• The Bulletin of The Korean Astronomical Society
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• v.42 no.2
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• pp.55.5-56
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• 2017

Galaxy dynamics probes weak gravity at accelerations below the de Sitter scale of acceleration adS = cH, where c is the velocity of light and H is the Hubble parameter. Low and high redshift galaxies hereby offer a novel probe of weak gravity in an evolving cosmology, satisfying H(z) = H0(1 + A(6z + 12z^2 +12z^3+ 6z^4+ (6/5)z^5)/(1 + z) with baryonic matter content A sans tension to H0 in surveys of the Local Universe. Galaxy rotation curves show anomalous galaxy dynamics in weak gravity aN < adS across a transition radius r beyond about 5 kpc for galaxy mass of 1e11 solar mass. where aN is the Newtonian acceleration based on baryonic matter content. We identify this behavior with a holographic origin of inertia from entanglement entropy, that introduces a C0 onset across aN=adS with asymptotic behavior described by a Milgrom parameter satisfying a0=omega/(2pi), where omega=sqrt(1-q)H is a fundamental eigenfrequency of the cosmological horizon. Extending an earlier confrontation with data covering 0.003 < aN/adS < 1 at redshift z about zero in Lellie et al. (2016), the modest anomalous behavior in the Genzel et al. sample at redshifts 0.854 < z <2.282 is found to be mostly due to clustering 0.36 < aN/adS < 1 close to the C0 onset to weak gravity and an increase of up to 65% in a0.

• 한국약용작물학회:학술대회논문집
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• 2011.09a
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• pp.31-45
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• 2011

The amyloid ${\beta}$-peptide ($A{\beta}$), which originates from the proteolytic cleavage of amyloid precursor protein (APP), plays a central role in the pathogenesis of Alzheimer's disease (AD). Mounting evidence indicates that different species of $A{\beta}$, such as $A{\beta}$ oligomers and fibrils, may contribute to AD pathogenesis via distinct mechanisms at different stages of the disease. Importantly, elevation and accumulation of soluble $A{\beta}$ oligomers closely correlate with cognitive decline and/or disease progression in animal models of AD. In agreement with these studies, oligomers of $A{\beta}$ have been shown to directly affect synaptic plasticity, a neuronal process that is known to be essential for memory formation. Our previous studies showed that $A{\beta}$ induces the breakdown of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), a phospholipid that regulates key aspects of neuronal function. PI(4,5)P2 breakdown was found to be a key step toward synaptic and memory dysfunction in a mouse model of AD. To this end, we seek to identify small molecules that could elevate the levels of PI(4,5)P2 and subsequently block $A{\beta}$ oligomer-induced breakdown of PI(4,5)P2 and synaptic dysfunction.. We found that (20S)Rg3, an active triterpene glycoside from heat-processed ginseng, serves as an agonist for phosphatidylinositol 4-kinase IIalpha (PI4KIIalpha), which is a lipid kinase that mediates a rate-limiting step in PI(4,5)P2 synthesis. Consequently, (20S)Rg3 stimulates PI(4,5)P2 synthesis by directly stimulating the activity of PI4KIIalpha. Interestingly, treatment of a mouse model of AD with (20S)Rg3 leads to reversal of memory deficits. Our data suggest that the PI(4,5)P2-promoting effects of (20S)Rg3 may help mitigate the cognitive symptoms associated with AD.

• Korean Journal of Soil Science and Fertilizer
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• v.39 no.6
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• pp.409-414
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• 2006

Sulfur-oxidizing bacteria were enumerated and isolated from a steady-state anaerobic master culture reactor (MCR) operated for over six months under a semi-continuous mode and nitrate-limiting conditions using thiosulfate as an electron donor. Most are Gram-negative bacteria, which have sizes up to 12 m. Strains AD1 and AD2 were isolated from the plate count agar (PCA), and strains BD1 and BD2 from the solid thiosulfate/nitrate medium. Based on the morphological, physiological, FAME and 16S rDNA sequence analyses, the two dominant strains, AD1 and AD2, were identified as Paracoccus denitrificans and Paracoccus versutus (formerly Thiobacillus versutus), respectively. From the physiological results, glucose was assimilated by both strains AD1 and AD2. Heterotrophic growth of strains AD1 and AD2 could be a more efficient way of obtaining a greater amount of biomass for use as an inoculum. Even though facultative autotrophic bacteria grow under heterotrophic conditions, autotrophic denitrification would not be reduced.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.17 no.2
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• pp.495-502
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• 2013

In the mobile Ad hoc Network(MANET), improving technique for management and control of topology is recognized as an important part of the next generation network. In this paper, we proposed an efficient node life time management of ATICC(Adaptive Time Interval Clustering Control) in Ad-hoc Networks. Ad-hoc Network is a self-configuration network or wireless multi-hop network based on inference topology. This is a method of path routing management node for increasing the network life time through the periodical route alternation. The proposed ATICC algorithm is time interval control technique depended on the use of the battery energy while node management considering the attribute of node and network routing. This can reduce the network traffic of nodes consume energy cost effectively. As a result, it could be improving the network life time by using timing control method in ad-hoc networks.

• The Journal of Pediatrics of Korean Medicine
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• v.29 no.1
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• pp.27-43
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• 2015

Objectives The purpose of this study was to investigate the effects of AI on AD induced by DNCB in mice. AI has antiallergic property that is useful in treating allergy-related-diseases, such as asthma, anaphylactic shock, acute bronchitis and skin diseases, skin pruritus from gastrointestinal diseases. However, AI has not been studied intensively yet regarding anti-inflammatory effect on AD. Therefore, this study was conducted on 2,4-dinitrochlorobezene (DNCB)-induced mice to investigate effects of AI in AD. Methods In the experiment, we divided mice into four groups: a normal group (NOR), a control group (CON), an AI spread group (AI spread), and an AI spread and feeding group (AI spread & feeding). Then examined the changes in the body weight, weights of spleen and ear, thickness of dorsum skin and ear skin, clinical aspects on dorsum skin, historical assessments, proliferation of splenocytes in vitro and in vivo, and cytokine (TNF-${\alpha}$, IL-10). Results From the experiment, the ear weight of AI spread & feeding group was significantly dropped and the ear thickness of both AI spread and AI spread & feeding were decreased significantly. Dorsum skin thickness was also decreased significantly in both AI spread and AI spread & feeding group. Also, AI treatment improved the symptoms of AD, such as coloration, erythema and desquamation and had a better effect on AI spread & feeding group. In histopathological observation, thickened epidermis, hyperkeratosis, pigmentation, hypergranulosis, parakeratosis were diminished as well in both AI spread and AI spread & feeding group. In vitro, we could observe when AI was increased as proliferation rate of splenocytes were increased, too. Conclusions In conclusion, these data suggest that AI can decrease symptoms of AD and show AI can be useful herbal therapy for AD.

• Korean Journal of Community Nutrition
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• v.17 no.3
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• pp.271-279
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• 2012

The prevalence of atopic dermatitis (AD) has increased recently all over the world. Several studies worldwide reported growth retardation associated with AD, but few studies were reported in Korea. Therefore, the objective of this study was to identity the differences in growth and nutrient intakes between Korean children with and without AD. The participants were 71 AD children and age, gender-matched 81 control children aged 10 to 36 months. Demographic information was gathered by questionnaires. Height and weight were measured at clinic and health centers. Height and weight for age, and weight for height were converted as deviation in Z scores using World Health Organization Standard. A 24 hour dietary recall method was performed to estimate nutrient intakes. A higher percentage of AD children had insufficient energy and intakes of calcium, phosphorus, iron, zinc and vitamin B2, defined as intakes lower than 75% of the Dietary Reference Intakes for Korean, compared to the control group (P < 0.001, P < 0.001, P = 0.003, P = 0.001, P = 0.014, P = 0.001, respectively). The percentages of children with height and weight for age Z score below than-1 (stunted) were significantly higher in the AD group (P < 0.001 and P < 0.001, respectively). Multiple food restriction, defined as ${\geq}$ 3 food elimination, was associated with insufficient energy and intakes of calcium, phosphorus, iron, zinc, vitamins A and B2. In conclusion, children with AD need regular nutrient assessment and education about alternative food choices to avoid r food elimination in order to prevent growth retardation or inadequate nutrient intakes. Further longitudinal studies for growth and nutrient intakes should be performed to understand the patterns of growth in children with AD.

• YAKHAK HOEJI
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• v.56 no.2
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• pp.92-98
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• 2012

This study was conducted to determine if YJ-1, a novel herbal complex from a mixture of six oriental herbs (Hydnocarpi Semen, Sesami Semen, Dictamni Radicis Cortex, Momordicae Semen, Xanthii Fructus, and Sophorae Radix), has therapeutic properties for the treatment of atopic dermatitis (AD). Using AD like symptom-induced NC/Nga mice by 1-chloro 2,4-dinitrobenzene (DNCB), the effectiveness of YJ-1 on AD was evaluated. Elidel cream$^{(R)}$ (1% pimecrolimus) was used as a control. Dermal application of YJ-1 reduced major clinical signs of AD such as erythema, pruritus, lichenification, edema/escoriations, and dryness. Interestingly, YJ-1 more improved AD-related symptoms including decrease of spleen weight, IL-4, and IgE level in the serum as well as reduction of scratching counts and clinical skin severity in the NC/Nga AD mouse model. Especially, treatment of YJ-1 at 20% in NC/Nga mice more effected than Elidel cream. These results suggest that the ointment of YJ-1 may enhance the process of AD healing by alleviating allergic reaction and has potential for therapeutic reagent for the treatment of AD.

• Journal of Environmental Science International
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• v.16 no.4
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• pp.399-407
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• 2007

The characteristics of meteorological conditions relevant to Asian dust (AD) outbreaks and their occurrence frequencies were analyzed in four source regions (R1 to R4) during spring months (March to May) of 1995-2002. Moreover, the concentration variations of AD (e.g., $PM_{10}$) observed in Korea were investigated during the study period. In the relationship between AD outbreaks and three meteorological parameters (i.e., air temperature, wind speed, and aridity), the largest AD outbreaks in April (${\sim}250$ observations) mostly occurred in R2 when air temperature ranging from 10.0 to $15^{\circ}C$ and surface wind speed from 7 to $9m\;s^{-1}$ were recorded. Moreover, the aridity ($\geq4$) in April was significantly high in R2 with the maximum frequency of AD outbreaks (i.e., 206 observations). On the other hand, the number (percentage) of days belonging to AD events observed in five Korean cities were found to be 116 (44%), 121 (46%), and 26 days (10%) in March, April, and May, respectively. The mean $PM_{10}$ concentrations were found to range from 150 to 220, 150 to 200, and 95 to $120{\mu}g\;m^{-3}$ in March, April, and May, respectively. Consequently, this implied that the AD events in Korea were found to be gradually frequent in early spring and to be affected from the large AD outbreaks observed in the source regions.

• The KIPS Transactions:PartC
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• v.11C no.7 s.96
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• pp.905-916
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• 2004

Self-organizing hierarchical ad hoc network (SOHAN) is a new ad-hoc network architecture designed to improve the scalability properties of conventional 'flat' ad hoc networks. This network architecture consists of three tiers of ad-hoc nodes, i.e.. access points, forwarding nodes and mobile nodes. This paper presents a topology discovery and routing protocol for the self-organization of SOHAN. We propose a cross-layer path metric based on link quality and MAC delay which plays a key role in producing an optimal cluster-based hierarchical topology with high throughput capacity. The topology discovery protocol provides the basis for routing which takes place in layer 2.5 using MAC addresses. The routing protocol is based on AODV with appropriate modifications to take advantage of the hierarchical topology and interact with the discovery protocol. Simulation results are presented which show the improved performance as well as scalability properties of SOHAN in terms of through-put capacity, end-to-end delay, packet delivery ratio and control overhead.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.27 no.5
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• pp.1049-1058
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• 2017

The rapid evolution of mobile technologies and proliferation of mobile devices have created a new channel for marketing by mobile advertising. As mobile advertising is a close relative to online advertising, it also has similar problems such as advertisement injections (Ad injections). Users are exposed to unwanted advertisements and redundant web traffic by injected ads can cause additional charges of mobile devices. Although mobile ad injection can cause many problems it has been merely studied. In this paper, we analyze ad injection activities by mobile applications that exploit a legitimate application (Naver mobile application). We reverse-engineered 2 mobile applications and find out characteristics of mobile ad injections. We compare mobile ad injections with online ad injections and suggest feasible mitigations.