• 대한임상검사과학회지
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• 제49권3호
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• pp.203-213
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• 2017

혈청 크레아티닌 기반 eGFR과 혈청 Cystatin C 기반 eGFR을 측정하는 것은 신장기능을 평가하기 위하여 가장 널리 이용되는 방법이다. 갑상선호르몬은 혈청 크레아티닌 기반 eGFR과 혈청 Cystatin C 기반 eGFR에 영향을 미치는 것으로 알려져 있다. 갑상선기능이상 환자에게서 신장기능평가에 대한 위의 두마커의 임상적 의미는 아직 명료하게 밝혀지지 않았다. 이에 본 연구에서는 갑상선기능이상 환자에서 혈청 크레아티닌 기반 eGFR과 혈청 Cystatin C 기반 eGFR에 대한 갑상선호르몬의 영향과 상관성에 대하여 알아보고자 한다. 442명의 갑상선기능저하 환자와 284명의 갑상선기능항진 환자를 대상으로 갑상선호르몬과 혈청 크레아티닌 기반 eGFR, 혈청 Cystatin C 기반 eGFR과의 상관관계 분석을 하였다. 상관관계 분석 결과는 갑상선기능이상 환자들에서 갑상선호르몬과 혈청 Cystatin C 기반 eGFR이 갑상선호르몬과 혈청 크레아티닌 기반 eGFR보다 독립적으로 신장기능을 평가할수 있는 지표로 나타났다. 결론적으로 갑상선기능이상 환자에서 혈청 Cystatin C 기반 eGFR이 혈청 크레아티닌 기반 eGFR보다 정확하게 신장의 기능을 반영할 수 있는 지표인 것을 알 수 있다.

• Childhood Kidney Diseases
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• 제5권2호
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• pp.87-99
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• 2001

목 적 : 본 연구는 소아 미세변화 신증후군 환자와 IgAN에서 apoE 유전자형의 다형성을 알아보고, 스테로이드 반응과 빈발 재발 신증후군에서 apo-E 유전자형의 연관성을 관찰하므로 신증후군 예후인자로의 가능성을 밝히고, 신증후군에서 나타나는 고지질혈증과의 연관성을 알아보고자 하였다. 대상 및 방법 : 43명의 소아 신증후군 환자와 15명의 IgA신병증 한자를 대상으로 apo-E 유전자형을 조사하였다. 대조군은 50명의 혈연관계가 없는 건강한 혈액 공여자를 대상으로 하였다. Genomic DNA는 standard procedure에 따라 말초혈액의 백혈구로부터 분리하였다. 결 과 : 신증후군 환자에서 대조군보다 e4의 빈도가 유의하게 높았다(P<0.01). 그러나 IgAN에서는 e2가 대조군보다 2.6배나 높았다(P<0.01). 빈발재발군 신증후군에서 e4의 빈도가 대조군 보다 4.6배, 비재발군 신증후군 보다 2배 높았다. 특히 e4/4는 빈발 재발군에서만 3명이 발견되었다. apo-E 유전자형에 따른 혈중 알부민, 콜레스테롤, 지질을 비교하였으나 정상 E3군과 E4 변이형에서 유의한 차이는 없었다(P> 0.05). 결 론 :소아 미세변화 신증후군에서 apo-E 유전자형의 연구에서 e4가 대조군 보다 높은 빈도를 보였으며, IgAN에서는 e2와의 연관성을 보였다. e4 유전자형이 특히 빈발 재발군에서 비재발군에서 보다 2배나 높았으며, e4 homozygote는 빈발 재발군에서만 나타나 신증후군의 빈발재발과 스테로이드 의존성의 예후인자의 이용할 수 있으리라 생각된다.

• 지능정보연구
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• 제9권2호
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• pp.121-133
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• 2003

Due to the rapid growth of Internet, means of communication with customers in a traditional customer support environment such as telephone calls are being replaced by mainly e-mail in a Web-based customer support system. Although such a Web-based support is efficient and promises potential benefits for firms, including reduced transaction costs, reduced time, and high quality of support, there are some difficulties associated with responding to many types of customer's inbound e-mails appropriately. As many types of e-mail are received, considerable attention is being paid to methods for increasing the efficiency of managing and responding e-mails. This research proposes an intelligent system for managing customer's inbound e-mails in organizations by applying case based reasoning technique for responding to various customers' inbound e-mails more effectively. In this approach, a case is represented as a frame-typed data structure corresponding to an inbound e-mail, keywords, and its reply e-mail. In the retrieval procedure, keywords and affinity set is developed to index a case, and then the case is represented as a vector, a case vector. Also, cosines value is calculated to measure the similarity between a new inbound e-mail and the cases in the case base. In the adaptation procedure, we provide several adaptation strategies to adapt and modify the retrieved case. The strategies guide to make an outbound e-mail using product databases, databases for customer support, etc. Additionally, the Web-based system architecture is proposed to implement our methodology. The proposed methodology and system will be helpful for developing more efficient Web-based customer support.

• 한국산학기술학회:학술대회논문집
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• 한국산학기술학회 2003년도 Proceeding
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• pp.185-190
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• 2003

Due to the rapid growth of Internet, means of communication with customers in a traditional customer support environment such as telephone calls are being replaced by mainly e-mail in a Web-based customer support system. Although such a Web-based support is efficient and promises potential benefits for firms, including reduced transaction costs, reduced time, and high quality of support, there are some difficulties associated with responding to many types of customer’s inbound e-mails appropriately .As many types of e-mail are received, considerable attention is being paid to methods for increasing the efficiency of managing and responding e-mails. This research proposes an intelligent system for managing customer’s inbound e-mails in organizations by applying case based reasoning technique for responding to various customers' inbound e-mails more effectively. In this approach, a case is represented as a frame-typed data structure corresponding to an inbound e-mail, keywords, and its reply e-mail. In the retrieval procedure, keywords and affinity set is developed to index a case, and then the case is represented as a vector, a case vector. Also, cosines value is calculated to measure the similarity between a new inbound e-mail and the cases in the case base. In the adaptation procedure, we provide several adaptation strategies to adapt and modify the retrieved case. The strategies guide to make an outbound e-mail using product databases, databases for customer support, etc. Additionally, the Web-based system architecture is proposed to implement our methodology. The proposed methodology and system will be helpful for developing more efficient Web-based customer support.

• 디지털융복합연구
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• 제6권2호
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• pp.135-143
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• 2008

The remarkable growth of the Internet since mid-l990s has expanded the e-learning market and brought the transformation of educational environments and methodology. It can be said that the e-learning has changed the educational paradigm. Korean government is firmly determined to support the diffusion of e-learning because of the benefits of e-learning. People seem to accept the e-learning when its contents have high quality. A lot of research have been conducted on e-learning, however, it was mostly about user's usage intention, satisfaction and educational effect. It can't seem that sufficient research efforts have been put into figuring out the role of e-learning contents quality in the expansion of e-learning. In this paper, we present the empirical study on the influence of e-learning contents quality on user's satisfaction and educational effect. We conducted an questionnaire survey on college students to collect data and found that the quality of e-learning contents has significant influence on the users' satisfaction.

• Journal of Information Technology Applications and Management
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• 제22권2호
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• pp.219-230
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• 2015

Recently, electronic-book (e-book) market is growing rapidly due to the evolution of information technology and e-book standard EPUB. Users can search e-book on-line and download easily to their e-book readers such as amazon's kindle or smartphones. On the other hand, there is lack of e-book contents for the reading disabled people because of high cost of making e-book accessibility for the reading disabled people. If we can translate EPUB specified e-book contents to the alternative e-book contents suitable for the reading disabled people, then there are many advantages to acquire various types and large volumes of e-book contents for the reading disabled people. This paper suggests a new electronic publishing ecosystem for the reading disabled people using e-book translation method. It also suggests a promotion strategy of e-book market for the reading disabled people.

• 한국식품영양과학회지
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• 제19권3호
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• pp.207-214
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• 1990

Amish 집단(미국 오하이오주 홈스카운터 거주)의 vitamin E 영양상태를 24시간 회상법, 영양보충제의 사용량 조사 colorimetric법에 의한 혈장 vitamin E의 분석으로 평가하였다 평균식이 섭취 vitamin E는 7.4mg a-tocopherol equivalent였으며 평균 181.4 IU는 영양보충제로 섭취했다 전체 vitamin E의 67.7% 는 식이를 통해 섭취했으며 32.4%는 영양보충제를 복용함으로 섭취했다 평균 혈장 vitamin E 농도는 13.4mg/ml였다 혈장 vitamin E와 영양제로 복용한 vitamin E 사이에는 유의적인 상관과계가(r=0.489 p=0.0001)를 보여주었고 혈장 vitamin E와 연령과도 상관관계(r-0.216, p=0.0017)가 있었다 Amish 집단의 vitamin E 영양상태는 충분했으며 이집단 중의 어떤 자들은 고단위의 다량의 vitamin E 영양제를 복용하고 있어 vitamin E에 대한 올바른 정보를 알려주고 효율적인 영양교육을 시킬 필요성이 요청되었다.

• Asia pacific journal of information systems
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• 제20권4호
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• pp.1-23
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• 2010

Some researches insist that, to participate in an e-partnership, a distributor needs a given level of trust to reduce the perceived risk of an e-partnership to his/her own threshold. However, other researches insist that if a distributor has only a given level of trust in his/her suppliers, irrelevant of the perceived risk level, he/she participates in the e-partnership. Thus, from the perspective of a distributor, this study built a trust model in which these two viewpoints were reflected. And then this study examined whether or not perceived risk mediates an influence of trust to e-partnership. The proposed trust model was tested with 265 questionnaires about a distributor-supplier e-partnership in food wholesale markets. The analysis results Indicated that perceived risk partially had a mediating effect between trust and e-partnership Intention. That is, of the two risk types, only perceived performance risk mediated an influence from competence trust to e-partnership intention. Relational risk did not play a mediating role between goodwill trust and e-partnership intention. This result Implies two managerial meanings. First, a distributor Intends to engage In e-partnership with his/her supplier, irrelevant of relational risk's level if goodwill trust level surpasses his/her own threshold. Thus, suppliers should concentrate more effort in developing goodwill trust than in reducing relational risk. To develop goodwill trust, they should endeavor to establish mutual interests and individual trust with their distributor, and to utilize institutional trust bases. Second, a distributor requires a certain competence In his/her suppliers to sufficiently reduce performance risk caused bye-partnership. Thus, to develop competence trust in e-partnership, suppliers should improve on any lack of competence and build a good reputation.

• Journal of Microbiology and Biotechnology
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• 제24권2호
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• pp.287-294
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• 2014

The transcription factor E2F1 is active during G1 to S transition and is involved in the cell cycle and progression. A recent study reported that increased E2F1 is associated with DNA damage and tumor development in several tissues using transgenic models. Here, we show that E2F1 expression is regulated by tristetraprolin (TTP) in prostate cancer. Overexpression of TTP decreased the stability of E2F1 mRNA and the expression level of E2F1. In contrast, inhibition of TTP using siRNA increased the E2F1 expression. E2F1 mRNA contains three AREs within the 3'UTR, and TTP destabilized a luciferase mRNA that contained the E2F1 mRNA 3'UTR. Analyses of point mutants of the E2F1 mRNA 3'UTR demonstrated that ARE2 was mostly responsible for the TTP-mediated destabilization of E2F1 mRNA. RNA EMSA revealed that TTP binds directly to the E2F1 mRNA 3'UTR of ARE2. Moreover, treatment with siRNA against TTP increased the proliferation of PC3 human prostate cancer cells. Taken together, these results demonstrate that E2F1 mRNA is a physiological target of TTP and suggests that TTP controls proliferation as well as migration and invasion through the regulation of E2F1 mRNA stability.

• Nutritional Sciences
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• 제1권1호
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• pp.22-28
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• 1998

Plasma concentrations of Vitamins E and A were measured in 15 non-insulin dependent Korean female subjects and 15 age-matched normal subjects using reversed-phase high-performance liquid chromatography. No differences were found in plasma Vitamin E concentrations between the 2 groups. Plasma Vitamin A concentrations were higher in subjects with non-insulin dependent diabetes melitus (NIDDM). The effects were evaluated of 4 weeks of daily supplementation of 400 mg Vitamin E on plasma levels of these two vitamins. In addition, the effects were observed for Vitamin E supplementation on oxidative stress and immune-related compound productions in non-insulin dependent diabetic patients and control subjects. After treatment with Vitamin E, plasma Vitamin E concentrations were significantly elevated in both groups. Basal plasma thiobarbituric acid reactive substances (TBABS) were identical, and a decreased level of TBARS caused by Vitamin E was observed only in the diabetic group (0.02739$\pm$0.0024 versus 0.01814$\pm$0.0008 nmols malondialdehyde equivalents/dl plasma ; p<0.05). The basal and after-treatment levels of immunoglobulins A, G, M were identical in control and diabetic groups, indicating that Vitamin E did not appear to alter gross humoral responses in this study. However, elevation of Complement 3 ($C_3$) was noticed due to Vitamin E supplementation, revealing a possible effect of vitamin E on one aspect of humoral immunity, Furthermore, an increase in prostaglandin E_2 ($PGE_2$) levels in diabetic patients was normalized by Vitamin E supplementation. This suggests indirectly that the depressed cell-mediated response due to elevated $PGE_2$ could be normalized. For the definitive antioxidant intake recommendations for prevention and treatment of adverse effects of non-insulin dependent diabetes, evidence from intervention trials like this study should be collected. The present data suggests that Vitamin E may oxen some protective effects against oxidative damage and might have beneficial effects of partial immune-stimulation.