• Biomolecules & Therapeutics
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• v.28 no.6
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• pp.542-548
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• 2020

Naturally derived diosmetin and its glycoside diosmin are known to be effective in treating inflammatory disease. This study was performed to determine whether diosmin and diosmetin have the effect of improving atopic dermatitis in a 2,4-dinitrochlorobenzen (DNCB)-induced atopic dermatitis (AD) model. DNCB was used to establish AD model in hairless mice. Skin moisture, serum immunoglobulin E (IgE), interleukin 4 (IL-4), and histological analysis were performed to measure the effectiveness of diosmin and diosmetine to improve AD. IL-4 levels were also measured in RBL-2H3 cells. Administration of diosmetin or diosmin orally inhibited the progress of DNCB-induced AD-like lesions in murine models by inhibiting transdermal water loss (TEWL) and increasing skin hydration. Diosmetin or diosmin treatment also reduced IgE and IL-4 levels in AD-induced hairless mouse serum samples. However, in the in vitro assay, only diosmetin, not diosmin, reduced the expression level of IL-4 mRNA in RBL-2H3 cells. Diosmin and diosmetine alleviated the altered epidermal thickness and immune cell infiltration in AD. Diosmin is considered effective in the cure of AD and skin inflammatory diseases by being converted into diosmetin in the body by pharmacokinetic metabolism. Thus, oral administration of diosmetin and diosmin might be a useful agent for the treatment of AD and cutaneous inflammatory diseases.

• Nutrition Research and Practice
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• v.16 no.5
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• pp.577-588
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• 2022

BACKGROUND/OBJECTIVES: Poorly regulated inflammation is believed to be the most predominant factor that can result in a wide scope of diseases including atopic dermatitis (AD). Despite many studies on the effect of pear pomace in obesity-related disorders including dysregulated gut microbiota, the protective effect of pear pomace in AD is still unknown. This study aimed to evaluate the effect of pear pomace ethanol extract (PPE) on AD by inhibiting inflammation. MATERIALS/METHODS: In the in vivo experiment, 2, 4-dinitrochlorobenzene (DNCB) was applied to NC/Nga mice to induce AD-like skin lesions. After the induction, PPE was administered daily by oral gavage for 4 weeks. The clinical severity score, serum IgE levels, spleen weight, histological changes in dorsal skin, and inflammation-related proteins were measured. In the cell study, RAW 264.7 cells were pretreated with PPE before stimulation with lipopolysaccharide (LPS). Nitrite oxide (NO) production and nuclear factor kappa B (NF-𝛋B) protein expression were detected. RESULTS: Compared to the AD control (AD-C) group, IgE levels were dramatically decreased via PPE treatment. PPE significantly reduced scratching behavior, improved skin symptoms, and decreased ear thickness compared to the AD-C group. In addition, PPE inhibited the DNCB-induced expression of inducible nitrite oxide synthase (iNOS), the receptor for advanced glycation end products, extracellular signal-regulated kinase (ERK) 1/2, and NF-𝛋B. PPE inhibited the LPS-induced overproduction of NO and the enhanced expression of iNOS and cyclooxygenase-2. Moreover, the phosphorylation of ERK1/2 and NF-𝛋B in RAW 264.7 cells was suppressed by PPE. CONCLUSIONS: These results suggest that PPE could be explored as a therapeutic agent to prevent AD.

• Biomedical Science Letters
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• v.23 no.4
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• pp.303-309
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• 2017

${\beta}$-sitosterol, one of phytosterols, exhibited numerous pharmacological effect including anti-inflammatory, anti-cancer and immune-modulating properties. This study attempted to determine the pharmacological effects of ${\beta}$-sitosterol on atopic dermatitis (AD). We investigated to ascertain the pharmacological effects of ${\beta}$-sitosterol on 2, 4-dinitrochlrobenzene (DNCB)-induced AD symptom and histamine-induced scratching behaviors in mice. Additionally, we evaluated the effects of ${\beta}$-sitosterol on the interleukin (IL)-6 levels in HaCaT cells and skin tissue of AD. The findings of this study demonstrated that ${\beta}$-sitosterol reduced AD clinical symptoms such as eczematous, erythema and dryness and serum histamine and IgE levels in DNCB-induced AD model and histamine-induced scratching behaviors in mice. Additionally, ${\beta}$-sitosterol inhibited the IL-6 expression in AD-like skin lesion and HaCaT cells. Collectively, these findings provide that ${\beta}$-sitosterol could be a therapeutic agent for skin inflammation including AD.

• Sleep Medicine and Psychophysiology
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• v.5 no.2
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• pp.134-154
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• 1998

This paper first reviewed the definition, criteria, and neurological theories concerning the etiology of AD/HD, and the empirical studies dealing with the comorbidity of AD/HD with other psychiatric disorders. Secondly, results of studies using various neuropsychological tests for assessing the cognitive and behavioral problems in AD/HD children were examined, which suggest the possibility that dysfunction may exist in neural pathways involving many areas of the brain in AD/HD. However, because most of neuropsychological test used in Korea for ADHD children had been developed abroad, further study involving AD/HD, normal control, and other psychiatric control groups is needed to obtain developmental norms for interpreting the results, and to make more accurate diagnosis, and to clarify comorbidity of AD/HD with other disorders.

• Electronics and Telecommunications Trends
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• v.18 no.2 s.80
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• pp.11-24
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• 2003

이동 Ad Hoc 네트워크는 고정적이고 계층적인 인프라스트럭처 네트워크와는 비교되는, 이동 노드만으로 구성된 자율적이고 수평적인 네트워크이다. 이동 Ad Hoc 네트워크의 이동 노드는 중재자의 도움 없이 능동적인 연결 설정이 가능하고 네트워크의 참여 또는 이탈이 자유로우며 에너지원의 공급이 제한되어 빈번하게 네트워크의 토폴로지를 변화시킨다. 이러한 망의 특성상 이동 Ad Hoc 네트워크 기술은 하위 계층의 전파 전파, 전파 간섭 및 전력 제어에서부터 링크 계층의 다중 접속 및 자원 할당, 네트워크 계층의 라우팅, 트랜스포트 계층의 연결 설정 및 유지, 그리고 보안 및 상위 계층 애플리케이션에 이르기까지 다양한 기술적 해결 요구사항을 갖는다. 본 고에서는 이러한 Ad Hoc 네트워크의 특징과 특성을 살펴보고 관련 주요 요소 기술과 과거부터 현재까지 이동 Ad Hoc 네트워크 기술 분야에서 진행되어온 연구동향을 살펴본다.

• Journal of the Korean Graphic Arts Communication Society
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• v.30 no.2
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• pp.13-22
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• 2012

This research attempts to analyze communication effects of print ad having pictorial typography. 150 Questionnaires were distributed to respondents staying Daejeun City and 148 copies were retreated for five days from April 22nd to 26th, 2012. Frequency analysis, factor analysis, Cronbach's alpha for reliability analysis were utilized for data analysis with SPSS 12.0. For testing hypothesis, regression analysis was used. As result of testing hypothesis, 'informative, beneficial, creative, reliable' were partially significant to attitude towards print ad having pictorial typography. That means 'creative' and 'reliable' were insignificant, while 'informative' and 'beneficial' are significant. Variable of the most influencing on attitude towards advertising is 'informative.' 'Informative, beneficial, creative, and reliable' were partially significant to brand attitude, too. That means 'beneficial' and 'creative' were insignificant, while 'informative' and 'reliable' were significant. Variable of the most influencing on brand attitude was 'reliable.' Therefore, to enhance communication effect of print ad having pictorial typography, 'informative' and 'reliable' are most significant variables.

• Journal of the Korean Graphic Arts Communication Society
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• v.30 no.2
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• pp.69-78
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• 2012

This research attempts to analyze how attributes of ad model influence on brand familiarity, personality, and preference among consumers. Attributes of ad model was classified into three; attractiveness, professionalism, and reliability. One hundred of consumers who lived in Daejeun City were selected as respondents for this research. The result of hypothesis I showed that attributes of ad model significantly influenced on brand familiarity. it was the result of hypothesis II that both Attractiveness and professionalism of ad model affected brand personality. It was also found that attractiveness and professionalism are significantly brand preference from the result of hypothesis III. In conclusion, findings showed that attractiveness of ad model mostly influenced on brand familiarity, personality, preference.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.21 no.3
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• pp.150-165
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• 2008

Objective : An adequate measurement for Atopic Dermatitis(AD) is essential for studies about the treatment of AD. To establish a new and adequate scoring system for AD in Korean medicine, we reviewed existing studies on AD outcome measurement in Korean medicine. Method : We searched for reviews on measurements of AD or studies which used an AD outcome measurement at the Korean Traditional Knowledge Portal from 1995 to June, 2008. And then we reviewed the pattern identification in AD patients and the outcome measurements for AD in each study. Results : 1. Among 25 studies, the most common measurement for AD was SCORAD(the severity SCORing of Atopic Dermatitis index), there were 16 studies. There was one study which used the Jakob T scoring system, one study which used ADSI(the Atopic Dermatitis Severity Index), and there were 7 studies which established or used a new severity scoring system for AD. 2. In Korean medicine, AD caused by Damp-Heat is accompanied by erythema, papulation, oozing and crust, Damp-Heat accompanied by Spleen-Gi deficiency is frequently found in pediatric patients, and in adults who have indigestion. Symptoms of AD caused by blood deficiency and Wind-Dryness include lichenification, dryness, scale and pigmentation. AD caused by toxic Heat in the blood system has symptoms similar to some Damp-Heat pattern along with symptoms of blood deficiency and Wind-Dryness. Conclusion : We need to establish a new severity scoring system which reflects pattern identifications and treatments with Korean medicine, and we should assess the validity, reliability, and sensitivity of the new scoring system.

• Journal of Satellite, Information and Communications
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• v.6 no.2
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• pp.60-65
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• 2011

Wireless devices can communicate between each other without existing infrastructure in mobile Ad-hod network. Ad hoc networks can be used under difficult conditions, where it is difficult to construct infrastructures, such as shadowing areas, disaster areas, war area, and so on. In order to support to considerable and various wireless services, more spectrum resources are needed. However, efficient utilization of the frequency resource is difficult because of spectrum scarcity and the conventional frequency regulation. Ad-hoc networks employing cognitive radio (CR) system that guarantee high spectrum utilization provide effective way to increase the network capacity. In this paper, to improve detection performance of the energy detection which is widely used in CR based ad-hoc network, we propose multiple antenna system for CR based ad-hoc networks.

• Journal of the Korea Computer Industry Society
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• v.2 no.9
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• pp.1219-1224
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• 2001

There can exist unidirectional links due to asymmetric property of mobile terminals or current wireless environments on practical mobile ad hoc networks. However, at present, the existing mobile ad hoc routing protocols are implemented to support only bidirectional links. Thus, in this paper, we extend the existing dynamic source routing protocol in order to implement a new routing protocol, which is fit to mobile ad hoc networks containing unidirectional links. For performance evaluation, we use combinations of mobility scenario files and connection pattern files from Carnegimelon Univ. We consider received data rate and average route discovery time as evaluation items, which are compared and evaluated for three suggested route discovery methods.