• Title/Summary/Keyword: 6R-1

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[$(3aR^*,6aS^*)$-6a-Hydroxy-Asymmetric Synthesis of cyclopenta[b]pyrrole-3a-carboxylate and Determination of Its Stereostructure via NMR Spectrum ($(3aR^*,6aS^*)$-6a-Hydroxy-cyclopenta[b]pyrrole-3a-carboxylate의 부제합성 및 NMR 스텍트럼을 통한 입체구조의 결정)

  • Kwon, Soon-Kyoung;Park, Myoung-Suk;Seo, Won-Jun
    • YAKHAK HOEJI
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    • v.38 no.5
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    • pp.544-554
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    • 1994
  • Pyrrolidine-2,3-dione derivative A was synthesized from oxalylation of chiral enamine Ba. The stereostructure of its major diastereomer $(A_{maj})$ was determined as octahydro-2,3-dioxo-6aS-hyd roxy-1-(1S-methoxycarbonyl-2-phenylethyl)-cyclopenta[b]pyrrole-3aR-carboxylic acid ethyl ester Aa by means of NMR spectrum. This result implied that the asymmetric carbon-carbon bond forming reaction occurred preferentially at the ${\beta}-face$ of Ba.

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Complete Assignment of the $^H1$ and $^{13}C$ NMR Spectra of a Sucrose Ester from Euphorbia Lathyris L.

  • Jung, Min-Hwan;Kim, Hyun-Sik;Sangdoo Ahn;Kim, Cheong-Taek;Jin, Mu-Hyun;Yim, Yong-Hyeon;Kim, Young-Kook;Jong hoa Ok
    • Journal of the Korean Magnetic Resonance Society
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    • v.4 no.2
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    • pp.125-132
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    • 2000
  • The detailed $^1$H and $^{13}$ C NMR assignments of a novel sucrose isovaleryl ester isolated from the seed of Euphorbia Lathyris L., were achieved by one-and two-dimensional techniques. The new sucrose ester was characterized as an $\alpha$-D-glucopyranoside, 3,4,6-tris-O-(3-methyl-1-oxobutyl)-$\beta$-D-fructofuranosyl, 2,6-bis(3-methylbutanoate); sucrose 4,7,8,11,12-pentaisovalerate by MS and NMR experiments.

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Effects of Herbal Recipe Herb Mix Gold® on the Performance of Laying Birds (개량 한방제제(Herb Mix Gold®) 첨가가 산란계 생산성에 미치는 영향)

  • Lee, W.S.;Paik, I.K.
    • Korean Journal of Poultry Science
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    • v.34 no.1
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    • pp.37-42
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    • 2007
  • This study was conducted to investigate the effects of graded levels of a herbal recipe(Herb Mix $Gold^{(R)}$, Herb BIO Co.) supplemented to a commercial layer diet. The Herb Mix $Gold^{(R)}$ is an improved recipe of Herb $Mix^{(R)}$, fortified with Angelica gigas, Discorea japonica and Ligusticum jeholense. A total of 720 layers (Hy-Line Brown) of 45 wks old were assigned to one of six treatments; control, 0.2% Herb $Mix^{(R)}$, 0.1%, 0.2%, and 0.3% Herb Mix $Gold^{(R)}$, and 6 ppm Avilamycin. Each treatment had 6 replicates of 20 birds each housed in 2 birds cages. Birds were fed diets and water ad libitum for 5 weeks. Hen-day egg production was significantly (P<0.05) different among treatments. Herb Mix $Gold^{(R)}$ 0.2% treatment showed the highest egg production followed by Herb Mix $Gold^{(R)}$ 0.3%, Herb $Mix^{(R)}$ 0.2%, Herb Mix $Gold^{(R)}$ 0.1%, Avilamycin 6 ppm and the control. Hen-housed egg production, egg weight, soft and broken egg ration, feed intake, feed conversion ratio, shell strength, shell thickness, shell color index, Haugh unit and yolk color index were not significantly different among treatments. Nor was cfu of Cl. perfringens and E. coli and Lactobacilli in the small intestinal content significantly different among treatments. The number of white and red blood cells, hemoglobin, heterophil, lymphocyte, thus heterophil to lymphocyte ratio were not significantly modified. It was concluded that Herb Mix $Gold^{(R)}$ at the level of 0.2% in the layer diet improves laying performance.

Effect of Planting Density on Growth and Yield Components of the Sweet Sorghum Cultivar, 'Chorong' (재식밀도가 '초롱' 단수수의 생육 및 수량구성요소에 미치는 영향)

  • Choi, Young Min;Han, Hyun-Ah;Shin, So-Hee;Heo, Byong Soo;Choi, Kyu-Hwan;Kwon, Suk-Ju
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.64 no.1
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    • pp.40-47
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    • 2019
  • This study was conducted to investigate the effect of planting density on plant growth, yield, and quality in the sweet sorghum cultivar 'Chorong' (Sorghum bicolor (L.) Moench). Plants were cultivated at densities of 16.7, 11.1, 8.3, 6.7, and $5.6plants{\cdot}m^{-2}$. Factors related to yield and yield components were analyzed using correlation and multivariate analyses. There was no significant difference among plant densities in stem length from 20 to 110 days after sowing. But the stem diameter was thin, and a decrease in number of tillers occurred more rapidly as planting density increased. At harvest, juice and sugar yield were higher at densities of 16.7 (42.9, $4.16Mg{\cdot}ha^{-1}$, respectively) and 11.1 (37.1, $3.73Mg{\cdot}ha^{-1}$) $plants{\cdot}m^{-2}$ than at 8.3 (30.5, $2.96Mg{\cdot}ha^{-1}$), 6.7 (26.6, $2.41Mg{\cdot}ha^{-1}$), and 5.6 (24.7, $2.22Mg{\cdot}ha^{-1}$) $plants{\cdot}m^{-2}$. The soluble solids and total sugar contents were not different among treatments, but relatively high values were observed at the density of 11.1 and $8.3plants{\cdot}m^{-2}$. As plant density was increased from 5.6 to $11.1plants{\cdot}m^{-2}$, the lodging index (1 = no, 9 = lodging) increased rapidly from 2.00 to 6.33. To determine the optimal planting density, the number of typhoons and topographical characteristics should be considered. Correlation and principal components analyses revealed that plant density exhibited a positive relationship with fresh stem yield ($r=0.62^{**}$), dry stem yield ($r=0.58^{**}$), juice ($r=0.63^{**}$), and sugar yield ($r=0.66^{**}$), but a negative with stem diameter ($r=-0.65^{**}$). The yield factors were not statistically related to stem height, diameter, and number of nodes.

Spectrophotometric Determination of Scandium(III) with Eriochrome Cyanine R in the Presence of Cetyltrimethylammonium bromide (Cetyltrimethylammonium bromide에서 Eriochrome Cyanine R에 의한 스칸듐(III)의 분광광도법 정량)

  • Cha, Ki-Won;Park, Chan-Il;Kim, Jong-Whon
    • Analytical Science and Technology
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    • v.9 no.2
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    • pp.139-144
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    • 1996
  • The spectrophotometric determination method of scandium with eriochrome cyanine R(ECR) and the composition ratio of the complex were investigated in the presence of surfactants. The absorbance increase and red shift of maximum adsorption wavelength of Sc(III)-ECR complex were observed in cetyltrimethylammonium bromide (CTMAB), but those changes were not observed in the sodium dodecyl sulfate(SDS) and Triton X-100. A volume of 5ml of $1{\times}10^{-3}M$ ECR and 10ml of $2{\times}10^{-4}M$ CTMAB are necessary for the determination of $1{\times}10^{-7}{\sim}3.0{\times}10^{-6}M$ Sc(III) at pH 6.5. The apparent molar absorption coefficient of the Sc(III)-ECR-CTMAB, temary complex at 610nm is $5.6{\times}10^5mol^{-1}cm^{-1}L$ and its detection limit is $1.0{\times}10^{-7}M$. The binary complex composition of Sc(III)-ECR is 1:2 and the ternary complex composition of Sc(III)-ECR-CTMAB is 1:3:1.

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Direct Synthesis of ${\eta}^6$-1-Functionally Substituted 2,3,4,5-Tetraphenyl-1-Silacyclopentadiene Complexes of Chromium

  • Wan-Chul Joo;Jang-Hwan Hong;Hong Lae Sohn;Eun-Kyoung Kang;Chang-Hwan Kim
    • Bulletin of the Korean Chemical Society
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    • v.11 no.1
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    • pp.31-33
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    • 1990
  • We synthesized the novel complexes of (1,1-dimethyl-3,4-diphenyl-1-silacyclopenta-2,4-di ene-2,5-yldibenzene)bis(tricarbonylchromium) and tricarbonyl (R,R'-3,4,5-triphenyl-1-silacyclopenta-2,4-diene-2 -ylbenzene)chromium(R,R' = Me, R = Me/R' = Cl, R = Ph/R' = Cl) from the reaction of the corresponding R,R'-2,3,4,5-Tetraphenyl-1-silacyclopenta-2,4-dien e (abr. R,R'-TPSCp) with chromiumhexacarbonyl. These results reveal that chromium prefer to coordinate to the phenyl substituents of 1-silacyclospentadiene rather than the butadiene moiety of the ring.

A Study on the Factors of the school health Teachers' Self-confidence Affecting the School Nursing Activities in Jeonbuk Province (전북지역 양호교사의 업무수행과 자신감과 그에 영향하는 요인에 관한 연구)

  • Yang, Koung-Hee
    • Research in Community and Public Health Nursing
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    • v.1 no.1
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    • pp.582-594
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    • 1989
  • The purpose of this study is to analyze the factors affecting the school health teachers' self-confidence. This study was conducted with 87 school health teachers working in Jeonbuk province, from September to December, 1986, The results are follows; 1. Demographic characteristics of school health teachers 1) Age mean ; 34, range; 23-54 2) School Nursing experience mean; 11 years, range; 0-24 3) Clinical experience mean; 1.5 years, range: 0-13 2. Status of school health resources & nursing activities 1) Personnel resource school health teacher: pupils : 1 : 1,436 'classes=1:31 'general teacher=1:39 2) Budget Total school operating budget: School health budget : 100 : 4.2 (52.2 thousand Won) Half of the school health budget expend on medicine. 3) Clinic 80% of all schools have health clinic seperately. 71.32 of all schools have less than $35m^2$, 23.9%, $36-66m^2$. 4) Only 20% of all schools have organization for health 5) Average of clinic visitor for 1 year; 2,084 Major problem is on digestive system. And other problem: respiratory, skin, musculo - skeletal system, dental problem, etc... 6) Literal message for 1 year; 12 times. For health education (4), vaccination (3), examination of parasites (2), etc... 3. The degrees of the school health teachers' self-confidence 1) Program planning & evaluation; 2.9. 2) Clinic management; 2.8 3) Health education; 2.8 4) Management of school environment; 2.7 5) Health care services; 2.5. 6) Operating of school health organization; 2.3 4. Significances to self-confidence on school health nursing activities 1) Program planning & evaluation: home message (r=.228, p<.05) No. of clinic visitor (r=.220, p<.05) expending time for clinic management (r=.229, p<.05) religion (t: 2.5, p<.05) level of school (F=6.3, p<.005) 2) Clinic management: age of school health teacher (r=-.202, p<.05) school health experience (r=-.211, p<.05) salary step (r=.187, p<.05) expending time for clinic management (r=.315, p<0.1) marital status (t=3.97, p<.005) level of school (F=3,139, p<0.5) 3) Management of school environment: level of school (F=3.899, p<.05) expending time for clinic management (r=-,216, p<0.5) 4) Health care service: age of school health teacher (r=-.186, p<.05) marital status (t= 3.67, pH.005) 5) Health education: expending times for clinic management (r=-.252, p<05) level of school (F=5.343, p<.01) 6) Operating of health organization; age of school health teacher (r=-.258, p<.01)salary step (r=.188, p<.05) Based on the above results, the suggestions are as follows; 1. Need to raise ,appointment rate school health teacher. 2. Need to raise self-confidence on school health nursing activities through the inservice education or re-inforcement. 3. Need to secure adequate budget for school health. 4. Participation of school health teacher and support of school master for school health services are required. 5. Need for use the health clinic seperately, adequate facilities and free utilization by visitors.

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Studies on the Mutation Breeding in Castanea SP. (방사선(放射線)에 의(依)한 밤나무의 돌연변이(突然變異) 육종(育種)에 관(關)한 연구(硏究))

  • Kim, Chi Moon
    • Journal of Korean Society of Forest Science
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    • v.25 no.1
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    • pp.80-84
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    • 1975
  • The seeds, scions and plants of chestnut tree (Castanea. crenata) and Chinese chestnut tree (C. bungeana) were irradiated by gamma ray in order to know their biological effects on germination, plant growth and mutation at several accumulative doses and dose rates. The results of this study could be summarized as follows: 1. In general, the radio-sensitivity of scions was more sensitive to irradiation, showing 50% reduction dose of the control for grafting percentage at 3.1 kR as compared with 4.6 kR for the above reduction dose in germination rates of seeds. 2. The seeds treated by 5 kR dose resulted in some albino mutants at a rate of 0.84%. There was a general tendency that the seedling height reduced significantly as the irradiation dose increased. 3. The scions treated by an acute irradiation showed their 50% reduction dose in grafting at 3.2 kR for Chinese chestnut and at 3.1 kR for chestnut, respectively, while their irradiation doses increased three times, having 10.2 kR for the 50% reduction dose in the case of semi-acute irradiation. 4. When Chinese chestnut trees were irradiated during their dormant period with a total dose of 7.5 kR to 4.9 kR at a dose rate of 150 R to 98 R per day, there were induced giant leaf bud-sports at a frequency of 16.6%. The averag leaf area of the giant leaf bud-sports were measured at 96.36 square centimeters, while the area of normal leaf was only 26.28 square centimeters.

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HQSAR Analysis on Novel series of 1-(4-Phenylpiperazin-1-yl-2-(1H-Pyrazol-1-yl) Ethanone Derivatives Targeting CCR1

  • Balasubramanian, Pavithra K.;Cho, Seung Joo
    • Journal of Integrative Natural Science
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    • v.6 no.3
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    • pp.163-169
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    • 2013
  • The chemokine receptor CCR1 a GPCR super family protein contains seven transmembrane domains. It plays an important role in rheumatoid arthritis, organ transplant rejection, Alzheimer's disease and also causes inflammation. Because of its role in disease processes, antagonism of CCR1 became an attractive therapeutic target. In the current study, we have taken a novel series of recently reported CCR1 antagonist of 1-(4-Phenylpiperazin-1-yl_-2-(1H-Pyrazol-1-yl) ethanone derivatives and performed a HQSAR analysis. The model was developed with Atom (A) and bond (B) parameters and with different set of atom counts to improve the model. The results of HQSAR showed good predictive ability in terms of $r^2$ (0.904) and $q^2$ (0.590) with 0.710 as standard error of prediction and 0.344 as standard error of estimate. The contribution map depicted the atom contribution in inhibitory effect. Compound-14 which was reported to be a highly active compound showed positive atom contribution in three R groups ($R^3$. $R^{5a}$ and $R^{2b}$) in inhibitory effect, which could be the reason why this compound is highly active compound whereas, the lowest active compound-6 showed negative contribution to inhibitory effect.

Karyotype Analysis and Physical Mapping of rDNAs Using McFISH in Jeffersonia dubia Benth (깽깽이풀의 핵형분석과 McFISH를 이용한 rDNA의 물리지도 작성)

  • Kim, Soo-Young;Choi, Hae-Woon;Koo, Dal-Hoe;Kim, Chan-Soo;Bang, Jae-Wook
    • Korean Journal of Medicinal Crop Science
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    • v.13 no.1
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    • pp.48-51
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    • 2005
  • Karyotype analysis and chromosomal locailization of 45S and 5S rDNAs using McFISH (multi-color fluorescence in situ hybridization) were carried out in Jeffersonia dubia Benth., which is one of medicinal plants belonging to Berberidaceae. The somatic metaphase chromosome number was 2n=2x=12 and the size of chromosomes ranged $1.95{\sim}3.50\;{\mu}m$. The chromosome complement consisted of two pairs of metacentrics (chromosomes 1 and 3), two pairs of submetacentrics (chromosomes 2 and 4) and two pairs of subtelocentrics (chromosomes 5 and 6). In McFISH, one pair of 45S rDNA site was detected on the centromeric region of chromosome 2 and three pairs of 5S rDNA sites were detected on the short arm of chromosomes 4, 5 and 6, respectively.