• Title/Summary/Keyword: AM80

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Changes of Serum VEGF and b-FGF in 26 Patients with Breast Cancer after Treatment with Hang-Am-Dan (HAD), an Antiangiogenic Botanical Prescription

  • Yoo Hwa Seung;Lee Nam Heon;Cho Jung Hyo;Lee Yeon Weol;Son Chang Gue;Kang Wee Chang;Cho Chong Kwan
    • The Journal of Korean Medicine
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    • v.26 no.4
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    • pp.22-30
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    • 2005
  • Objectives: Recently, angiogenesis has gained an increasing interest as a prognostic factor in breast cancer. In this study we aimed to assess the anti angiogenic effects of HAD, a botanical anticancer remedy which has been prescribed in Daejeon University Oriental Hospital in Korea, on patients with breast carcinoma by measuring the serum vascular endothelial growth factor (VEGF), basic fibroblast growth factor (b-FGF) and platelets levels. Methods: The study included 26 consecutive breast cancer patients (mean age$\pm$standard deviation: 47.5$\pm$8.7 years) with stage II to IV disease who were treated with HAD (mean duration $\pm$ standard deviation: 264.5$\pm$121.6 days). In addition to routine laboratory and staging procedures, serum VEGF, b-FGF levels and platelet counts were determined as antiangiogenic markers. The antiangiogenic effects of HAD were evaluated by analyzing the differences between the values of the antiangiogenic markers before and after the treatment with HAD. Results: Serum b-FGF concentrations were significantly reduced after the treatment with HAD (P=0.042). Serum VEGF concentrations were found to have a somewhat decreasing change, though the change was not statistically significant (P=0.229). Platelet counts had little changes (P=O.80). Conclusions: It is supposed that HAD has effects on decreasing the serum b-FGF levels related with the clinical outcome of breast cancer patients.

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Physical Properties of Fe Particles Fine-dispersed in AlN Thin Films (Fe 입자를 미세 분산 시킨 AlN 박막의 물리적 성질)

  • Han, Chang-Suk;Kim, Jang-Woo
    • Korean Journal of Materials Research
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    • v.21 no.1
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    • pp.28-33
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    • 2011
  • This paper describes the fabrication of AlN thin films containing iron and iron nitride particles, and the magnetic and electrical properties of such films. Fe-N-Al alloy films were deposited in Ar and $N_2$ mixtures at ambient temperature using Fe/Al composite targets in a two-facing-target DC sputtering system. X-ray diffraction results showed that the Fe-N-Al films were amorphous, and after annealing for 5 h both AlN and bcc-Fe/bct-$FeN_x$ phases appeared. Structure changes in the $FeN_x$ phases were explained in terms of occupied nitrogen atoms. Electron diffraction and transmission electron microscopy observations revealed that iron and iron nitride particles were randomly dispersed in annealed AlN films. The grain size of magnetic particles ranged from 5 to 20 nm in diameter depending on annealing conditions. The saturation magnetization as a function of the annealing time for the $Fe_{55}N_{20}Al_{25}$ films when annealed at 573, 773 and 873 K. At these temperatures, the amount of iron/iron nitride particles increased with increasing annealing time. An increase in the saturation magnetization is explained qualitatively in terms of the amount of such magnetic particles in the film. The resistivity increased monotonously with decreasing Fe content, being consistent with randomly dispersed iron/iron nitride particles in the AlN film. The coercive force was evaluated to be larger than $6.4{\times}10^3Am^{-1}$ (80 Oe). This large value is ascribed to a residual stress restrained in the ferromagnetic particles, which is considered to be related to the present preparation process.

A Study on Optimum Takeoff Time of the Hybrid Electric Powered Systems for a Middle Size UAV (중형무인기용 하이브리드 전기동력시스템의 최적 이륙시간에 관한 연구)

  • Lee, Bohwa;Park, Poomin;Kim, Keunbae;Cha, Bongjun
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.40 no.11
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    • pp.940-947
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    • 2012
  • The target system is a middle size UAV, which is a low-speed long-endurance UAV with a weight of 18 kg and wingspan of 6.4 m. Three electric power sources, i.e. solar cells, a fuel cell, and a battery, are considered. The optimal takeoff time is determined to maximize the endurance because the generated solar cell's energy is heavily dependent on it. Each power source is modeled in Matlab/Simulink, and the component models are verified with the component test data. The component models are integrated into a power system which is used for power simulations. When takeoff time is at 6 pm and 2 am, it can supply the power during 37.5 hrs and 27.6 hrs, respectively. In addition, the thermostat control simulation for fuel cell demonstrates that it yields more power supply and efficient power distribution.

Concentration and Distribution of Heavy Metals in Sediments and Bivalves(Solen Strictus Gould) from Tidal Flats along the Mid-Western Coast, Korea (서해 중부연안 갯벌에서의 저질 및 패류 (Solen Strictus Gould) 중 중금속 분포특성)

  • 황갑수;신형선;김강주;여성구;김진삼
    • Journal of Environmental Health Sciences
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    • v.27 no.4
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    • pp.25-34
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    • 2001
  • Heavy metal level and distribution in sediment and bivalves from the tidal flats along the mid-western coast, Korea. were investigated in this study. The averages of heavy metal concentrations in sediments from 5 sampling sites ranged from 86.35-187.77mg/kg for Mn. 13.25-17.73mg/kg for Zn.6.80-11.85mg/kg for Cr,4.28-6.25mg/kg for Ni, 1.85-3.09mg/kg for Cu, 0.004-0.02()mg/kg for Cd and 5.70-10.41 mg/kg for Pb, respectively. From the results of heavy metal concentrations in mussels, the levels of Mn and Fe concentrations in S. strictus collected from S1 antral S2 sites were particularly high. Deviations of heavy metal concentrations am(Ing the individual mussels from the same site could be largely minimized by selecting mussel samples of the limited range in body size(8.5-11cm). Among the mussels of the limited body size, heavy metal concentrations both in the flesh and in the whole soft part were not strongly related to the body size. It was shown that ,in S. strictus, Cu moves fast into the flesh parts after absorption, while Pb and Fe move fast into the non-flesh parts. Overally. the heavy metal concentration in the tends to increase with that in the whole soft parts. The concentration factors(heavy metal concentration in 5. strictus/heavy metal concentration in sediment) showed that, of the examined meta1s. Cd is the most cumulative in the body of S. strictus followed by Zn and Cu, while Mn, Cr. Ni and Pb are not cumulative.

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Mobile Energy Shelter House(MeSH) for victims when a disaster occurs - Focused on Indoor Thermal Environmental Performance - (재난·재해 시 이재민을 위한 이동형 에너지 셜터하우스 (MeSH) 계획 -실내 온열환경 성능을 중심으로-)

  • Shin, Hwayeon;Kim, Jeonggook;Kim, Jonghun;Jeong, Hakgeun;Jang, Cheolyong;Hong, Wonhwa
    • KIEAE Journal
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    • v.14 no.6
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    • pp.75-80
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    • 2014
  • Development of temporary housing for victims whose house damaged is required. In this study is to plan temporary house space 'Mobile Energy Shelter House ; MeSH' that can be inhabited for a long time. And measure the indoor Environmental performance. 'Mobile Energy Shelter House : MeSH' was made by reflecting Passive Design, Universal Design. Also, thermal insulation that meets the 'Korea standard insulation' for use low energy. Winter season, measuring temperature, humidity, air velocity and radiation temperature when floor heating that temperature controllers ware installed is used. Confirmed the data for the 8:00pm to 8:00am because evening hours are expected as residents live. Average outdoor temperature was $-11.3^{\circ}C$ and Indoor temperature was from $16.09^{\circ}C$ to $20.63^{\circ}C$. Calculated the TDRi of the window surface for checked condensation risk. TDRi value was 0.185. Furthermore, PMV value was -0.08 to -0.85. It was satisfied to ISO comfort criterion ranged.

A Study on the Development of Medical Service Robot (의료용 서비스 로봇 개발에 관한 연구)

  • Kang, Sung-In;Park, Yoon-A;Oh, Am-Suk;Jean, Je-Hwan
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2011.05a
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    • pp.77-80
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    • 2011
  • Medical robot has four fields. Surgery assistant robot, robotic surgery, Surgery Simulator, rehabilitation robot. Thus, medical robots is often high precision and reliability requirements for operations are being developed. Medical service robot's another sector is care for service robots. Care services robot is the hospital's reception work and biometric data acquisition of patients, the hospital in location and content information provide to patients. But now medical service robot practical acceptance process failed to progress. In this paper were the medical service robot systems design and implementation. Implemented the robot system is using the standard protocols for the exchange of medical information and can be linked with hospital information system. The hospital's patient reception and processing, to provide care waiting number information.

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Analysis of Irradiation and Power per Each Seasons of Photovoltaic Systems (태양광 발전시스템의 계절별 일사량과 전력량 분석)

  • Kim, Seok-Gon;Hwang, Jun-Won;Lee, Ying;Choi, Yong-Sung;Lee, Kyung-Sup
    • Proceedings of the KIEE Conference
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    • 2009.04a
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    • pp.43-45
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    • 2009
  • In case of favourable irradiation conditions, the ratio of irradiation to the total irradiation went up and then the irradiation increased in the area with high angle of inclination. The study showed that on a clear day with the irradiation of more than 80$[W/m^2]$, the pattern of alternating current power change in the fixed system was similar with that in the single-axis tracker. On the contrary, in case of unfavourable irradiation conditions, the ratio of diffuse irradiation to the total irradiation went up and then the horizontal irradiation increased. In the demo system, the fixed system, the single-axis tracker and the dual-axis tracker all had low generation power and similar generation pattern with each other. The study showed the generation power varied with the irradiation in the fixed system, while in the single-axis tracker and the dual-axis tracker, the amount of the generation Power variation was much more than the irradiation variation. The demo system was operated from 11:00 AM to 2:00 PM for generating power, during which time, 46[%] to 56[%] of the total generation power was produced. In this study, the generation power was increased by 147[%] in the fixed system, by 136[%] in the single-axis tracker, and by 164[%] in the dual-axis tracker, and the pattern of generation power was similar with the generation power variation in the situation where the irradiation increased by 140[%] in the spring with plenty of insolation. The alternating current power was more sensitive to variation of the irradiation than to that of the surface temperature of a module. The variation of the irradiation had a more positive effect on the generation power than the type of array.

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Hall 소자용 InAs 박막성장

  • 김성만;임재영;이철로;노삼규;신장규;권영수;유연희;김영진
    • Proceedings of the Korean Vacuum Society Conference
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    • 1999.07a
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    • pp.94-94
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    • 1999
  • 반도체 Hall 효과를 이용하여 자계를 검출하여 이를 전압신호로 출력하는 자기센서로는 주로 GaAs, InSb, InAs 등의 박막이 사용되고 있다. 자기센서의 응용분야가 최근에는 직류전류의 무접촉 검출, 자동차의 무접촉 회전 검출, 산업용 기계의 제어용 무접촉 위치검출 분야로 확대되고 있어 그 수요가 급증하고 있다. 이중 Hall 소자의 응용분야중 많은 활용이 기대되고 있는 자동차용 무접촉 센서는 -4$0^{\circ}C$~15$0^{\circ}C$의 온도범위에서 안정하게 작동하여야 하므로 온도 안정성이 매우 중요하다. 그러나 Hall 소자 시장의 80%를 점유하고 있는 InSb Hall 소자는 온도가 올라감에 따라 저항이 급격히 낮아지는 성질을 가지고 있으므로 10$0^{\circ}C$ 이상의 온도에서 사용하는 것이 불가능하다. 한편 InAs(에너지갭~0.18eV)는 InSb보다 에너지 갭이 크므로 고온에서도 작동이 가능하고 자계변화에 따른 출력의 직진성이 매우 좋다는 장점을 가지고 있다. 이러한 InAs Hall 소자를 실현하기 위해서 가장 중요한 것이 고품위의 InAs의 박막 성장기술이다. InAs 박막을 성장하기 위해서 사용되고 있는 기판은 GaAs이다. 그러나 GaAs 기판과 InAs 박막 사이에는 약 7% 정도의 격자부정합이 존재하기 때문에 높은 이동도를 가지는 고품위 박막을 성장시키기가 매우 어렵다. 이에 본 연구에서는 분자선에피택시 방법을 이용하여 GaAs 기판위에 고품위의 InAs 박막을 성장하는 기술을 연구하였으며, 성장된 InAs 박막의 특성을 DCX 및 Hall effect 등으로 조사하였다. InAs 박막 성장시 기판은 <0-1-1> 방향으로 2$^{\circ}$ off 된 GaAs(100)를 사용하였다. InAs 박막성장시 기판온도는 48$0^{\circ}C$로 하고 GaAs buffer 두께는 2000$\AA$로 하여 As flux 및 Si doping 농도등을 변화시켰다. 그 결과 Si doping 농도 2.21$\times$1017/am에서 10,952cm2/V.s의 이동도를 얻었다.

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Comparison of Venting Modes for Bench Scale Treatment of Diesel Contaminated Soil (디젤오염토양의 Bench Scale 처리에 있어서 벤팅모드 비교)

  • Kim, Young-Am;Lee, Yong-Hee;Lee, Dong-Sun;Suh, Myung-Gyo
    • Journal of Environmental Health Sciences
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    • v.32 no.5 s.92
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    • pp.499-505
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    • 2006
  • Bioventing efficiency was compared in a continuous and an intermittent(6hr injection and 6hr rest) air injection mode. Two lab-scale columns which packed with 5 kg of soil artificially contaminated by diesel oil were operated. The columns were maintained at the $25^{\circ}C{\pm}2.5$ in order to minimize the effect of exterior temperature variation. The flow rate of air injection mode were maintained constantly at the flow rate of 10 ml/min. The moisture of the columns was stably maintained at $60{\sim}80%$ of field capacity. The nutrient compounds were added to make C:N:P ratio as 100:10:l. The continuous and intermittent injection modes showed 67.56% and 69.63% reduction of initial TPH concentration during 90 days, respectively. Two venting modes showed similar results in the analysis of the trends of the hydrocarbon utilizing bacterial counts for operating periods. The carbon dioxide production rate of the continuous injection mode was higher than that of intermittent injection mode. The loss of diesel oil by volatilization in the continuous and intermittent injection modes were about 5% and 1%, respectively. The lower volatilization loss in the intermittent injection mode suggested that the biodegradation of TPH in the intermittent injection mode was greater than that of the continuous mode. These results suggested that the intermittent injection mode is more efficient than the continuous venting mode.

Distribution of Larvae of the Common Squid Todarodes pacificus in the Northern East China Sea (동중국해 북부해역에서의 살오징어(Todarodes pacificus) 유생의 분포)

  • Kim, Jung-Jin;Lee, Hwa-Hyun;Kim, Su-Am;Park, Chul
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.44 no.3
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    • pp.267-275
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    • 2011
  • The common squid Todarodes pacificus is an ecologically and commercially important species in Korea and Japan. However, the distribution pattern of its eggs and larvae in Korean waters has not yet been clarified. To determine the horizontal and temporal distribution of common squid larvae in the northern East China Sea, samples collected using paired, 60 cm diameter Bongo nets from the three surveys conducted in August 2003, May 2004 and November 2005 were examined. In addition, the vertical distribution was examined from the samples collected using a $1\;m^2$ MOCNESS in April 1999 (20 m interval down to 100 m). A total of 218 larvae ranging in mantle length (ML) from 1.2 to 17.0 mm were counted at 27 stations. Larval abundance was highest in May 2004. The larvae mainly occurred in the southeastern area of Jeju Island, where the water temperature and salinity at 50 m deep ranged from $15-23^{\circ}C$ and 34-34.6 psu, respectively. Most larvae were collected in the frontal zone, where the Tsushima Warm Current and inshore waters meet. The results from the MOCNESS samples showed that the larvae occurred mostly in 20-80 m depth ranges (about 90%), although collections were only conducted above 100 m. No significant differences in larval mantle lengths (ANOVA, P>0.05) were found among each depth interval. Given the occurrence sites of the larvae <2.0 mm ML, the spawning ground of this species appears to be within the northern East China Sea, mainly to the southeast and northeast of Jeju Island, in early spring.