• 대한임상검사과학회지
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• 제36권2호
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• pp.110-114
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• 2004

Apolipoprotein E is the major lipid-carrier protein in the brain, and several studies provided evidence that apolipoprotein E(ApoE) epsilon4 allele can be considered a genetic risk factor for Alzheimer's disease(AD). Inheritance of the APOE gene has three alleles: ${\varepsilon}2$, ${\varepsilon}3$ and ${\varepsilon}4$. There are six possible genotypes: ${\varepsilon}2/{\varepsilon}2$, ${\varepsilon}3/{\varepsilon}3$, ${\varepsilon}4/{\varepsilon}4$, ${\varepsilon}2/{\varepsilon}3$, ${\varepsilon}2/{\varepsilon}4$, ${\varepsilon}3/{\varepsilon}4$. AD is characterized by a progressive loss of function and death of nerve cells in several areas of the brain. The ${\varepsilon}4$ allele is associated with a risk for developing AD. People with the ${\varepsilon}4/{\varepsilon}4$ genotype have the highest risk, but people with the ${\varepsilon}2/{\varepsilon}4$ or ${\varepsilon}3/{\varepsilon}4$ genotypes are also likely to develop the disease. 64.3% of people carry the is ${\varepsilon}3/{\varepsilon}3$ genotype, 22.1% carry the second ${\varepsilon}3/{\varepsilon}4$ genotype but, ${\varepsilon}2/{\varepsilon}2$ genotype is not usually found of people carry the 3.6% is ${\varepsilon}4/{\varepsilon}4$ genotype in a total of a test group of 140 people. The ratio of ${\varepsilon}4/{\varepsilon}4$ genotype related directly with AD is less than the ${\varepsilon}3/{\varepsilon}3$ genotype, but the ${\varepsilon}2/{\varepsilon}4$ and ${\varepsilon}3/{\varepsilon}4$ genotype ratio of indirect AD risk is 25.7% in the group of people, regardless. Thus, we have referred to the benefit from the treatment of AD through apoE genotype diagnosis.

• 대한간호학회지
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• 제42권7호
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• pp.992-1000
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• 2012

Purpose: The purpose of this study was to verify prevalence rates of atopic dermatitis (AD) in middle school students in Korea and to define AD and associated factors. Methods: This study was conducted using secondary analysis of raw data from the 'The 6th Korean National Adolescent Health Behavior Survey, 2010' conducted by the Korea Centers for Disease Control. The participants were 37,570 students. General characteristics and health behavior-related characteristics were analyzed using descriptive statistics, ${\chi}^2$-test and logistic regression analysis. Results: Results are as follows. 1. There were 8,494 middle school students (22.6%), who had been diagnosed with AD during the last 12 months. 2. Factors associated with AD in middle school students were gender (p<.001), grade level (p=.001), father's education (p<.001), mother's education (p=.032), regular dietary habits (breakfasts, p=.025; lunches; p=.003), stress (p<.001), recognition of subjective awareness of one's health conditions (p<.001), hand washing before meals at school (p=.013), and cessation education for both smoking (p=.002) and alcohol (p=.031). Conclusion: Results of the study indicate that in order to alleviate AD symptoms in these students, there is a need to develop nursing interventions and education programs taking into consideration these variables and verifying the effects of interventions and programs.

• 한국통신학회논문지
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• 제33권4A호
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• pp.411-417
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• 2008

본 논문에서는 multi-hop 블루투스 스캐터넷을 형성하는 BSFP (Bluetooth Scatternet Formation Protocol)을 제안한다. BSFP는 각각의 블루투스 기기에서 독립적으로 수행되고, 초기단계에서 주변 기기들에 대한 정보를 요구하지 않으며, 모든 기기들이 블루투스의 통신 가능 범위 안에 위치하지 않아도 스캐터넷을 형성할 수 있다. BSFP는 1) 자신의 주위에 어떤 노드들이 있는지를 찾는 Init 단계, 2) 각각의 노드가 국부적 정보만을 가지고 스캐터넷을 형성하는 Ready 단계, 3) 연결된 링크를 이용하여 통신을 하는 Complete 단계로 구성된다. BSFP에서는 스캐터넷 형성을 완료할 때까지 걸리는 실행시간이 기기들의 수가 늘어나도 크게 변하지 않으며, 인접 기기들 간의 통신 링크의 수가 많은 스캐터넷을 형성하여 신뢰도 높은 mobile ad hoc network을 구성할 수 있도록 해 준다.

• 한국멀티미디어학회논문지
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• 제23권2호
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• pp.368-375
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• 2020

In this study, the area of interest(AOI) of Soju ad poster was tracked for analysis the time to frist fixation, the average of fixation duration and count by the study indexes. As a result of the analysis, Visual attention was higher the face than the body shape of the ad model. This means "when we look at printed ads, we see picture elements first, not language one" but language elements can't be overlooked either. Also, the importance of the model role could be verified by measuring the visual attention on the Soju ad poster. Based on the results of this study, if further research on ad posters is carried out and scientific and quantitative interpretation methods are presented, it can be used as product marketing data that can be reflected in ad model selection and poster design.

• 한국전자통신학회논문지
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• 제15권6호
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• pp.1011-1016
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• 2020

고속 VANET(: Vehicular Ad Hoc Network)에서 네트워크 토폴로지의 급속한 변화는 라우팅 프로토콜 설계에 중요한 과제이다. 라우팅 프로토콜의 성능에 영향을 미치는 다음 홉 릴레이 노드를 선택하는 작업은 어려운 과정이다. VANET과 관련된 AODV(: Ad Hoc On-Demand Distance Vector)의 단점은 종단 간 지연 및 패킷 손실이다. 본 논문은 AODV 라우팅 프로토콜을 수정하여 방향 매개 변수와 2단계 필터링을 추가하여 RREQ(: Route Request) 및 RREP(: Route Reply) 메시지 수를 줄이는 AAODV(: Advanced AODV)기법을 제안한다. 제안된 AAODV는 패킷 손실을 줄이고 방향 매개 변수의 영향을 최소화 함으로서 패킷전달율이 증가하고, 종단 간 지연이 감소됨을 알 수 있다.

• Journal of Microbiology and Biotechnology
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• 제33권6호
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• pp.823-830
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• 2023

Lactococcus lactis is a lactic acid bacterium and used in the dairy food industry. The ameliorating effects of Lactobacillus species on atopic dermatitis (AD) have been extensively studied, but the specific effect of L. lactis strains has not yet been investigated. In this study, the efficacy of L. lactis LB 1022, isolated from natural cheese, was evaluated using RAW 264.7, HMC-1 and HaCaT cell lines and an ovalbumin-sensitized AD mouse model. L. lactis LB 1022 exhibited nitric oxide suppression and anti-allergy and anti-inflammatory activity in vitro. Oral administration of L. lactis LB 1022 to AD mice significantly reduced the levels of IgE, mast cells, and eosinophils, and a range of T cell-mediated T helper Th1, Th2, and Th17-type cytokines under interleukin (IL)-10, transforming growth factor-β (TGF-β), thymus and activation-regulated chemokine (TARC), and thymic stromal lymphopoietin (TSLP). In addition, L. lactis LB 1022 treatment increased the concentration of short-chain fatty acids. Overall, L. lactis LB 1022 significantly modulated AD-like symptoms by altering metabolites and the immune response, illustrating its potential as candidate for use in functional food supplements to alleviate AD.

• 대한임베디드공학회논문지
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• 제19권2호
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• pp.107-114
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• 2024

Mobile ad hoc networks represent self-configuring networks of mobile devices that communicate without relying on a fixed infrastructure. However, traditional routing protocols in such networks encounter challenges in selecting efficient and reliable routes due to dynamic nature of these networks caused by unpredictable mobility of nodes. This often results in a failure to meet the low-delay and low-energy consumption requirements crucial for such networks. In order to overcome such challenges, our paper introduces a novel multi-objective and adaptive routing scheme based on the Q-learning reinforcement learning algorithm. The proposed routing scheme dynamically adjusts itself based on measured network states, such as traffic congestion and mobility. The proposed approach utilizes Q-learning to select routes in a decentralized manner, considering factors like energy consumption, load balancing, and the selection of stable links. We present a formulation of the multi-objective optimization problem and discuss adaptive adjustments of the Q-learning parameters to handle the dynamic nature of the network. To speed up the learning process, our scheme incorporates informative shaped rewards, providing additional guidance to the learning agents for better solutions. Implemented on the widely-used AODV routing protocol, our proposed approaches demonstrate better performance in terms of energy efficiency and improved message delivery delay, even in highly dynamic network environments, when compared to the traditional AODV. These findings show the potential of leveraging reinforcement learning for efficient routing in ad hoc networks, making the way for future advancements in the field of mobile ad hoc networking.

• 대한수의학회지
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• 제37권4호
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• pp.863-873
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• 1997

Electrical stimulation and vitamin $AD_3E$ administration have been shown to enhance the repair of biological tissues such as bone, ligament and tendon, The objective of this study were (a) to investgate the therapeutic effects of different levels of electrical stimulation and vitamin $AD_3E$ administration on fracture healing in a rat model and (b) to identify the most effective voltage level. Ninety Sprague-dawley rats were divided into electrical stimulation group and vitamin $AD_3E$ administration group. Electricla stimulation group was divided into four groups on the basis of the level of current delivered. The experimental groups received current (which varied by group), while the controls, with identical electrodes, received no current. In vitamin $AD_3E$ administration group, experimental group was injected 2,500 IU of vitamin A, 1,250 IU of vitamine $D_3$, 1mg of vitamine E intramuscularly. And in control group 0.1ml of saline was injected intramuscularly. After time periods (7-day, 14-day, 21-day for stimulation all rats were tested with combination of biochemical, roentgenologic and histomorphological methods. The results obtained were as follows ; In electrical stimulation groups, serum calcium and inorganic phosphorus level of experimental and control groups showed non specific change within normal physiological ranges. In vitamin $AD_3E$ administration group, serum calcium level of experimental and control groups showed non specific changes within normal physiological ranges, while experimental group showed slightly higher serum inorganic phosphorus level. According to roentgenologic and histomorphological examination, 2V 25Hz electrical stimulation group and vitamine $AD_3E$ administration group showed statistically significant improvements in bone density and ossification reaction until day 14. The terapeutic effect of stimulation on fracture healing was similiar to that of vitamin $AD_3E$ administration. In this study stimulation of 2V 25Hz was the most effective level of electrical stimulation for the healing of fracture of rats.

• Journal of Microbiology and Biotechnology
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• 제29권11호
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• pp.1693-1706
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• 2019

Atopic dermatitis (AD) is a chronic inflammatory skin disease of mainly infants and children. Currently, the development of safe and effective treatments for AD is urgently required. The present study was conducted to investigate the immunomodulatory effects of yeast-extracted β-1,3/1,6-glucan and/or Lactobacillus plantarum (L. plantarum) LM1004 against AD-like symptoms. To purpose, β-1,3/1,6-glucan and/or L. plantarum LM1004 were orally administered to AD-induced animal models of rat (histamine-induced vasodilation) and mouse (pruritus and contact dermatitis) exhibiting different symptoms of AD. We then investigated the treatment effects on AD-like symptoms, gene expression of immune-related factors, and gut microbiomes. Oral administration of β-1,3/1,6-glucan (0.01 g/kg initial body weight) and/or 2 × 10¹² cells/g L. plantarum LM1004 (0.01 g/kg initial body weight) to AD-induced animal models showed significantly reduced vasodilation in the rat model, and pruritus, edema, and serum histamine in the mouse models (p < 0.05). Interestingly, β-1,3/1,6-glucan and/or L. plantarum LM1004 significantly decreased the mRNA levels of Th2 and Th17 cell transcription factors, while the transcription factors of Th1 and Treg cells, galactin-9, filaggrin increased, which are indicative of enhanced immunomodulation (p < 0.05). Moreover, in rats with no AD induction, the same treatments significantly increased the relative abundance of phylum Bacteroidetes and the genus Bacteroides. Furthermore, bacterial taxa associated with butyrate production such as, Lachnospiraceae and Ruminococcaceae at family, and Roseburia at genus level were increased in the treated groups. These findings suggest that the dietary supplementation of β-1,3/1,6-glucan and/or L. plantarum LM1004 has a great potential for treatment of AD as well as obesity in humans through mechanisms that might involve modulation of host immune systems and gut microbiota.

• 한국염색가공학회지
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• 제24권3호
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• pp.189-195
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• 2012

The purpose of this study was to investigate the possibility of bamboo extract as natural dye having the effect on atopic dermatitis(AD). To investigate the effect of bamboo extract on AD in vivo, we applied bamboo extract to the AD-like skin lesion the backs of atopic of NC/Nga mice, an animal model of AD. NC/Nga mice were challenged with DNCB(2.4-Dinitrochlorbenzene) to develope AD-like skin lesions. The efficacy of bamboo extract in the NC/Nga mice was evaluated by measurement of the skin lesion severity(NC mouse score), the serum IgE level, epidermal thickness changes, and mast cell number. Bamboo extracts improved skin lesions in NC/Nga mice. The serum IgE levels were decreased after treatment with bamboo extract. Histological examinations revealed a decrease in epidermal thickness and mast cell number after treatment with bamboo extract. To conclude, the topical application of bamboo extract suppressed the progression of AD-like skin lesions.