Browse > Article

Biological activities of Solvent Fractions Isolated from Areca catechu L  

Kim, Jun-Ho (Department of Fine Chemistry and New Materials, Sangji University)
Oh, Hae-Sook (Department of Food and Nutrition, Sangji University)
Publication Information
Biomedical Science Letters / v.16, no.4, 2010 , pp. 271-277 More about this Journal
Abstract
This study was conducted to investigate the biological activities of Areca catechu L. The antioxidative, fibrinolytic, thrombin inhibitory, and ${\alpha}$-glucosidase inhibitory activities of Areca catechu L extracted with hexane, $CHCl_3$, ethyl acetate, butanol, and water were measured. The water fraction showed the highest extraction yield at 3.65% (w/w). The butanol, $CHCl_3$, water, and ethyl acetate fractions showed strong antioxidative activities at 81.6%, 87.1%, 88.0%, and 89.5%, respectively. The fibrinolytic activity was strong only in the ethyl acetate fraction at 0.84 plasmin units/ml. The 100-fold dilution of the water fraction had the strongest thrombin inhibitory activity at 59.2%. The 100-fold dilution of butanol fraction displayed the strongest ${\alpha}$-glucosidase inhibitory activity at 88.6%. In conclusion, the extracts of Areca catechu L hold promise for use in the development of biofunctional foods to prevent cardiovascular diseases.
Keywords
Antioxidative activity; Areca catechu L; Fibrinolytic activity; ${\alpha}$-Glucosidase inhibitory activity; Thrombin inhibitory activity;
Citations & Related Records
Times Cited By KSCI : 5  (Citation Analysis)
연도 인용수 순위
1 Kim HK, Kim GT, Park SH. Characterization of a novel fibrinolytic enzyme from Bacillus sp. KA38 originated from fermented fish. J Ferment Biotech. 1997. 84: 307-312.   DOI   ScienceOn
2 Doljak B, Stegnar M, Urleb U, Kreft S, Umek A, Ciglaric M, Strukelj B, Popovic T. Screening for selective thrombin inhibitor in mushrooms. Blood Coagul Fibrinolysis. 2001. 12: 123-128.   DOI   ScienceOn
3 Haverkate F, Traas DW. Dose-response curves in the fibrin plate assay. Fibrinolytic activity of protease. Thromb Haemost. 1974.32: 356-365.
4 Kim SH. New trends of studying on potential activities of Doen-Jang. Korea Soybean Digest. 1998. 15: 8-15.
5 Chin JE, Cho NC. The Effects of Areca catechu Extracts on Tyrosinase Gene Expression in B 16 Mouse Melanoma Cells. Kor J Food Nutr. 2007. 20: 240-244.   과학기술학회마을
6 Daka MD, Semba CP. Thrombolytic therapy in venous occlusive disease. J Vasc Interv Radiol. 1995.6: 73-77.   DOI   ScienceOn
7 Oh HS, Kim JH. Development of functional soy-based stew sauce including hot water extract of Comus officinalis S. et Z. Kor J Food Culture. 2006. 21: 550-558.   과학기술학회마을
8 Ames BN, Shigenaga MK, Hagen. Oxidant, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA. 1933.90: 7915.
9 Blois MS. Antioxidant determinations by the use of a stale free radical. Nature 1958.181: 1199-1120.   DOI   ScienceOn
10 Lim DK, Choi UC, Shin DH. Antioxidative activity of ethanol extract from korean medicinal plants. Kor J Food Sci Technol. 1996. 29: 601-608.
11 Oh HS, Kim JR. Physiological functionalities of hot water extract of Codonopsis lanceolata and some medicinal materials, and their mixtures. Korean J Community Living Sci. 2007. 18: 407-415.   과학기술학회마을
12 Oh HS, Kim JH. Bioactive compounds of hot-water extracts from medicinal plants. J Life Natural Sci (Sangji university). 2007. 14: 83-89.
13 Oh HS, Kim JH. Physiological functionalities of solvent fractions isolated from Crataegi fructus. Kor J Biomed Lab Sci. 2008. 14: 249-255.   과학기술학회마을
14 Sohn HY, Kwon YS, Kim YS, Kwon BY, Kwon GS, Kim KJ, Kwon CS, Son KH. Screening of thrombin inhibitors from medicinal and wild plants. Kor J Phannacogn. 2004. 35: 52-61.   과학기술학회마을
15 Watanabe J, Kawabata J, Kurihara H, Niki R. Isolation and identification of alpha-glucosidase inhibitors from Tochu-cha (Eucommia ulmoides). Biosci Biotechnol Biochem. 1997.61: 177-178.   DOI   ScienceOn
16 Lee KS, Kim SR, Chun SH, Park SS, Park CS, Shin YS. Antimicrobial activity of Areca catachu L. Extract of against intestinal pathogens. Kor J Food Nutr. 1998. 11: 36-40.
17 Kim YJ, Kim CK, Kwon YJ. Isolation of antioxidative components of Perillae semen. Kor J Food Sci Technol. 1997.29: 38-43.
18 Kim YT, Kim WK, Oh HS. Purification and characterization of a fibrinolytic enzyme produced from Bacillus sp. Strain CK 11-4 screened from ChungkookJang. Appl Environm Microbiolo. 1996. 2482-2488.
19 Lee JM, Lee SH, Kim HM. Use of oriental herbs as medicinal food. Food Industry and Nutrition. 2000. 5: 50-56.
20 Lee KS, Kim SH, Kim SS, Park SS, Chun JY, Shin YS. Antimicrobial activity of herbs related with treatments of intestinal disease against intestinal pathogens Kor J Food Nutr. 1998. 11: 31-35.
21 Lee SH, Kim SY, Son KH, Kang SJ, Chang SY, Park JH, Lee KS. Isolation and quantitative determination of Arecoline from Arecae semen. Kor J Pharmacogn. 2001. 32: 39-42.