• The Korean Journal of Physiology and Pharmacology
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• 제2권6호
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• pp.671-676
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• 1998

In the present study, we first examined whether the changes in the DNA binding activities of the transcription factors, cAMP response element binding protein (CREB) and activator protein-1 (AP-1) mediate the long-term effects of morphine in differentiated SH-SY5Y human neuroblastoma cells. The increases in CREB and AP-1 DNA binding activities were time-dependent up to 6 days of morphine treatment (1, 4, and 6 days). However, the significant reduction in the DNA binding activities of CREB and AP-1 was observed after 10 days of chronic morphine $(10\;{\mu}M)$ administration. Secondly, we examined whether the changes of CREB and AP-1 DNA binding activities could be modulated by dopamine and haloperidol. Dopamine cotreatment moderately increased the levels of the CREB and AP-1 DNA binding activities induced by 10 days of chronic morphine treatment, and haloperidol cotreatment also resulted in a moderate increase of the CREB and AP-1 DNA binding activities. However, dopamine or haloperidol only treatment showed a significant increase or decrease of the CREB and AP-1 DNA binding activities, respectively. In the case of acute morphine treatment, the CREB and AP-1 DNA binding activities were shown to decrease in a time-dependent manner (30, 60, 90, and 120 min). Taken these together, in differentiated SH-SY5Y cells, morphine tolerance seems to involve simultaneous changes of the CREB and AP-1 DNA binding activities. Our data also suggest the possible involvement of haloperidol in prevention or reversal of morphine tolerance at the transcriptional level.

• 한국대기환경학회지
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• 제31권1호
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• pp.83-91
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• 2015

Biomass burning is known to be one of the main sectors emitting greenhouse gases as well as air pollutants. Unfortunately, the inventory of biomass burning sector has not been established well. We estimated greenhouse gas (GHG) and air pollution (AP) integrated emissions from biomass burning sector in Seoul during year 2010. The data of GHG and AP emissions from biomass burning, classified into open burning, residential fireplace and wood stove, meat cooking, fires, and cremation, were obtained from Statistics Korea and Seoul City. Estimation methodologies and emission factors were gathered from reports and published literatures. Estimated GHG and AP integrated emissions during year 2010 were $3,867tonCO_{2eq}$, and 2,320 tonAP, respectively. Major sources of GHG were forest fires ($1,533tonCO_{2eq}$) and waste open burning ($1,466tonCO_{2eq}$), while those of AP were meat cooking (1,240 tonAP) and fire incidence (907 tonAP). Total emissions by administrative district in Seoul, representing similar patterns in both GHG and AP, indicated that Seocho-gu and Gangseo-gu were the largest emitters whereas Jung-gu was the smallest emitter, ranged in $2{\sim}165tonCO_{2eq}$ and 0.1~8.31 tonAP. GHG emissions per $km^2$ showed different results from total emissions in that Gwanak-gu, Jungnang-gu, Gangdong-gu and Seodaemun-gu were the largest emitters, while Seocho-gu and Gangseo-gu were near-averaged emission districts, ranged in $0.2{\sim}21tonCO_{2eq}/km^2$. However, AP emissions per $km^2$ revealed relatively minor differences among districts, ranged in $2.3{\sim}6.1tonAP/km^2$.

• International Journal of Internet, Broadcasting and Communication
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• 제11권1호
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• pp.17-26
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• 2019

The Constrained Application Protocol (CoAP) is a specialized web transfer protocol proposed by the IETF for use in IoT environments. CoAP was designed as a lightweight machine-to-machine protocol for resource constrained environments. Due to the strength of low overhead, the number of CoAP devices is expected to rise rapidly. When CoAP runs over UDP for wireless sensor networks, CoAP needs to support congestion control mechanisms. Since the default CoAP defines a minimal mechanism for congestion control, several schemes to improve the mechanism have been proposed. To keep CoAP lightweight, the majority of the schemes have been focused mainly on how to measure RTT accurately and how to set RTO adaptively according to network conditions, but other approaches such as rate-based congestion control were proposed more recently. In this paper, we survey the literature on congestion control for CoAP and discuss the future research directions.

• 대한수의학회지
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• 제20권2호
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• pp.113-118
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• 1980

Total of 11 strains of Ldctobacillus isolated from lactobacillus-fermented milk and-beverage in March 1980 were examined for susceptibility to 8 drugs, and transferability and transfer frequency of R plasmids by conjugation. Of 11 isolates each 2 strains were classified as L. cellobiosus and L. helveticus, each 1 strain as L. plantarum, L. lactis, L. acidophilus, L. delbrueckii, L. casei subsp. casei, L. casei subsp, tolerans and L. salivarius subsp, salivarius by Bergey's manual. Resistance was the most active to na lidixic acid(NA), followed in decreasing order by chloramphenicol(CP), ampicillin(AP), kanamycin(KM) and streptomycin(SM). All of isolates were resistant to NA, each 10 strains to CP and AP, 7strains to KM and 6 strains to SM, indicating all of the isolates were resistant to two or more drugs in combination. No strain was resistant to erythromycin(EM), penicillin(PC) and tetracycline(TC). The most frequently encountered resistant patterns were CP NA AP SM KM, followed by CP NA AP KM, NA AP, CP NA, CP NA AP and CP NA AP SM in order. Transfer experiment of drug resistance showed that of 11 resistant strains, 9 strains transferred parts of their resistance to AP or AP CP or SM AP, indicating 9 strains carried R plasmids determining R(AP), R(AP CP) and R(SM AP). The conjugal frequency of R(AP) from Lactobacillus to E. coli ranged from 2.5{\times}10^{-1} to $5.6{\times}10^{-4}%$, that of R(CP) ranged from 5.0{\times}10^{-1} to 5.0{\times}10^{-3}% and that of R(SM) ranged from 6.0{\times}10^{-5} to 1.4{\times}10^{-5}%, at $37^{\circ}C$ for 18 hours of incubation.

• 한국방사선학회논문지
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• 제5권6호
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• pp.377-381
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• 2011

이 연구의 목적은 일반방사선촬영에서 입사표면선량에 대하여 나노도트선량계의 측정값과 Non Dosimeter Dosimetry-Method(NDD-M)의 계산값과 비교 평가하는 데 있다. 입사표면선량들의 측정과 계산은 두부(AP), 복부(AP), 골반(AP), 흉추(AP)와 요추(AP)에 대하여 수행하였다. 결과로서, 계산값에 대한 측정값의 상대비들은 각 부위에 대하여 1.5-2.1을 얻었다. 재현성은 변동계수로서 0.035를 얻었다.

• 한국추진공학회지
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• 제20권1호
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• pp.14-19
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• 2016

HTPB/AP계 혼합형 고체 추진제의 점도와 기계적 특성은 산화제인 AP의 입자 크기에 크게 영향을 받는다. $190{\mu}m$의 크기의 AP와 $7{\mu}m$ 크기의 AP를 사용한 HTPB/AP 추진제에서 큰 입자/작은 입자의 비율이 70/30~60/40 범위인 조성의 추진제가 매우 낮은 점도를 나타났는데, 이것은 고체입자의 충전율이 높은 상태이기 때문이다. 추진제의 인장강도 시험에서 Toughness는 큰 입자의 함량이 많아질수록 증가하는 것으로 나타났다. 낮은 점도와 좋은 인장강도를 동시에 고려할 때, AP 큰 입자와 작은 입자를 70/30으로 사용하는 것이 가장 효과적인 것으로 분석되었다.

• 한국정보전자통신기술학회논문지
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• 제9권1호
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• pp.114-119
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• 2016

사물 인터넷과 멀티미디어 협동 작업 환경의 필요성을 기술하고, 그 기반 하에 CoAP 기반 스택에서의 오류 처리에 대해서 제안하였다. 본 논문은 CoAP 기반 게이트웨이 소프트웨어 스택에서의 오류 동기화에 대한 내용을 기술한다. 이 시스템은 CS_EDA, CS_ESA로 구성되어 있다. CS_EDA는 CoAP 기반 게이트웨이 소프트웨어 스택 환경에서 멀티미디어 원격 제어를 위하여 오류를 감지하는 에이전트이다. CS_ESA는 CoAP 기반 게이트웨이 소프트웨어 스택 환경에서 멀티미디어 원격 제어를 위하여 오류를 동기화하는 에이전트이다. CoAP 기반 게이트웨이 소프트웨어 스택에서의 멀티미디어 공동 작업 환경의 관점에서 오류 동기화는 협동 작업에 참가하는 참가자에게 상호작용적으로 오류를 동기화한다.

• Biomolecules & Therapeutics
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• 제22권4호
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• pp.308-313
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• 2014

Activator protein-1 (AP-1) is an inducible transcription factor that contributes to the generation of chronic inflammation in response to oxidative and electrophilic stress. Previous studies have demonstrated that the PI3K/Akt1 pathway plays an important role in the transcriptional regulation of AP-1 expression. Although the histone post-translational modifications (PTMs) are assumed to affect the AP-1 transcriptional regulation by the PI3K/Akt pathway, the detailed mechanisms are completely unknown. In the present study, we show that heterochromatin 1 gamma ($HP1{\gamma}$) plays a negative role in TPA-induced c-Jun and c-Fos expression. We show that TPA-induced Akt1 directly phosphorylates $HP1{\gamma}$, abrogates its suppressive function and increases the interaction between histone H3 and 14-3-$3{\varepsilon}$. Collectively, these our data illustrate that the activation of PI3K/Akt pathway may play a permissive role in the recruitment of histone readers or other coactivators on the chromatin, thereby affecting the degree of AP-1 transcription.

• 충청수학회지
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• 제17권1호
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• pp.103-110
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• 2004

In this paper, we define the ap-Denjoy integral and investigate some properties of the ap-Denjoy integral.

• 한국토양비료학회지
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• 제33권2호
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• pp.71-78
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• 2000

사과 과수원 토양(송정통, the fine loamy, mesic family of Typic Hapludults)을 층위별로 채취하여 토양 수리적 특성과 누적공극분포를 조사하고 표토인 Ap1층과 점토집적층인 B1층에서 각각 토양코아시료 (지름 7.4 cm, 높이 7.4 cm)를 채취하여 포화조건에서 $Cl^-$와 $Cu^{2+}$로 혼성치환실험을 수행하고 그 출현곡선으로부터 선택류(選擇流)를 검증하고자 하였다. Ap1층과 B1층은 사질 식양토로 같은 토성이나 Ap1층의 포화수리전도도는 $2.0cmhr^{-1}$로 B1층($0.27cm hr^{-1}$)의 약 7배에 달하였다. C층은 포화수리전도도 $5.2cmhr^{-1}$인 구조가 없는 사양토로 물과 용질의 이동을 제한하는 역할이 가장 낮을 것으로 판단되었다. 누적 공극분포에서 Ap1층과 B1층의 대공극량(토양수분포텐셜 - 6 kpa에 해당하는 지름 $49{\mu}m$ 이상의 공극)은 각각 총 공극량의 24%, B1층은 14%이었다. 염소출현곡선에서 Ap1층 코아와 B1층 코아의 수력학적 분산계수는 각각 $34cm^2hr^{-1}$, $1.3cm^2hr^{-1}$이었고 이때 B1층 코아의 지연계수는 1인 반면 Ap1층 코아는 0.6으로 부동수분과 유동수분의 분배가 일어났다. 양이온 치환용량이 Ap1층이 B1층보다 높음에도 불구하고 Ap1층 코아의 구리지연효과가 B1층보다 더 작게 나타났다. 이 결과는 포화수리전도도와 대공극 함량이 큰 Ap1층에서 선택류(選擇流)가 일어날 수 가능성을 보여 주었다. 그러나 투수성이 좋은 모재층을 가진 이 토양단면에서 Ap1층에서 선택류(選擇流)가 일어난다 하더라도 B1층에 의해 제한될 것으로 사료된다.