• Journal of Microbiology and Biotechnology
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• 제24권12호
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• pp.1654-1663
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• 2014

To examine the effect of tumor suppressor protein p53 on the antitumor activity of 2-methoxyestradiol (2-MeO-$E_2$), 2-MeO-$E_2$-induced cell cycle changes and apoptotic events were compared between the human colon carcinoma cell lines HCT116 ($p53^{+/+}$) and HCT116 ($p53^{-/-}$). When both cell types were exposed to 2-MeO-$E_2$, a reduction in the cell viability and an enhancement in the proportions of $G_2/M$ cells and apoptotic sub-$G_1$ cells commonly occurred dose-dependently. These 2-MeO-$E_2$-induced cellular changes, except for $G_2/M$ arrest, appeared to be more apparent in the presence of p53. Immunofluorescence microscopic analysis using anti-${\alpha}$-tubulin and anti-lamin B2 antibodies revealed that after 2-MeO-$E_2$ treatment, impaired mitotic spindle network and prometaphase arrest occurred similarly in both cell types. Following 2-MeO-$E_2$ treatment, only HCT116 ($p53^{+/+}$) cells exhibited an enhancement in the levels of p53, p-p53 (Ser-15), $p21^{WAF1/CIP1}$, and Bax; however, the Bak level remained relatively constant in both cell types, and the Bcl-2 level decreased only in HCT116 ($p53^{+/+}$) cells. Additionally, mitochondrial apoptotic events, including the activation of Bak and Bax, loss of ${\Delta}{\psi}m$, activation of caspase-9 and -3, and cleavage of lamin A/C, were more dominantly induced in the presence of p53. The Bak-specific and Bax-specific siRNA approaches confirmed the necessity of both Bak and Bax activations for the 2-MeO-$E_2$-induced apoptosis in HCT116 cells. These results show that among 2-MeO-$E_2$-induced apoptotic events, including prometaphase arrest, up-regulation of Bax level, down-regulation of Bcl-2 level, activation of both Bak and Bax, and mitochondria-dependent caspase activation, the modulation of Bax and Bcl-2 levels is the target of the pro-apoptotic action of p53.

• 한국컴퓨터정보학회:학술대회논문집
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• 한국컴퓨터정보학회 2021년도 제63차 동계학술대회논문집 29권1호
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• pp.53-55
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• 2021

2020년은 COVID-19 바이러스로 인해 e스포츠는 새로운 가능성을 보여주고 있다. 전통적인 스포츠의 경기 진행 및 현장 관람이 어려워 고전하고 있는 반면에 대부분의 e스포츠 경기가 온라인 중계로 정상적인 일정을 진행하였다. 그러나 국내 e스포츠의 종목은 LOL을 비롯하여 극히 일부 게임만 성공적으로 운영되고 있다는 문제가 있다. 본 논문에서는 e스포츠로 성공한 게임을 분석하여 e스포츠 활성화를 위한 제안을 한다.

• Korean Journal of Radiology
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• 제22권8호
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• pp.1310-1322
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• 2021

Immunotherapy is an effective treatment option for gynecological malignancies. Radiologists dealing with gynecological patients undergoing treatment with immune checkpoint inhibitors should be aware of unconventional immune-related imaging features for the evaluation of tumor response and immune-related adverse events. In this paper, immune checkpoint inhibitors used for gynecological malignancies and their mechanisms of action are briefly presented. In the second part, patterns of pseudoprogression are illustrated, and different forms of immune-related adverse events are discussed.

• 한국정보과학회논문지:소프트웨어및응용
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• 제29권6호
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• pp.377-385
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• 2002

다양한 사건들의 무대로서의 시공간 상황의 구축을 위한 정통적 시뮬레이션 기반을 개발한다. 사이버 세계의 정통성, 다시 말해 실제에 대한 논리적 충실성은 그 세계에서 일어나는 사건들의 다양성과 예측 불가성을 최대화함으로써 실현한다. 시공간에서 일어나는 사건의 시뮬레이션을 위한 지식 컴포넌트는 환경 요인, 객체, 사건, 상관관계가 있다. 자유 재량적 사건의 정통 시뮬레이션을 실현하기 위해 사건 활성화, 실행 방법과 사건 인지 함수들을 고안하였다. 본 시뮬레이션 환경에서 자주적인 에이전트들은 독자적인 존재와, 사건의 실행과 분리된 계획을 하는 능력을 가지고 있다. 사람의 의도를 반영할 수 있는 자유 재량적 사건의 정통 시뮬레이션과 관련 있는 기본적인 구성 요소들을 확인하였다. 시뮬레이션 방법의 실행 가능성을 보이기 위해 핵심적인 기술들을 중심으로 구현의 예를 보인다.

• 융합보안논문지
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• 제17권3호
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• pp.41-49
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• 2017

글로벌 IT 시장조사기관인 IDC의 조사에 따르면 국내 융합보안 시장은 2010년 기준으로 1조 7,000 억 원 규모였으며, 이후 매년 32%씩 성장해서 2018년에는 12조 8,000 억 원 규모가 될 것으로 전망하고 있다. 이처럼 전 세계적으로 융합보안의 중요성은 증가하고 있다. 기존의 융합보안관제 솔루션은 다양한 솔루션시스템(방화벽, 네트워크 침임 탑지 시스템 등) 및 장비들(CCTV, Access Control System 등)로부터 수집된 데이터를 기반 하여 이벤트를 발생시키고, 이를 보안관제 요원들이 상황을 판단 및 조치하는 방식으로 구성되어 있다. 하지만 최근 IoT 산업의 발전으로 IoT 장비들의 수가 급격히 증가하고 있고, 이러한 장비들이 보안관제에 사용될 수 있음에 따라 발생할 수 있는 이벤트의 양 역시 증가할 것이다. 물론 많은 이벤트들을 통해 보다 더 많은 상황에 대한 판단 및 조치를 할 수 있는 이점은 있지만, 반대로 너무 많은 이벤트들을 처리해야 하는 부담감 역시 존재한다. 따라서 본 논문에서는 융합보안관제 시스템에서 발생 할 수 있는 이벤트들을 3가지 종류로 구분 짓고, 효과적으로 이벤트들을 분류 및 처리할 수 있는 모델을 제안하여 융합보안관제 시스템의 효율성을 향상시키고자 한다.

• 한국콘텐츠학회논문지
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• 제21권12호
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• pp.896-905
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• 2021

인공지능 기반 보안관제 시스템은 운영환경에서 발생할 수 있는 학습 데이터 오류, 신규 공격 이벤트 발생으로 인한 오탐 증가 등 문제를 해결하기 위해 피드백 기능이 연구되고 있다. 그러나 한정된 관제 인력의 피드백 수행 방식은 모델 개선에 오랜 시간이 걸리고 숙련되지 않은 관제 인력의 피드백은 오히려 모델 성능 저하의 원인이 될 수 있다. 본 논문에서는 관제 인력 한계 극복, 신규 오탐 개선, 빠른 모델 성능 향상을 위한 능동형 보안관제 모델 개선 프로세스를 제안하였다. 운영 중 예측된 유사 이벤트를 군집화 하고, 피드백이 우선적으로 필요한 군집을 계산하여 운영자에게 대표 이벤트 설명이 가능한 인공지능(eXplainable AI) 기반 시각화도 함께 제시하였다. 수신된 대표 피드백은 동일 군집과 다른 데이터를 계산하여 제외하고 피드백 전파 학습 데이터를 생성한다. 준비된 학습 데이터는 초기 모델과 함께 점진적 학습을 통해 모델을 생성함으로써 성능을 향상시키는 프로세스이다. 제안 프로세스의 실효성 검증을 위해 웹 어플리케이션 방화벽 데이터셋 PKDD2007과 CSIC2012를 선택하여 3개의 시나리오를 통해 실험을 진행하였다. 실험 결과 제안된 프로세스는 피드백을 주지 않았거나 소수 운영자 피드백을 적용한 모델 성능에 비해 모든 지표에서 약 30% 이상의 성능 향상을 확인하였다.

• Journal of Smart Tourism
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• 제3권4호
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• pp.33-41
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• 2023

This study examines the factors influencing e-sports product consumption among Chinese e-sports game players. We focus on the popular game "King of Glory" and use surveys to collect player data. Our findings show that e-sports product characteristics significantly impact consumption experiences, while incentive factors also influence consumption willingness. External factors have minimal impact. Additionally, souvenir products and festival events are key in driving e-sports consumption. This research explores the consumption willingness of Chinese e-sports players, the world's largest consumer market. Understanding their needs can help companies develop targeted marketing strategies, unlocking the commercial potential of e-sports and promoting industry growth.

• 대한조선학회논문집
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• 제59권3호
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• pp.164-172
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• 2022

A HAZID is a brainstorming workshop to identify hazards in an early phase of a project. It should be flexible to capture all probable accidents allowing experienced participants to exploit their expertise and experiences. A bowtie analysis is a graphical representation of major accident hazards elaborating safety measures i.e. barriers. The result of these workshops should be documented in an organized manner to share as good as possible details of the discussion through the lifetime of the project. Currently results are documented using a three-step representation of an accident; causes, top event and consequences, which cannot capture correctly sequence of events leading to various accidents and roles of barrier between two events. Another problem is that barriers would be shown repeatedly leading to a misunderstanding that there are an enough number of safety measures. A new bowtie analysis method is proposed to describe an accident in multiple steps showing relations among causes or consequences. With causes and consequences shown in a format of a tree, the frequencies of having the top event (Fault tree analysis) and various consequences (Event tree analysis) are evaluated automatically based on the frequency of initiating causes and the probabilities of failure of barriers. It will provide a good description of the accident scenario and help the risk to be assessed transparently.

• Journal of Astronomy and Space Sciences
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• 제39권1호
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• pp.1-10
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• 2022

The universe is thought to be filled with not only Standard Model (SM) matters but also dark matters. Dark matter is thought to play a major role in its construction. However, the identity of dark matter is as yet unknown, with various search methods from astrophysical observartion to particle collider experiments. Because of the cross-section that is a thousand times smaller than SM particles, dark matter research requires a large amount of data processing. Therefore, optimization and parallelization in High Performance Computing is required. Dark matter in hypothetical hidden sector is though to be connected to dark photons which carries forces similar to photons in electromagnetism. In the recent analysis, it was studied using the decays of a dark photon at collider experiments. Based on this, we studies double dark photon decays at lepton colliders. The signal channels are e⁺e^- → A'A' and e⁺e^- → A'A'γ where dark photon A' decays dimuon. These signal channels are based on the theory that dark photons only decay into heavily charged leptons, which can explain the muon magnetic momentum anomaly. We scanned the cross-section according to the dark photon mass in experiments. MadGraph5 was used to generate events based on a simplified model. Additionally, to get the maximum expected number of events for the double dark photon channel, the detector efficiency for several center of mass (CM) energy were studied using Delphes and MadAnalysis5 for performance comparison. The results of this study will contribute to the search for double dark photon channels at lepton colliders.

• 한국의료질향상학회지
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• 제22권2호
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• pp.43-73
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• 2016

Purpose: The aims of this study were to assess the presence of core patient safety practices in Korean hospitals and assess the differences in reporting and learning systems of patient safety, infrastructure, and safe practices by hospital characteristics. Methods: The authors developed a questionnaire including 39 items of patient safety staffing, health information system, reporting system, and event-specific prevention practices. The survey was conducted online or e-mail with 407 tertiary, general and specialty hospitals. Results: About 90% of hospitals answered the self-reporting system of patient safety related events is established. More than 90% of hospitals applied incidence monitoring or root cause analysis on healthcare-associated infection, in-facility pressure ulcers and falls, but only 60% did on surgery/procedure related events. More than 50% of the hospitals did not adopted present on admission (POA) indicators. One hundred (80.0%) hospitals had a department of patient safety and/or quality and only 52.8% of hospitals had a patient safety officer (PSO). While 82.4% of hospitals used electronic medical records (EMRs), only 53% of these hospitals adopted clinical decision support function. Infrastructure for patient safety except EMRs was well established in training, high-level and large hospitals. Most hospitals implemented prevention practices of adverse drug events, in-facility pressure ulcers and falls (94.4-100.0%). But prevention practices of surgery/procedure related events had relatively low adoption rate (59.2-92.8%). Majority of prevention practices for patient safety events were also implemented with a relatively modest increase in resources allocated. Conclusion: The hospital-based reporting and learning system, EMRs, and core evidence-based prevention practices were implemented well in high-level and large hospitals. But POA indicator and PSO were not adopted in more than half of surveyed hospitals and implementation of prevention practices for specific event had low. To support and monitor progress in hospital's patient safety effort, national-level safety practices set is needed.