• 대한약침학회지
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• 제12권2호
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• pp.77-84
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• 2009

Objective : Patients with spinal cord injury are increasing in numbers. However, there is no reliable treatment guide in both conventional & complementary medicine. Also, there are not much clinical case of patients with spina cord injury in oriental medical field. We investigated effect of sweet BV on subacute stage patient with spinal cord injury. Method : 31-year old female patient with spinal cord injury was treated with herb medicine(TID), electro arcupunture (BID), sweet BV injection(QOD), Physical treatment(QD), and conventional-medicine. Result : We had a satisfactory result with using sweet BV injection. The patient's ASIA grade improved from 34 to 52. And Frankle classification of the patient shifted from A to B. Conclusion : We reach a conclusion Using Sweet BV improve the sensation of patient with spinal cord injury. And more study about this disease is needed.

• 한국컴퓨터산업학회논문지
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• 제3권7호
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• pp.861-870
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• 2002

최근 컴퓨팅 기술과 통신 기술의 급속한 발전으로 클라이언트/서버 컴퓨팅 환경에서 네트워크 컴퓨팅 시대를 지나 인터넷 컴퓨팅 시대가 도래하고 있다. 인터넷 사용이 보편화되어 감에 따라 기업의 정보 시스템이 인터넷 기반의 인트라넷/익스트라넷 시스템으로 구축되어 가고 있으며 인터넷 환경에서의 기업과 소비자(Business to Customer)간 또는 기업과 기업간(Business to Business)의 전자 거래 관련 응용 프로그램의 개발이 다양해지고 있다. 본 논문에서는 인터넷 환경에서 기업과 기업간 전자 거래에 있어서 기업의 글로벌화를 통해 조달 업무의 투명성과 신속성 및 질적 향상을 추구할 수 있도록 제공하기 위한 웹 기반 전자 입찰 시스템을 구현하는데 있어서 클라이언트와 서버 및 데이터베이스를 연동하기 위한 웹 기술, 기업간의 문서 교환을 위한 XML/EDI기술 및, 입찰과 계약과정, 조달과정에서 안전성 및 신뢰성을 보장하기 위해 공개키 암호화 기술인 PKI기반 구조의 인증 및 전자서명을 활용한 보안 기능을 설계 및 구현한다.

• 정보처리학회논문지B
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• 제8B권6호
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• pp.601-608
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• 2001

The automated assignment of multiple tasks to executing agents is a key problem in the area of multi-agent systems. In many domains, significant savings can be achieved by reallocating tasks among agents with different costs for handling tasks. The automation of task reallocation among self-interested agents requires that the individual agents use a common negotiation protocol that prescribes how they have to interact in order to come to an agreement on "who does what". In this paper, we introduce the multi-agent Traveling Salesman Problem(TSP) as an example of task reallocation problem, and suggest the Vickery auction as an interagent negotiation protocol for solving this problem. In general, auction-based protocols show several advantageous features: they are easily implementable, they enforce an efficient assignment process, and they guarantce an agreement even in scenarios in which the agents possess only very little domain-specific Knowledge. Furthermore Vickrey auctions have the additional advantage that each interested agent bids only once and that the dominant strategy is to bid one′s true valuation. In order to apply this market-based protocol into task reallocation among self-interested agents, we define the profit of each agent, the goal of negotiation, tasks to be traded out through auctions, the bidding strategy, and the sequence of auctions. Through several experiments with sample multi-agent TSPs, we show that the task allocation can improve monotonically at each step and then finally an optimal task allocation can be found with this protocol.

• 헤리티지:역사와 과학
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• 제50권3호
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• pp.88-109
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• 2017

현재 비가역성 재료로 알려져 있는 Paraloid b-72의 제거방법으로는 대상재질의 종류에 따라 차이는 있지만 유기용매 및 가열 방식을 이용한 방법들이 일반적으로 사용되었으나, 흙벽화에 적용시키는 문제는 처리방법의 한계성과 손상위험 때문에 지금까지 적용되지 못하였고, 제거 효율 또한 검증되지 못하였다. 이에 따라 본 연구에서는 흙벽화에 사용된 Paraloid b-72를 가장 안전하게 제거할 수 있는 방법을 모색하였으며, 가장 효율적일 것으로 판단되는 습포방식을 적용하여 실험하였다. Paraloid b-72에 대한 용해성이 확인된 용해제들을 흡착제인 활성탄소섬유와 Methyl Cellulose에 적용시켜 동일한 크기와 조건으로 제작된 흙벽화 시료표면에 일정시간 흡착용출 시킨 후 제거하여 안정성과 제거효과를 비교하였으며, 이를 통해 과거 Paraloid b-72로 보존처리 되었던 금산사 미륵전 벽화 및 다른 벽화 문화재에 대한 적용가능성을 확인하고자 하였다. 실험결과, 흡착제인 활성탄소섬유와 Xylene을 단독 또는 빠른 기화성을 가진 다른 용해제와 혼합하여 적용하였을 때 효과적이고, 그 중 Acetone:Xylene(1:1wt%)이 가장 안정적임을 알 수 있었다. 이 결과는 향후 진행될 수 있는 금산사 미륵전 벽화의 Paraloid b-72 제거와 그밖의 다른 벽화 문화재의 원형복원을 위한 기초자료로 활용될 수 있을 것으로 본다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권7호
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• pp.3131-3138
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• 2016

Several studies have addressed the possible role of hepatitis C virus genotype-4 (HCV GT4) in apoptosis. However, this still not fully understood. In the current study a re-constructed clone of E1/E2 polyprotein region of the HCV GT4 was transfected into the Huh7 cell line and a human apoptotic PCR array of 84 genes was used to investigate its possible significance for apoptosis. Out of the 84 genes, only 35 showed significant differential expression, 12 genes being up-regulated and 23 down-regulated. The highest-up regulated genes were APAF1 (apoptotic peptidase-activating factor 1), BID (BH3 interacting domain death agonist) and BCL 10 (B-cell CLL/lymphoma protein 10) with fold regulation of 33.2, 30.1 and 18.9, respectively. The most down-regulated were FAS (TNF receptor super family), TNFRSF10B (tumor necrosis factor receptor super-family member 10b) and FADD (FAS-associated death domain) with fold regulation of -30.2, -27.7 and -14.9, respectively. These results suggest that the E1/E2 proteins may be involved in HCV-induced pathogenesis by modulating apoptosis through the induction of the intrinsic apoptosis pathway and disruption of the BCL2 gene family.

• 한국IT서비스학회지
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• 제7권2호
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• pp.1-12
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• 2008

The development of IT and explosively growing number of Internet users are rapidly spreading and developing e-commerce, while creating diverse on-line transaction methods such as a negotiation, a reverse auction, and a bid. Among these transaction methods, the transactions by means of a negotiation are being made for goods that have no posted price. In particular, the transactions by means of a negotiation are expected to be widely used in the B2B. In order to determine their transportation costs, shippers usually make negotiations with many transporters and logistics companies. And before long, these negotiations are expected to be made on an on-line automated negotiation system. Because of this, this study has tried to develop an automated negotiation methodology that is absolutely necessary for an on-line automated negotiation. This study has estimated and selected the evaluation functions for multi-lateral negotiators' proposals, thus developing an automated negotiation methodology. As a result of this study, a new direction for an automated negotiation has been suggested. Also we expect that this study will be widely used in the automated negotiation of diverse fields.

• 한국초등수학교육학회지
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• 제15권2호
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• pp.437-461
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• 2011

본 연구는 초등 수학영재들이 'n${\times}$n 격자점에서 정사각형 개수 구하기' 과제를 해결하는 과정에서 나타나는 메타인지 요소를 분석하여 이것이 문제해결과정에 어떻게 서로 상호작용을 하며, 또 메타인지 요소가 문제해결의 성패에 어떤 영향을 미치는 지를 살펴보고자 하였다 이를 위하여 현재 우리나라의 대표적인 3가지 영재교육기관(지역공동영재학급, 교육지원청부설 영재교육원, 대학부설 과학영재교육원)별로 각 1명씩 총 3명(기관의 순서대로 각각 학생 C, 학생 B, 학생 A라 함)을 대상으로 3시간 정도가 걸리는 수업을 연구자가 직접 참여한 관찰과 수업 녹화용 비디오 및 활동지 분석, 그리고 수업 후 면담 등을 통해 질적 사례 연구를 실시하였다.

• 한국환경복원기술학회지
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• 제10권4호
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• pp.83-94
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• 2007

Test application of revegetation measure was made on the roadside slope damaged by Gimcheon-Eomo national road improvement project in a bid to prevent the soil from being washed out as well as to restore the ecological environment, and the survey for assessing the effect of slope revegetation measures was conducted, beginning Sep 7 through Sep 20, 2006. In the wake of comprehensive reviewing and evaluating the surrounding topographic environment, physical and chemical characteristics of soil, germination of revegetation plants, analysis of bio mass, covering ratio and the plants appeared, revegetation measure C was found to have been most effective and desirable for further application in the area. Viewing the specific applicability by the area, revegetation measure C and C-1 appeared to be appropriate for blasting rock slope and ripping rock slope as they are efficient in preventing the slope from being washed out and in early revegetating. And revegetation measure B deemed to be effective to blasting rock slope or ripping rock slope as an alternative. And for cut slope, vegetation measure C-2 was judged to be more effective than measure D or E, while measure C-3 would be appropriateto embankment slope.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2007년도 춘계종합학술대회
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• pp.619-622
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• 2007

PDA는 비교적 작은 크기로 인하여 휴대하기 쉽고 간편하다는 장점이 있어 학습자에게 언제, 어디서나 학습할 수 있는 기회를 제공한다. 그러나 작은 스크린 사이즈로 인하여 동영상에서 제공되는 학습 내용을 정확하게 인식하기에는 많은 제약이 있다. 본 논문에서는 이러한 PDA의 문제점을 해결하기 위해 관심 영역(ROI)의 추출(Detection)과 이미지 스케일링(Image Scaling) 기법을 이용하여 학습에 필요한 영역을 중심으로 강의 영상의 크기를 적응적으로 변환하고 전송하는 원격 강의 시스템을 제안한다. 제안된 시스템은 802.11b 무선 네트워크상에서 실험을 통해 기존의 방법에서 보다 최적화된 강의 영상을 제공할 수 있음을 증명한다.

• 대한약침학회지
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• 제18권2호
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• pp.26-32
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• 2015

Objectives: Rheum undulatum L. has traditionally been used for the treatment of many diseases in Asia. However, its anti-proliferative activity in cancer has still not been studied. In the present study, we investigated the anti-cancer effects of methanol extract of Rheum undulatum L. (MERL) on human adenocarcinoma gastric cell lines (AGS). Methods: To investigate the anti-cancer effect of MERL on AGS cells, we treated the AGS cells with varying concentrations of MERL and performed 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assays. Cell cycle analyses, measurements of the mitochondrial membrane potential (MMP), caspase activity assays and Western blots were conducted to determine whether AGS cell death occurred by apoptosis. Results: Treatment with MERL significantly inhibited growth of AGS cells in a concentration dependent manner. MERL treatment in AGS cells leaded to increased accumulation of apoptotic sub G1 phase cells in a concentration dependent manner. In control cultures, 5.38% of the cells were in the sub G1 phase. In MERL treated cells, however, this percentage was significantly increased (9.95% at $70{\mu}g/mL$, 15.94% at $140{\mu}g/mL$, 26.56% at $210{\mu}g/mL$ and 38.08% at $280{\mu}g/mL$). MERL treatment induced the decreased expression of pro-caspase-8 and -9 in a concentration dependent manner, whereas the expression of the active form of caspase-3 was increased. A subsequent Western blot analysis revealed increased cleaved levels of poly (ADP-ribose) polymerase (PARP) protein. Also, treatment with MERL increased the activities of caspase-3 and -9 compared with the control. MERL treatment increased the levels of the pro-apoptotic truncated Bid (tBid) and Bcl2 Antagonist X (Bax) proteins and decreased the levels of the anti-apoptotic B-cell lymphoma 2 (Bcl-2) protein, whose is the stabilization of mitochondria. However, inhibitions of p38, extracellular signal regulated kinases (ERKs) and C-Jun N-terminal kinases (JNK) by MERL treatment did not affect cell death. Conclusion: These results suggest that MERL mediated cell death is associated with an intrinsic apoptotic pathway in AGS cells.