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Topiramate for the Treatment of Binge Eating Disorder or Bulimia Nervosa : A Systemic Review of Human Clinical Studies and Case Reports (Topiramate의 신경성 폭식증 치료효과: 국내외 보고된 임상연구결과 및 치험사례 중심으로)

  • Lee, Yu-Jeung;Bang, Joon-Seok
    • Korean Journal of Clinical Pharmacy
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    • v.17 no.1
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    • pp.6-12
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    • 2007
  • The clinical investigations above suggest that topiramate may be an effective agent in the treatment of BED or BN by reducing binging/purging episodes, improving the HRQOL, and decreasing weight. The case report and case series also support these findings. However, there are several limitations in the above studies and cases. All these had relatively small sample size, and two of them were only 10-week-period studies. Optimal duration of treatment with topiramate in patients with BED or BN is unknown. As most clinicians treat the patient with BED or BN for 6 to 12 months and then reassess, at least 6 months period is needed to show its efficacy. One of studies included only women in the patient group. In the case series, all patients had severe comorbid mood disorders such as major depression and bipolar disorder besides BN. Therefore, notwithstanding its clinical usefulness, additional researches are needed to define the role and the benefits of topiramate in the treatment of BED or BN more thoroughly.

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Comparative Analysis of Drug Information Resources for Dose Adjustment in terms of Renal and Hepatic Function (신장 및 간 기능별 약물용량조절에 관한 국내외 약물문헌정보 비교)

  • Ryu, Ji Hyeon;Kyoung, Eun Jung;Lee, Hee Young;Oh, Mina;Kim, Eun Young
    • Korean Journal of Clinical Pharmacy
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    • v.22 no.3
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    • pp.220-227
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    • 2012
  • Kidney and liver are the major organs of metabolism and excretion of drugs. Renal and Hepatic impairment may affect the pharmacokinetics/pharmacodynamics and the safety of drugs. Adjusting the dosage based on organ function is the essential role of pharmacists. However, differences have been noted on the recommended dosage among the literatures. We compared and analyzed the recommendations of 4 literature sources which are commonly used for dosage adjustment. From April, 2011 to August, 2011, we selected data on recommendations for dosage adjustment for impaired renal and hepatic function of 100 drugs through a protocol. We analyzed the definition terms of renal and hepatic impairment, recommendations for dosage adjustment, evidenced references in four literature sources: Korean National Formulary (KNF), American Hospital Formulary System Drug Information (AHFS), Micromedex (MM) and Drug Prescribing of Renal Failure (DPRF). We further examined the data homogeneity by comparing how drugs that required no adjustment according to one source were categorized by the other. Sources use different definition terms among themselves except DRPF. Presence or absence of evidenced references about renal/hepatic functional states are KNF (0%/0%), AHFS (78%/62.6%), MM (87.5%/65.6%) and DPRF (93.2%/no recommendation) respectively. Recommendations of specific dosage and dosing interval are KNF (24%/13%), AHFS (39.6%/12.1%), MM (50%/17.7%), and DPRF (55.4%/no recommendation) respectively. Regarding the data homogeneity, the differences were remarkable. Drugs with no adjustment according to AHFS were categorized to be adjusted/ contraindicated by KNF, MM, DPRF and the values were (44%/5.6%), (22%/0%), and (36%/0%) in renal function, (39%/6.5%), (19%/3.2%), and (no recommendation/no recommendation) in hepatic function respectively. Our study shows remarkable definite variation in definitions and recommendations about definition terms, information of dosage and interval, presence or absence of evidenced references. Especially for KNF, quantitative recommendations on dosages and dosing intervals should be made in the near future. To maximize the drug effect and safety and to minimize the heterogeneity of the literature sources, reviewing at least two sources are suggested when recommending the proper dosage adjustment based on organ function.

A study on sexual experiences and behaviors of aged in community (노인의 성생활 경험에 대한 서술적 연구)

  • Oh Jin Joo
    • Journal of Korean Public Health Nursing
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    • v.12 no.2
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    • pp.236-251
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    • 1998
  • This study aimed at comprehending the meaning of sexual life for aged people, their strength of sexual desire and causes of change in their sexual life. It was another purpose to understand the extent of aged people's acknowledging the necessity of sexual consultation. This study adopted descriptive method using open-ended questionaires. The data for study was collected from 26 people over 65 years who reside in communities. It was gathered from April to June of 1998 through interview. The interviewee includes 16 males, 9 females and their average age was 73.3. 19 people among them have spouses. The conclusion of this study can be summarized as follows. 1) Attitude to sexual life: The meaning of sexual life for aged people is categorized as 'sense of duty', 'feeling of intimacy', 'basic desire', 'decrease of meaning' and 'meaningless'. 2) Sexual desire: Sexual desire of aged people is categorized as 'extinction', 'decrease', 'continuation' and 'restraint'. Restraint of sexual desire is due to social convention or the difficulty in fulfilling desire. 3) Causes of troubles in sexual life Causes which lead to troubles in sexual life of aged people can be categorized as 'physical', 'psychological' and 'social'. 'Physical' elements include 'incompetence of erection', 'decrease in duration of erection', 'increase in time needed to re-erection', 'declining of physical strength', 'decrease in vagina secretion' and 'worsening of health'. Among 'psychological' elements 'decrease of self-confidence', 'diminished concern of female aged people' are. 'Social elements' are 'absence of sexual parter', 'circumstances of living' and 'recognition of neighbor'. 4) Response to change of sexual life The reaction of aged people to change of sexual activities is classified as 'positive' and 'negative'. 5) Attitude to the consultation of sexual life of aged people The attitude to the consultation of sexual life in old age is classified as 'negative', 'doubtful' and 'positive'. This study explored the meaning which aged people in community attach to sexual life, the extent of their sexual desire, the causes of troubles in their sexual life, their emotional response to changes in sexual life, their recognition of necessity in sexual consultation. Considering the frequency of the statement, most of aged people who were interviewed thought much of sexual life and put emphasis on it. Those who said that sexual life has decreased meaning or is not important to them are few, Though aged people still maintain sexual desire, most of them have some trouble in sexual life. These trouble changes the sexual life, and results in negative feeling such as depression, renunciation and difficulty in relations. So they acknowledged that sexual consultation is necessary to them.

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The Experimental Study on the Heat Hydration Properties of Concrete According to Binder Conditions (결합재 조건에 따른 콘크리트의 수화발열 특성에 관한 연구)

  • Choi, Sung-Woo;Jo, Hyun-Tae;Ryu, Deuk-Hyun
    • Journal of the Korea Concrete Institute
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    • v.18 no.6 s.96
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    • pp.769-776
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    • 2006
  • Recently, owing to the development of industry and the improvement of building techniques, concrete structures are becoming larger and higher. In hardening of these large connote structures, the heat of hydration gives rise to considerable thermal stress depending on the size and environmental condition of concrete, which might cause thermal cracking. Especially, the crack may cause severe damage to the safety and the durability of concrete structure. This study investigates the thermal properties of concrete according to several binder conditions, such as OPC, Belite rich cement(BRC), slag cement(SC), blast furnace slag(B) added cement fly ash(F) added cement and blast-furnace-slag and fly ash added cement. As a result of this study, the properly of concrete is most better BRC than others, and fly ash(25%) added cement and BFS(35%)-fly ash(15%) added cement gets superior effect in the control of heat hydration. But synthetically considered properties of concrete, workablity, strength heat hydration, etc, it is more effective to use mineral admixture. Especially, to be used Blast Furnace slag is more effective.

Effects of Aggregate Size and Steel Fiber Volume Fraction on Compressive Behaviors of High-Strength Concrete (골재크기 및 섬유혼입률에 따른 강섬유 보강 고강도 콘크리트의 압축거동)

  • Ahn, Kyung-Lim;Jang, Seok-Joon;Jang, Sang-Hyeok;Yun, Hyun-Do
    • Journal of the Korea Concrete Institute
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    • v.27 no.3
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    • pp.229-236
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    • 2015
  • This paper describes the effect of aggregate size on compressive behavior of high-strength steel fiber reinforced concrete. The Specified compression strength is 60 MPa and the range of fiber volume fraction is 0~2%. The main variable is the aggregate size, which was used for the aggregate size of 8 and 20 mm. So, ten concrete mixtures were prepared and tested to evaluate the fresh and hardened properties of SFRC at curing ages (7, 14, 28, 56 and 91 days), respectively. Items estimated in this study are the fresh properties (air contents, slump), hardened properties (compressive strength, modulus of elasticity, post-peak response and compressive toughness). As a result, the aggregate size has little effect on the compressive strength and modulus of elasticity. On the other hand, the ductile behavior was shown after post peak and the compressive toughness was increasing as decreasing the aggregate size. These effects are clearly represented in the fiber volume fraction 2%, which are the point appeared fiber ball. It is considered that the decreasing the aggregate size has effect on the fiber dispersibility.

An Enhanced Fast Handover for Proxy MIPv6 Scheme for Efficient Mobile Environment of The Future Network (미래네트워크의 효율적인 모바일 환경 구축을 위한 향상된 Fast Handover for Proxy MIPv6 기법)

  • Go, Kwang-Sub;Jung, Ui-Seok;Mun, Young-Song
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.48 no.1
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    • pp.84-91
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    • 2011
  • To develop the new network, the future network architecture is studied. Since the mobile devices are also advanced, they need for the mobility protocols. The one of the protocols, Fast handovers for proxy MIPv6(PFMIPv6) has studied by the Internet Engineering Task Force(IETF). Since PFMIPv6 adopts the entities and the concepts of fast handovers for MIPv6(FMIPv6) in proxy MIPv6(PMIPv6), it reduces the packet loss. Although the conventional scheme has proposed that it cooperated with an Authentication, Authorization and Accounting (AAA) infrastructure for authentication of a mobile node in PFMIPv6, it has the drawbacks such as high signaling cost and long handover latency. To reduce the signaling cost and the handover latency, we propose an enhanced authentication scheme in Fast handover for Proxy MIPv6. The proposed scheme reduces the handover latency and the signaling cost because the registration procedure and the authentication procedure are simultaneously performed. We also compare the proposed scheme with the conventional scheme in terms of the signaling cost and the handover latency.

Encryption Method Based on Chaos Map for Protection of Digital Video (디지털 비디오 보호를 위한 카오스 사상 기반의 암호화 방법)

  • Yun, Byung-Choon;Kim, Deok-Hwan
    • Journal of the Institute of Electronics Engineers of Korea CI
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    • v.49 no.1
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    • pp.29-38
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    • 2012
  • Due to the rapid development of network environment and wireless communication technology, the distribution of digital video has made easily and the importance of the protection for digital video has been increased. This paper proposes the digital video encryption system based on multiple chaos maps for MPEG-2 video encoding process. The proposed method generates secret hash key of having 128-bit characteristics from hash chain using Tent map as a basic block and generates $8{\times}8$ lattice cipher by applying this hash key to Logistic map and Henon map. The method can reduce the encryption overhead by doing selective XOR operations between $8{\times}8$ lattice cipher and some coefficient of low frequency in DCT block and it provides simple and randomness characteristic because it uses the architecture of combining chaos maps. Experimental results show that PSNR of the proposed method is less than or equal to 12 dB with respect to encrypted video, the time change ratio, compression ratio of the proposed method are 2%, 0.4%, respectively so that it provides good performance in visual security and can be applied in real time.

The Prediction of Mastery-Approach Goal Orientation, Task Value, and Self-Regulated Learning Strategy on Academic Satisfaction and Achievement of Cyber Engineering University Students (사이버대학교 공학계열 학생들의 숙달접근목표지향성, 과제가치, 자기조절학습전략의 학업만족도와 학업성취도 예측력 규명)

  • Joo, Young-Ju;Chung, Ae-Kyung;Seol, Hyun-Nam;Yi, Sang-Hoi
    • 전자공학회논문지 IE
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    • v.49 no.2
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    • pp.65-74
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    • 2012
  • The purpose of this study is to verify the prediction of mastery-approach goal orientation, task value, and self-regulated learning strategy on academic satisfaction and achievement of cyber engineering university students. For this study, 219 engineering students of H cyber university who enrolled in the spring semester of 2011 was chosen and completed web surveys. A hypothetical model proposed included mastery-approach goal orientation, task value, and self-regulated learning strategy as predictors, and academic satisfaction and achievement as criteria variables. The results of this study through multiple regression analysis indicated that task value(${\beta}$=.401) and self-regulated learning strategy(${\beta}$=.401) predicted significantly on academic satisfaction. In addition, self-regulated learning strategy(${\beta}$=.301) and mastery-approach goal orientation(${\beta}$=.196) predicted significantly on academic achievement. The result of this study suggested that mastery-approach goal orientation, task value, and self-regulated learning strategy should be considered for improving academic satisfaction and achievement in cyber engineering education.

Spawning Density and Recruitment of Janpanese Anchovy, Engraulis japonica in the Southern Sea of Korea in 2007 (2007년 남해안 멸치의 산란밀도와 어장가입)

  • CHA, Byung Yul;Yang, Won Seok;Kim, Joo Il;Jang, Sun Ik;Chu, Eun Kyeong;Park, Ju Sam
    • Korean Journal of Ichthyology
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    • v.20 no.3
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    • pp.190-197
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    • 2008
  • Spatio-temporal distribution of eggs and larvae of Japanese anchovy Engraulis japonica in the southern sea of Korea was determined using data obtained from icthyoplanktonic surveys and oceanographic observations between Goheung Peninsula and Goeje Island from May to August 2007. Commercial anchovy catch and size composition from four local fishery cooperative associations were also analyzed in relation to the geographic distribution of eggs and larvae. The abundance of anchovy eggs increased from May to July and was lowest in August. Eggs were mainly distributed between Namhae Island and Goeje Island, where water temperatures were $15{\sim}24^{\circ}C$ and salinities were 32~35‰. In 2007 anchovy landings between Namhae Island and Goeje Island were 11,409 tons at Tongyeong association, 4,137 tons at Masan association, and 2,487 tons at Sacheon association. However, landings between Goheung and Yeosu Peninsula were only 4,411 tons (at Yeosu association). The catch by anchovy tow net was high in the area where eggs were abundantly distributed. This indicates that the distribution of egg density was directly correlated with recruitment of E. japonica. All growth stages were abundant in the study area, indicating that this area is a major spawning and growing ground of E. japonica in Korean waters.

The Effect of Using Analogies in High School Earth Science Classes (고등학교 10학년 과학 '지구의 변동' 단원에서 비유물 활용의 효과)

  • Kim, Sang-Dal;Kim, Jong-Hee;Lee, Ji-Eun
    • Journal of the Korean earth science society
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    • v.24 no.5
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    • pp.393-401
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    • 2003
  • The purpose of this study is to research the effect of using analogies in high school earth science classes. According to the usage of TWA model, three types of teaching strategies were developed: text developer-generated, teacher-generated, and student-generated analogies. The model described in this paper began with a task analysis of highschool science textbooks for grade 10 to identify how the textbook authors used analogies to explain plate tectonics concepts. In this study, 210 students were sampled from first graders of high school. After 7 classes, the consciousness of students was investigated with questionnaires. The results are as follows: 1. Many plate-tectonics analogies are used in high school science textbooks (total 25). Teachers and authors construct effective analogies to help students build on their relevant knowledge by applying it to new knowledge acquired from textbooks. 2. Analysis of the data indicate that instruction using student-generated analogies was more effective than others. But in the class in conveying complicated concepts (ex. transform fault), teacher-generated instruction was effective. Teachers need to be aware of the weakness of using analogies in order to select the most appropriate analogies. 3. Making analogies in general, as well as using analogies have systematic steps. Analogies should be used after considering student's preconception, teacher's consciousness and text author's intention to use analogies as powerful instructional tools.