-SY5Y human neuroblastoma cells. The increases in CREB and AP-1 DNA binding activities were time-dependent up to 6 days of morphine treatment (1, 4, and 6 days). However, the significant reduction in the DNA binding activities of CREB and AP-1 was observed after 10 days of chronic morphine $(10\;{\mu}M)$ administration. Secondly, we examined whether the changes of CREB and AP-1 DNA binding activities could be modulated by dopamine and haloperidol. Dopamine cotreatment moderately increased the levels of the CREB and AP-1 DNA binding activities induced by 10 days of chronic morphine treatment, and haloperidol cotreatment also resulted in a moderate increase of the CREB and AP-1 DNA binding activities. However, dopamine or haloperidol only treatment showed a significant increase or decrease of the CREB and AP-1 DNA binding activities, respectively. In the case of acute morphine treatment, the CREB and AP-1 DNA binding activities were shown to decrease in a time-dependent manner (30, 60, 90, and 120 min). Taken these together, in differentiated SH-SY5Y cells, morphine tolerance seems to involve simultaneous changes of the CREB and AP-1 DNA binding activities. Our data also suggest the possible involvement of haloperidol in prevention or reversal of morphine tolerance at the transcriptional level.

• Journal of Korean Society for Atmospheric Environment
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• v.31 no.1
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• pp.83-91
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• 2015

Biomass burning is known to be one of the main sectors emitting greenhouse gases as well as air pollutants. Unfortunately, the inventory of biomass burning sector has not been established well. We estimated greenhouse gas (GHG) and air pollution (AP) integrated emissions from biomass burning sector in Seoul during year 2010. The data of GHG and AP emissions from biomass burning, classified into open burning, residential fireplace and wood stove, meat cooking, fires, and cremation, were obtained from Statistics Korea and Seoul City. Estimation methodologies and emission factors were gathered from reports and published literatures. Estimated GHG and AP integrated emissions during year 2010 were $3,867tonCO_{2eq}$, and 2,320 tonAP, respectively. Major sources of GHG were forest fires ($1,533tonCO_{2eq}$) and waste open burning ($1,466tonCO_{2eq}$), while those of AP were meat cooking (1,240 tonAP) and fire incidence (907 tonAP). Total emissions by administrative district in Seoul, representing similar patterns in both GHG and AP, indicated that Seocho-gu and Gangseo-gu were the largest emitters whereas Jung-gu was the smallest emitter, ranged in $2{\sim}165tonCO_{2eq}$ and 0.1~8.31 tonAP. GHG emissions per $km^2$ showed different results from total emissions in that Gwanak-gu, Jungnang-gu, Gangdong-gu and Seodaemun-gu were the largest emitters, while Seocho-gu and Gangseo-gu were near-averaged emission districts, ranged in $0.2{\sim}21tonCO_{2eq}/km^2$. However, AP emissions per $km^2$ revealed relatively minor differences among districts, ranged in $2.3{\sim}6.1tonAP/km^2$.

• International Journal of Internet, Broadcasting and Communication
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• v.11 no.1
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• pp.17-26
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• 2019

The Constrained Application Protocol (CoAP) is a specialized web transfer protocol proposed by the IETF for use in IoT environments. CoAP was designed as a lightweight machine-to-machine protocol for resource constrained environments. Due to the strength of low overhead, the number of CoAP devices is expected to rise rapidly. When CoAP runs over UDP for wireless sensor networks, CoAP needs to support congestion control mechanisms. Since the default CoAP defines a minimal mechanism for congestion control, several schemes to improve the mechanism have been proposed. To keep CoAP lightweight, the majority of the schemes have been focused mainly on how to measure RTT accurately and how to set RTO adaptively according to network conditions, but other approaches such as rate-based congestion control were proposed more recently. In this paper, we survey the literature on congestion control for CoAP and discuss the future research directions.

• Korean Journal of Veterinary Research
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• v.20 no.2
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• pp.113-118
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• 1980

Total of 11 strains of Ldctobacillus isolated from lactobacillus-fermented milk and-beverage in March 1980 were examined for susceptibility to 8 drugs, and transferability and transfer frequency of R plasmids by conjugation. Of 11 isolates each 2 strains were classified as L. cellobiosus and L. helveticus, each 1 strain as L. plantarum, L. lactis, L. acidophilus, L. delbrueckii, L. casei subsp. casei, L. casei subsp, tolerans and L. salivarius subsp, salivarius by Bergey's manual. Resistance was the most active to na lidixic acid(NA), followed in decreasing order by chloramphenicol(CP), ampicillin(AP), kanamycin(KM) and streptomycin(SM). All of isolates were resistant to NA, each 10 strains to CP and AP, 7strains to KM and 6 strains to SM, indicating all of the isolates were resistant to two or more drugs in combination. No strain was resistant to erythromycin(EM), penicillin(PC) and tetracycline(TC). The most frequently encountered resistant patterns were CP NA AP SM KM, followed by CP NA AP KM, NA AP, CP NA, CP NA AP and CP NA AP SM in order. Transfer experiment of drug resistance showed that of 11 resistant strains, 9 strains transferred parts of their resistance to AP or AP CP or SM AP, indicating 9 strains carried R plasmids determining R(AP), R(AP CP) and R(SM AP). The conjugal frequency of R(AP) from Lactobacillus to E. coli ranged from 2.5{\times}10^{-1} to $5.6{\times}10^{-4}%$, that of R(CP) ranged from 5.0{\times}10^{-1} to 5.0{\times}10^{-3}% and that of R(SM) ranged from 6.0{\times}10^{-5} to 1.4{\times}10^{-5}%, at $37^{\circ}C$ for 18 hours of incubation.

• Journal of the Korean Society of Radiology
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• v.5 no.6
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• pp.377-381
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• 2011

The purpose of this study is an assessment between the measured value of the nanoDot dosimeter and the calculated value of Non Dosimeter Dosimetry-Method(NDD-M) for entrance surface dose in general radiography. Measurement and calculation of the entrance surface doses were performed for head(AP), abdomen(AP), pelvis(AP), thoracic spine(AP) and lumbar spine(AP). As a result, the relative ratios of the measured value to the calculated value were acquired 1.5-2.1 for each region. Reproducibility acquired 0.035 as a coefficient of variation.

• Journal of the Korean Society of Propulsion Engineers
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• v.20 no.1
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• pp.14-19
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• 2016

The viscosity and mechanical property of HTPB/AP composite solid propellant are profoundly affected by particle size of AP. In HTPB/AP propellant formulated by two mode of AP size such as $190{\mu}m$ and $7{\mu}m$, the propellant was found to be much less viscose at end of mix when coarse/fine AP ratio is ranged from 70/30 to 60/40 due to high solid packing fraction. It was shown that the toughness of tensile strength test for HTPB/AP propellant increased with the increase in coarse AP. Considering both lower viscosity and better tensile strength, the optimum ratio of AP coarse/fine was estimated to be 70/30.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.9 no.1
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• pp.114-119
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• 2016

The necessity of IoT(Internet of Things) and Multimedia CSCW is described, and error control for multimedia CSCW(Computer Supported Cooperated Works) based on CoAP stack is suggested. This paper describes an error synchronization running on gateway software stack based CoAP. This system consists of an CS_EDA, and CS_ESA. CS_EDA is an agent that detects an error for multimedia distance system based on gateway software stack based CoAP environment. CS_ESA is an agent that is an error synchronization system for multimedia distance control based on gateway software stack based CoAP environment. From the perspective of multimedia collaborative environment of gateway software stack based CoAP, an error application becomes another interactive presentation error is synchronized with participants engaged in a cooperative work.

• Biomolecules & Therapeutics
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• v.22 no.4
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• pp.308-313
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• 2014

Activator protein-1 (AP-1) is an inducible transcription factor that contributes to the generation of chronic inflammation in response to oxidative and electrophilic stress. Previous studies have demonstrated that the PI3K/Akt1 pathway plays an important role in the transcriptional regulation of AP-1 expression. Although the histone post-translational modifications (PTMs) are assumed to affect the AP-1 transcriptional regulation by the PI3K/Akt pathway, the detailed mechanisms are completely unknown. In the present study, we show that heterochromatin 1 gamma ($HP1{\gamma}$) plays a negative role in TPA-induced c-Jun and c-Fos expression. We show that TPA-induced Akt1 directly phosphorylates $HP1{\gamma}$, abrogates its suppressive function and increases the interaction between histone H3 and 14-3-$3{\varepsilon}$. Collectively, these our data illustrate that the activation of PI3K/Akt pathway may play a permissive role in the recruitment of histone readers or other coactivators on the chromatin, thereby affecting the degree of AP-1 transcription.

• Journal of the Chungcheong Mathematical Society
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• v.17 no.1
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• pp.103-110
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• 2004

In this paper, we define the ap-Denjoy integral and investigate some properties of the ap-Denjoy integral.

• Convergence Security Journal
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• v.11 no.1
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• pp.33-38
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• 2011

Current IEEE 802.11 standard is very vulnerable that between the AP and STA authentication and security mechanisms is widely known. Therefore, IEEE has proposed security architecture RSN (Robust Security Network) for 802.11. RSN is used the access control, authentication, and key management based on the IEEE 802.1X standard. In this paper, IEEE 802.1X or 802.11 a combination of several models proposed for the vulnerability, and session hijacking or MiM (Man-in the-Middle) attacks to respond, the authentication mechanism Was designed to the access control between the STA and the AP.