Korean Journal of Clinical Laboratory Science (대한임상검사과학회지)

Korean Society for Clinical Laboratory Science (대한임상검사과학회)
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A Correlation Analysis of Serum Creatinine Based eGFR and Serum Cystatin C Based eGFR with Thyroid Dysfunction Patients

갑상선기능이상 환자에서 크레아티닌과 시스타틴을 이용한 사구체여과율 검사결과의 상관성 연구

  • Lim, Gu (Department of Biomedical Laboratory Sciences, College of Health Science, Eulji University) ;
  • Park, Hyung-Doo (Department of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Sung, Ho Joong (Department of Biomedical Laboratory Sciences, College of Health Science, Eulji University)
  • 임구 (을지대학교 보건과학대학 임상병리학과) ;
  • 박형두 (성균관대학교 의과대학 삼성서울병원 진단검사의학교실) ;
  • 성호중 (을지대학교 보건과학대학 임상병리학과)
  • Received : 2017.07.25
  • Accepted : 2017.08.02
  • Published : 2017.09.30
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Abstract

Serum creatinine-based eGFR and serum cystatin C-based eGFR are the most popular methods for measuring renal function. Thyroid hormone is known to affect serum creatinine-based eGFR and serum cystatin C-based eGFR; however, the clinical significance of thyroid dysfunctional patients of renal function evaluation has not been fully elucidated to date. This study examined the effect of thyroid hormone on serum creatinine-based eGFR and serum cystatin C-based eGFR. Moreover, we also evaluated the correlation analysis between serum creatinine-based eGFR and serum cystatin C-based eGFR in patients with thyroid dysfunction. A total of 442 patients with hypothyroidism and 284 patients with hyperthyroidism were investigated. A correlation analysis between thyroid hormone and serum creatinine- (and cystatin C-) based eGFR was performed. A correlation analysis between thyroid hormone and serum cystatin-C based eGFR indicated that serum cystatin-C based eGFR is more of an independent biomarker than serum creatinine-based eGFR in thyroid dysfunction patients. Therefore, serum cystatin C-based eGFR more accurately reflects renal function than serum creatinine-based eGFR in thyroid dysfunction patients.

혈청 크레아티닌 기반 eGFR과 혈청 Cystatin C 기반 eGFR을 측정하는 것은 신장기능을 평가하기 위하여 가장 널리 이용되는 방법이다. 갑상선호르몬은 혈청 크레아티닌 기반 eGFR과 혈청 Cystatin C 기반 eGFR에 영향을 미치는 것으로 알려져 있다. 갑상선기능이상 환자에게서 신장기능평가에 대한 위의 두마커의 임상적 의미는 아직 명료하게 밝혀지지 않았다. 이에 본 연구에서는 갑상선기능이상 환자에서 혈청 크레아티닌 기반 eGFR과 혈청 Cystatin C 기반 eGFR에 대한 갑상선호르몬의 영향과 상관성에 대하여 알아보고자 한다. 442명의 갑상선기능저하 환자와 284명의 갑상선기능항진 환자를 대상으로 갑상선호르몬과 혈청 크레아티닌 기반 eGFR, 혈청 Cystatin C 기반 eGFR과의 상관관계 분석을 하였다. 상관관계 분석 결과는 갑상선기능이상 환자들에서 갑상선호르몬과 혈청 Cystatin C 기반 eGFR이 갑상선호르몬과 혈청 크레아티닌 기반 eGFR보다 독립적으로 신장기능을 평가할수 있는 지표로 나타났다. 결론적으로 갑상선기능이상 환자에서 혈청 Cystatin C 기반 eGFR이 혈청 크레아티닌 기반 eGFR보다 정확하게 신장의 기능을 반영할 수 있는 지표인 것을 알 수 있다.

Keywords

References

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