• 제목/요약/키워드: AJ

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Cytoprotective effect exerted by geraniin in HepG2 cells is through microRNA mediated regulation of BACH-1 and HO-1

  • Aayadi, Hoda;Mittal, Smriti P.K.;Deshpande, Anjali;Gore, Makarand;Ghaskadbi, Saroj S.
    • BMB Reports
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    • 제50권11호
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    • pp.560-565
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    • 2017
  • Geraniin, a hydrolysable tannin, used in traditional medicine in Southeast Asia, is known to exhibit various biological activities. As an antioxidant it is known to up-regulate phase II enzyme Heme oxygenase-1 (HO-1). However its mechanism is not clearly understood. Nuclear factor erythroid-derived 2 related factor 2 (Nrf-2) is transcriptionally up-regulated by Extracellular signal-regulated kinase (ERK) 1/2 and retained in nucleus due to inactivated Glycogen synthase kinase 3 beta ($GSK-3{\beta}$). Geraniin additionally down-regulates expression of microRNA 217 and 377 (miR-217 and miR-377) which target HO-1 mRNA. Expression of BTB and CNC homolog 1 (BACH-1), another regulator of HO-1, is also down-regulated by up-regulating microRNA 98 (miR-98), a negative regulator of BACH-1. Thus, geraniin up-regulates HO-1 expression both through activating its positive regulator Nrf-2 and by down-regulating its negative regulator BACH-1. Up-regulation of HO-1 also confers protection to HepG2 cells from tertiary butyl hydroperoxide (TBH) induced cytotoxicity.

토지이용 변화가 물순환에 미치는 영향과 침투트렌치 설치 효과 분석 - A 신도시 지구를 중심으로 - (Impacts on water-cycle by land use change and effects of infiltration trenches in Asan New town)

  • 현경학;이정민
    • 상하수도학회지
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    • 제24권6호
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    • pp.691-701
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    • 2010
  • As the water-cycle is transformed by increasing of the impermeable area in process of urbanization, decentralized rainwater management facilities(infiltration, harvesting and retention facilities) as source control are considered to be a method of restoring water-cycle of urban and reducing runoff. SWMM model was used to analyse the change of water-cycle structure before and after development in A new town watershed. Modified SWMM code was developed to apply infiltration facilities. The modified SWMM was used to analyse the change of water-cycle before and after infiltration trench setup in AJ subcatchment. Changes of the impervious area by development and consequent increase in runoff were analyzed. These analyses were performed by a day rainfall during ten years from 1998 to 2007. According to the results, surface runoff increased from 51.85% to 65.25 %, and total infiltration volume decreased from 34.15 % to 21.08 % in A newtown watershed. If more than 80 infiltration trenches are constructed in AJ subcatchment, the low flow and the drought flow increases by around 47%, 44%, separately. The results of this study, infiltration trench is interpreted to be an effective infiltration facility to restore water-cycle in new town.

Biological Control of Sclerotinia sclerotiorum Using Indigenous Chitinolytic Actinomycetes in Jordan

  • Tahtamouni M.E.W.;Hameed K.M.;Saadoun I.M.
    • The Plant Pathology Journal
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    • 제22권2호
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    • pp.107-114
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    • 2006
  • The white cottony stem rot pathogen Sclerotinia scierotiorum was subjected to 70 different isolates of actinomycetes indigenous to Jordan as biological control agents. Forty of them demonstrated chitinase activity on crab shell chitin agay (CCA) media and they were segregated into three groups: 14 highly active, 12 moderately active, and 14 with low activity, with average clearing zones of (4.7-8.3), (3.7-4.3), and (2.3-3.3) mm surrounding colonies on CCA, respectively. Further, these isolates were able to inhibit radial mycelium growth of the pathogen and were categorized into three antagonistic groups: 13 strong, 13 moderate, and 14 weak antagonists, with antibiosis inhibition Bones of (32.0-45.7), (22.7-31.3), and (3.7-22.3) mm, respectively. High levels of chitinase activity of the isolates Ma3 (8.3 mm), Jul (7.7 mm), and Sa8 (7.7 mm) with their antagonistic activity against mycelium growth of 45.7, 44.3, and 40.7 mm were observed, respectively. These isolates exhibited fungicidal activity against sclevotia of S. sclerotiorum. On the other hand, isolates Na5, Aj3, and Aj2 that produced no chitinase showed fungistatic effect only.

THE CENTRAL LIMIT THEOREMS FOR STATIONARY LINEAR PROCESSES GENERATED BY DEPENDENT SEQUENCES

  • Kim, Tae-Sung;Ko, Mi-Hwa;Ryu, Dae-Hee
    • Journal of applied mathematics & informatics
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    • 제12권1_2호
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    • pp.299-305
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    • 2003
  • The central limit theorems are obtained for stationary linear processes of the form Xt = (equation omitted), where {$\varepsilon$t} is a strictly stationary sequence of random variables which are either linearly positive quad-rant dependent or associated and {aj} is a sequence of .eat numbers with (equation omitted).

0 - 1 배낭문제의 Algorithm 개발에 관한 연구 (The Development of Algorithm Method for 0-1 Knapsack Problem)

  • 신현재
    • 산업경영시스템학회지
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    • 제7권10호
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    • pp.29-33
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    • 1984
  • Many methods have been developed to get a good Computation steps. I think that almost methods of them have been solved by using a theory of [Vj]. But I have thought that it Can be solved by an other method. This method is a way to get a Computations steps by using [Aj] instead of [Vj]. It requires less Computation time than [Vj]. So I think that method is an efficient Algorithm about "the Development of Algorithm method for the 0 - 1 Knapsack problem."

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Determining the Specific Status of Korean Collared Scops Owls

  • Hong, Yoon Jee;Kim, Young Jun;Murata, Koichi;Lee, Hang;Min, Mi-Sook
    • Animal Systematics, Evolution and Diversity
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    • 제29권2호
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    • pp.136-143
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    • 2013
  • The collared scops owl that occurs in Korea is a protected species but its exact specific status has been questioned. To resolve the species status, a molecular phylogenetic analysis was conducted using two fragments of mitochondrial DNA, cytochrome b (cyt b, 891 bp) and NADH dehydrogenase subunit 2 (ND2, 627 bp) genes. Phylogenetic trees of cyt b revealed that all Korean specimens formed a monophyletic group with Japanese scops owl Otus semitorques with very low sequence divergence (d=0.008). We obtained a similar ND2 tree as well (d=0.003); however, the genetic distance between Korean individuals and O. lempiji from GenBank (AJ004026-7, EU348987, and EU601036) was very high and sufficient enough to separate them as species (cyt b, d=0.118; ND2, d=0.113). We also found that Korean species showed high differentiation from O. bakkamoena (AJ004018-20 and EU601034; cyt b, d=0.106; ND2, d=0.113) and O. lettia (EU601109 and EU601033, cyt b, d=0.110; ND2, d=0.117) as well. Therefore, we suggest that the Korean collared scops owl should be designated as Otus semitorques.

Trumpis 길쌈부호를 적용한 FH/MFSK 시스템의 잡음재밍에 대한 성능 분석 (Trumpis Coded FH/MFSK Performance in Noise Jamming Environments)

  • 송문규;사공석진;차균현
    • 한국통신학회논문지
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    • 제17권10호
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    • pp.1100-1108
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    • 1992
  • AJ 시스템의 비트 오류 확률의 정확한 계산은 매우 어렵거나 불가능하므로 비트 오류 확률의 Chernoff상한을 구하여 시스템의 성능 분석을 하는 것이 매우 유용하다. 부호 채널에 대한 cutoff rate의 계산은 비교적 용이하므로, AJ 시스템의 부호화 비트 오율의 상한은 AWGN 채널에서의 비트오율의 상한이 cutoff rate의 항으로 직접 구해지는 관계를 이용하여 구할 수 있다. 본 논문에서는 부호 기법을 적용한 통신 시스템에 대하여 적용할 수 있는 비트 오류 확률의 상한에 대한 일반적인 표현식을 소개하고 그 결과를 이용하여 Trumpis 부호를 적용한 FH/MFSK 시스템의 광대역 및 부분 대역 잡음 재밍에 대한 성능 분석을 하였고 아울러 채널 측정을 통해 부가적으로 제공될 수 있는 재머의 상태 정보가 비트 오류 확률에 미치는 효과도 계산함으로써 위의 사실을 입증하였다.

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오미자를 함유한 복합물의 항균, 발한억제 및 소취효과 (Antimicrobial, Antiperspirant and Deodorant Effect of Herbal Extract Mixtures Including Schisandra chinensis)

  • 안지영;김준호;권세욱;김대기;이강수;이영미
    • 동의생리병리학회지
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    • 제26권1호
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    • pp.53-58
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    • 2012
  • The aim of this study was to investigate the antimicrobial, antiperspirant and deodorant effect of herb mixtures including Schisandra chinensis(SC). This herb mixtures including Schisandra chinensis was made of Astragalus membranaceus(AM), Triticum aestivum(TA), Atractylodes japonica(AJ) and peppermint essential oil extracted from Mentha piperita(MP). We examined antimicrobial activity, antiperspirant activity and L-leucine dehydrogenase activity of the herbal extracts. We found that the mixture of SC and MP have the best antimicrobial effects on B. subtilis subsp. spizizenii and mixture of SC, AJ, AM and TA have best antiperspirant effect. Moreover, the combination of SC and AM showed the most inhibitory effect on L-leucine dehydrogenase activity. These results suggested that the herb mixtures Including Schisandra chinensis have good antimicrobial and antiperspirant effects.