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Pharmacological Actions of New Woohwangchungsimwon Pill on Cardiovascular System (신우황청심원의 심혈관계에 대한 약효)

  • Cho, Tai-Soon;Lee, Sun-Mee;Kim, Nak-Doo;Huh, In-Hoi;Ann, Hyung-Soo;Kwon, Kwang-Il;Park, Seok-Ki;Shim, Sang-Ho;Shin, Dae-Hee;Park, Dai-Kyu
    • YAKHAK HOEJI
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    • v.41 no.6
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    • pp.802-816
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    • 1997
  • In order to investigate the pharmacological properties of New Woohwangehungsimwon Pill (NWCH). Effects of Woohwangehungsimwon Pill (WCH) and NWCH were compared using various experimental models. In isolated rat aorta, NWCH and WCH showed the relaxation of blood vessels in maximum contractile response to phenylephrine ($10^{-6}$M) without regard to endothelium containing or denuded rings of the rat aorta. Furthermore, the presence of the inhibitors of NO synthase and guanylate cyclase did not affect significantly the relaxative effects of NWCH and WCH. NWCH and WCH inhibited the vascular contractions induced by acethylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats(SHRs), NWCH and WCH decreased significantly heart rate. These, at high doses, had a negative inotropic effect that was a decrease of LVDP and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In excised guinea-pig papillary muscle, these had no effects on parameters of action potential at low doses, whereas inhibited the cardiac, contractility at high doses. Furthermore, these had a significant inhibitory effects on heart acceleration in normotensive rats and SHRs. These results suggested that NWCH and WCH have weak cardiovascular effects, and that there is no significant differences between two preparations.

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Development of the ice resistance series chart for icebreaking ships

  • Lee, Chun-Ju;Joung, Tae-Hwan;Lew, Jae-Moon
    • International Journal of Naval Architecture and Ocean Engineering
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    • v.10 no.6
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    • pp.794-802
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    • 2018
  • The ice resistance series charts for icebreaking ships were developed through a series of systematic model tests in the ice tank of the Korean Research Institute of Ship and Ocean Engineering (KRISO). Spencer's (1992) component-based scaling system for ship-ice model tests was applied to extend the model ship correlations. Beam to draft ratio (B/T), length to beam ratio (L/B), block coefficient ($C_B$) and stem angle (${\alpha}$) were selected as geometric parameters for hull form development. The basic hull form (S1) of twin pod type with B/T of 3.0, L/B of 6.0, $C_B$ of 0.75 and stem angle of $25^{\circ}$ was generated with a modern hull design concept. A total of 13 hulls were designed varying the geometric parameters; B/T of 2.5 and 3.5, L/B of 5.0 and 7.0, $C_B$ from 0.65 to 0.85 in intervals of 0.05, and 5 stem angles from $15^{\circ}$ to $35^{\circ}$. Ice resistance tests were first carried out with the basic hull form in level ice with suitable speed. Four more tests for $C_B$ variations from 0.65 to 0.85 were conducted and two more for beam to draft and length to beam ratios were also performed to study the effect of the geometric parameters on ice resistance. Ice resistance tests were summarized using the volumetric coefficient, $C_V$ ($={\nabla}/L^3$), instead of L/B and $C_B$ variations. Additional model tests were also carried out to account for the effect of the stem angle, ice thickness and ice strength on ice resistance. In order to develop the ice resistance series charts with a minimum number of experiments, the trends of the ice resistance obtained from the experiments were assumed to be similar for other model ship with different geometric parameters. A total of 18 sheets composed of combinations of three different beam to draft ratios and six block coefficients were developed as a parameter of $C_V$ in the low speed regions. Three correction charts were also developed for stem angles, ice thickness and ice strength respectively. The charts were applied to estimate ice resistance for existing icebreaking ships including ARAON, and the results were satisfactory with reasonable accuracy.

Experimental analysis of the sedimentation processes by variation of standing angle in the improved-pneumatic-movable weir (실내실험에 의한 가동보 기립각도 변화에 대한 토사의 퇴적 과정 분석)

  • Lee, Kyung Su;Jang, Chang-Lae
    • Journal of Korea Water Resources Association
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    • v.51 no.9
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    • pp.795-802
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    • 2018
  • This study investigates the hydraulic characteristics and the delta development processes in the improved-pneumatic-movable weir by considering the standing angle of the weir through laboratory experiments. The delta migration speed decreases rapidly with time. As the ratio of delta height to water depth increases, the dimensionless delta migration speed decreases at the delta point. Therefore, the water depth decreases as the delta height increases. Although the delta volume is large due to the effective height of the delta, the delta migration speed and sediment deposition decreases because of the backwater effect on the delta. On the same bed slope condition, the larger the weir height, the larger the delta volume and the ratio of delta height to delta front length is close to 1.0. The delta development could be suppressed when the weir is high. Therefore, the condition that the weir is high has the suppressing effect on the delta developments.

The study on scheme for train position detection based on GPS/DR (GPS/DR기반의 차상열차위치검지방안 연구)

  • Shin, Kyung-Ho;Joung, Eui-Jin;Lee, Jun-Ho
    • Proceedings of the KSR Conference
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    • 2006.11b
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    • pp.802-810
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    • 2006
  • For a thorough train control, the precise train position detection is necessarily required. The widely used current way for train position detection is the one of using track circuits. The track circuit has a simple structure, and has a high level of reliability. However trains can be detected only on track circuits, which have to be installed on all ground sections, and much amount of cost for its installation and maintenance is needed. In addition, for the track circuit, only discontinuous position detection is possible because of the features of the closed circuit loop configuration. As the recent advances in telecommunication technologies and high-tech vehicle-based control equipments, for the train position detection, the method to detect positions directly from on trains is being studied. Vehicle-based position detection method is to estimate train positions, speed, timing data continuously, and to use them as the control information. In this paper, the features of GPS navigation and DR navigation are analyzed, and the navigation filters are designed by constructing vehicle-based train position detection method by combining GPS navigation and DR navigation for their complementary cooperation, and by using kalman filter. The position estimation performance of the proposed method is also confirmed by simulations.

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Comparison of Volatile Organic Components in Fresh and Freeze Dried Garlic (생마늘과 동결건조마늘의 휘발성 유기성분 비교)

  • Kim, Youn-Soon;Seoa, Hye-Young;No, Ki-Mi;Shim, Sung-Lye;Yang, Su-Hyeong;Park, Eun-Ryong;Kim, Kyong-Su
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.34 no.6
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    • pp.885-891
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    • 2005
  • The study was carried out to find the effect of freeze drying on the volatile organic components in garlic (Allium sativum L.). The volatile organic compounds from fresh and freeze dried garlic were extracted by simultaneous steam distillation and extraction (SDE) method and identified with GC/MS analysis. A total of 42 and 32 compounds were identified in fresh and freeze-dried garlic, respectively. Sulfur containing compounds in the garlic samples were detected as the major compounds, and alcohols, aldehydes and esters were detected as minor compounds. Diallyl disulfide, diallyl trisulfide, allyl methyl disulfide and ally1 methyl trisulfide were the main sulfur compounds in fresh and freeze dried garlic. The amount of sulfur containing compounds were decreased freeze-drying but methyl propyl trisulide, 3- allylthiopropionic acid, cyclopentyl ethyl sulfide etc. were increased. The others, non- sulfur containing compounds such as ethyl acetate, ethanol, 2-propenol, 2- propenal and hexanal were increased in freeze-dried garlic. Consequently, the total amount of volatile organic compounds in garlic became lower during freeze-drying from 853.42 mg/kg to 802.21 /kg, and the composition of major components were nearly same in fresh and freeze-dried garlic.

Effect of Co-existence of Carbaryl and Chlorothalonil on the Short-term Bioconcentration Factor in Carassius auratus(goldfish) (Carbaryl과 Chlorothalonil의 공존이 Carassius auratus(goldfish)를 이용한 생물농축계수에 미치는 영향)

  • 민경진;김근배;차춘근;박천만;강회양
    • Journal of Environmental Health Sciences
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    • v.22 no.4
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    • pp.16-24
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    • 1996
  • This study was performed to investigate the effect of co-existence of carbaryl and chlorothalonil on the short-term bioconcentration factor in Carassius auratus(goldfish). The fishes were exposed to the combined treatment of carbaryl and chlorothalonil(0.05 ppm+0.005 ppm, 0.05 ppm+0.010 ppm, 0.10 ppm+0.005 ppm) for 1, 3 and 5 days, respectively. Carbaryl and chlorothalonil in fish and in test water were extracted with n-hexane and acetonitrile. GC-ECD was used to detect and quantitate carbaryl and chlorothalonil. 1-day, 3-day and 5-day bioconcentration factors($BCF_1, BCF_3$ and $BCF_5$) of each pesticide were calculated from the quantitation results. The depuration rate of each pesticide from the whole body of fish was determined over the 72-h period after combined treatment. The results were as follows: $BCF_1$ values of carbaryl were 3.521, 3.802 and 3.587, respectively, when the concentration of carbaryl and chlorothalonil in combined treatment were 0.05+0.005, 0.05+0.010 and 0.10+0.005 ppm. BCF3 values of carbaryl were 4.825, 4.556 and 3.828, respectively, and $BCF_5$ values of carbaryl were 3.974, 3.921 and 4.186, respectively, under the conditions. While $BCF_1$ of chlorothalonil were 0.829, 0.829 and 1.540, respectively, under the same condition of pesticide concentrations $BCF_3$ of chlorothalonil were 2.040, 2.208 and 3.633, respectively, and $BCF_5$ of chlorothalonil were 6.222, 6.667 and 7.095, respectively, under the conditions. Depuration rate constants of carbaryl were 0.022, 0.022 and 0.152, respectively, when the concentration of carbaryl and chlorothalonil in combined treatment were 0.05+0.005, 0.05+0.010 and 0.10+0.005 ppm. While depuration rate constants of chlorothalonil were 0.004, 0.004 and 0.006, respectively, under the same condition of pesticide concentrations. It was observed that no significant differences of carbaryl and chlorothalonil concentration in fish extracts, test water and $BCF_s$ of carbaryl and chlorothalonil between combined treatment and single treatment. It was considered that no appreciable interaction at experimental concentrations was due to low concentrations, 0.005~0.1 ppm. Co-existence of carbaryl and chlorothalonil had no effect on excretion of each pesticide and depuration rate of chlorothalonil was investigated 1/8 slower than that of carbaryl in combined treatment. Therefore, it is considered that the persistence of chlorothalonil in fish body would be higher than that of carbaryl.

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Application of Priority Order Selection Technique for Water Quality Improvment in Stream Watershed by Relationship of Flow and Water Quality (유량-수질관계 비교를 통한 하천 수질개선 우선순위 선정기법 적용)

  • Lim, Bong-Su;Cho, Byung-Wook;Kim, Young-Il;Kim, Do-Young
    • Journal of Korean Society of Environmental Engineers
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    • v.32 no.8
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    • pp.802-808
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    • 2010
  • This study was carried out to apply the method of priority order selection for water quality improvement of watershed. The monitoring of flow and water quality, grouping branch streams and discharge load density were estimated on 18 branch streams located in middle and lower area of Geum River, Chungcheongnam-do. Based on average BOD concentration of stream at low flow, the results of the water quality analysis of stream which excess river living standard class 2 (less than BOD 3 mg/L) are Jeongancheon, Bangchukcheon, Gilsancheon, Jocheon, Seokseongcheon and Ganggyeongcheon. As a result of grouping stream, stream that have more than $10\;m^3/min$ of flow and more than 3.0 mg/L of average BOD concentration such as Group A are Jocheon, Seokseongcheon, Ganggyeongcheon and Jeongancheon. In Group A, stream corresponds to over than discharge load density as of 10 BOD kg/$day{\cdot}km^2$ is Jocheon, Seokseongcheon and Ganggyeongcheon. In view of the selected results to improve water quality basin through monitoring of flow and water quality, grouping stream, and estimation of discharge load density, Jocheon in Yeongi, Seokseongcheon located on the border of Buyeo and Nonsan, Ganggyeongcheon on Nonsan such as stream basin were urgent to improve water quality.

A study on improving fairness and congestion control of DQDB using buffer threshold value (버퍼의 문턱치값을 이용한 DQDB망의 공평성 개선 및 혼잡 제어에 관한 연구)

  • 고성현;조진교
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.22 no.4
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    • pp.618-636
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    • 1997
  • DQDB(Distributed Queue Dual Bus) protocol, the IEEE 802.6 standard protocol for metropolitan area networks, does not fully take advantage of the capabilities of dual bus architecture. Although fairness in bandwidth distribution among nodes is improved when using so called the bandwidth balancing mechanism, the protocol requires a considerable amount of time to adjust to changes in the network load. Additionally, the bandwidth balancing mechanism leaves a portion of the available bandwidth unused. In a high-speed backbone network, each node may act as a bridge/ router which connects several LANs as well as hosts. However, Because the existence of high speed LANs becomes commonplace, the congestionmay occur on a node because of the limitation on access rate to the backbone network and on available buffer spaces. to release the congestion, it is desirable to install some congestion control algorithm in the node. In this paper, we propose an efficient congestion control mechanism and fair and waster-free MAC protocol for dual bus network. In this protocol, all the buffers in the network can be shared in such a way that the transmission rate of each node can be set proportional to its load. In other words, a heavily loaded node obtains a larger bandwidth to send the sements so tht the congestion can be avoided while the uncongested nodes slow down their transmission rate and store the incoming segments into thier buffers. this implies that the buffers on the network can be shared dynamically. Simulation results show that the proposed probotol significantly reduces the segment queueing delay of a heavily loaded node and segment loss rate when compared with original DQDB. And it enables an attractive high throughput in the backbone network. Because in the proposed protocol, each node does not send a requet by the segment but send a request one time in the meaning of having segments, the frequency of sending requests is very low in the proposed protocol. so the proposed protocol signigificantly reduces the segment queuing dely. and In the proposed protocol, each node uses bandwidth in proportion to its load. so In case of limitation of available buffer spaces, the proposed protocol reduces segment loss rate of a heavily loaded node. Bandwidth balancing DQDB requires the wastage of bandwidth to be fair bandwidth allocation. But the proposed DQDB MAC protocol enables fair bandwidth without wasting bandwidth by using bandwidth one after another among active nodes.

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Comparative Analysis of Economic Efficiency by Major Sericultural Farming Areas in Korea (잠업단지의 경제효율에 관한 비교분석)

  • 이질현;김문협;강석권
    • Journal of Sericultural and Entomological Science
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    • v.14 no.2
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    • pp.95-103
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    • 1972
  • The major purpose of this study is to collect the information related on the aspects of economic efficiency for solving the problems which are faced by farmers and areas, and providing scientific facts to farmers and related institutions for further development of sericultural sector in Korea. In order for obtaining the related information 12 sample areas among 23 major sericultural farming areas and 30 farm units in each area are selected and analyzed in this study. The fold suevey is made by member of this study team and graduate students in the Department of Sericultural Science with a prepared questionnaires. Cross-section and regression analysis methods are employed for processing the data in this study. The major findings obtained are as followings. 1. Sericultural earnings per Tanbo is, on the average, 22, 752 won in new cultivated areas and 29, 403 won in ordinary ones. There are big difference in the size of earnings by areas, especially, 46, 968 won in Kumo mountain area, compared with 16, 798 won in Yeoju and Yichun areas. General trend is finded that small scale farming units are made higher earnings and operating their farms efficiently. 2. Cocoon production expences per Tanbo is 16, 737 won in new cultivated areas and 19, 802 won in ordinary areas. There are also big difference in farming expences, especially, 27, 389 won in Sudang area, compared with 11, 689 won in Emjin area. 3. Sericultural income per Tanto is 10, 664 won in ordinary areas and 6, 898 won in new cultivated areas. Farmers in Kumo mountain area make the highest income of 21, 164 won and lowest income of 1, 296 won in Sudang area. It can be generized that about 30-50 a sized farmers make higher income. 4. Land, labor and capital productivities estimated by fitting Cobb-Douglas functions in ordinary areas are higher than in new cultivated areas, especially, labor productivity is higher in ordinary areas. 5. Changsung, Kwangna, Yunsun and Kumo mountain areas are technically and economically efficient. Sudang and Mujinchang areas are technically successful but economically inefficient and Emjin and Honam areas are technically inefficient but economically efficient. YeojuYichun, Chunwon and West Kyongnam are technically and economically inefficient. Technical and economic improvement program should be implemented for these areas. 6. Estimated Internal Rate of Return (IRR) on capital investment in Chongwon are is 23.5 percent. It is economically feasible, if we consider 20 percent of opportunity cost of capital in our economy.

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Effects of Natural Antioxidants on Lipid Oxidation of Ground Pork (천연항산화제가 분쇄돈육의 지질산화에 미치는 효과)

  • Shin, Teak-Soon;Moon, Jeom-Dong;Kim, Yong-Kon;Kim, Young-Jik;Park, Tea-Seon;Lee, Jeong-Ill;Park, Gu-Boo
    • Korean Journal of Food Science and Technology
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    • v.30 no.4
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    • pp.794-802
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    • 1998
  • This study was conducted to investigate the effects of antioxidants on lipid oxidation in uncooked ground pork which was treated with ${\alpha}-tocopherol$, GFSE (grapefruit seed extract), carnosine and rosemary, respectively. The ground pork samples were uncooked and cooked during 10 days of storage at $4{\pm}1^{\circ}C$, respectively. The lipid oxidation and fatty acids composition were analyzed for over a periods of storage day. From the results mentioned above, antioxidative activity on lipid oxidation of uncooked ground pork appeared to be in order of carnosine > rosemary > ${\alpha}-tocopherol$ > GFSE. It would not be problem that addition of carnosine in uncooked ground of resulted in an increase of pH because the high pH could be advantageous on processing of meat. Antioxidative activity on lipid oxidation of cooked ground pork appeared to be in order of carnosine > rosemary > ${\alpha}-tocopherol$ > GFSE. Although the antioxidants were not lost their antioxidative }ctivities after cooking, their antioxidative activities in cooked ground pork were not higher than that of uncooked ground pork. That addition of carnosine increased the pH of cooked ground pork, too.

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