• The Journal of Pediatrics of Korean Medicine
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• v.23 no.2
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• pp.179-195
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• 2009

Objectives : Paeonia lactiflora Pall(芍藥) is known for curing caking muscular contraction(結實而拘攣) according to Yakucho(藥徵) published by Yoshimasu Todo(吉益東洞), but the descriptions of caking muscular contraction(結實而拘攣) are not fully provided. Methods : In order to further investigate and review the exact meaning of caking muscular contraction(結實而拘攣), present study has been conducted on the basis of researches of Yoshimasu Todo's literatures, focusing on Yakucho. Results : As a result of wide range of investigation, it is concluded that caking muscular contraction(結實而拘攣) indicates an abnormal muscular contraction of rectus abdominis. Conclusions : This study will provide helpful clinic information to doctors who will apply medical treatment specified in Yoshimasu Todo's Yakucho(藥徵) to patients in the future.

• Journal of the Korean Mathematical Society
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• v.40 no.6
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• pp.933-942
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• 2003

It is shown that if a paranormal contraction T has no nontrivial invariant subspace, then it is a proper contraction. Moreover, the nonnegative operator Q = T/sup 2*/T/sup 2/ - 2T/sup */T ＋ I also is a proper contraction. If a quasihyponormal contraction has no nontrivial invariant subspace then, in addition, its defect operator D is a proper contraction and its itself-commutator is a trace-class strict contraction. Furthermore, if one of Q or D is compact, then so is the other, and Q and D are strict ontraction.

• The Korean Journal of Physiology
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• v.23 no.1
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• pp.99-108
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• 1989

The effects of prostaglandin $(PGF_{2{\alpha}})$ on the contractility of vascular smooth muscle were investigated in the helical strip of the rabbit aorta. The aortic strip was immersed in the phosphate-buffered Tyrode's solution which was equilibrated with 100% $O_{2}$ at $35^{\circ}C$ and its isometric tension was measured. The contraction was induced by $(PGF_{2{\alpha}})$, norepinephrine (NE), or potassium (40 mM) in the nomal Tyrode's solution (1 mM, $Ca^{2+}$) or $Ca^{2+}-free$ Tyrode's solution. Effects of verapamil and phentolamine on the contraction were also observed. The aortic strip began to contract at the concentration of $5\;{\mu}g%$ and reached the maximal contraction at the concentration of $150\;{\mu}g%$ $(PGF_{2{\alpha}})$. The maximal contraction was corresponded respectively to $52.2{\pm}3.0%$ and $81.5{\pm}3.5%$ of maximal contraction by NE $(1{\times}10^{-5}M)$ and 40 mM $K^{+}$. And the maximal contractions by $(PGF_{2{\alpha}})$ or NE were induced at the concentration of about 1 mM $Ca^{2+}$. $(PGF_{2{\alpha}})$ induced the contraction of aortic strip even after induction of contraction by 40 mM $K^{+}$ and the contraction by $(PGF_{2{\alpha}})$ was not blocked by the ${\alpha}-receptor$ blocker, phentolamine. And the contraction by the $(PGF_{2{\alpha}})$ was inhibited partially by a verapamil at the concentration of $1{\times}10^{-5}M$ and the contraction began to increase at the concentration of $1{\times}10^{-4}M$ verapamil. Whereas the contraction by NE was completely blocked by verapamil. Though both the $(PGF_{2{\alpha}})$ and NE induced the contraction in the $Ca^{2+}-free$ Tyrode's solution, the peak tension was not maintained. But the rate of tension decline was lower in the contraction by $(PGF_{2{\alpha}})$ than in that by NE. The verapamil did not inhibit the contraction by $(PGF_{2{\alpha}})$ in the $Ca^{2+}-free$ Tyrode's solution and increased the contraction at the concentration of above $1{\times}10^{-4}M$. The NE-induced contraction in the $Ca^{2+}-free$ Tyrode's solution was inhibited completely by a verapamil. From the above results it is suggested that the contraction induced by $(PGF_{2{\alpha}})$ results from the promotion of the both $Ca^{2+}$ influx and the intracellular $Ca^{2+}$ release by different way from NE.

• The Korean Journal of Physiology
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• v.25 no.2
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• pp.159-170
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• 1991

In the rabbit renal artery, mechanisms of contraction by sodium depletion were investigated. The helical strips of isolated renal artery were immersed in the Tris-buffered salt solution. The contractions were recorded isometrically using a strain-gauge transducer. Na-free solution (Na was substituted by Li, choline or sucrose) produced contractions which were dependent on the nature of the Na substitutes. Na-free solution (choline) produced the contraction in ouabain-pretreated artery (Na loaded artery) even in the presence of verapamil. The amplitude of the contraction was dependent on the duration of the pretreatment with ouabain $(10\;^5M)$. Monensin potentiated the effect of ouabain on the contraction. Removal of Ca from bathing solution abolished the contraction and the substitution of Sr for Ca produced the contraction. Divalent cations such as Mg, Mn blocked the depolarization-induced contraction, while they had little effect on the Na-free contraction in Na loaded artery. These results suggest that the contraction induced by Na removal is dependent on the cellular Na content and may be caused by Ca influx via the Na-Ca exchange carrier.

• Journal of the Korean Society of Clothing and Textiles
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• v.23 no.3
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• pp.353-360
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• 1999

An investigation made of the variations of angle of bias on the top of the sleeve cap curve line and calculated easing contraction ratio by capheights(A ; a,h$\times$5,/6) B: A, H/4 +4cm C:A.H/3 D: A.H/ 4+3cm E:AH/4+2cm, F: A,H/4+1cm, G: A,H/4, H:A,H/6, I:A,H/8) and the efects of easing contraction on the cap curve lines of sleeve A, D, G by easing stitch density with the gathering foot: sewing condition-lockstitch industrial machine stitch density(N1.0 ; 38stitches/3cm N1.5: 26stitches/3cm, N2.0 ; 19stitches/3cm, N2.5 ; 14stitches/ 3cm) The results obtained were as follows; 1) The variations of the angle of bias on the top of the sleeve cap curve line by cap heights can be done according to the angle balance (front; $\alpha$-$\beta$ back ; $\alpha$'- $\beta$') between the angle (front ;$\alpha$, $\beta$, back ; $\alpha$'- $\beta$') of bias of the two base-lines. 2) The higher cap height the more higher the calculated easing contraction ratio. 3) The lower the stitch density the higher easing contraction ratio. 4) The effects of easing contraction was that sleeve G was more than sleeve A, D.

• Physical Therapy Rehabilitation Science
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• v.10 no.3
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• pp.278-288
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• 2021

Objective: The purpose of this study is to investigate the effect of stabilization exercise on whole-body vibration on pain, dysfunction, psychosocial factors, balance ability, and abdominal contraction with patients with low back pain. Design: A randomized controlled trial Methods: A total of 34 patients with low back pain were assigned randomly to experimental group (n=17) and control group (n=17). Both groups underwent a neuromuscular stabilization exercise program. In addition, the experimental group implemented the neuromuscular stabilization exercise program using whole-body vibration. All interventions were applied 60 min per session, 3 times per week for total 4 weeks. Numeric Rating Scale (NRS), Korean version of Oswestry Disability Index (K-ODI), Fear-Avoidance Beliefs Questionnaire (FABQ), balance ability, muscle thickness and contraction ratio were compared to evaluate the effect on intervention. Results: Both groups showed significant differences in NRS, balance ability, and muscle thickness in contraction, contraction ratio before and after intervention (p<0.05). In addition, the experimental group showed significant difference in the amount of change in NRS, balance ability and muscle thickness in contraction, contraction ratio values than the control group (p<0.05). Conclusions: Neuromuscular stabilization exercise program combined with whole-body vibration stimulation has been proven to be an effective and clinically useful method to decrease pain, dysfunction, increase balance ablilty, and transverse abdominis muscle thickness in contraction and contraction ratio for patients with low back pain.

• The Korean Journal of Physiology and Pharmacology
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• v.14 no.1
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• pp.29-35
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• 2010

We have shown that myosin light chain kinase (MLCK) was required for the off-contraction in response to the electrical field stimulation (EFS) of feline esophageal smooth muscle. In this study, we investigated whether protein kinase C (PKC) may require the on-contraction in response to EFS using feline esophageal smooth muscle. The contractions were recorded using an isometric force transducer. On-contraction occurred in the presence of $N^G$-nitro-L-arginine methyl ester (L-NAME), suggesting that nitric oxide acts as an inhibitory mediator in smooth muscle. The excitatory composition of both contractions was cholinergic dependent which was blocked by tetrodotoxin or atropine. The on-contraction was abolished in $Ca^{2+}$-free buffer but reappeared in normal $Ca^{2+}$-containing buffer indicating that the contraction was $Ca^{2+}$ dependent. 4-aminopyridine (4-AP), voltage-dependent $K^+$ channel blocker, significantly enhanced on-contraction. Aluminum fluoride (a G-protein activator) increased on-contraction. Pertussis toxin (a $G_i$ inactivator) and C3 exoenzyme (a rhoA inactivator) significantly decreased on-contraction suggesting that Gi or rhoA protein may be related with $Ca^{2+}$ and $K^+$ channel. ML-9, a MLCK inhibitor, significantly inhibited on-contraction, and chelerythrine (PKC inhibitor) affected on the contraction. These results suggest that endogenous cholinergic contractions activated directly by low-frequency EFS may be mediated by $Ca^{2+}$, and G proteins, such as Gi and rhoA, which resulted in the activation of MLCK, and PKC to produce the contraction in feline distal esophageal smooth muscle.

• The Pure and Applied Mathematics
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• v.14 no.4
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• pp.283-287
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• 2007

An extension of the contraction mapping theorem is provided in a Banach space setting to approximate fixed points of operator equations. Our approach is justified by numerical examples where our results apply whereas the classical contraction mapping principle cannot.

• The Korean Journal of Physiology and Pharmacology
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• v.4 no.3
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• pp.211-217
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• 2000

Paxillin is a regulatory component of the complex of cytoskeletal proteins that link the actin cytoskeleton to the plasma membrane. However, the role of paxillin during smooth muscle contraction is unclear. We investigated a possible role for the membrane-associated dense plaque protein paxillin in the regulation of contraction in rat aortic vascular smooth muscle. The tyrosine phosphorylation of paxillin, which was increased by norepinephrine, reached a peak level after 1 min stimulation and then decreased with time. However, norepinephrine induced a sustained contraction that reached a steady state 30 min after application. Pretreatment with tyrphostin, an inhibitor of tyrosine kinase, inhibited the tyrosine phosphorylation of paxillin and also the contraction stimulated by norepinephrine. Both inhibitions were concentration-dependent, and the degree of correlation between them was high. These results show that, in rat aortic smooth muscle, tyrosine kinase(s) activated by norepinephrine may phosphorylate the tyrosine residues of paxillin, thereby providing a source of regulation during vascular smooth muscle contraction.

• Nonlinear Functional Analysis and Applications
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• v.29 no.2
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• pp.581-596
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• 2024

A new variety of non-self generalized proximal contraction, called Hardy-Rogers α⁺F-proximal contraction, is shown in this work. Also, with an example, we prove that such contractions satisfying some conditions must have a unique best proximity point. For some particular values of the constants, that we have used to generalize the proximal contraction, we conclude different α⁺F-proximal contraction results of the types Ćirić, Chatterjea, Reich, Kannan, and Banach with proof, that all such type of contractions must have unique best proximity point. We also apply our result to solve a functional equation.