• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.1823-1828
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• 2016

Background: Biological and pharmacological activities of dryocrassin ABBA, a phloroglucinol derivative extracted from Dryopteris crassirhizoma, have attracted attention. In this study, the apoptotic effect of dryocrassin ABBA on human hepatocellular carcinoma HepG2 cells was investigated. Materials and Methods: We tested the effects of dryocrassin ABBA on HepG2 in vitro by MTT, flow cytometry, real-time PCR, and Western blotting. KM male mice were used to detect the effect of dryocrassin ABBA on H22 cells in vivo. Results: Dryocrassin ABBA inhibited the growth of HepG2 cells in a concentration-dependent manner. After treatment with 25, 50, and $75{\mu}g/mL$ dryocrassin ABBA, the cell viability was 68%, 60% and 49%, respectively. Dryocrassin ABBA was able to induce apoptosis, measured by propidium iodide (PI)/annexin V-FITC double staining. The results of real-time PCR and Western ting showed that dryocrassin ABBA up-regulated p53 and Bax expression and inhibited Bcl-2 expression which led to an activation of caspase-3 and caspase-7 in the cytosol, and then induction of cell apoptosis. In vivo experiments also showed that dryocrassin ABBA treatment significantly suppressed tumor growth, without major side effects. Conclusions: Overall, these findings provide evidence that dryocrassin ABBA may induce apoptosis in human hepatocellular carcinoma cells through a caspase-mediated mitochondrial pathway.

• 전자공학회논문지
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• 제50권1호
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• pp.21-26
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• 2013

본 논문에서는 그룹(group)을 2개의 심볼(symbol)로 나누는 시스템을 제안하는데, 이 두 개의 더해진 심볼들은 다중화에 의해 분리된 후 역다중화 기술을 이용해 다시 합해진다. 제안된 시스템에서 간단한 PIC(Partial Interference Cancelation) 그룹 복호화 기술은 Double-ABBA(D-ABBA) 유사 직교(Quasi-Orthogonal) 시공간 부호(Space Time Code)를 위해 사용된다. 이 부호는 고차 MIMO(Multiple Input Multiple Output) 시공간 블록 부호화에서 복호화시에 복잡도를 줄여준다. 그리고 기존의 방법과 제안된 방법과의 성능을 비교한다.

• 한국산학기술학회논문지
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• 제15권7호
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• pp.4105-4110
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• 2014

앙상블에서 베이스라는 악기의 역할은 화음의 토대를 만들어주는 것이다. 우선은 그 기본 임무에 충실해야 한다. 그러나 그 역할에만 집중하다보면 다소 밋밋하고 안정적이기만 한 연주가 되기 때문에 보다 재미있는 연주를 위해서라면 다양한 아이디어를 반영해야 할 필요가 있다. 그런 의미에서 볼 때, Rutger Gunnarsson은 연주곡 위주의 음악이 아닌 대중음악에 이러한 사례를 적용한 예를 ABBA라는 대 그룹에서의 연주를 통해 뚜렷하게 보여주었다. 화려한 테크닉이나 고난이도의 기교에 의존하지 않고 기본기에 충실한 연주만으로도 이처럼 다양한 느낌을 낼 수 있다는 것에 주목해야 한다.

• 한국통신학회논문지
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• 제33권12C호
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• pp.1062-1067
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• 2008

ABBA codes, a class of quasi-orthognal space-time block codes (QoSTBC) proposed by Tirkkonen and others, allow full rate and a fast maximum likelihood (ML) decoding, but do not have full diversity. In this paper, a linear complex precoder is proposed for ABBA codes to achieve full rate and full diversity. Moreover, the same diversity produce as that of orthogonal space-time block code with linear complex precoder (OSTBC-LCP) is achieved. Meanwhile, the size of the linear complex precoder can be reduced by half without affecting performance, which means the same complexity of decoding as that of the conventional ABBA code is guaranteed.

• Computers and Concrete
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• 제19권1호
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• pp.51-58
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• 2017

The paper presents the experimental investigations for studying the effect of ground granulated blast furnace slag (GGBFS) on the time-dependent deflection of reinforced concrete (RC) beams due to creep and shrinkage. The RC beams were reinforced with 2-10 mm bars at tension side and subjected to constant sustained two-point loading for the period of 150 days. The amount of cement replacement by GGBFS was varied from 0 to 60% with an increment of 20%. The total deflection was measured at different ages of up to 150 days under sustained loads. The experiments revealed that the time-dependent deflection of the reinforced concrete RC beams containing GGBFS was higher than that of plain concrete RC beams. At 150 days, the average creep and shrinkage deflection of RC beams containing 20%, 40% and 60% GGBFS was 1.25, 1.45 and 1.75 times higher than the plain concrete beams. A new model, which is an extension of authors' earlier model, is proposed to incorporate the effect of GGBFS content in predicting the long-term deflection of RC beams. Besides validating the new model with the current data with higher percentage of tension reinforcement, it was also used to predict the authors' earlier data containing lesser percentage of tension reinforcement with reasonable accuracy.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제15권6호
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• pp.2225-2239
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• 2021

To assist in data collection, the use of a mobile sink has been widely suggested in the literature. Due to the limited sensor node's storage capacity, this manner to collect data induces huge latencies and drop packets. Their buffers will be overloaded and lead to network congestion. Recently, a new bio-inspired optimization algorithm appeared. Researchers were inspired by the swarming mechanism of salps and thus creating what is called the Salp Swarm Algorithm (SSA). This paper improves the sink mobility to enhance energy dissipation, throughput, and convergence speed by imitating the salp's movement. The new approach, named the Mobile Sink based on Modified Salp Swarm Algorithm (MSSA), is approved in a heterogeneous Wireless Sensor Network (WSN) data collection. The performance of the MSSA protocol is assessed using several iterations. Results demonstrate that our proposal surpass other literature algorithms in terms of lifespan and throughput.

• 한국초전도ㆍ저온공학회논문지
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• 제24권4호
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• pp.29-35
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• 2022

We fabricated MHOS (multi-HTS layers on one substrate) high-temperature superconducting (HTS) REBCO conductors using HTS REBCO coated conductor (CC) A-specimen, which induces an artificial magnetic flux pinning effect, and HTS REBCO CC B-specimen, that does not induce this effect. The superconducting magnetic properties of the fabricated MHOS conductors were examined by measuring their magnetic moment m(H) curves using a physical property measurement system (QD PPMS-14). The critical current density (J_c) characteristics of our four-layered MHOS HTS REBCO conductor specimens such as BAAB, BBBB, and AAAA were lower than those of their two-layered and three-layered counterparts. At a temperature T of 30 K the magnetic flux pinning physical indicator δ values (obtained from the relationship J_c ∝ H^-δ) of the three-layer ABA (δ = 0.35) and two-layer AB (δ = 0.43) specimens were found to be significantly lower than those of the four-layer ABBA (δ = 0.51), BAAB (δ = 0.60), AAAA (δ = 0.78) and BBBB (δ = 0.81) structures.

• 4차산업연구
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• 제2권2호
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• pp.11-23
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• 2022

Purpose - The ability to meet the high demand for education in Nigeria is lacking, making the region remain backwards in education. Given this reason, the study investigates the role of innovation capability in the relationship between intellectual capital and competitive advantage in tertiary institutions in Nigeria. Research design, data, and methodology - The study is cross-sectional research, a total of 427 questionnaires were administered to respondents. The study distributed its questionnaire across 12 faculties at the University of Ibadan using a random sampling technique. Data were analyzed using ADANCO 2.1.1. Result - The study reveals that human capital, structural capital, relational capital, and innovation capability positively affect competitive advantage. Innovation capability mediates the relationship between human capital and relational capital. However, structural capital was not mediated by innovation capability. Conclusion - The study concludes that intellectual capitals and innovation capability are crucial to maintaining a competitive advantage over their peers. Achieving more significant success in the variables mentioned earlier will help Nigeria's tertiary institutions compete locally and internationally.

• Journal of Preventive Medicine and Public Health
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• 제47권1호
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• pp.57-63
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• 2014

Objectives: We established a Wistar rat model of asthma caused by toluene diisocyanate (TDI) exposure, and investigated the relationship between TDI exposure concentrations and respiratory hypersensitivity, airway inflammation, and cytokine secretions in animals, to better understand the mechanism of TDI induced occupational asthma. Methods: Wistar rats were exposed to two different concentrations of TDI vapor four hours a day for five consecutive days. Bronchoalveolar lavage (BAL) was performed, and differential leucocytes from the BAL fluid were analyzed. Lung histopathological examination was carried out to investigate the inflammatory status in the airways. Production of cytokines interleukin (IL)-4 and IL-5 productions in the BAL fluid in vivo was determined with enzyme-linked immunosorbent assay kits. Results: The TDI-exposed rats exhibited greater airway hypersensitivity symptoms than the control rats. The BAL differential cell count and lung histopathological examination demonstrated that inflammation reactions were present in both the central and peripheral airways, characterized with marked infiltration of eosinophils in the TDI-exposed rats. The cytokine assay showed that IL-4 and IL-5 were predominantly produced in the BAL fluid in vivo. Conclusions: These findings imply that TDI exposure concentrations may greatly affect the occurrence and extent of inflammatory events and that Th2 type cytokines may play an important role in the immunopathogenesis of TDI-induced occupational respiratory hypersensitivity.

• Asian Pacific Journal of Cancer Prevention
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• 제17권11호
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• pp.4977-4982
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• 2016

Introduction: Elevated serum interleukin (IL) 6 has been reported in patients infected with the hepatitis C virus (HCV), but it remains debatable whether this influences the production of autoantibodies and the biochemical profile of HCV disease. Therefore, this current study was conducted to evaluate the relationship between IL-6 and circulating autoantibody levels in HCV positive patients. Methods: Levels of IL-6 in serum samples from 102 patients with HCV and 103 normal controls were determined by enzyme linked immunosorbent assay (ELISA). Autoantibodies were detected by immunofluorescence. Results: Levels of IL-6 were significantly higher (p=0.028) in patients infected with (HCV) compared with normal group. Autoantibodies were noted in in 43.1% of the patients; of these, 23.5% featured anti-nuclear antibodies (ANA+), 16.7% anti-smooth muscle antibodies (ASMA+), 7.8% anti-mitochondrial antibodies (AMA+), 17.6% anti-parietal cell antibodies (APCA+), 7.8% anti canalicular antibodies, and 2.9% anti reticulin antibodies (ARA+). No patients were found to be positive for anti-brush border antibodies (ABBA) or anti-ribosomal antibodies. (ARiA). No links with IL-6 levels were apparent. Conclusions: IL-6 levels are increased in patients infected with HCV disease and could influence the production of autoantibodies. However, this study did not provide evidence of a specific relationship between IL6 and circulating autoantibodies in such cases.