• 한국과학교육학회지
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• 제37권4호
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• pp.763-773
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• 2017

이 연구는 현장의 과학 수업의 학생들의 인성 여량에 미치는 영향을 분석하여 교과교육을 통한 인성 교육의 가능성을 제시하기 위해 탐구 전 과정에서 논의와 글쓰기를 강조한 논의-기반 탐구(Argumentbased Inquiry, ABI) 과학수업을 교수학습 전략으로 적용하였다. 논의-기반 탐구(ABI) 과학수업에서 역할분담을 변인으로 하여 역할분담을 한 집단(ABI-R집단)과 역할분담을 하지 않은 집단(ABI집단)의 두 집단으로 나누어 집단별 인성 역량 변화를 분석하였다. 이를 위해 광역시에 위치한 남녀공학 일반계 고등학교 2학년을 대상으로 하여 2개 학급 51명은 논의-기반 탐구(ABI) 과학수업에서 역할분담을 하고(ABI-R집단), 2개 학급 46명은 역할분담을 하지 않았다(ABI집단). 4개의 탐구 주제를 총 10시간에 걸쳐 진행하였으며, 처치 전 동일시기에 인성지수 검사를 실시하고 사후 인성지수 검사를 실시하여 변화를 분석하였다. 논의-기반 탐구(ABI) 과학수업의 마지막 단계의 반성 글쓰기에 나타나는 인성 역량을 알아보았고, 과학 수업을 통한 인성 역량 함양에 대한 설문지를 통해 학생들의 인성 교육에 대한 인식 조사를 실시하였다. 과학교과의 논의-기반 탐구(ABI) 과학수업에서 역할분담을 적용한 집단(ABI-R집단)이 역할분담을 하지 않은 집단(ABI집단)의 인성지수 검사 결과, ABI-R집단이 ABI집단 보다 인성 역량 변화가 통계적으로 유의미하게 높았다. 특히, 인성 역량의 하위 요소 중 공감, 책임, 존중에서 역할분담을 적용한 그룹이 역할분담을 나누지 않은 통계적으로 유의미하게 높았다. 모둠 활동과 같은 협동학습에서 역할분담을 통해 학생들은 자신의 역할을 명확하게 인지함으로써 수업에 대한 참여도가 높아지게 되고, 학생들 사이의 상호작용이 촉진되며 다른 사람을 배려하고 존중하게 된다. 그러나 협력 항목에서는 이와는 반대로 역할분담을 적용하지 않은 그룹이 통계적으로 유의미하게 높게 나타났다. 이는 개인이 하나의 역할을 유지하지 않고, 모둠내에서 자연스럽게 자신의 역할을 형성하고 상황에 따라 역할을 교대하면서 공동의 문제를 해결하기 위해 노력하면서 협동이 높아진 것으로 보인다. 논의-기반 탐구(ABI) 과학수업에 대한 학생들의 인식 조사를 분석한 결과, 학생들은 자신들의 인성 역량 변화에 도움이 된다는 인식이 많았고, 협력 항목이 가장 크게 증가할 것으로 기대하고 있었다. 이는 학생들이 논의-기반 탐구(ABI) 과학수업이라는 모둠 활동에서 서로의 이해를 공유하고, 지식 및 정보를 의사소통을 통해 공유함으로써 공동의 문제를 해결하는 것을 강조하기 때문에 인성 역량을 키우는데 도움이 될 것이라고 생각하는 것으로 볼 수 있다. 과학교과에서 모둠 활동에서 역할분담을 통해 학생들이 수업에 적극적으로 참여하도록 하되, 주어진 역할 수행에만 고정되지 않고 문제 상황에 따라 능동적으로 임할 수 있도록 수업상황을 제시할 필요가 있음을 제안하고자 한다.

• 디지털융복합연구
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• 제15권1호
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• pp.267-275
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• 2017

본 연구는 심혈관 질환자의 발목-상완 지수(ankle-brachial index, ABI)에 따른 심혈관 질환 중증도를 분석하여 ABI의 임상적 유용성을 확인하기 위함이다. 연구 대상자는 일개 종합병원의 ABI를 측정한 심장내과 환자 441명 이었으며, 전자 의무 기록을 통해 ABI와 심혈관 질환 중증도를 나타내는 vessel disease 및 Gensini score를 조사하였다. 수집된 자료는 SPSS 21.0을 이용하여 분석하였다. ABI 0.90 이하인 비정상군과 0.90 초과인 정상군으로 나누어 비교하였을 때, vessel disease 분포 비율의 차이가 있었다($x^2=4.731$, p=.030). ABI 두 군과 Gensini score에 대한 비교분석에서 비정상군 $39.1{\pm}32.7$점, 정상군 $27.4{\pm}27.4$점으로 유의한 차이가 있었다(t=2.351, p=.019). 본 연구의 결과에서 ABI 비정상군이 중증도 높은 심혈관 질환자들의 분포가 많았으며, 평균 Gensini score도 높은 것을 확인할 수 있었다. 따라서 ABI를 시행하는 것은 비침습적인 방법으로 중증도 높은 심혈관 질환자를 예측하는데 도움이 되어 허혈성 심장 질환의 조기 발견에 유용하게 활용 가능할 것으로 기대된다.

• Journal of Plant Biotechnology
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• 제45권2호
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• pp.83-89
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• 2018

The interplay of plant hormones is one of the essential mechanisms for plant growth and development. A recent study reported that Brassinosteroids (BR) and ABSCISIC ACID (ABA) interact antagonistically in early seedling developments through the BR-mediated epigenetic repression of ABSCISIC ACID-INSENSITIVE 3 (ABI3). However, the other physiological roles of the BR-mediated regulation of ABI3 and ABA responses beyond early seedling developments remain largely unknown. Here, we showed that the activation of BR signaling by high temperatures promotes flowering time through the suppression of ABI3 expressions. Elevated ambient temperature induced early flowering in wild type Col-0 plants, but not in BR-defective bri1-116 mutant plants. Conversely, a hyper BR biosynthetic dwf4-D mutant displayed more sensitive thermomorphic long shoot elongation and early flowering. Both expression patterns and physiological responses supported the biological roles of ABI3 in the regulation of floral transition and reproduction under high temperature conditions. Finally, we confirmed that the lowered expressions of the transcript and protein levels of ABI3 brought on by elevated temperature were correlated with warmth-induced early flowering phenotypes. In conclusion, our data suggest that the BR- and warmth-mediated regulation of ABI3 are important in thermomorphic reproductive phase transitions in plants.

• 대한한방부인과학회지
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• 제23권1호
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• pp.53-64
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• 2010

Purpose: This study was performed to observe the correlation between Hot flush and pulse wave velocity(PWV), ankle brachial index(ABI) in the Climacteric women. Methods: We studied 63 climacteric women visiting OO hospital from 8th January 2007 to 22nd April 2009. The subjects were categorized in two groups, the hot flush group(37) and normal group(26). For the study, the subjects were selected by excluding the patients who receive treatment affect hot flush or have disease affect arterial states. We assessed PWV and ABI of two groups by Oscillometric method using VS-1000(Form PWV/ABI; Fukuda Denshi, Co., Ltd., Japan). From these results, we studied the correlation between hot flush and PWV/ABI by Wilcoxon Mann Whitney Test. Results: 1. It is shown that hot flush group was no significant correlation with normal group. There is no significant factor among R-PWV, L-PWV, R-ABI, L-ABI. However, L-ABI have shown relatively higher correlation with comparison to the other factors.(p-value<0.05) 2. R-PWV, L-PWV significantly increased in menopause group than in premenopause group though there is no relation to the hot flush. (p-value<0.01) Conclusion: Though the results showed no correlations between Hot flush and PWV/ABI in the Climacteric women, L-ABI showed relatively higher correlation with hot flush than others. R-PWV, L-PWV showed significant correlation between premenopause and menopause.

• 대한한방내과학회지
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• 제41권3호
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• pp.434-446
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• 2020

Objectives: The cardio-ankle vascular index (CAVI) and ankle-brachial index (ABI) are non-invasive methods to evaluate cardiovascular disease and arteriosclerosis. This study investigated the relationship between CAVI, ABI, and factors related to arteriosclerosis. Methods: This study included 535 healthy adults who underwent health examinations in 2019. We analyzed the correlation between CAVI, ABI and clinical variables. Multiple regression analysis was performed on the independent clinical variables associated with CAVI and ABI. Results: The correlation analysis of CAVI showed that body mass index (BMI) and HDL-cholesterol (HDL-C) had a negative correlation, and the other variables had a significant positive correlation. The correlation analysis with ABI on the right side showed that age, diastolic blood pressure (DBP), gender, and LDL-cholesterol (LDL-C) had a significant positive correlation, while HDL-C had a significant negative correlation. There was no statistical significance on the left. In the multiple regression analysis, DBP, age, BMI, gender, and HDL-C were proved to be independent factors in CAVI (right) (R²=0.365); DBP, age, gender, BMI, fasting blood sugar, and total cholesterol in CAVI (left) (R²=0.357); and age, gender, DBP, and systolic blood pressure in ABI (right) (R²=0.133). There were no statistically significant factors in ABI (left). It could be inferred that smoking and drinking are determinants that play an important role in CAVI. Conclusion: CAVI showed a high correlation with gender, age, and blood pressure. A significant correlation between CAVI and serum lipid values could be observed, but this showed a low correlation coefficient. ABI showed a high correlation with age and DBP. These results support the use of CAVI and ABI as primary diagnostic devices in medical treatment.

• Biomolecules & Therapeutics
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• 제30권4호
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• pp.340-347
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• 2022

Advanced or metastatic breast cancer affects multiple organs and is a leading cause of cancer-related death. Cancer metastasis is associated with epithelial-mesenchymal metastasis (EMT). However, the specific signals that induce and regulate EMT in carcinoma cells remain unclear. PRR16/Largen is a cell size regulator that is independent of mTOR and Hippo signalling pathways. However, little is known about the role PRR16 plays in the EMT process. We found that the expression of PRR16 was increased in mesenchymal breast cancer cell lines. PRR16 overexpression induced EMT in MCF7 breast cancer cells and enhances migration and invasion. To determine how PRR16 induces EMT, the binding proteins for PRR16 were screened, revealing that PRR16 binds to Abl interactor 2 (ABI2). We then investigated whether ABI2 is involved in EMT. Gene silencing of ABI2 induces EMT, leading to enhanced migration and invasion. ABI2 is a gene that codes for a protein that interacts with ABL proto-oncogene 1 (ABL1) kinase. Therefore, we investigated whether the change in ABI2 expression affected the activation of ABL1 kinase. The knockdown of ABI2 and PRR16 overexpression increased the phosphorylation of Y412 in ABL1 kinase. Our results suggest that PRR16 may be involved in EMT by binding to ABI2 and interfering with its inhibition of ABL1 kinase. This indicates that ABL1 kinase inhibitors may be potential therapeutic agents for the treatment of PRR16-related breast cancer.

• 한국한의학연구원논문집
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• 제10권2호
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• pp.73-78
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• 2004

Purpose : The aim of this study was to investigate correlation between retention of fluid and PWV/ABI. Methods : The sample consists of 35 women who took plethynography(VS-1000;Fukuda Co.Ltd, Japan) at Oriental medicine exhibition held in COEX mall from August. 26. 2004 to August. 29. 2004. They were asked the intensity of the symptoms like dizziness or headache, nausea or bowel trouble, coldness in knee, and palpitation(1:none, 2:a little, 3:mild, 4:moderate, 5:severe). Women who answered 1,2 were classified as control group, and women who answered 3,4,5 were experimental group. Result : There was stastically significant correlation between dizziness and ABI Conclusion : It is believed that ABI may be the favorable alternative to the diagnosis of dizziness or headache.

• Archives of Plastic Surgery
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• 제39권3호
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• pp.227-231
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• 2012

Background : The ankle brachial pressure index (ABI) is a simple, useful method for diagnosing peripheral artery disease (PAD). Although the ABI is an objective diagnostic method, it has limited reliability in certain scenarios. The aim of the present study was to determine the accuracy and reliability of the toe brachial index (TBI) as a diagnostic tool for detecting stenosis in PAD, associated with normal or low ABI values. Methods : ABI and TBI values were measured in 15 patients with diabetic gangrene who were suspected of having lower extremity arterial insufficiency. The ABI and TBI values were measured using a device that allowed the simultaneous measurement of systolic blood pressure in the upper and lower extremities. In addition, the ABI and TBI values were compared pre- and post-angiography. Results : Patients with an ABI of 0.9-1.3 showed almost no difference between the 2 measurements. The patients with TBI >0.6 had no arterial insufficiency. The patients with TBI <0.6 required vascular intervention with ballooning. After the angiography, the gangrenous wounds decreased in size more rapidly than they did prior to the intervention. Conclusions : Our findings suggest that TBI is the method of choice for evaluating lower limb perfusion disorders. This result requires further studies of TBI in a larger number of patients. Future long-term studies should therefore evaluate the utility of TBI as a means of screening for PAD and the present findings should be regarded as preliminary outcomes.

• 식물조직배양학회지
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• 제22권3호
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• pp.149-155
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• 1995

국내에서 분리 동정한 오이모자이크 바이러스(CMV)로부터 외피단백질(CP) 유전자를 분리하였고 이의 염기서열을 결정한 결과 129번째 아미노산이 proline으로서 mosaic symptom을 보이고 염기 및 아미노산 서열의 유사성을 비교한 결과 subgroup I (type I)에 속한다는 것을 확인하였다. 분리한 CP 유전자를 식물형질전환용 운반체에 삽입하여 담배 재배종인 NC82와 바이러스 증식용인 Samsun에 잎절편을 통하여 형질전환시켰다. 형질전환된 담배의 DNA를 분리하여 Southern blotting과 PCR을 수행한 결과 대부분의 형질전환체에 CP 유전자가 삽입되였음을 확인하였고 T$_1$ 종자를 kanamycin이 첨가된 배지에서 후대 항생제 저항성 검정을 실시한 결과 1개의 CP 유전자가 삽입된 경우가 50%에 달했고 2개와 3개의 유전자가 삽입된 경우도 각각 39%와 11%에 달했다.

• Molecules and Cells
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• 제42권9호
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• pp.646-660
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• 2019

Abscisic acid (ABA) is a phytohormone essential for seed development and seedling growth under unfavorable environmental conditions. The signaling pathway leading to ABA response has been established, but relatively little is known about the functional regulation of the constituent signaling components. Here, we present several lines of evidence that Arabidopsis Raf-like kinase Raf10 modulates the core ABA signaling downstream of signal perception step. In particular, Raf10 phosphorylates subclass III SnRK2s (SnRK2.2, SnRK2.3, and SnRK2.6), which are key positive regulators, and our study focused on SnRK2.3 indicates that Raf10 enhances its kinase activity and may facilitate its release from negative regulators. Raf10 also phosphorylates transcription factors (ABI5, ABF2, and ABI3) critical for ABA-regulted gene expression. Furthermore, Raf10 was found to be essential for the in vivo functions of SnRK2s and ABI5. Collectively, our data demonstrate that Raf10 is a novel regulatory component of core ABA signaling.