• The Journal of the Korea Contents Association
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• v.11 no.4
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• pp.312-320
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• 2011

The goal of this paper is to examine the effects of a CDSS(Clinical Decision Support System) for drug prescription on organizational performance in medical institutions using POC(Point Of Care) systems. For achieving this goal, evaluation factors for influencing performance of information system were identified by using the performance evaluation model for CDSS. In the results, there was significant causality between each evaluation domain except system quality domain. In addition, the system quality of CDSS for optimal drug prescription has no influence on user satisfaction. But information quality has positive influence on user satisfaction which has also a positive influence on organizational performance.

• Proceedings of the Korean Vacuum Society Conference
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• 2013.08a
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• pp.273-273
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• 2013

Recently, Point-of-care (POC) testing microdevices enable to do the patient monitoring, drug screening, pathogen detection in the outside of hospital. Immunochromatographic strip (ICS) is one of the diagnostic technologies which are widely applied to POC detection. Relatively low cost, simplicity to use, easy interpretations of the diagnostic results and high stability under any circumstances are representative advantages of POC diagnosis. It would provide colorimetric results more conveniently, if the genetic analysis microsystem incorporates the ICS as a detector part. In this work, we develop a reverse transcriptase-polymerase chain reaction (RT-PCR) microfluidic device integrated with a ROSGENE strip for colorimetric influenza H1N1 virus detection. The integrated RT-PCR- ROSGENE device is consist of four functional units which are a pneumatic micropump for sample loading, 2 ${\mu}L$ volume RT-PCR chamber for target gene amplification, a resistance temperature detector (RTD) electrode for temperature control, and a ROSGENE strip for target gene detection. The device was fabricated by combining four layers: First wafer is for RTD microfabrication, the second wafer is for PCR chamber at the bottom and micropump channel on the top, the third is the monolithic PDMS, and the fourth is the manifold for micropump operation. The RT-PCR was performed with subtype specific forward and reverse primers which were labeled with Texas-red, serving as a fluorescent hapten. A biotin-dUTP was used to insert biotin moieties in the PCR amplicons, during the RT-PCR. The RT-PCR amplicons were loaded in the sample application area, and they were conjugated with Au NP-labeled hapten-antibody. The test band embedded with streptavidins captures the biotin labeled amplicons and we can see violet colorimetric signals if the target gene was amplified with the control line. The off-chip RT-PCR amplicons of the influenza H1N1 virus were analyzed with a ROSGENE strip in comparison with an agarose gel electrophoresis. The intensities of test line was proportional to the template quantity and the detection sensitivity of the strip was better than that of the agarose gel. The test band of the ROSGENE strip could be observed with only 10 copies of a RNA template by the naked eyes. For the on-chip RT-PCR-ROSGENE experiments, a RT-PCR cocktail was injected into the chamber from the inlet reservoir to the waste outlet by the micro-pump actuation. After filling without bubbles inside the chamber, a RT-PCR thermal cycling was executed for 2 hours with all the microvalves closed to isolate the PCR chamber. After thermal cycling, the RT-PCR product was delivered to the attached ROSGENE strip through the outlet reservoir. After dropping 40 ${\mu}L$ of an eluant buffer at the end of the strip, the violet test line was detected as a H1N1 virus indicator, while the negative experiment only revealed a control line and while the positive experiment a control and a test line was appeared.

• Korean Journal of Ecology and Environment
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• v.47 no.2
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• pp.127-134
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• 2014

Organic carbon and nitrogen stable isotope ratios of particulate organic matter (POM) were determined at 7 stations (6 stations in Han river and Paldang dam outflow station) from May to October 2013, in order to understand the origin of POM at the Han river. ${\delta}^{13}C$ values of POM in four stations showed significant seasonal changes season, but ${\delta}^{15}N$ values were enriched in around Kyeongan stream (K). POC, PN and Chl-a concentration showed a similar seasonal pattern in Kyeongan stream, with an apparent decrease from July to August. POC and PN concentration has a higher correlation with Chl-a concentration in Kyeongan stream (K). ${\delta}^{13}C$ and ${\delta}^{15}N$ values of POM has a lighter value during lower Chl-a concentration peroid, compared to other seasons. Our results revealed that Kyeongan stream (K) seemed to be influenced by substantial amount of organic manure or fertilizer input in 2013, compared to the previous year (2012). These results suggest that the analysis of stable isotope ratios is a simple but useful tool for the identification of organic matter origin in aquatic environments.

• Nutrition Research and Practice
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• v.11 no.4
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• pp.319-326
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• 2017

BACKGROUND/OBJECTIVE: Effective weight reduction remains a challenge throughout the world as the prevalence of obesity and its consequences are increasing. This study aimed to determine the effects of an individualized nutrition counseling program (IC) matched with a transtheoretical model (TTM) for overweight and obese subjects. SUBJECTS/METHODS: Fifty overweight and obese subjects aged 19-60 years with a body mass index ${\geq}23kg/m^2$ were enrolled in the weight reduction study. They were randomized into two groups: Intervention group received an IC matched with a TTM; control group received an educational handbook. Body weight (BW), body fat (BF), waist circumference (WC), waist to height ratio (WHtR), stages of change (SOC), processes of change (POC), food intake, and physical activity (PA) were assessed at baseline and at 4, 8, and 12 weeks after program initiation in both groups. All data were analyzed by intention-to-treat, using SPSS software for hypothesis testing. RESULTS: Forty-five female subjects were included in the 12-week trial at Ramkhamhaeng Hospital, Bangkok, Thailand. The results showed significant weight loss ($1.98{\pm}1.75kg$; 3% loss of initial weight) in the intervention group at 12 weeks, compared to a $0.17{\pm}1.67kg$ loss in the control group. There were significant differences between intervention and control groups in BF mass ($-1.68{\pm}1.78$, $-0.04{\pm}1.62kg$); percentage BF ($-1.54{\pm}2.11$, $0.08{\pm}2.05$); WC ($-5.35{\pm}3.84$, $0.13{\pm}3.23cm$); WHtR ($-0.0336{\pm}0.02$, $-0.0004{\pm}0.02$), and energy consumption ($-405.09{\pm}431.31$, $-74.92{\pm}499.54kcal/day$) in the intervention and control groups, respectively. Intragroup SOC was improved in both groups. The POC for the weight management action (WMA) process was significantly different with POC scores increasing by $16.00{\pm}11.73$ and $7.74{\pm}14.97$ in the intervention and the control groups, respectively. PA level did not change in either group. CONCLUSIONS: The IC matched with a TTM resulted in reductions in BW, BF, and WC, thus reducing likely health risks by decreasing energy intake and inducing positive behavior changes while enhancing the WMA process.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.28 no.1
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• pp.40-45
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• 2015

Electrode systems: a protrusion on conductor (POC), a protrusion on enclosure (POE), a crack in epoxy plate and a free particle (FP) were fabricated to simulate insulation defects in a gas insulated switchgear (GIS). $SF_6$ gas was filled in the electrode systems by 3 bar and/or 5 bar, respectively. Partial discharge (PD) pulses were detected through a $50{\Omega}$ non-inductive resistor. A calibration test was carried out according to IEC 60270, and the sensitivity was 0.25 pC/mV. PD pulses were distributed in the phase of $50^{\circ}{\sim}135^{\circ}$ and over 95% of them existed in the phase of $55^{\circ}{\sim}120^{\circ}$ for the POC. PD pulses were distributed in the phase of $230^{\circ}{\sim}310^{\circ}$ and over 90% of them existed in phase of $220^{\circ}{\sim}300^{\circ}$ for the POE. PD pulses occurred in the phase of $40^{\circ}{\sim}60^{\circ}$ and $220^{\circ}{\sim}300^{\circ}$ for the crack, and pulse counts were 25% higher in negative polarity than in positive polarity. PD pulses were distributed in every phase unlike to other three electrode systems and the peak magnitude was measured at $118^{\circ}$ and $260^{\circ}$ for the FP. As described above, PD pulses were observed in positive polarity for the POC, in negative one for the POE, in both one for the crack and the FP. In conclusion, it is expected that the identification rate of defect type can be improved by considering the polarity ratio of PD pulses on the PRPDA method.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.27 no.4
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• pp.238-243
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• 2014

This paper dealt with the measurement and analysis of partial discharge (PD) under high voltage direct current (HVDC) in SF6 gas. Electrode systems such as a protrusion on conductor (POC), a protrusion on enclosure (POE), a crack on epoxy plate and a free particle (FP) were fabricated to simulate the insulation defects. The analysis system was designed with a Time-Frequency (T-F) map algorithm programed based on LabVIEW. This can arrange the acquired PD pulses into frequency and time domain. A HVDC power source is composed of a transformer (220 V/50 kV), a diode (100 kV) and a capacitor (50 kV, 0.5 ${\mu}F$). The gap between the electrodes is 3 mm, and the $SF_6$ gas was set at 5 bar. PD pulses were detected by a 50 ${\Omega}$ non-inductive resistor. In the analysis, PD pulses were distributed below 0.5 MHz and 20 ns ~ 35 ns for the POC, 0.7 MHz ~ 1.7 MHz, below 0.6 MHz and 10 ns ~ 40 ns and 60 ns ~125 ns for the POE, below 0.1 MHz and 135 ns ~ 215 ns for the crack, and below 1.6 MHz and 250 ns for the FP.

• Ocean and Polar Research
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• v.33 no.1
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• pp.55-68
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• 2011

The distribution and inter-annual variation of nutrients (N, P, Si) and dissolved/particulate organic carbon were investigated in the equatorial thermocline ridge ($7^{\circ}{\sim}11.5^{\circ}N$, $131.5^{\circ}W$) of the northeast Pacific. From the Oceanic Nino Index and Multivariate ENSO Index provided by NOAA, normal condition was observed in July 2003 and August 2005 on the aspect of global climate/ocean change. However, La Ni$\~{n}$a and El Ni$\~{n}$o episodes occurred in July 2007 and August 2009, respectively. Thermocline ridge in the study area was located at $9^{\circ}N$ in July 2003, $8^{\circ}N$ in August 2005, $10^{\circ}N$ in July 2007, and $10.5^{\circ}N$ in August 2009 under the influence of global climate/ocean change and surface current system (North Equatorial Counter Current and North Equatorial Current) of the northeast Pacific. Maximum depth integrated values (DIV) of nutrients in the upper layer (0~100 m depth range) were shown in July 2007 (mean 21.12 gN/$m^2$, 4.27 gP/$m^2$, 33.72 gSi/$m^2$) and higher variability of DIV in the equatorial thermocline ridge was observed at $10^{\circ}N$ during the study periods. Also, maximum concentration of dissolved organic carbon (DOC) in the upper 50 m depth layer was observed in July 2007 (mean $107.48{\pm}14.58\;{\mu}M$), and particulate organic carbon (POC, mean $9.42{\pm}3.02\;{\mu}M$) was similar to that of DOC. Nutrient concentration in the surface layer increased with effect of upwelling phenomenon in the equatorial thermocline ridge and La Ni$\~{n}$a episode, which had formed in the central Pacific. This process also resulted in the increasing of organic carbon concentration (DOC and POC) in the surface layer. From these results, it is suggested that spatial and temporal variation of chemical and biological factors were generated by physical processes in the equatorial thermocline ridge.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.40 no.11
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• pp.913-918
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• 2016

A three-way reversing valve, which provides rapid and accurate changes in the water flow direction without requiring any precise control device, is used in automotive washing machines to remove oil and dirt that remain on the machined engine and transmission blocks. Because of the complicated shape of the bottom-plug, however, cavitation occurs in the plug. In this study, the cavitation index and POC (percent of cavitation) were used to quantitatively evaluate the cavitation effect occurring in the bottom-plug on the downstream side. An optimal shape design was conducted via parametric study with a simple CAE model to avoid time-consuming CFD analysis and hard-to-achieve convergence. To verify the results of the numerical analysis, a flow visualization test was conducted using a specimen prepared according to ISA-RP75.23. In this test, the flow characteristics, such as cavitation occurring on the downstream side, were investigated using flow test equipment that included a valve, pump, flow control system, and high-speed camera.

• The Journal of the Korea institute of electronic communication sciences
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• v.14 no.2
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• pp.303-308
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• 2019

Spring framework is widely used as a base technology for e-government frameworks and to the extent it is a standard for web service development tools of Korean public institutions. However, recently, a remote code execution vulnerability(CVE-2018-1270) was found in an application using a spring framework. This paper proposes a method of analyzing the vulnerability experiment using a hacking scenario, Proof Of Concept(POC), in which the spring framework is a hazard to the server. We propose the patch to version 4.3.16 and version 5.0.5 or later as an ultimate response. It is also expected that the proposed experiment analysis on vulnerability of hacking scenario will be used as a data for improving performance of security programs and establishing a new authentication system.

• Journal of Medicine and Life Science
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• v.21 no.2
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• pp.21-30
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• 2024

The purpose of this prospective study was to investigate whether office hysteroscopy (OH) can be used to assess the mechanisms of action of progestogen-only contraceptives (POCs), diagnose possible local causes of abnormal uterine bleeding (AUB), and support the treatment plan of symptomatic patients using POCs compared with those who do not use hormones. The study included 140 women who were divided into two groups. Group A consisted of 70 women who used POCs, whereas group B consisted of 70 women who did not use hormones. They were successively examined using transvaginal ultrasonography (TVS), OH, and endometrial sampling. The TVS results were consistent with those of OH and histopathology. The changes in endometrial thickness and vasculature, as well as fallopian tube (FT) functions, were significantly more pronounced in POC users than in non-POC users. There was a significant reduction in the peristalsis of the proximal part of the FT, as well as a reduction in the bubble flow test in group A compared with group B. In addition, the combination of peristalsis and the bubble flow test (Darwishscope test) was significantly lower in group A. It was concluded that using OH as a simple diagnostic tool in women with POCs would contribute to a better understanding of the mechanisms of endometrial and FT effects and explain some local endometrial causes of AUB. This ensures that the combination of TVS and OH would limit routine endometrial sampling in POCs users.