• 동의생리병리학회지
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• 제20권2호
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• pp.449-454
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• 2006

This research was planned and executed to evaluate how the nutritional composition and antioxidants contents and antioxidative activity of Hongsambak. Also, can effect health conditions of people who are suffering from diet-related disease like obesity and hyperlipidemia by taking healthy foods with Hongsambak in a form of nutritional supplement with our daily meals. With this observation, we found out that Hongsambak has high content of dietary fiber and effect on antioxidative activity. We concluded that we could apply the components in a form of various foods. The information we received from this conclusion will be a basic information on how we can apply oriental medicinal resources into other foods and in the field of functional food research, which already draes sizable attention world-wide.

• Natural Product Sciences
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• 제12권4호
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• pp.226-231
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• 2006

Artemisia vulgaris, one of the most religious plants in Nepal, is used in the treatment of various ailments. In this study, antioxidative activity of essential oil from A. vulgaris was evaluated, using different in vitro methods and antimicrobial activity by disc diffusion method against skin disease microorganisms such as Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Candida albicans and Propionibacterium acnes. The essential oil exhibited a concentration-dependent antioxidant activity. It showed strong metal chelating activity with low reducing and antioxidant power. However, gradual increase in radical scavenging activity was obtained with increasing concentration and reaction time. It also possessed a broad spectrum of antimicrobial activity and notable susceptibility was observed against S. pyogenes and P. acnes.

• 동아시아식생활학회지
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• 제26권2호
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• pp.192-199
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• 2016

The antioxidative activity and antimutagenic activity of the ethanol extracts from pericarp and seeds of wild grape (Vitis coignetiea) were analyzed in this study. The antioxidative activity of the extracts from wild grape was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay. The antimutagenic activity of the extracts was evaluated on Salmonella typhimurium TA98 and TA100 by Ames test using 4-nitroquinoline 1-oxide (4-NQO) and sodium azide as mutagens. In the antioxidative activity determination, $IC_{50}$ values of the DPPH radical scavenging activity of the extracts from pericarp and seeds were 27.16 ppm and 7.61 ppm, respectively. Additionally, ABTS radical scavenging activities of pericarp and seed extract were 99.75% and 98.87% at 200 ppm, respectively. In the antimutagenic activity determination, pericarp extract at 5 mg/plate inhibited 72.6% and 74.3% of mutagenicity of S. typhimurium TA98 induced by 4-NQO and sodium azaid, respectively. Also, the mutagenicity inhibition rates of seed extract at 5 mg/plate were 77.8% and 74.5% in S. typhimurium TA100 induced by 4-NQO and sodium azaid, respectively. These results demonstrate that the ethanol extract from wild grape has remarkable antioxidant activity and antimutagenicity.

• Biomolecules & Therapeutics
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• 제8권4호
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• pp.349-353
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• 2000

Mefenamic acid has been widely used as clinical drug for anti-inflammatory and analgesic. This drug was known to non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen and indomethacin. Although the drugs which comprise this group are of diverse chemical structures, they all share the antipyretic, analgesic and anti-inflammatory actions which are characteristic of aspirin. Action of this drugs is caused by inhibitory effect of biosynthesis of prostaglandin that are synthesized from arachidonic acid via the endoperoxide biosynthesis pathway, the initial step of which is catalysed by cyclooxygenase. Mefenamic acid has more potent inhibitory action of prostaglandin biosynthesis than aspirin. Therefore, mefenamic acid is expected to have anticoagulant activity as aspirin-like drugs. This study was carried out to investigate the sinthesis of mefenamic acid derivatives from mefenamic acid and aromatic compound of antioxidant and its antioxidative and anticoagulant activities. Synthesis of mefenamic acid derivatives was conformed by conjugation as using esterification method. Biological activities was examined using effect of anticoagulant on bleeding time and effect of antioxidant by TBA method. As a result, SJ-202 showed strong antioxidative activity and anticoagulant activity among tested 4 compounds and exhibited similar activity to aspirin at anticoagulant activity.

• Journal of Ecology and Environment
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• 제29권2호
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• pp.157-163
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• 2006

Growth of G. max treated with $NO_3^-$-N was decreased by high NaCl treatments, but $NH_4NO_3$-fed plants showed good growth with enhanced activity of antioxidative enzymes (SOD and APX). Especially, activity of APX was higher in 5 mM $NH_4NO_3$-fed plants than other types of N-supplied plants throughout the stress period. Higher SOD activity under salt stress was accompanied by increase in APX activity in 5 mM $NH_4NO_3$-fed plants. Similarly, application of calcium confirmed somewhat positive effects on growth. Salt-treated soybean plants showed the best growth response with the increase of SOD and APX activity at an additional 5 mM calcium treatment. Especially, the increase of SOD activity through the strengthened CuZn-SOD isoform was remarkable.

• 대한의생명과학회지
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• 제16권4호
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• pp.271-277
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• 2010

This study was conducted to investigate the biological activities of Areca catechu L. The antioxidative, fibrinolytic, thrombin inhibitory, and ${\alpha}$-glucosidase inhibitory activities of Areca catechu L extracted with hexane, $CHCl_3$, ethyl acetate, butanol, and water were measured. The water fraction showed the highest extraction yield at 3.65% (w/w). The butanol, $CHCl_3$, water, and ethyl acetate fractions showed strong antioxidative activities at 81.6%, 87.1%, 88.0%, and 89.5%, respectively. The fibrinolytic activity was strong only in the ethyl acetate fraction at 0.84 plasmin units/ml. The 100-fold dilution of the water fraction had the strongest thrombin inhibitory activity at 59.2%. The 100-fold dilution of butanol fraction displayed the strongest ${\alpha}$-glucosidase inhibitory activity at 88.6%. In conclusion, the extracts of Areca catechu L hold promise for use in the development of biofunctional foods to prevent cardiovascular diseases.

• 생약학회지
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• 제39권3호
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• pp.265-269
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• 2008

This study was carried out to observe the antioxidative activity, fibrinolytic activity, nitrite savenging ability and adenosine content of three medicinal mushrooms. Among water and ethanol extract of each mushroom, water extract of Inonotus obliquus (Czech) showed the highest antioxidative activity $(57.1{\mu}g/ml)$, nitrite scavenging ability (52.04%), fibrinolytic activity (86.8%) and adenosin content $(94.3{\mu}g/g)$, whereas nitrite scavenging ability of ethanol extract of Phellinus linteus showed higher than that of water extract. Apart from the above statements, water was effective than ethanol as extracting solvent in general. These results suggest that Inonotus obliquus (Czech) showed higher activities such as antioxidative activity, nitrite scavenging ability, fibrinolytic activity and adenosin content and water was effective as solvent except for nitrite scavenging ability.

• 생명과학회지
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• 제6권1호
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• pp.66-71
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• 1996

동결건조한 김치를 물, 메탄올, 에칠 에테르로 각각 추출한 후 이들 용매추출물들이 지니고 있는 지질산화반응에서의 항산화력에 대하여 고찰하였다. 즉, linoleic acid mixture의 액상산화반응 조건($37^{\circ}C$)에서 과산화물 생성억제에 대한 용매별, 김치발효기간별, 농도별, 그리고 혼합용매종류별로 실험하여 추출물의 항산화능을 살펴보았다. 그 결과 물과 메탄올 추출물이 에틸에테르 추출물 보다 과산화물의 생성을 더 억제 하였다.그리고 첨가농도가 증가할수록 항산화성이 증대되었으며 발효 초일의 김치나 과숙김치보다 잘 숙성된 김치(15$^{\circ}C$에서 7일간 발효)의 추출물에 더 항산화성이 높았다. 또한 물과 메탄올의 비율을 달리 하여 추출한 경우 순수 메탄올보다 50~80% 메탄올 농도에서의 용매추출물에서 항산화효과가 높았다. 비록 75% 메탄올추출물의 항산화성은 BHA와 $\alpha$토코페롤보다는 낮았지만 동 추출물에서 계통적 분획 등에 의한 분획물의 항산화성을 계속 검토하므로서 보다 높은 항산화성 물질이 분리될 수 있음을 알 수 있었다.

• 한국식품조리과학회지
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• 제30권6호
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• pp.767-773
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• 2014

찹쌀풀과 생참기름을 이용한 전통적인 방법으로 제조한 연근, 김, 깻잎 부각의 산화방지활성과 산화방지 성분을 평가하였다. 깻잎 부각이 가장 높은 라디칼 소거 활성과 환원력을 보였으며 연근 부각의 활성이 가장 낮았는데 부각 원료인 데친 연근, 김, 깻잎의 활성과 동일한 순서이었다. 폴리페놀 화합물 함량은 연근, 김 부각보다는 깻잎 부각에서 더 높았고, 부각의 토코페롤은 대부분 튀김유인 참기름에서 유래하였다. 부각의 산화 방지 활성은 폴리페놀 화합물 함량과 높은 상관관계를 보였으나 토코페롤 함량과의 상관관계는 매우 낮아 폴리페놀 화합물이 부각의 산화 방지 활성에 더욱 긴밀하게 기여하고 있음을 의미하였다.

• 한국자원식물학회지
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• 제22권1호
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• pp.71-77
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• 2009

제주도에 자생하는 피자식물 289종 454점을 대상으로 항산화활성과 ${\alpha}$-amylase 저해활성을 검색하였다. DPPH radical에 대한 전자공여능으로 측정한 항산화활성은 붉나무의 오배자, 굴피나무의 열매, 참죽나무의 줄기 메탄올 조추출물에서 높은 활성을 보였다. 특히, 붉나무의 오배자의 항산화활성은 94.2${\pm}$0.8%로 본 실험에 동일 농도의 대조구로 사용된 BHA(61.7${\pm}$0.6%)와 ascorbic acid(53.6${\pm}$0.7%) 보다도 활성이 높았다. 그리고 붉나무, 굴피나무, 참죽나무 이외의 나머지 52점의 식물들도 차나무 잎의 활성보다 높았다. ${\alpha}$-Amylase 저해활성은 곰의말채의 줄기와 잎, 조록나무의 잎과 소지, 정금나무의 잎 등 9종 11점에서 80% 이상의 높은 활성을 보였다. 앞으로 식품 소재 또는 생약으로의 개발 가능성을 모색하기 위해서 활성성분의 분리 및 동정 그리고 이들 물질을 이용한 임상실험 등 보다 심도있는 연구가 요구된다.