• Title/Summary/Keyword: 6q24

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Identification of Genomic Aberrations by Array Comparative Genomic Hybridization in Patients with Aortic Dissections

  • Suh, Jong-Hui;Yoon, Jeong-Seob;Kwon, Jong-Bum;Kim, Hwan-Wook;Wang, Young-Pil
    • Journal of Chest Surgery
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    • v.44 no.2
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    • pp.123-130
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    • 2011
  • Background: The aim of the present study was to identify chromosomal loci that contribute to the pathogenesis of aortic dissection (AD) in a Korean population using array comparative genomic hybridization (CGH) and to confirm the results using real-time polymerase chain reaction (PCR). Materials and Methods: Eighteen patients with ADs were enrolled in this study. Genomic DNA was extracted from individual blood samples, and array CGH analyses were performed. Four corresponding genes with obvious genomic changes were analyzed using real-time PCR in order to assess the level of genomic imbalance identified by array CGH. Results: Genomic gains were most frequently detected at 8q24.3 (56%), followed by regions 7q35, 11q12.2, and 15q25.2 (50%). Genomic losses were most frequently observed at 4q35.2 (56%). Real-time PCR confirmed the results of the array CGH studies of the COL6A2, DGCR14, PCSK6, and SDHA genes. Conclusion: This is the first study to identify candidate regions by array CGH in patients with ADs. The identification of genes that may predispose an individual to AD may lead to a better understanding of the mechanism of AD formation. Further multicenter studies comparing cohorts of patients of different ethnicities are warranted.

Subjectivity study on the perception types of body shape in the pregnant women

  • Cha, Su-Joung
    • Journal of the Korea Society of Computer and Information
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    • v.24 no.12
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    • pp.101-108
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    • 2019
  • The purpose of this study was to investigate the subjective evaluation and the characteristics of each type of maternal self-awareness. It was to provide the basic data necessary for the development of clothing that can improve the satisfaction of the body shape of pregnant women. This study was conducted with Q methodology, and was performed for pregnant women over 6 months. Analysis was done with QUANL program. The recognition types of body shape of pregnant women was analyzed as three types: thin limbs and central hemispherical abdominal body shape, under abdomen protruding body shape, and thick upper arm and central abdomen protruding body shape. The thin limbs and central hemispherical abdominal body shape were considered to be normal, with the lowest BMI index before pregnancy. And the limbs were thin and the other parts were not overweight, but recognized that only the belly came out. The under abdomen protruding body shape was overweight with the highest BMI index before pregnancy. In addition to the circumference of the chest and hips, the body was gaining weight and was perceived to have a belly drooping down. The thick upper arm and central abdomen protruding body shape recognized that the middle part of the abdomen protruded like the first type, but it was different from the first type because the upper arm was thickened. In the future study, it would be a meaningful study to compare and analyze the difference with the recognition body of this study through analyzing the actual body shape of pregnant women.

Chocolate consumption and the prevalence of metabolic syndrome in the Korean adult population: an analysis based on the 2014-2016 Korea National Health and Nutrition Examination Survey

  • Kim, NaRae;Jeon, Min-Sun
    • Nutrition Research and Practice
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    • v.15 no.1
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    • pp.80-94
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    • 2021
  • BACKGROUND/OBJECTIVES: Recent studies have reported chocolate consumption has beneficial effects on blood pressure, obesity, and dyslipidemia, which are components of metabolic syndrome (MetS). However, evidence regarding these relationships in Asia is limited. The aim of this study was to investigate relations between chocolate consumption and MetS in Korea. SUBJECTS/METHODS: Study subjects were 6,982 adults aged 19-64 years free of major chronic diseases that participated in the 2014-2016 Korea National Health and Nutrition Examination Survey. Information on chocolate consumption was obtained using food frequency questionnaires. For primary analysis, subjects were divided into two groups: non-consumer (n = 3,741, 53.6%); consumer (n = 3,241, 46.4%). In order to investigate dose-response effects on MetS, chocolate consumers were divided into quartiles based on amounts consumed: Q1 (n = 789, 24.3%); Q2 (n = 837, 25.8%); Q3 (n = 863, 26.6%); Q4 (n = 752, 23.2%) in second analysis. RESULTS: Chocolate consumers; 1) were more physically active(P < 0.0001); 2) less likely to smoke(P < 0.0001); 3) paid more attention to food nutrition labels (P < 0.0001), and 4) had healthier dietary patterns, that is, they consumed vegetables, fruits, and dairy products more frequently(P < 0.0001) than non-consumers. Furthermore, chocolate consumers had a 30% lower risk of MetS (odds ratio, 0.70; 95% confidence interval, 0.58-0.86; P = 0.0005). However, dose-response effects between chocolate intake and MetS was not found by secondary analysis after excluding non-consumers. CONCLUSIONS: In conclusion, chocolate consumers had healthier lifestyles and dietary patterns and a lower prevalence of MetS than non-consumers, as determined by our primary analysis. Although dose-response effects were not found to be significant among chocolate consumers during secondary analysis, the patterns were partially similar. This cross-sectional finding shows chocolate consumption does not increase the risk of MetS. The prospective studies and intervention trials in Korea are needed to confirm this cross-sectional finding.

Surgical treatment of patent ductus arteriosus in adult (성인에 있어서 동맥관개존증의 외과적 치료)

  • Mun, Byeong-Tak;Kim, Sang-Hyeong;Lee, Dong-Jun
    • Journal of Chest Surgery
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    • v.17 no.1
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    • pp.32-40
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    • 1984
  • During the past six years from July 1977 to June 1983, fifteen adult patients of patent ductus arteriosus were surgically treated. The results were as follows: 1. Of the 15 patients, their age range was 17 to 34 years with a mean of 24 years, and sexual predominance was women [9. cf. 6 men]. 2. The most common symptom showed exertional dyspnea, and 10 patients were classed in NYHA class II, the rest were all class III. 3. On physical examination, all patients were auscultated continuous murmur, but concomitantly diastolic murmur was noted apical region in 2 patients. 4. On roentgenogram of chest, normal finding was 3 patients, and the other patients were revealed the evidence of pulmonary congestion. 5. The electrocardiogram was normal in 6 patients, but LVH was seen in 5, and 2 patients were LVH+ LAH. 6. Cardiac catheterization was performed in 12, and mean value of SO2[LPA-RV] was 6.3%, Q/Q 2.09, peak systolic pulmonary arterial pressure 45.3 mmHg, and Rp/Rs 0.365. 7. All operations were carried out by posterolateral thoracotomy. In 6 patients, division and suture of ductus were possible, the other patients were treated by division and ligation with heavy silk or Dacron patch. 8. Postoperative complications were hoarseness, persistent murmur, reoperation for bleeding, and atelectasis. Early and late mortality was 20% [3 patients], and cause of death was mainly aneurysmal rupture of previous operative site.

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Biomass and Net Primary Productivity in Natural Forests of Quercus mongolica and Quercus variabilis (신갈나무와 굴참나무 천연림(天然林) 생태계(生態系)의 현존량(現存量) 및 물질(物質) 생산성(生産性)에 관한 연구)

  • Song, Cheel Young;Lee, Soo Wook
    • Journal of Korean Society of Forest Science
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    • v.85 no.3
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    • pp.443-452
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    • 1996
  • A study has been made to estimate biomass and NPP based on equation form of $Wt=aD^bH^c$ for Quercus variabilis and Quercus mongolica natural stands(Mean age; 67, 62yrs old) in Chungju. Equation form of $Wt=aD^bH^c$ was more adequate than $Wt=a(D^2H)^b$ and $Wt=aD^b$ for the estimation of the biomass and NPP. Individual biomass was compared using a paired t-test by tree component which showed no significant differences. Total aboveground biomass of Quercus mongolica was 130.6 t/ha and that of Quercus variabilis was 137.4 t/ha. Biomass of Q. mongolica was composed of foliage 5.1 t/ha(3.9%), dead branch 3.5 t/ha(2.7%), live branch 29.7 t/ha(23.0%), bolebark 16.2 t/ha(12.5%), and bolewood 74.9 t/ha(58.0%), and that of Q. variabilis was composed of foliage 3.8 t/ha(2.9%), dead branch 2.9 t/ha(2.2%), live branch 24.3 t/ha(18.4%), bolebark 20.4 t/ha(15.5%), and bolewood 80.4 t/ha(61.0%). Net primary production was 10.0 t/ha/yr in the Q. mongolica stand and 8.6 t/ha/yr in the Q. variabilis stand, respectively. Net primary production of Quercus forest in Chungju was very close to the mean NPP of the broadleaved forest of temperate zone.

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Effects of Felling of Damaged Tree of Pine Wilt Disease on Soil Respiration in Pinus densiflora Stands (소나무재선충병 피해목 벌채가 토양호흡에 미치는 영향)

  • Cho, Min-Gi;Jeon, Kwon-Seok;Park, Jun-Ho;Kim, Jong-Kab;Moon, Hyun-Shik
    • Journal of agriculture & life science
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    • v.43 no.2
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    • pp.9-15
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    • 2009
  • The objectives of this study was to obtain the basic information for reasonable management of soil ecosystem damaged by pine wilt disease. Soil temperature and moisture content were $15.3{^{\circ}C}$ and 11.5% at whole-cut site, $14.4{^{\circ}C}$ and 13.5% at partial-cut site, and $13.7{^{\circ}C}$ and 14.8% at control site, respectively. The content of soil organic matter throughout the study period ranged from 2.11 to 2.64% at whole-cut site, 2.26 to 3.33% at partial-cut site, and 2.27 to 3.10% at control. Soil respiration rates showed seasonal fluctuations increasing in summer, which showed positive correlations between soil respiration and soil temperature. Average soil respiration were 0.24, 0.36 and $0.32gCO_{2}/m^{2}/hr$ at whole-cut site, partial-cut site, and control, respectively. $Q_{10}$ values ranged from 2.39 to 2.68 at Pinus densiflora stands damaged by pine wilt disease. Annual soil respiration rate at whole-cut site, partial-cut site and control were 8.1, 15.6 and $14.6tCO_{2}/ha/yr$, respectively.

QTL Analysis of Concerned on Ideal Plant Form in Rice (벼의 이상적인 초형에 관여하는 QTL 분석)

  • Chung, Il Kyung;Kim, Kyung-Min
    • Korean Journal of Plant Resources
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    • v.30 no.2
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    • pp.213-218
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    • 2017
  • Rice is the staple food of at least half of the world's population. Due to global warming, the weather is difficult to forecast nowadays. Therefore, it is necessary to breed various breeding to respond to such changes in the environment. This study was conducted to analyze the QTL about plant form, culm length, ear number and ear length by using 120 lines by anther culture, a cross between the Indica variety Cheongcheong and Japonica variety Nagdong. DNA marker was selected on the QTLs gene, and the following results were obtained. CNDH (Cheongcheong Nagdong Doubled Haploid) lines frequency distribution table curves about culm length, ear number and ear length exhibited showed a continuous variation close to a normal distribution. QTL analysis result, on culm length qPlL1-1 and qPlL1-2 were detected on the chromosome 1 and qPlL5 was detected on the chromosome 5. However, on ear length qPL2, qPL3 and qPL10, were detected on the chromosome 2, 3 and 10, while on ear number qPN1-1 and qPN1-2 were detected on the chromosome 1, qPN9 was detected on the chromosome 9. The QTLs related to culm length was found to chromosomes 5 and LOD scores were 3.81. The QTLs related to ear length was found to chromosomes 2 and 3 LOD scores were 7.13 and 3.20. The QTLs related to ear number was found to chromosome 9 and LOD scores were 4.27. Twenty two (22) Japonica cultivars and 12 Indica cultivars were analyzed polymorphisms, using selected 9 markers from the result about plant form analysis. RM5311, RM555 and RM8111 about the culm length, the ear length and number of ear were selected on the standard of Cheongcheong and Nagdong. Each rate of concordances about the culm length, the ear length and number of ear are 44.11%, 41.17% and 44.11%.

Mapping of Quantitative Trait Loci Associated with Viviparous Germination in Rice

  • Lee, Seung-Yeob;Ahn, Jeong-Ho;Cha, Young-Soon;Yun, Doh-Won;Lee, Myung-Cheol;Eun, Moo-Young
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.51 no.6
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    • pp.565-570
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    • 2006
  • The viviparous germination (VG) with lodging caused the yield reduction and quality deterioration in rice. We carried out the evaluation of VG tolerance (on the 40th day after heading) and mapping QTLs associated with VG tolerance using the recombinant inbred lines (M/G RILs) from a cross between Milyang 23 (japonica/indica) and Gihobyeo (japonica). The VG rates of Milyang 23 and Gihobyeo were 0.0 and 7.0%, respectively. The averaged VG rate of 162 M/G RILs was 7.7%, and their range was from 0.0 to 50.9%. Of the 162 RILs, 144 lines were tolerant less than 10%, and 18 lines were susceptible more than 10%. Using the M/G RIL Map, three QTLs associated with the viviparous trait were detected on chromosome 2 (qVG 2-1 and qVG 2-2) and 8 (qVG 8). qVG 2-1 was linked to RM 32D and RZ 166, and had LOD score of 2.97. qVG 2-2 was tightly linked to E13M59.119-Pl and E13M59.M003-P2, and showed higher LOD score of 3.41. qVG 8 was linked to RM33 and TCT116, and had LOD score of 2.67. The total phenotypic variance explained by the three QTLs was about 24.4% of the total variance in the population. The detection of new QTLs associated with VG tolerance will provide important informations for the seed dormancy, low temperature germination, or comparative genetics.

The Study of Kinetic Visual Acuity in College Students (대학생의 동적시력에 관한 연구)

  • Shim, Moon-Sik;Kim, Sang-Hyun;Kang, Hye-Sook;Shim, Hyun-Suk
    • Journal of Korean Ophthalmic Optics Society
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    • v.17 no.4
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    • pp.419-424
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    • 2012
  • Purpose: We were to obtain the basic data for studying kinetic visual acuity through the comparative analysis in kinetic visual acuity, visual acuity, refractive error, pupil size, and hand reaction time for college students. Methods: We had tested the kinetic visual acuity, visual acuity, refractive error and hand reaction time using the kinetic visual acuity tester (KOWA AS-4A), the hand reaction time program and auto-refractometer for thirty-nine male and same female optometry students with more than +0.1 LogMAR visual acuity in both eyes. And the results were examined gender differences of kinetic visual acuity and the factors correlation. Results: In the measured values of male, pupil size were 6.00 mm, hand reaction time 0.23 msec, refractive error -1.66 D, visual acuity -0.07, kinetic visual acuity 0.59 and pupil size 5.86 mm, hand reaction time 0.24 msec, refractive error -2.08 D, visual acuity -0.02, kinetic visual acuity 0.46 in female. It was significant difference for kinetic visual acuity values but other factors were not. The kinetic visual acuity and left visual acuity had the highest correlation, r=-0.406. The kinetic visual acuity indicated more excellent values in the case of increasing visual acuity and decreasing myopia amount. Conclusions: It was able to see that male college students were better than female for kinetic visual acuity and the visual acuity were related to kinetic visual acuity.

Big Data! What do you think about that ? ; Using the Subjectivity of Sports Practitioner (빅 데이터!, 당신의 생각은 어떠하십니까? : 스포츠실무자의 주관성을 바탕으로)

  • Choi, Jai Seuk;Lee, Doh-Hee
    • The Journal of the Korea Contents Association
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    • v.21 no.5
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    • pp.149-156
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    • 2021
  • This study started from the question of what we think about big data as the term "big data" was used and discussed in our daily lives in the era of the 4th industrial revolution. For the analysis, the final 30 Q samples were selected based on prior research related to big data, and 23 respondents were secured for Q analysis, and the following results were derived. First, the explanatory power of each type was 34.30% for , 8.03% for , 7.21% for , and 6.24% for , showing a total of 55.69%. Second, the Q sample emphasized by respondents by each type shows various occupational distributions in , and for 'big data', it is 'digital' and future'. So they were named 「Digital Type」. In , the distribution of 'social workers' was high, and for 'big data', 'future', 'collaboration', 'welfare', 'local residents', and 'defense' were emphasized. It was named 「welfare type」. In , the job distribution of respondents appeared evenly, and it was named as 「Convergence Type」. Because it emphasized statements such as 'convergence', 'digital', 'future', and 'sports'. is composed of association officials, sports instructors, and graduate students, and was named 「Artificial Intelligence Type」, because it emphasizes 'artificial intelligence', 'new paradigm', 'network', and 'sports'. In the age of knowledge industrialization and knowledge informatization that followed industrialization and informatization, how to process and utilize the numerous data accumulated over the years is an important task. Right now, in sports, more than anything else, it is necessary to continuously seek ways to utilize and activate accumulated big data.