• Journal of Ginseng Research
• /
• 제45권6호
• /
• pp.665-675
• /
• 2021

Background: Ginsenoside Rg1 (Rg1), an active ingredient in ginseng, may be a potential agent for the treatment of Alzheimer's disease (AD). However, the protective effect of Rg1 on neurodegeneration in AD and its mechanism of action are still incompletely understood. Methods: Wild type (WT) and APP/PS1 AD mice, from 6 to 9 months old, were used in the experiment. The open field test (OFT) and Morris water maze (MWM) were used to detect behavioral changes. Neuronal damage was assessed by hematoxylin and eosin (H&E) and Nissl staining. Immunofluorescence, western blotting, and quantitative real-time polymerase chain reaction (q-PCR) were used to examine postsynaptic density 95 (PSD95) expression, amyloid beta (Aβ) deposition, Tau and phosphorylated Tau (p-Tau) expression, reactive oxygen species (ROS) production, and NAPDH oxidase 2 (NOX2) expression. Results: Rg1 treatment for 12 weeks significantly ameliorated cognitive impairments and neuronal damage and decreased the p-Tau level, amyloid precursor protein (APP) expression, and Aβ generation in APP/PS1 mice. Meanwhile, Rg1 treatment significantly decreased the ROS level and NOX2 expression in the hippocampus and cortex of APP/PS1 mice. Conclusions: Rg1 alleviates cognitive impairments, neuronal damage, and reduce Aβ deposition by inhibiting NOX2 activation in APP/PS1 mice.

• 한국정보통신학회:학술대회논문집
• /
• 한국해양정보통신학회 2011년도 춘계학술대회
• /
• pp.393-395
• /
• 2011

본 논문은 에드 혹 네트워크(Ad hoc network)에서 각 노드는 베터리 기반의 한정된 에너지로 동작 하기 때문에 에너지 효율을 높이기 위한 다양한 라우팅 알고리즘이 연구되고 있다. 에드 혹 네트워크는 많은 수의 노드들이 거리 등의 상호 속성 정보에 의한 노드의 관리 기법에 따라 노드의 에너지를 관리해야 한다. 또한 주어진 망에서 관리 노드 또는 중계 노드 등의 동작 불가능한상태가 되었을 경우 라우팅 경로가 끊어짐으로서 통신이 불가능한 상태가 되는 문제점이 있다. 본 논문에서는 트리망에서 중계 노드로 사용되는 클러스터 헤드 노드가 동작 불가능한 상태가 되었을 경우, 노드의 위치정보를 이용하여 새로운 헤드 노드를 선출하는 ECOPS(Energy conserving Optimal Path Schedule) 알고리즘을 제안 하였다. 특히 제한된 ECOPS 알고리즘을 이용함으로 노드에 대한 라이프타임을 향상 시키고 전체 라우팅 경로가 오랜 시간 동안 지속되는 결과를 보여 주었다.

• 한국정보통신학회:학술대회논문집
• /
• 한국정보통신학회 2013년도 춘계학술대회
• /
• pp.870-873
• /
• 2013

본 논문에서는 이동 에드 혹 네트워크(Mobile Ad-hoc network: MANET)에서의 상황인식 기반의 스케쥴링 기법인 DDV(Dynamic Direction Vector)-hop 알고리즘을 제안한다. 기존 MANET에서는 노드의 이동성으로 인한 동적 네트워크 토폴리지, 네트워크 확장성 결여의 대한 취약성을 지니고 있다. 또한 노드들의 이동성에 따라 에너지 소모율이 다르며, 에너지 소모율을 최소화하는 라우팅 기법을 선택하는 것이 중요하다. 따라서 본 논문에서는 계층적 클러스터 단위의 동적이 토폴로지에서 노드가 이동하는 방향성 및 시간에 따른 노드의 이동 속성 정보를 고려하여 클러스터를 생성 및 유지하는 DDV-hop알고리즘을 제안한다. 또한 주어진 노드의 위치정보를 이용하여 토폴로지를 형성함에 있어 보다 에너지 효율적인 경로를 탐색하여 최적화된 경로를 제공함에 연구의 목적이 있다. 주어진 모의실험환경에서 노드의 방향성 및 시간에 따른 이동성을 반영함으로써 에너지 효율적인 클러스터링 및 라우팅 경로 알고리즘이 제공되어 네트워크의 최적화된 에너지 소모 결과를 보여주었다.

• International Journal of Computer Science & Network Security
• /
• 제21권3호
• /
• pp.165-171
• /
• 2021

Vehicular Ad hoc Network (VANET) is an extension paradigm of moving vehicles to communicate with wireless transmission devices within a certain geographical limit without any fixed infrastructure. The vehicles have most important participation in this model is usually positioned quite dimly within the certain radio range. Fuzzy based multi-hop broadcast protocol is better than conventional message dissemination techniques in high-mobility VANETs, is proposed in this research work. Generally, in a transmission range the existing number of nodes is obstacle for rebroadcasting that can be improved by reducing number of intermediate forwarding points. The proposed protocol stresses on transmission of emergency message projection by utilization subset of surrounding nodes with consideration of three metrics: inter-vehicle distance, node density and signal strength. The proposed protocol is fuzzy MHB. The method assessment is accomplished in OMNeT++, SUMO and MATLAB environment to prove the efficiency of it.

• 한국정보통신학회논문지
• /
• 제17권11호
• /
• pp.2699-2707
• /
• 2013

본 논문에서는 이동 에드 혹 네트워크(Mobile Ad-hoc network: MANET)에서의 상황인식 기반의 스케쥴링 기법인 DDV(Dynamic Direction Vector)-hop 알고리즘을 제안한다. 기존 MANET에서는 노드의 이동성으로 인한 동적 네트워크 토폴리지, 네트워크 확장성 결여의 대한 취약성을 지니고 있다. 또한 노드들의 이동성에 따라 에너지 소모율이 다르며, 에너지 소모율을 최소화하는 라우팅 기법을 선택하는 것이 중요하다. 따라서 본 논문에서는 계층적 클러스터 단위의 동적인 토폴로지에서 노드가 이동하는 방향성 및 시간에 따른 노드의 이동 속성 정보를 고려하여 클러스터를 생성 및 유지하는 DDV-hop알고리즘을 제안한다. 또한 주어진 노드의 위치정보를 이용하여 토폴로지를 형성함에 있어 보다 에너지 효율적인 경로를 탐색하여 최적화된 경로를 제공함에 연구의 목적이 있다. 주어진 모의 실험환경에서 노드의 방향성 및 시간에 따른 이동성을 반영함으로써 에너지 효율적인 클러스터링 및 라우팅 경로 알고리즘이 제공되어 네트워크의 최적화된 에너지 소모 결과를 보여주었다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권20호
• /
• pp.8829-8836
• /
• 2014

Background: Cyclooxygenase-2 (COX-2), considered to have tumor-promoting potential, is highly expressed in a variety of tumors, including breast cancer. Since the functions and action mechanisms of COX-2 in breast cancer have not been fully elucidated, in the present study, the effects of target inhibiting COX-2 with recombinant adenovirus Ad-COX-2-shRNA on malignant biological behavior were investigated in representative cell lines. Materials and Methods: Breast cancer MDA-MB-231 and MCF-7 cells were transfected with Ad-COX-2-shRNA and COX-2 expression was tested by RT-PCR and Western blotting. Changes in proliferation, apoptosis and invasion of breast cancer cells were detected with various assays including MTT, colony forming, flowcytometry and Transwell invasion tests. The expression of related proteins involved in the cell cycle, apoptosis, invasion and signaling pathways was assessed by Western blotting. Results: COX-2 expression was significantly reduced in both breast cancer cell lines infected with Ad-COX-2-shRNA, with obvious inhibition of proliferation, colony forming rate, G2/M phase passage and invasion, as well as induction of apoptosis, in MDA-MB-231 and MCF-7 cells, respectively. At the same time, proteins related to the cell cycle, anti-apoptosis and invasion were significantly downregulated. In addition, c-myc expression and phosphorylation activation of Wnt/${\beta}$-catenin and p38MAPK pathways were reduced by the Ad-COX-2-shRNA. Conclusions: COX-2 expression is associated with proliferation, apoptosis and invasion of breast cancer cells, and its mechanisms of action involve regulating expression of c-myc through the p38MAPK and Wnt/${\beta}$-catenin pathways.

• 전자공학회논문지
• /
• 제50권2호
• /
• pp.70-79
• /
• 2013

최근 이동 ad hoc 네트워크에 적합한 ID 기반의 암호시스템 구현을 위해서 다양한 페어링 연산들이 사용되고 있으며, 밀러 알고리듬은 Weil, Tate, Ate 페어링 연산에서 가장 많이 사용되는 알고리듬이다. 본 논문에서는 Whelan과 Scott에 의해 제안된 밀러 알고리듬의 중간 값에 대한 오류 공격을 구체화하여 라운드 위치와 상관없이 적용할 수 있는 데이터 오류 주입 공격의 가능성을 분석하였다. 시뮬레이션 결과, 제안하는 공격 방법이 라운드 위치나 사용하는 좌표계와 관계없이 적용 가능하여 효과적이며 강력한 오류 주입 공격 방법임을 확인하였다.

• 대한치매학회지
• /
• 제22권4호
• /
• pp.158-168
• /
• 2023

Background and Purpose: Facial emotion recognition deficits impact the daily life, particularly of Alzheimer's disease patients. We aimed to assess these deficits in the following three groups: subjective cognitive decline (SCD), mild cognitive impairment (MCI), and mild Alzheimer's dementia (AD). Additionally, we explored the associations between facial emotion recognition and cognitive performance. Methods: We used the Korean version of the Florida Facial Affect Battery (K-FAB) in 72 SCD, 76 MCI, and 76 mild AD subjects. The comparison was conducted using the analysis of covariance (ANCOVA), with adjustments being made for age and sex. The Mini-Mental State Examination (MMSE) was utilized to gauge the overall cognitive status, while the Seoul Neuropsychological Screening Battery (SNSB) was employed to evaluate the performance in the following five cognitive domains: attention, language, visuospatial abilities, memory, and frontal executive functions. Results: The ANCOVA results showed significant differences in K-FAB subtests 3, 4, and 5 (p=0.001, p=0.003, and p=0.004, respectively), especially for anger and fearful emotions. Recognition of 'anger' in the FAB subtest 5 declined from SCD to MCI to mild AD. Correlations were observed with age and education, and after controlling for these factors, MMSE and frontal executive function were associated with FAB tests, particularly in the FAB subtest 5 (r=0.507, p<0.001 and r=-0.288, p=0.026, respectively). Conclusions: Emotion recognition deficits worsened from SCD to MCI to mild AD, especially for negative emotions. Complex tasks, such as matching, selection, and naming, showed greater deficits, with a connection to cognitive impairment, especially frontal executive dysfunction.

• 대한간호학회지
• /
• 제33권2호
• /
• pp.256-264
• /
• 2003

Purpose: The purpose of this research was to find out tobacco control education taught graduate, baccalaureate and associate degree-nursing programs in Korea. Method: A valid and reliable questionnaire previously used to assess tobacco use in medical and nursing schools in the United States was translated and revalidated. Surveys were sent out to all the graduate, baccalaureate and associate nursing programs in Korea. All 6-tobacco curricula content areas recommended by the United States National Cancer Institute and the Agency for Health Care Policy and Research was included. Result: Majority of BSN (93.2%-75%) and AD (92.3%-64.1%) programs were teaching health hazards, cancer risk, health effects of tobacco, effects of ETS, contents of cigarette, withdrawal symptoms and high risk groups of smoking as a part of required courses. However, 87.5% (14/16) of graduate, 50.0% (22/44) in baccalaureate, 53.8% (21/39) in associate degree programs were not teaching about the 5 A's. Of those who reported teaching smoking cessation strategies, they were covered most frequently in Community Nursing (50%), Adult Health Nursing (43.8%) on the graduate level, and in Community Nursing (65.9%-BSN, 76.9%-AD) and Adult Health (54.5%-BSN, 74.4%-AD) on the undergraduate level. 31.1% (5/16) in Graduate, 18.2%(8/44) in BSN, 10.3% (4/39) in Associate Degree programs reported that there are no smoking students in their schools and rest of the schools reported either do not know or they have 1 to more than 21% of students smoking. Conclusion: The study results identifies the quantity and level of tobacco control content in three different nursing programs and will help in developing curricular guidelines in the future. Further survey needs to be done on nursing students' knowledge, attitude and belief on smoking and smoking cessation.

• 통합자연과학논문집
• /
• 제11권3호
• /
• pp.139-147
• /
• 2018

Hippocampal atrophy is a well-established imaging biomarker of Alzheimer disease (AD). However, hippocampus is a non-homogenous structure with cytoarchitecturally and functionally distinct sub-regions or subfield, with each region performing distinct functions. Certain regions of the subfield have shown selective vulnerability to AD. Here, we are interested in studying the effects of normal aging and mild cognitive impairment on these sub-regional volumes. With a reliable automated segmentation technique, we segmented these subregions of the hippocampus in 101 cognitively normal (CN), 135 early mild cognitive impairment (EMCI), 67 late mild cognitive impairment (LMCI) and 48 AD subjects. Thereby, dividing the hippocampus into hippocampal tail (tail), subiculum (SUB), cornu ammonis 1 (CA1), hippocampal fissure (fissure), presubiculum (PSUB), parasubiculum (ParaSUB), molecular layer (ML), granule cells/molecular layer/dentate gyrus (GCMLDG), cornu ammonis 3(CA3), cornu ammonis 4(CA4), fimbria and hippocampal-amygdala transition area (HATA). In this cross sectional study of 351 ADNI subjects, no differences in terms of age, gender, and years of education were observed among the groups. Though, the groups had statistically significant differences (p < 0.05 after the multiple comparison correction) in the Mini-Mental State Examination (MMSE) scores. There was asymmetrical volume loss in the early stages of AD with the left hemisphere showing volume loss in regions that were unaffected in the right hemisphere. Bilateral parasubiculum, right cornu ammonis 1, 3 and 4, right fimbria and right HATA regions did not show any volume loss till the late MCI stages. Our findings suggest that the hippocampal subfield regions are selectively vulnerable to AD and also that these vulnerabilities are asymmetrical especially during the early stages of AD.