• Interdisciplinary Bio Central
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• v.4 no.4
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• pp.12.1-12.6
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• 2012

The advanced glycation endproducts receptor (AGE-R) is a signal transduction receptor for multiligand such as S100b and AGEs. S100b has been demonstrated to activate various cells with important links to atherosclerosis initiation and progression including endothelial cells, and smooth muscle cells via AGE-R, triggering activation of multiple signaling cascades through its cytoplasmic domain. Many studies have suggested AGE-R might even participate in the cardiovascular complications involved in the pathogenesis of type I diabetes. Recently, Small Ubiquitin-Related Modifier 1 (SURM-1 also known as SUMO-1) has been recognized as a protein that plays an important role in cellular post-translational modifications in a variety of cellular processes, such as transport, transcriptional, apoptosis and stability. Computer Database search with SUMOplot Analysis program identified the five potential SURMylation sites in human AGE-R: K43, K44, K123, and K273 reside within the extracellular domain of AGE-R, and lastly K374 resides with the cytosolic domain of AGE-R. The presence of the consensus yKXE motif in the AGE-R strongly suggests that AGE-R may be regulated by SURMylation process. To test this, we decided to determine if AGE-R is SURMylated in living vascular cell system. S100b-stimulated murine aortic vascular smooth muscle cells were used for western blot analysis with relevant antibodies. Taken together, bioinformatics database search and molecular biological approaches suggested AGE-R is SURMylated in living cardiovascular cell system. Whilst SURMylation and AGE-R undoubtedly plays an important role in the cardiovascular biology, it remains unclear as to the exact nature of this contribution under both physiological and pathological conditions.

• Journal of the Korean Society of Costume
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• v.38
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• pp.323-336
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• 1998

The purpose of this study was to classify the contents of self-image of college men and to investigate how clothing behavior was influenced by self-image, age, major, and the expenses of clothing. Samples were 342 male students of univer-sity in Seoul. Results of this study were following : 1. Four factors of self-image derived by factor analysis : F. 1‘mature-unmatured’;F. 2‘characteristic-ordinary’; F. 3‘conservative-open’; F. 4‘dominant-submissive’.2. 5 variables of clothing behavior were influenced by real self-image. Fashion was influenced by characteristic, open, dominant image, and the expenses of clothing. The ex-planatory power of the 4 variables was 29.3%. Aesthetics was influenced by characteristic, submissive, conservative image, the expenses of clothing, and age(R2=28.7%). Modesty was influenced by conservative and ordinary im-age(R2=6.5%). Coformity was influenced by ordinary image and the expenses of clothing (R2=5.7%). Comfort was influenced by dominant image and age(R2=5.3%). 3. 5 variables of clothing behavior were influenced by ideal self-image. Fashion was influenced by unmatured, characteristic, sub-missive image, and the expenses of clothing (R2=28.9%). Aesthetics was influenced by characteristic image, the expenses of clothing, and age(R2=23.5%). Modesty was influenced by conservative, mature, and ordinary image (R2=8.3%). Coformity was influenced by ordinary image(R2=1.9%). Comfort was influenced by mature image and age(R2=5.6%). The findings indicated that self-image had a significant effect on fashion and aesthetics, and characteristic image and conservative image were important variables that affected clothing behavior of college men.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.10 no.2
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• pp.124-128
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• 2005

Marine reservoir correction $({\Delta}R)$ values are measured using two species of mollusk tests collected by NFRDI in 1942 before nuclear bomb testing to convert the radiocarbon age to calendar age in Korean coastal waters more accurately. The ${\Delta}R$ values are calculated to be $-117\pm45\;^{14}C\;yr$ in the southwestern coast of Korea and $-160\pm35\;^{14}C\;yr$ in southeastern coast. These values are similar to those in Chinese coast of the Yellow Sea $(-81\pm60\~-178\pm50\;^{14}C\;yr$, indicating that regional reservoir $^{14}C$ ages of these areas are lower than mean global reservoir $^{14}C$ age. The lower ${\Delta}R$ values in these areas are presumed to be mainly caused by influence of fresh-water inflow. The ${\Delta}R$ values presented In this study enhance the accuracy in converting radiocarbon age to calendar age in Korean coastal waters.

• Interdisciplinary Bio Central
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• v.4 no.4
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• pp.13.1-13.6
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• 2012

The advanced glycation endproducts receptor (AGER) is a multiligand signal transduction receptor. One of its ligands, S100b molecules activates vascular smooth muscle cells and endothelial cells via its receptor, thus triggering activation of signaling cascades and generation of cytokines and proinflammatory molecules. Ubiquitin-conjugating enzyme Ubc9 is an E2 conjugating enzyme that transfers the activated small ubiquitin-related modifier to protein substrates, and thus it plays a critical role in SUR-Mylation-mediated cellular pathways. Previous studies have shown that both AGE-R and Ubc9 play roles in diverse cellular signaling pathways. However, until recently, little attention has been paid to interactions between AGE-R and Ubc9. In this study, sequence database searches allowed us to identify a potential interaction motif between AGE-R and Ubc9. The subsequent biochemical and molecular biological analysis suggested that there may be specificity in AGE-R and Ubc9 complex signaling in atherosclerosis and cancer cells in a cell-type specific manner. Although the determinant for specificity in AGE-R and Ubc9 complex signaling in cancer cells and atherosclerosis is yet to be determined, this study provides the basis to develop a specific therapeutic application of AGE-R, SURM (small ubiquitin-related modifier)-1, and Ubc9 complex activation pathways in atherosclerosis, diabetes, cancer and inflammatory diseases.

• Journal of Oral Medicine and Pain
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• v.10 no.1
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• pp.73-89
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• 1985

This study comprised 157 extracted teeth, 73 of the teeth originated from mates and 84 from females, the age range was 12-79 years. The correlation coefficient of each Gustafson's criteria in relation to age was carried out. Age estimation were performed on 157 teeth according to the method by Gustafson and by use of multiple regression, as used by Johanson, after evaluating the six criteria of Gustafson by multiple regression computer analysis. Two prediction formulas and standard deviations were compared with each other. The results were as follows : 1. The author found that six Gustafson's criteria had strong correlation with age except root resorption, and correlation coefficients were r = 0.79 (Transparent dentin), r=0.72 (Secondary dentin), r 0.69 (Periodontal change), r=0.63(Attrition), r = 0.39 (Root resorption), respecti vely. 2. The age estimation formula by Gustafson's method was calculated as follows: Y 8.88 + 3.52X r =0.87, r2 = 0.76, SD = 8.18, F = 483.56, P < 0.01 The age estimation formula by multiple regression was calculated as follows: Y 8.57 + 6.37T + 6.37T + 4.63P + 2.70S + 2.40C + 3.08A + 1.34R r= 0.89, r2 = 0.78, SD = 7.82, F = 91.62, P < 0.01, Durbin-Watson Coefficient = 1.09 3. In comparison of two estimation formulas, the formula by multiple regression, the method of Johanson, was found to be slightly more reliable than Gustafson's method. Gustafson's method SD = 8.18, Multiple regression (Johanson's method) SD = 7.82 4. It was reaffirmed that Gustafson's six criteria could be a independent variable in multiple regression analysis.

• Journal of Korea Entertainment Industry Association
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• v.14 no.8
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• pp.231-236
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• 2020

The purpose of this study was to investigate the correlation between craniovertebral angle(CVA), age, and body mass index(BMI) in middle-aged people in their 40s and 50s. The forward head posture(FHP) was measured using a posture measuring device using a 3D sensor for 456 healthy men and women. As a result of the study, the middle-aged CVA had a high level of negative correlation with age (r=-.937; p<.01) and a very low level of positive correlation with BMI (r=.071). CVA of middle-aged men had a high negative correlation with age (r=-.932; p<.01) and a very low positive correlation with BMI. There was a correlation (r=.056), whereas, for middle-aged women, there was a high level of negative correlation (r=.939, p<.01) only with age, but had a weak (low level of negative) correlation with BMI. This study suggests that CVA has a significant negative correlation with age in both males and females however, has a weak relationship with BMI.

• Journal of muscle and joint health
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• v.3 no.1
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• pp.90-103
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• 1996

The purpose of this paper is to compare two approach to assessment of coping patterns. The sampling method was a purposive sampling technique. The study participants were out patients 113 of rheumatoid arthritis center of one University hospitals in Seoul. Datas were collected from Nov. 13 to Nov. 24, 1995. The instruments used for this study were Graphic Rating Scales of pain, The Beck Depression Inventory and Coping Patterns tool. The collected data were analyzed for frequency, means, SD, factor analysis., Pearsons' correlations and ANOVA. The results were summerized as follows ; 1. When raw scores were used : there were not correlation in all three coping patterns. 2. When relative scores were used : there were significantly correlated in all three coping patterns. 1) Active coping and Positive-cognitive coping (r=-0.352, p< 0.0001) 2) Positive-cognitive coping and Negative-cognitive coping (r=-0.594, p< 0.0001) 3) Active coping and Negative-cognitive coping(r=-0.544, p< 0.0001) The results of this research with relative scales provided more insight into the correlation in all three coping patterns. 3. Pearsons' Correlations were computed for each coping pattern, age, pain level, duration of pain and BDI. 1) Using raw score : (1) Active coping was significantly related to pain level(sensory score ; r=0.268, p<0.05, affective score ; r=0.266, p< 0.05) (2) Positive-cognitive coping was significantly related to age (r=-0.252, p< 0.05), pain level (sensory score ; r= -0.244, p< 0.05) (3) Negative-cognitive coping was significantly related to depression level (r=0.312 p< 0.0001). 2) Using relative score (1) Active coping was significantly related to pain level(sensory score ; r=0.299, p<0.05, affective score ; r=0.246, p< 0.05) (2) Positive-cognitive coping was significantly related to age (r= -0.187, P< 0.05), pain level (sensory score ; r=-0.317, p<0.0001, affective score : r=-0.305, p<0.0001) and depression level(-0.339, p<0.0001)) (3) Negative-cognitive coping was significantly related to depression. level(r=0.313, p<0.0001). 4. When raw and realtive coping scores were compared to those of age groups, religious groups and BDI level(high, middle, low) ; 1) Using raw score : (1) Active coping : there were not significantly difference (2) Positive-cognitive coping ; 20-39 age group and 50-59age group had significantly higher scores than over 60age group. BDI-low level group had significantly higher scores than other groups. (3) Negative-cognitive coping : 20-39age group and over 60age group had significantly higher scores than 40-49age group. Non-religious group had significantly higher scores than christian group. BDI-high level group had significantly higher scores than other groups. 2) Using relative score : (1) Active coping : over 60 age group had significantly higher scores than 20-39 age group and 40-49age group had significantly higher scores than 20-39 age group (2) Positive-cognitive coping ; 40-49age group, 20-39age group and 50-59age group had significantly higher scores than over 60age group. Christian group had significantly higher scores than non-religious group. BDI-low level group had significantly higher scores than other groups. (3) Negative-cognitive coping ; Non-religious group had significantly higher scores than christian group and buddhistic group. BDI-high level group had significantly higher scores than other groups. The current data suggest that relative scores may yield a different perspective on coping patters than raw scores. The use of relative scores reveals the relation clearly, without its being blurred statistically by the effect of other coping strategies or being relegated to a partial correlation. The use of relative scores holds promise for delineating the relations between ways of coping and health-related behavior.

• Neonatal Medicine
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• v.28 no.2
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• pp.65-71
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• 2021

Purpose: We investigated whether consecutive levels of new emerging renal biomarkers, including serum cystatin C (CysC) and urinary neutrophil gelatinase-associated lipocalin (NGAL)/creatinine (Cr) ratio, were affected by postconceptional age in very-low-birth-weight (VLBW) infants. Methods: Repeatedly measured samples for each infant were divided into four groups according to postnatal age: at birth (stage I), 3 to 7 days postnatally (stage II), 8 to 28 days postnatally (stage III), and >28 days postnatally (stage IV). The association between renal biomarkers and postconceptional age was assessed using Pearson's correlation coefficient, and the mean values of renal biomarkers in the four stages were compared using repeated-measures analysis of variance. Results: For samples measured at birth, serum CysC (r=-0.358, P=0.032) and urinary NGAL/Cr ratio (r=-0.522, P=0.001) were negatively correlated with gestational age, whereas serum Cr (r=0.148, P=0.390) was not. In addition, for all samples measured, serum CysC (r=-0.209, P=0.012), urinary NGAL/Cr ratio (r=-0.536, P<0.001), and serum Cr (r=-0.311, P<0.001) were negatively correlated with postconceptional age. Compared with the mean values of the postnatal age-specific stages, serum CysC showed no significant differences in any of the four stages. However, the urinary NGAL/Cr ratio in stage IV was significantly different from those in stages I to III. Conclusion: Although urinary NGAL/Cr ratio and serum CysC were negatively correlated with postconceptional age considering renal development, serum CysC showed no significant differences in any of the four postnatal age-specific stages. Urinary NGAL/Cr ratio at >28 days postnatally seems to be more affected by postconceptional age than serum CysC in VLBW infants.

• Korean Journal of Community Nutrition
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• v.9 no.5
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• pp.644-653
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• 2004

This study was conducted to detennine the dietary and lifestyle factors related to bone the mineral density (BMD) of postmenopausal women with decreased BMD. The subjects (N =163) were recruited from women who visited a orthopedic clinic for BMD check up. A trained dietition interviewed subjects individually to obtain data about dietary behavior, consumption frequency of foods known as main dietary source of calcium and potassium, and clinical symptoms. The risk factors were identified by correlation and multiple regression analysis of variables. The mean age of the subjects was 66.8 yews. Most of them showed low levels of education and monthly income. The mean age of menarche and menopause were 17.2 and 48 year, respectively. The mean menopause duration was 18.7 year. Most of the consumption of calcium was centered to vegetable foods. Education level were positively correlated (r =0.272, P < 0.05) with BMD whereas age, menarch age, menopause duration, number of children were negatively correlated (r=-0.355, r=-0.240, r=-0.283, r=-0.193, respectively, p < 0.05) with BMD. The consumption of soybean, radish were positively correlated (r=0.187, r=0.158, respectively, p < 0.05) with BMD. Potassium intake with rice showed significantly negative correlation with BMD (r =-0.189, P < 0.05), but calcium intake with brown seaweeds, bean sprouts were positively correlated (r =0.247, r =0.254 respectively, p < 0.05) with BMD. Protein intake with roasted pork was also positively correlated (r =0.216, P < 0.05) with BMD. Multiple regression analysis showed that the most prominent negative predictor influencing the BMD was age. Minor negative factors influencing the BMI were age of menarche, potassium intake from rice. But the significantly positively factors influencing the BMD were consumption of radish and soybean intake, education, and protein intake with roasted pork. In conclusion brown seaweeds, radish or soybeans can be promoted as cheap foods replacing milk and milk products for menopausal women with low income.

• Journal of Oral Medicine and Pain
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• v.17 no.2
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• pp.119-128
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• 1992

In order to evaluate the relationship of age with the developmental stage on mandibular second molars in female, the author examined the radiographs in standard films taken by intraoral paralleling technic and analysed the development of 620 roots of 310 females ranged from 10 to 18 years. The development was divided into 7 stages : Crown complete (Cr.C.), Root lengthed 1/4(R.1/4), Root length 1/2 (R.1/2), Rooth length 3/4 (R.3/4), Rooth length complete (R.C), Apex 1.2 closed (A. 1/2), Apical closure complete (A.C) The obtained results were as follows : 1. The formation of roots in fulllength of mandibular second molars was completed at 14.21-year-age in mesial root and at 14.96-year-age in distal root. 2. The formation of apical foramen of mandibular second molars was completed at 17.11-year-age in mesial root and at 17.53-year-age in distal root. 3. The mesial root of mandibular second molar was generally developed earlier than distal root (p<0.01) 4. Coefficients of correlation and regression equations between for age(Y) and the developmental stage of mandibular second molar(X) were "Y=1.53X+6.54, r=0.91 (p<0.01)" in mesial root and "Y=1.52X+7.11, r=0.92(p<0.01)" in distal root respectively.l root respectively.