• Journal of Life Science
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• v.25 no.2
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• pp.231-236
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• 2015

Angiotensin II (AngII) is an essential hormone that affects vascular physiology. For example, stimulation of vascular smooth muscle cells (VSMCs) rapidly induces vasoconstriction and results in the up-regulation of blood pressure. Chronic stimulation of VSMCs with AngII also results in hypertrophy. In this study, we confirmed an involvement of phosphatidylinositol 3-kinase (PI3K)-dependent calcium mobilization in AngII-induced generation of reactive oxygen species (ROS). Stimulation of rat aortic smooth muscle cells (RASMCs) with AngII significantly induced the generation of ROS in a dose- and time-dependent manner. AngII-induced generation of ROS was completely abolished by pharmacological inhibition of PI3K (with LY294002), but inhibition of the ERK signaling pathway had no effect. AngII-induced calcium mobilization was completely blocked by inhibition of PI3K, whereas inhibition of the ERK signaling pathway by PD98059 was ineffective. Depletion of extracellular calcium or inhibition of the L-type calcium channel by nifedipine completely blocked AngII-induced calcium mobilization. Depletion of extracellular calcium by EGTA and incubation of RASMCs with calcium-free medium both significantly blocked AngII-induced ROS generation. Inhibition of the L-type calcium channel also significantly blocked AngII-induced ROS generation. These results suggest that AngII-induced ROS generation is regulated by calcium mobilization, which, in turn, is modulated by a PI3K/L-type calcium channel signaling pathway.

• The Korean Journal of Physiology and Pharmacology
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• v.7 no.3
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• pp.131-142
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• 2003

We have studied mutant forms of Kir2.1 in which an aspartate residue (D172), important for gating by intracellular polyamines, is replaced by one of three basic residues (Arg, Lys or His). Such channels are highly selective for $K^+$, but show inward rectification that is a shallow function of voltage compared with that found in wild type. This inward rectification occurs with a reduced affinity for spermine and persists in the absence of polyamines. Though the unitary current-voltage relation shows some inward rectification, it is insufficient to account for that seen under whole cell recording. Channels open and shut under single channel recording, and changes of $P_{open}$ appear to generate inward rectification. In D172H, the reduction in affinity for spermine is greater when His is protonated at low $pH_i$. The effective valency for spermine is reduced from $3.09{\pm}0.07$ in wild type to $1.95{\pm}0.09$ in D172H at $pH_i$ 6.3. In the presence of dual mutants of Kir2.1, where E224 is also replaced, spermine affinity becomes undetectable. However, channels still show inward rectification and open and shut under hyper- and depolarisation, respectively. We suggest that Kir2.1 channel are able to undergo conformation changes; these changes may be important physiologically in generating inward rectification, the normal parameters of which are set by the binding of polyamines such as spermine.

• Journal of Power System Engineering
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• v.12 no.3
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• pp.26-31
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• 2008

This experimental study investigates the local heat transfer enhancement characteristics and the associated frictional head loss in the rectangular channel with a single inclined baffle. Four different types of the baffle are used. The inclined baffles have the width of 19.8 cm, the square diamond of $2.55cm{\times}2.55cm$, and the inclination angle of 5o, and number of holes of up to 9. Reynolds number is varied between 23,000 and 57,000. Results show that the heat transfer and friction factor depend significantly on the number of baffle holes and Reynolds number. The friction factor decreases with increasing Reynolds number and the number of holes on the baffle. It is found that the heat transfer performance of baffle type II(3 hole baffle) has the best values.

• International Journal of Air-Conditioning and Refrigeration
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• v.16 no.2
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• pp.70-76
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• 2008

The effects of the inclined perforated baffles on the distributions of the local heat transfer coefficients and friction factors for air flows in a rectangular channel were determined for Reynolds numbers from 23,000 to 57,000. Four different types of the baffle are used. The inclined baffles have the width of 19.8cm, the square diamond type hole having one side length of 2.55cm, and the inclination angle of $5^{\circ}$, whereas the corresponding channel width-to-height ratio was 4.95. Results show that the heat transfer and friction factor depend significantly on the number of baffle holes and Reynolds number. The friction factor decreases with increasing Reynolds number and the number of holes on the baffle, and the heat transfer performance of baffle type II (3 hole baffle) has the best value.

• ETRI Journal
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• v.41 no.6
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• pp.829-837
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• 2019

The p-type nanowire field-effect transistor (FET) with a SiGe shell channel on a Si core is optimally designed and characterized using in-depth technology computer-aided design (TCAD) with quantum models for sub-10-nm advanced logic technology. SiGe is adopted as the material for the ultrathin shell channel owing to its two primary merits of high hole mobility and strong Si compatibility. The SiGe shell can effectively confine the hole because of the large valence-band offset (VBO) between the Si core and the SiGe channel arranged in the radial direction. The proposed device is optimized in terms of the Ge shell channel thickness, Ge fraction in the SiGe channel, and the channel length (L_g) by examining a set of primary DC and AC parameters. The cutoff frequency (f_T) and maximum oscillation frequency (f_max) of the proposed device were determined to be 440.0 and 753.9 GHz when L_g is 5 nm, respectively, with an intrinsic delay time (τ) of 3.14 ps. The proposed SiGe-shell channel p-type nanowire FET has demonstrated a strong potential for low-power and high-speed applications in 10-nm-and-beyond complementary metal-oxide-semiconductor (CMOS) technology.

• 한국정보디스플레이학회:학술대회논문집
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• 2004.08a
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• pp.711-714
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• 2004

A new design for improving the aperture ratio of bottom emission type AMOLED is investigated. In conventional, the TFT of AMOLED fabrication method is "Etch Stopper (7-mask)", so the aperture ratio is limited in 28${\sim}$33% by Cs(Storage Capacitor). A high aperture ratio TFT is designed by using BCE(Back Channel Etching 5-mask) fabrication way and the aperture ratio is up to 40% shown in 2.2"AMOLED display.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.44 no.11
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• pp.1-10
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• 2007

In this paper, we proposed channel estimation scheme for LR-UWB system which has low data rate for WPAN in IEEE 802.15.4a. At the transmitter, we proposed dynamic power level allocation depends on channel condition in specific period when we modulate signal. We use two orthogonal code to estimate channel at once. It can estimate channel more accurately by using two code which shows good correlation characteristic then it can estimate more accurately by spreading gain. Using estimated channel condition, we synchronize symbol timing of transmitted signal. Then determined power allocation scheme and channel information is transmitted to transmiter side. Finally, using these information, transmiter side change the power level of repeated pulse to adopt to channel condition. Simulation is performed under S-V channel for LR-WPAN in IEEE 802.15.4a and we compare the performance with a different type of receiver type. We use coherent and non-coherent method at the receiver. Simulation result shows us at the NLOS channal performance evaluation is greater than that of LOS channel and the result is independent of receiver type. In the NLOS channel, as the signal delay spreading is big, performance evaluation is also increased.

• Electrical & Electronic Materials
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• v.9 no.3
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• pp.259-264
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• 1996

In this study, we performed a modeling for $K^{+}$ ion-exchanged diffused channel waveguide and waveguide-type optical coupler by Wentzel-Kramer-Brillouin(WKB) dispersion equation, normalized field distribution equation for mode and coupled mode theory, and examined the optical-power-dividing of the optical coupler fabricated by using the modeling condition. The optical-power-dividing was observed at the waveguide-type optical coupler with 3[.mu.m] line-width, 6[.mu.m] space between channel waveguides, and 3[mm] interaction length.h.

• The Korean Journal of Physiology and Pharmacology
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• v.10 no.5
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• pp.255-261
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• 2006

Melittin-induced nociceptive responses are mediated by selective activation of capsaicin-sensitive primary afferent fibers and are modulated by excitatory amino acid receptor, cyclooxygenase, protein kinase C and serotonin receptor. The present study was undertaken to investigate the peripheral and spinal actions of voltage-gated calcium channel antagonists on melittin-induced nociceptive responses. Changes in mechanical threshold and number of flinchings were measured after intraplantar (i.pl.) injection of melittin $(30\;{\mu}g/paw)$ into mid-plantar area of hindpaw. L-type calcium channel antagonists, verapamil [intrathecal (i.t.), 6 or $12\;{\mu}g$; i.pl.,100 & $200\;{\mu}g$; i.p., 10 or 30 mg], N-type calcium channel blocker, ${\omega}-conotoxin$ GVIA (i.t., 0.1 or $0.5\;{\mu}g$; i.pl., $5\;{\mu}g$) and P-type calcium channel antagonist, ${\omega}-agatoxin$ IVA (i.t., $0.5\;{\mu}g$; i.pl., $5\;{\mu}g$) were administered 20 min before or 60 min after i.pl. injection of melittin. Intraplantar pre-treatment and i.t. pre- or post-treatment of verapamil and ${\omega}-conotoxin$ GVIA dose-dependently attenuated the reduction of mechanical threshold, and melittin-induced flinchings were inhibited by i.pl. or i.t. pre-treatment of both antagonists. P-type calcium channel blocker, ${\omega}-agatoxin$ IVA, had significant inhibitory action on flinching behaviors, but had a limited effect on melittin-induced decrease in mechanical threshold. These experimental findings suggest that verapamil and ${\omega}-conotoxin$ GVIA can inhibit the development and maintenance of melittin-induced nociceptive responses.

• Journal of Korean Society on Water Environment
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• v.30 no.6
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• pp.638-646
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• 2014

Soil erosion from agricultural fields leads to various environmental problems weakening the capabilities of flood control and ecosystem in water bodies. Regarding these problems, Ministry of Environment of South-Korea prepared various structural and non-structural best management practices (BMPs) to control soil erosion. However, a lot of efforts are required to monitor and develop BMPs. Thus, modeling techniques have been developed and utilized for these issues. This study estimated the effectiveness of BMPs which are a vegetation mat with infiltration roll and Roll type vegetation channel using Soil and Water Assessment Tool (SWAT) model through the adjustment of the conservation practice factors, P factors, for Universal Soil Loss Equation which were calculated by monitoring data collected at the segment plots. Each BMP was applied to the areas with slopes ranged from 7% to 13% in the Haeanmyeon watershed. As a result of simulation, the vegetation mat with infiltration roll and Roll type vegetation channel showed 55% and 59% efficiency of soil erosion reduction, respectively. Also, Vegetation mat with infiltration roll and Roll type vegetation channel showed each 11.2% and 11.8% efficiency in reduction of sediment discharge. These roll type vegetation channel showed greater efficiency of soil erosion reduction and sediment discharge. Based on these results, if roll type vegetation channel is widely used in agricultural fields, reduction of soil erosion and sediment discharge of greater efficiency would be expected.