• Journal of the Korean Home Economics Association
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• v.46 no.8
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• pp.97-107
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• 2008

This study was conducted in order to identify the relationship between psychological factors, such as depression and self-esteem, and nutritional status, such as nutritional risk index and nutrient intake, among the elderly in Chunnam Province. The participants were 119 elderly individuals over the age of 65 years who visited the Senior Welfare Center in Chunnam province between January 29 and February 2, 2007. This study was conducted using a structured questionnaire that included, the Center for Epidemiologic Studies Depression Scale (CES-D), General Self Efficacy Scale (GSES), Nutritional Screening Initiative Checklist (NSI checklist), questions pertaining to the general characteristics of the participants and an estimation of nutrient intake using the 24-hour recall method. Data were analyzed by the SPSS program. Analysis of the participant's CES-D scores revealed that 43.7% of the subjects were normal and 56.3% had more than mild depression. The mean GSES score was 45.9 for the entire group of subjects (51.9 for men, 43.6 for women). The mean nutritional risk index value was 4.30 (5.03 for men, 4.01 for women). Analysis of the participant's scores on the NSI checklist revealed that 69.7% of the subjects were normal and 30.3% exhibited a moderate nutritional risk. The CES-D was positively correlated with the NSI checklist (p < 0.05) but negatively correlated with nutrient intake. However, the GSES was negatively correlated with the NSI checklist (p < 0.05), but positively correlated with nutrient intake (P < 0.01 for protein, calcium, phosphorus, zinc etc.). The results of this study indicate that it is necessary to manage psychological factors, including depression and self-esteem, in the elderly in order to decrease their nutritional risk and increase their nutrient intake.

• Fire Science and Engineering
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• v.24 no.5
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• pp.39-49
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• 2010

In order to find out the environment vulnerable to cigarette fire in which smoldering fire grows into flame fire, a cigarette combustion test and numerical analysis were performed using fallen leaves of P. densiflora and Q. variabilis. Tests were repeated five times on 2,304 conditions with four cases of fuel moisture content, six cases of velocity, two cases of cigaret location against direction of the wind, three cases of cigaret location against fallen leaves, two species of thickness of cigaret, two cases of slope conditions and two cases of fragileness of fallen leaves. Cigaret fire's flammability to the fallen leaves was monitored by analyzing heat transfer process using CFD (Computational Fluid Dynamic) under the most optimal condition through an ignition test on 2,304 conditions. The result of a cigaret fire ignition test for fallen leaves, found ignition in 197 conditions out of 2,304 conditions representing 8.6% while 13 conditions representing approximately 0.6% saw ignition across five repeated tests. The result of CFD analysis, the temperature of the bottom of fallen leaves was reached on self-ignition and pilot-ignition temperature.

• Phonetics and Speech Sciences
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• v.6 no.3
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• pp.23-32
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• 2014

This study presents the prosodic characteristics of 'Motherese' and 'Teacherese (child care teacher and kindergarten teacher)'. 21 mothers and 24 teachers spoke to children in the child care center or kindergarten. Children are in their 4;00-6;11. Speech and articulation rate, number of accentual phrases (APs), number of intonational phrases (IPs), pitch-related factors (f0, pitch range, f0 standard deviation), and intonation slope (mean Absolute, f0, q-tone slope) were measured. 2 groups spoke 2 sentential types (interrogative_ alternative question, declarative_ coordinated sentence) in 2 situations (one accompanied with the children, the other done without children, but pretending as if they were in front of the children). The results indicate that teachers show more noticeable prosodic characteristics than mothers do.

• Analytical Science and Technology
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• v.32 no.1
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• pp.24-34
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• 2019

The safety of food is occasionally questionable, as there have been some reports of products contaminated with illegal adulterants. In this study, the presence of 16 sedative-hypnotics and sleep inducers in dietary supplements was determined by ultra-high-performance liquid chromatography with UV detection (UPLC-UV) and quadruple Orbitrap mass spectrometry (Q-Orbitrap-MS). The UPLC method was validated, providing a linearity (R2) of more than 0.999, and LODs and LOQs that ranged from 0.2 to 0.5 and 0.6 to $1.5{\mu}g\;mL^{-1}$, respectively. The repeatabilities were 0.2-8.4 % (intra-day) and 0.3-4.5 % (inter-day), and the accuracies were 89.0-117.0 % (intra-day) and 87.8-111.9 % (inter-day). The mean recoveries of the spiked samples ranged from 98.7 to 107.3 %. The relative standard deviation (%RSD) of the stability was less than 2.4 %. Using the developed method, one sedative-hypnotic compound, phenobarbital, was detected in one of the nineteen samples tested. In addition, the major characteristic fragment ions of each target compound were confirmed using Q-Orbitrap-MS for higher accuracy. Monitoring the presence of these 16 sedative-hypnotics and sleep inducers in dietary supplements should be pursued in the interest of human health, and the results of this study confirmed that the developed method has value for this application.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.6
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• pp.2231-2235
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• 2015

Genome-wide association studies (GWASs) of the entire genome provide a systematic approach for revealing novel genetic susceptibility loci for breast cancer. However, genetic association studies have hitherto been primarily conducted in women of European ancestry. Therefofre we here performed a pilot GWAS with a single nucleotide polymorphism (SNP) array 5.0 platform from $Affymetrix^{(R)}$ that contains 443,813 SNPs to search for new genetic risk factors in 89 breast cancer cases and 46 healthy women of Indonesian ancestry. The case-control association of the GWAS finding set was evaluated using PLINK. The strengths of allelic and genotypic associations were assessed using logistic regression analysis and reported as odds ratios (ORs) and P values; P values less than $1.00{\times}10^{-8}$ and $5.00{\times}10^{-5}$ were required for significant association and suggestive association, respectively. After analyzing 292,887 SNPs, we recognized 11 chromosome loci that possessed suggestive associations with breast cancer risk. Of these, however, there were only four chromosome loci with identified genes: chromosome 2p.12 with the CTNNA2 gene [Odds ratio (OR)=1.20, 95% confidence interval (CI)=1.13-1.33, $P=1.08{\times}10^{-7}$]; chromosome 18p11.2 with the SOGA2 gene (OR=1.32, 95%CI=1.17-1.44, $P=6.88{\times}10^{-6}$); chromosome 5q14.1 with the SSBP2 gene (OR=1.22, 95%CI=1.11-1.34, $P=4.00{\times}10^{-5}$); and chromosome 9q31.1 with the TEX10 gene (OR=1.24, 95%CI=1.12-1.35, $P=4.68{\times}10^{-5}$). This study identified 11 chromosome loci which exhibited suggestive associations with the risk of breast cancer among Indonesian women.

• Clinical and Experimental Pediatrics
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• v.53 no.3
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• pp.432-436
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• 2010

Transient neonatal diabetes mellitus (TNDM) has been associated with paternal uniparental isodisomy of chromosome 6, paternally inherited duplication of 6q24, or a methylation defect at a CpG island of the ZAC or HYMAI gene. We experienced a case of TNDM in which the patient presented with hyperglycemia, macroglossia, and intrauterine growth retardation, caused by a paternally derived HYMAI. An 18-day-old female infant was admitted to the hospital because of macroglossia and recurrent hyperglycemia. In addition to the macroglossia, she also presented with large fontanelles, micrognathia, and prominent eyes. Serum glucose levels were 200-00 mg/dL and they improved spontaneously 2 days after admission. To identify the presence of a maternal methylated allele, bisulfite-treated genomic DNA from peripheral blood was prepared and digested with BssHII after polymerase chain reaction (PCR) amplification with methylation-specific HYMAI primers. PCR and restriction fragment length polymorphism analysis showed that the patient had only the paternal origin of the HYMA1 gene. TNDM is associated with a methylation defect in chromosome 6, suggesting that an imprinted gene on chromosome 6 is responsible for this phenotype.

• Journal of Life Science
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• v.29 no.5
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• pp.514-523
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• 2019

We investigated the gene expression patterns and the mechanisms of action of the apoptotic response by microarray analysis of human keratinocyte HaCaT cells treated with ginsenoside Rb1, a saponin of Panax ginseng C. A. Meyer. Genes related to apoptosis, the G2/M transition of the mitotic cell cycle, cell division, mitotic nuclear division, and intracellular protein transport were 2-fold up-regulated in HaCaT cells treated with the ginsenoside Rb1, whereas genes related to DNA repair, regeneration fission, and extracellular matrix organization were 2-fold down-regulated. Apoptosis signaling may be mediated by FAS and PLA2G4A, and pathway analysis indicated that STAT3 might be an upstream regulator of these genes. The activity of FAS and PLA2G4A was verified by qPCR, which showed that FAS was increased about 2-fold in HaCaT cells treated with $10{\mu}g/ml$ of ginsenoside Rb1 for 24 hr, PLA2G4A was increased about twice after 6 hours, and gene expression was increased more than 2-fold after 24 hr. Knockdown of STAT3 with siRNA decreased FAS expression and increased PLA2G4A expression but only FAS was passed from the upstream regulator STAT3. These results indicate that STAT3, which is an upstream regulator, induces apoptosis via FAS during treatment with ginsenoside Rb1.

• The Korean Journal of Ecology
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• v.24 no.6
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• pp.371-376
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• 2001

The rate of soil respiration to varying stand ages was studied in four Robinia pseudoacacia stands(18-, 23-, 28- and 35-year old) throughout one year from September 1998 to August 1999. Soil temperatures showed a pronounced seasonal pattern, in contrast to soil moisture. The highest rate of soil respiration was generally found in August when soil temperatures were the highest, and the lowest in January. The daily rate of soil respiration amounted to 5.51($g\;CO_2{\cdot}m^{-2}{\cdot}day^{-1}$) for 18-year old stand, 5.28 for 23-year old stand, 8.29 for 28-year stand, and 2.67 for 35-year old black locust stand, respectively. The $Q_{10}$ values were ranged between 1.63 and 1.66, averaging 1.65 for the R. pseudoaca'cia stands. The results indicate significant correlation between soil temperature and soil respiration for all four stands(r=0.96 to 0.97). Among the study stands, the annual rate of soil respiration was the highest ($3.03kg\;CO_2{\cdot}m^{-2}{\cdot}yr^{-1}$) for 28-year old stand.

• The Korean Journal of Ecology
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• v.24 no.6
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• pp.341-348
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• 2001

Population dynamics of the oldest relic stand of Pinus densiflora for. erecta which remains as a status of patch in Sokwang-Ri area, Uljin-Gun, was studied to provide the basic data for conservation of the oldest pine stand in Korea. The upper slope site and ridge site including total 12 plots mainly represented Pinus densiflora for. erecta and Quercus mongolica. These two tree species showed reverse J-shaped distribution. From this information, it was concluded that intensive interspecific competition between two species could be occurring. Age distribution of P. densiflora for. erecta on the sites above middle slope area was indicated bi-modal type or tri-modal type which was known as an age structure of climax forest. Therefore, it was estimated that Pinus densiflora for. erecta population could be continuously maintained in the each patch above middle slope area. In the valley sites, hardwood species such as Q. mongolica, Q. variabilis, Styrax obassia and Acer pseudosieboldianum occupied most part of the under crown-cover area and their seedlings and saplings were developing into the closed upper layer crown because the height of upper layer crown reached about 35 meters and such a high crown height was more suitable for light utilization by plants of under layer. The growth patterns were mainly fluctuated for the entire life time of the oldest tree caused by frequent disturbance. And the initial growth curves of the mature trees and suppressed juvenile trees showed different tendencies along the sites.

• Journal of Veterinary Clinics
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• v.16 no.2
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• pp.469-473
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• 1999

A 120 kg, 3-year-old, male ostrich (Struthio camelus) was submitted to the veterinary teaching hospital, Chonbuk national university, for chronic weight loss, anorexia, small hard fecal pellets, and lethargy. Illness was first noticed approximately 2 weeks before submission. Although the bird was able to stand, he was extremely weak and cachectic. Blood examination indicated that the bird was dehydration (PCV: 55%). Fluoroscopic and lateral abdominal radio-graphic view indicated impaction of distended proventriculus with bigger rocks than normal. Anesthesia was induced with ketamine (10 mg/kg, IV)-xylazine (1 mg/kg, IV) combination and maintained with ketamine (10 mg/kg, IV) at intervals of 8 to 15 minutes during the entire procedure. After induction of general anesthesia, the bird was positioned in dorsal recumbency. The skin was incised approximately 15cm caudal to the caudal margin of the sternum and extended 20 to 25 cm caudally. After the proventriculotomy was peformed, the impacted material that weighed 3kg contained rocks in 4 to 6cm diameter was removed. The incision of proventriculus was closed in 2 layers. Cephalothin sodium (30 mg/kg, IV, q12hrs) and dexamethazone (2 mg/kg, IM, q24hrs) was administered before and after 5 days of the operation. The bird was eating well and defecating normal feces after 3 weeks of the surgery