• 전기학회논문지
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• 제56권8호
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• pp.1424-1429
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• 2007

This paper presents a simple and reliable one-touch type multi-immunosensing lab-on-a-chip (LOC) detecting antibodies as multi-disease markers using electrochemical method suitable for a portable point-of-care system (POCS). The multi-stacked LOC consists of a PDMS space layer for liquids loading, a PDMS valve layer with 50 im in height for the membrane, a PDMS channel layer for the fluid paths, and a glass layer for multi electrodes. For the disposable immunoassay which needs sequential flow control of sample and buffer liquids according to the designed strategies, reliable and easy-controlled on-chip operation mechanisms without any electric power are necessary. The driving forces of sequential liquids transfer are the capillary attraction force and the pneumatic pressure generated by air bladder push. These passive fluid transport mechanisms are suitable for single-use LOC module. Prior to the application of detection of the antibody as a disease marker, the model experiments were performed with anti-DNP antibody and anti-biotin antibody as target analytes. The flow test results demonstrate that we can control the fluid flow easily by using the capillary stop valve and the PDMS check valves. By the model tests, we confirmed that the proposed LOC is easily applicable to the bioanalytic immunosensors using bioelectrocatalysis.

• 한국대기환경학회지
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• 제26권5호
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• pp.567-580
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• 2010

Organic carbon (OC) and elemental carbon (EC) concentrations were determined for $PM_{10}$, $PM_{2.5}$ and $PM_{1.0}$ aerosols particles collected at Gosan Superstation on Jeju Island from August 2007 to September 2008. Aerosols were collected on quartz filters for 24 hours and then OC and EC were analyzed by TOR/IMPROVED method. Mean concentrations of OC and EC were $4.66\;{\mu}g/m^3$ and $1.69\;{\mu}g/m^3$ for $PM_{10}$, $3.95\;{\mu}g/m^3$ and $1.69\;{\mu}g/m^3$ for $PM_{2.5}$, and $3.16\;{\mu}g/m^3$ and $1.42\;{\mu}g/m^3$ for $PM_{1.0}$, respectively. The concentrations of OC and EC comprised 16.4% and 6.0% of $PM_{10}$, 22.9% and 9.8% of $PM_{2.5}$, and 23.0% and 10.0% of $PM_{1.0}$. OC and EC showed a clear seasonal variation with the highest in winter and the lowest in summer. The correlations between the two were also the best during the winter ($R^2$=0.87, 0.94, and 0.95 for $PM_{10}$, $PM_{2.5}$ and $PM_{1.0}$). The ratio of OC/EC exhibited the maximum (7.24) during an Asian dust event due to an increase of OC, which was possibly derived from soil. The mass fraction of both OC and EC was the highest in fall. When OC and EC concentrations were highly elevated, EC1 (the first EC fraction determined at $550^{\circ}C$) and pyrolyzed OC (POC) were dominant subcomponents in winter and OC3 (the third OC fraction determined at $450^{\circ}C$) and POC in spring.

• 한국수산과학회지
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• 제28권1호
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• pp.105-113
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• 1995

요각류 Calanu sinicu의 생물량과 산란의 계절성을 조사하였다. 조사해역인 아산만에서는, 성체는 봄철에 가장 많은 양이 출현하고, 다른 계절에는 소량 분포하는 연중 1회 peak를 보였지만, 산란에서는 봄철(4-5월)과 가을철 (9월)의 연중 2회 peak를 보였다 산란기의 개체군 평균 산란은 봄철에는 16.3 eggs/female/day, 가을철에는 7.6 eggs/female/day였으며, 1개체가 생산하는 최대 값은 39.0이었다. 타 해역에 비하여 비교적 풍부한 유기탄소량과 알 생산과의 상관관계가 유의적이지 않아 (r=0.43, p=0.3), 먹이 농도는 알 생산에 큰 영향을 주지 않는 것으로 판단되었다. 그러나 실험실에서 제공된 먹이를 충분히 섭취하면서도 처음 며칠이 지난 뒤에는 산란이 중지되는 것으로 보아, 먹이의 질과 과거의 섭식경력 (feeding history)이 산란과 밀접한 관계가 있을 것으로 유추되었다. 비록 통계적으로 유의적인 상관관계는 얻지 못하였으나, 상대적으로 높거나 낮은 수온에서는 산란하지 않아 대상해역의 수온 변화도 산란과 관계가 있을 것으로 유추되었다. 알 생산율 자료로부터 제한된 해역인 아산만에서는 연중 두 세대의 생활사가 진행되는 것으로 파악되었으며, 분포의 계절 변화와 생활사의 진행이 직접적으로 관련된 시기가 있는가 하면, 생활사 이외에 상위 영양단계의 포식압력 등에 의한 이주 등이 분포의 계절변화와 관련된 시기가 있는 것으로 추정되었다. 종전의 결과와 비교할 때, 계절에 따라 비교적 광범위한 해역을 이주하면서, 알 생산은 연중 간헐적으로 계속될 가능성도 배제할 수 없었다.

• 생태와환경
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• 제41권spc호
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• pp.27-34
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• 2008

본 연구는 부영양상태의 신구저수지에서 강우기 전 후의 수질 변화와 강우기 유입수의 영향을 평가하기 위해 이루어졌다. 강우기 전에는 수심에 따른 수온차가 $1^{\circ}C$이하였지만 강우기 후에는 $4^{\circ}C$차 이상까지 벌어져 수온 약층이 뚜렷하게 형성되었다. 탁도는 강우기 전보다 강우기 후에 표층에서 12NTU, 저층 120NTU로 크게 증가하였다. POC의 농도는 강우기 전의 조사에서 수심에 따라서 $4.96{\sim}6.68mg\;L^{-1}$의 범위를 나타내고 강우기 후의 조사에서는 $1.73{\sim}5.32mg\;L^{-1}$의 범위를 나타내고 있어 전체적으로 강우기 전보다 강우기 후의 POC의 농도가 낮았으나 수심에 따라서 크게 증가하는 경향을 보이고 있다. 또한, DOC의 농도는 강우기 전의 조사에서 $3.82{\sim}3.96mg\;L^{-1}$의 범위를 나타내고 있고, 강우기 후의 조사에서 $2.18{\sim}2.57mg\;L^{-1}$의 범위를 나타내고 있어 전체적으로 강우기 전보다 강우기 후의 DOC농도는 감소하고 있다. 또한 강우기 후 저층의 높은 탁도층에서 강우기 전보다 입자성유기물의 C/N비가 크게 증가하였고 입자성 유기물의 ${\delta}^{13}C$와 ${\delta}^{15}C$값이 뚜렷하게 가벼운 값을 보이는 것으로 볼 때 저수지 주변 유역에서 유입된 유기물의 영향을 크게 받았다는 것을 알 수 있다. 본 연구 결과로 볼 때 농업용 저수지인 신구저수지는 하계 강우기시 유입하천을 통해 외부로부터 유입된 육상식물 유기물이 저층에 부유된 상태로 존재하며 이는 저수지 내 저층 수생태계의 에너지 흐름에 영향을 줄 수 있는 것으로 사료된다.

• 한국물환경학회지
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• 제39권2호
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• pp.162-174
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• 2023

In order to prevent water pollution caused by organic matter, Total Organic Carbon(TOC) has been adopted indicator and monitored. TOC can be divided into Dissolved Organic Carbon(DOC) and Particulate Organic Carbon(POC). POC is largely precipitated and removed during stream flow, which making DOC environmentally significant. However, there are lack of studies to define spatio-temporal distributions of DOC in stream affected by various land use. Therefore, it is necessary to estimate the past DOC concentration using other water quality indicators to evaluate status of watershed management. In this study, DOC was estimated by correlation and regression analysis using three different organic matter indicators monitored in mixed land-use watersheds. The results of correlation analysis showed that DOC has the highest correlation with TOC. Based on the results of the correlation analysis, the single- and multiple-regression models were developed using Biochemical Oxygen Demand(BOD), Chemical Oxygen Demand(COD), and TOC. The results of the prediction accuracy for three different regression models showed that the single-regression model with TOC was better than those of the other multiple-regression models. The trend analysis using extended average concentration DOC data shows that DOC tends to decrease reflecting watershed management. This study could contribute to assessment and management of organic water pollution in mixed land-use watershed by suggesting methods for assessment of unmeasured DOC concentration.

• 산업공학
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• 제23권3호
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• pp.246-256
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• 2010

As wireless and mobile technologies have advanced significantly, lots of large sized healthcare organizations have implemented so called mobile hospital (m-Hospital) which provides a location independent and point of care (POC) clinical environment. Implementation of m-Hospital enhances quality of care because health professionals such as physicians and nurses can use hospital information systems at the very place where patients are located without any delay. This paper presents a real-time patient monitoring system based on wireless network technologies. A general framework for the patient monitoring process is introduced and the architecture and components of the proposed monitoring system is described. The system collects and analyzes biometric signals of in-patients who suffer from cancer. Specifically, it continuously monitors oxygen saturation of patients in bed and alarms health professionals instantly when an abnormal status of the patient is detected. The monitoring system has been used and clinically verified in a university hospital.

• 한국정밀공학회지
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• 제32권8호
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• pp.755-760
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• 2015

For proper wound healing, dermal contraction and remodeling are critical; during the natural healing process, differentiated fibroblasts called "myofibroblasts" typically undertake these functions. For severe wounds, however, a critical mass of dermal matrix and fibroblasts are lost, making self-regeneration impossible. To overcome this impairment, synthetic wound patches with embedded functional cells can be used to promote healing. In this study, we developed a polydioxanone (PDO)-based cell-embedded sheet on which dermal fibroblasts were cultured and induced for differentiation into myofibroblasts, whereby the following combinatorial physicochemical stimuli were also applied: aligned topology, electric field (EF), and growth factor. The results show that both the aligned topology and EF synergistically enhanced the expression of alpha smooth-muscle actin (${\alpha}$-SMA), a key myofibroblast marker. Our proof-of-concept (POC) experiments demonstrated the potential applicability of a myofibroblast-embedded PDO sheet as a wound patch.

• Ocean and Polar Research
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• 제32권3호
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• pp.291-297
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• 2010

In the summer of 2008 (August 4-14), vertical and horizontal distributions of inorganic nutrients and dissolved organic carbon (DOC) were measured in the southwestern East Sea. Concentrations of DOC were determined for the first time in the southwestern East Sea using the high-temperature combustion oxidation (HTCO) method, and results were compared with those measured by another laboratory. Concentrations of DOC ranged from 58 to 104 ${\mu}M$ in the upper 200 m, showing a typical decreasing pattern with depth. Generally, concentrations of DOC were relatively lower, with higher nutrient concentrations, in the upper layer of the coastal upwelling zone. Concentrations of DOC ranged from 54 to 64 ${\mu}M$ in the deep Ulleung Basin (200-1500 m), and were higher than those in the Pacific and Atlantic oceans. In association with rapid vertical ventilation of the euphotic, this difference indicates a larger accumulation of semi-labile DOC in the deep East Sea than in the major oceans. A correlation between apparent oxygen utilization (AOU) and DOC in the deep ocean of the East Sea revealed that only a small portion (<10%) of the sinking DOC, relative to the sinking particulate organic carbon (POC), contributes to microbial degradation. Our results present an important data set of DOC in the East Sea, which plays a critical role in carbon cycle modeling and sequestration.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2001년도 제14회 신호처리 합동 학술대회 논문집
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• pp.755-758
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• 2001

In this paper. Ive propose a postprocessing technique based on the theory of projection on convex sets(POCS) to reduce the blocking artifacts in HDTV decoded images. In BDCT of HDTV. the image is divided into a grid of non-overlapped 8 ${\times}$ 8 blocks. and then each block is coded separately. A block which is located one pixel apart from the grid of BDCT will include the boundary of the original 8 ${\times}$ 8 block. If the blocking artifact is Introduced alone the block boundary. this block will have different frequency characteristic from that of the original block. Thus, a comparison of frequency characteristics of these two overlapping blocks can detect the undesired high-frequency components mainly caused by the blocking artifact. By eliminating these undesired high-frequency components adaptively, robust smoothing projection operator can be obtained. Simulation results with real image sequences indicate that the proposed method performs better than conventional algorithms.

• 한국컴퓨터정보학회논문지
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• 제8권4호
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• pp.87-91
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• 2003

본 논문에서는 현재 주차장에서 사용되는 입출 차량의 관리를 정기권 카드나 티켓발행기와 병행하여 사용될 수 있는 자동차 번호 인식 시스템을 개발하였다. 주차장은 차량의 흐름을 원활하고 신속하게 처리해야 하기 때문에 많은 자동차 번호 인식시스템을 도입했으나 운영 면에서 여러 가지 문제점을 가지고 있었다. 본 논문에서는 이러한 단점을 보완하기 위하여 기존의 시스템을 바탕으로 유동적인 시스템을 개발하였다. 자동차 번호 인식시스템은 주차장에 설치될 경우 99%의 성능을 가져야 하지만 날씨의 변화와 계절이 변동함에 따라 많은 영향을 받고 있다. 따라서 본 논문에서는 4계절과 날씨에 민감함을 고려하여 차량번호판 영역을 히스토그램 모폴로지를 사용하여 번호판 영역을 추출하고 신경망을 사용하여 숫자만을 인식하는 시스템을 개발하였다.