• Title/Summary/Keyword: AD education

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Heterogeneity in liver histopathology is associated with GSK-3β activity and mitochondrial dysfunction in end-stage diabetic rats on differential diets

  • Lee, Jun-Ho;Choi, Soo-Bong;Sung, Dong-Jun;Jin, Mingli;Lee, Ju-Han;Mun, Ji-Young;Hwang, Tae-Sook;Han, Sang-Don;Ro, Young-Tae;Kim, Sung-Young;You, Jueng-Soo;Lim, Inja;Noh, Yun-Hee
    • BMB Reports
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    • v.53 no.2
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    • pp.100-105
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    • 2020
  • While liver histopathology is heterogeneous in diabetes, the underlying mechanisms remain unclear. We investigated whether glycemic variation resulting from differential diets can induce heterogeneity in diabetic liver and the underlying molecular mechanisms. We generated end-stage non-obese diabetic model rats by subtotal-pancreatectomy in male Sprague-Dawley rats and ad libitum diet for 7 weeks (n = 33). The rats were then divided into three groups, and fed a standard- or a low-protein diet (18 or 6 kcal%, respectively), for another 7 weeks: to maintain hyperglycemia, 11 rats were fed ad libitum (18AL group); to achieve euglycemia, 11 were calorie-restricted (18R group), and 11 were both calorie- and protein-restricted with the low-protein diet (6R group). Overnight-fasted liver samples were collected after the differential diets together with sham-control (18S group), and histology and molecular changes were compared. Hyperglycemic-18AL showed glycogenic hepatopathy (GH) without steatosis, with the highest GSK-3β inactivation because of Akt activation during hyperglycemia; mitochondrial function was not impaired, compared to the 18S group. Euglycemic-18R showed neither GH nor steatosis, with intermediate GSK-3β activation and mitochondrial dysfunction. However, euglycemic-6R showed both GH and steatosis despite the highest GSK-3β activity and no molecular evidence of increased lipogenesis or decreased ApoB expression, where mitochondrial dysfunction was highest among the groups. In conclusion, heterogeneous liver histopathology developed in end-stage non-obese diabetic rats as the glycemic levels varied with differential diets, in which protein content in the diets as well as glycemic levels differentially influenced GSK-3β activity and mitochondrial function in insulin-deficient state.

Mediating and Moderating Effects of Self-esteem, Social Participation and Discrimination Experience in the Relationship between Acceptance of Disability and Social Competence in Adults with Physical Disabilities (지체장애인의 장애수용과 사회적 유능감 간의 관계에서 자존감, 사회참여, 차별경험의 매개 및 조절효과)

  • Kim, Do-Hee
    • Journal of Digital Convergence
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    • v.17 no.7
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    • pp.377-386
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    • 2019
  • The purpose of this study is to identify effective strategies for promoting psycho-social adjustment by examining the mediating effects of self-esteem (SE) and moderating effects of social participation (SP) and discrimination experience (DE) in predicting social competence (SC) with acceptance of disability (AD). The subjects of the study were 1943 adults with a physical disability (1338 males and 605 females) and 233 adults with brain lesions (160 males and 73 females) aged between 19 and 65 years. Data were analyzed using SPSS and Process macro software, and conditional process analysis (model 18) in which the degree and onset of disability were controlled was performed. The results are as follows. First, SE was found to partially mediate the relationship between AD and SC. Second, the relationship between SE and SC was found to be moderated by SP but not by DE, and the relationship between SP and SC was found to be moderated by DE. In addition, the mediating effects of SE, which was moderated by SP, were found to not be moderated by DE. The clinical implication and suggestion for future research is discussed.

Application and Effectiveness of a Preceptorship for the Improvement of Clinical Education (임상실습 교육개선을 위한 일 실습지도자 활용모델 (preceptorship model)의 적용 및 효과에 관한 연구 -암센타, 재활센타, 중환자실 실습을 중심으로-)

  • 이원희;김소선;한신희;이소연;김기연
    • Journal of Korean Academy of Nursing
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    • v.25 no.3
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    • pp.581-596
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    • 1995
  • Clinical practice in nursing education provides an opportunity for students, through the process of ap-plying theoretical knowledge to practice, and to learn nursing skills as well as being socialized into nursing and as such decrease the reality shock of actual nursing practice. Because of a shortage of nursing faculty, the job of achieving the objectives of the clinical practice had been turned over to the head nurses. This resulted in many problems, such as, unclear location of responsibilities and inadequate feedback from head nurses. Therefore this study was done to introduce and evaluate the use of preceptors as a way to minimize the above problems, and to maximize the achievement of the clinical practice objectives. Using an adaptation of Zerbe's (1991) three-tiered team model, clinical practice was done using a preceptor, a head nurse and a clinical instructor, each with different and well defined roles. The subjects of this study were 67 senior students of the College of Nursing of Y University in Seoul whose clinical practice in adult nursing was carried out between May 1, 1994 and December 8, 1994. There were 22 preceptors who had at least two years of clinical experience and who were recommended by their head nurses. They were given additional education on the philosophy and objectives of the College of Nursing, on communication skills, on the theory and practice of education, and on nursing diagnosis and education evaluation. The role of the preceptor was to work one-to-one with students in their practice. The role of the head nurse was to supervise and evaluate the preceptors. The role of the clinical instructor was to provide the education program for the preceptors, to provide ad-vice and suggestions to the preceptors and to maintain lines of communication with the college. With each of these roles in place, it was thought that the effectiveness and efficiency of the clinical practice could be increased significantly. To evaluate the effectiveness of the preceptorship, the three - tiered model, Lowery's Teacher Evaluation Opinion Form translated and adapted to Korea was used to measure student statisfaction. The Clinical Practice Compentency Evaluation Tool developed by Lee et ai was also used to measure student competencies. The results of this study are as follows 1. The satisfaction with clinical practice was higher with the introduction of the perceptors than it was before they were used. (t=-5.96, p=<.005) 2. The clinical practice competencies were higher with the introduction of the preceptors than it was before they were used(t=-5.l3, p<.005) 3. In order to analyze areas not measured by the quantitative tools additional analysis of the open questions was done. The results of this analysis showed that : 1) The students felt positive about their sense of security, confidence, handling of responsbility, and being systematic. They also felt positive about improvements in knowledge, opportunities for direct care, and socialization. 2) The students felt negative about the technical part of their role, lack of knowledge by the preceptor, unprofessional attitudes on the part of the preceptor, difficulty in the role of the professional nurse(student). 3) The preceptors felt positive about their responsibility, motivation, and relationship with the college. 4) The preceptors felt negative about their bur-den. Introduction of the preceptorship model will lead to change and improvement in the negative factors discussed above, solve problems in the present clinical education system, increase continuity in the education of the students, help with socialization of the students and motivation of the preceptors to up-grade their education and increase their confidence. These objectives must be obtained to further the development of professional nursing, and thus, making the preceptorship a reality is our job for the future.

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Some Evidences for Glacial Landforms on the Baekdusan and Its Implications to Quaternary Volcanic Eruptions (백두산 빙하지형의 존재 가능성과 제4기 화산활동과의 관계)

  • Lee, Sung-Ee;Seong, Yeong-Bae;Kang, Hee-Cheol;Choi, Kwang-Hee
    • Journal of the Korean Geographical Society
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    • v.47 no.2
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    • pp.159-178
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    • 2012
  • Since the suggestions on the paleo-glacial landforms in and around the northern high mountains of Korean Peninsula by some western and Japanese scientists in the early 1900s, the likelihood of the glacier existence in the Baekdusan over the Quaternary glacial period has been had in common among most of the Korean geomorphologists. In the other meaning, some have cast doubt on the likelihood the paleo-glacier in the Baekdusan because there has been no unequivocal evidences for the glacier such as striation, moraines, except morphologic characteristic landforms possibly related to glacier. Here we show some evidences for the existence of the glacier in the Baekdusan and their cosmogenic $^{36}Cl$ exposure ages over the late Quaternary and would put forward a model on the Quaternary landscape evolution of the Baekdusan, with a focus on the relationship of 1000 AD explosive eruption and the glacial landforms. The exposure ages constrained by cosmogenic $^{36}Cl$ abundances of the col surface of the western slope located below the glacier yield 46~26 ka, which is inphase with the last glacial period. Given all the evidences above, we can draw a conclusion that the glacier existed on the Baekdusan over the late Quaternary and the style of glaciation changed from extensive ice cap through valley glacier to restricted cirque.

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Seminiferous Epithelium Cycle of Apodemus speciosus peninsulae (흰넓적다리 붉은쥐(Apodemus speciosus peninsulae)의 세정관 상피주기)

  • Kim, Mi-Jin;Lee, Jung-Hun
    • Development and Reproduction
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    • v.13 no.1
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    • pp.25-33
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    • 2009
  • The cycle of the seminiferous epithelium and development of spermatids of Apodemus speciosus peninsulae were observed using a light microscope. On the basis of developing spermatocyte and spermatid, the cycle of the seminiferous epithelium was divided into 9 stages. Type Ad spermatogonia were appeared in all stages ($I{\sim}IX$). The Ap, In, and B types of spermatogonia were appeared from stage I, II and III, and IV, respectively. In prophase of first meiosis, the leptotene spermatocytes appeared from stage V and VI, zygotene spermatocytes from stages I, II, VII, VIII, and IX, pachytene spermatocytes from stage III to VII, diplotene spermatocytes in the stage VIII, and secondary spermatocytes in stage IX. On the basis of morphology of spermatid head, developing of nuclear and acrosome and the morphological change of cytoplasm, the developing of spermatids was divided into 12 steps. Considering all the results, A. s. peninsulae displayed very similar result with A. agrarius coreae that is allied species when compare correct characters developing of spermatids with spermatogonia and appearance time of the spermatocyte. Appearance time of the same cell and number of spermatogonial generation was thought that characters of the species, and information may be useful in identifying the species.

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A Longitudinal Study on the Influence of Learning Effort, Attitude, and Achievement Goal on Mathematics Academic Achievement : For elementary and secondary school students (학습노력, 태도 및 성취목표가 수학 학업성취도에 미치는 직·간접적인 영향에 대한 종단연구: 초·중학생을 대상으로)

  • Kim, YongSeok
    • Education of Primary School Mathematics
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    • v.24 no.1
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    • pp.1-20
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    • 2021
  • Factors influencing mathematics academic achievement are constantly changing and have direct and indirect effects on mathematics achievement, so longitudinal studies that can predict and analyze their growth are needed. This study uses longitudinal data on students from 2011 (5th grade of elementary school) to 2015 (2nd grade of middle school) of the Seoul Education Longitudinal Study, and divides them into groups with similar longitudinal changes in mathematics academic achievement. The direct and indirect effects of learning attitudes and achievement goals were examined. As a result of the study, it was found that learning effort and learning attitude had a direct effect on mathematics achievement in 1 group (2277 students, 67.7%), and learning attitude had a direct effect on mathematics achievement in 3 groups (958 students, 28.5%). And it was found that learning effort h ad an indirect effect. In addition, it was found that both learning attitudes, learning efforts, and achievement goals had no effect on the academic achievement of mathematics in the second group (127 students, 3.8%).

The Effects of Treadmill Exercise on Cognitive Performance, Brain Mitochondrial Aβ-42, Cytochrome c, SOD-1, 2 and Sirt-3 Protein Expression in Mutant (N141I) Presenilin-2 Transgenic Mice of Alzheimer's Disease (트레드밀 운동이 mutant (N141I) presenilin-2 유전자를 이식한 알츠하이머질환 모델 생쥐 뇌의 Aβ-42, cytochrome c, SOD-1, 2와 Sirt-3 단백질 발현에 미치는 영향)

  • Koo, Jung-Hoon;Eum, Hyun-Sub;Kang, Eun-Bum;Kwon, In-Su;Yeom, Dong-Cheol;An, Gil-Young;Oh, Yoo-Sung;Baik, Young-Soo;Cho, In-Ho;Cho, Joon-Yong
    • Journal of Life Science
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    • v.20 no.3
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    • pp.444-452
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    • 2010
  • The purpose of this study was to investigate the effects of treadmill exercise on $A{\beta}$-42, cytochrome c, SOD-1, 2 and Sirt-3 protein expressions in brain cytosol and mitochondria in mutant (N141I) presenilin-2 transgenic mice with Alzheimer's disease (AD). The mice were divided into four groups (Non-Tg-sedentary, n=5; Non-Tg treadmill exercise, n=5; Tg-sedentary, n=5; Tg treadmill exercise, n=5). To evaluate the neuroprotective effect of treadmill exercise, Non-Tg and Tg mice were subjected to exercise training on a treadmill for 12 wk, after which their brain cytosol and mitochondria were evaluated to determine whether any changes in the cognitive performance, $A{\beta}$-42 protein, cytochrome c protein, anti-oxidant enzymes (SOD-1, SOD-2) and Sirt-3 protein had occurred. The results indicated that treadmill exercise resulted in amelioration in cognitive deficits of Tg mice. In addition, the expressions of mitochondrial $A{\beta}$-42 and cytosolic cytochrome c protein were decreased in the brains of Tg mice after treadmill exercise, whereas antioxidant enzymes, SOD-l and SOD-2 were significantly increased in response to treadmill exercise. Furthermore, treadmill exercise significantly increased the expression of Sirt-3 protein in Non-Tg and Tg mice. Taken together, these results suggest that treadmill exercise is a simple behavioral intervention which can sufficiently improve cognitive performance and inhibit $A{\beta}$-induced oxidative stress in AD.

A Study on Type of Clinical Experience of Adaptation of New Nursing Staffs in a General Hospital (일 종합병원 신규간호사의 실무적응 경험 유형)

  • Kim, Yun-Jeong
    • Journal of Digital Convergence
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    • v.12 no.4
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    • pp.443-454
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    • 2014
  • This study designed to know subjective structure about clinical experience of adaptation of new nursing staffs in a general hospital and using Q-methodology. Using Q-methodology, 40 new nursing staffs sorted working a general hospital through personal interview. The statement positions on the sorting continuum were scored from +4(representing the highest level of agreement) through 0(at the neutral position on the continuum) through to -4(representing the highest level of disagreement). Factor analysis of the data was undertaken using PC QUANL program to determine if any patterns were discernible. The five types extracted all had eigenvalues greater than 1.0 and explained 62.38% of the variation in responses.: (1) New workload type, (2) Interest and responsibility type, (3) Improve the situation type, (4) Lack of knowledge and technology type, and (5) Excessive workload type. The significant differences found in the subjective structure of clinical experience of adaptation of new nursing staffs in ad general hospital. The findings of this study could contribute to the development of an effective programmes of education and personnel clinical practice strategies.

Implementation of VANET Simulator using Matlab (Matlab을 이용한 VANET 시뮬레이터 구현)

  • Nam, Jae-hyun
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.20 no.6
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    • pp.1171-1176
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    • 2016
  • VANET are a special kind of MANET adapted to the communications between vehicles. In this work, we propose the models used for representing the communication among vehicles, vehicles mobility features, and VANET simulator using realistic vehicular mobility models. VANET requires that a traffic and network simulator should be used together to perform this test. But, simulator tool has been preferred over traffic simulation because it simple, easy and cheap. Goal of this paper is to create a simulation of Vehicular Ad-Hoc network for urban scenario which can be used for testing purposes. Such environment can be used while designing better MAC protocols in VANETs. We are evaluating the performance of two routing protocols namely AODV and DSDV. The comparison was based on the throughout, packet loss and end-to-end delay. We found that DSDV has less throughput performance and high routing overhead than AODV. On average end-to-end delay and packet loss, AODV performs better than DSDV.

Historical Geography of Mu-Sim River and Nam-Suk Bridge in Chongju City (청주 무심천과 남석교에 관한 역사지리적 고찰)

  • Yeh, Kyong-Hee
    • Journal of the Korean association of regional geographers
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    • v.9 no.4
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    • pp.437-460
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    • 2003
  • It is recorded that the orignal Nam-Suk Bridge is constructed at the first year of Oh-Bong(B.C. 57). But I believe that it can be back to the 19 year of Jin-Hung King(AD. 558) by discovered bibliographies. The Nam-Suk Bridge is improved and remodelled from past to the late of Zosun dynasty by the development of walled city of Chongju. By the late of Gojong Empire, the Nam-Suk Bridge has stone post and monument of Nam-Suk Bridge. Because the alternations of Mu-Sim River channel, heavy floods, extension of built, up area and Japanese unconcern, the stone post and monument of Nam-Suk Bridge is lost approximately by 1910s and Nam-Suk Bridge is completely buried by the early 1930s. The Mu-Sim Hiver has negative aspects from past to the Japanese rule but has increasingly the positive aspects after the liberation of Korea. We must reconstruct these buried cultural resources to highlight the cultural identity of Chongju City.

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