• Transactions of the Korean Society of Automotive Engineers
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• v.2 no.6
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• pp.94-101
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• 1994

About vibration model of Six-degrees-of-freedom(DOF), in mass load, examined results for knowing dynamic interference and response variation is as follows; In case of putting mass load upon the object, experimented results on two-degrees-of-freedom of the translation-1 direction and the rotation-1 direction at open-loop-control system, about 0.19 arcsed in input of the translation-$0.1{\mu}m$ and $0.022{\mu}m$ on input of the rotation-0.5 arcsec, the justicse of motion equation is acknowledged as confirming the appearance of the interference-$0.022{\mu}m$. In establishing calculation of transformation matrix by using analogue circuit, as simulating results that used incomplete differentiation, interference is $1.7{\times}10^{-3}$ arcsec on input of the translation-$0.1{\mu}m$ and $1.4{\times}10^{4}{\mu}m$ on input of the rotation-0.5 arcsec in open-loop-control system. Also it is $4.2{\times}10^{-4}$ arcsec on input of the translation-$0.1{\mu}m$ and $5.6{\times}10^{-5}{\mu}m$ on input of the rotation-0.5 arcesc in closed-loop-control system. As closed-loop-control system is better than open-loop-control system, equivalent accordance is confirmed on original response. Finally, fundamental validity of this theory is acknowledged.

• The Journal of Korean Medicine
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• v.24 no.3
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• pp.145-154
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• 2003

Background : Production of cytokines by bronchial epithelial cells may contribute to the local accumulation of inflammatory cells in patients with bronchial asthma. In many recent studies, molecular biological methods have been used to investigate the role of cytokines in pathogenesis and new therapeutic targets of asthma. Objective : We aimed to identify the dose-dependent inhibitory effects of Lonicerae Flos and Paeoniae Radix on the mRNA expression of IL-6, IL-16, and GM-CSF involved in the asthma model. Materials and Methods : In the study BEAS-2B cell lines, human epithelial cells were used. These cells were stimulated with tumor necrosis factor $(TNF)-\alpha$ for artificial inflammatory expression. ${\beta}-actin$ messenger RNA (mRNA) was used for internal standard. After 24 hours of Lonicerae Flos, Paeoniae Radix, total cellular RNAs were collected treating RNA zol directly on the living cells. Then the transcriptional activities of IL-6, 16, GM-CSF were measured by RT- PCR with electrophoresis. Results : In the Lonicerae Flos study, the mRNA expression of IL-6, IL-16 and GM-CSF was showed no inhibitory effect compared to the control group in all concentrations. In the Paeoniae Radix study, the mRNA expression of IL-6, IL-l6 and GM-CSF was showed no inhibitory effect compared to the control group in all concentrations. Conclusion : This study shows that Lonicerae Flus and Paeuniae Radix have no inhibitory effects on the mRNA expression of IL-6, IL-16 and GM-CSF in BEAS-2B cell lines, human epithelial cells. Advanced studies are required to investigate the other mechanisms of inhibitory effect by Lonicerae Flus and Paeoniae Radix in the asthma model.

• The Journal of Korean Medicine
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• v.23 no.1
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• pp.11-23
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• 2002

Objectives: We aimed to identify the dose-dependent inhibitory effects of Maekmundongcheongpye-eum and Liriopis Tuber on the mRNA expression of IL-6, IL-16, GM-CSF involved in the asthma model. Methods: In the study BEAS-2B cell lines, human epithelial cells were used. These cells were stimulated with tumor necrosis factor $(TNF)-{\alpha}$ for artificial inflammatory expression. ${\beta}-actin$ messenger RNA (mRNA) was used by internal standard. After 24 hours of Maekmundongcheongpye-eum, Liriopis Tuber-treatment, total cellular RNAs were collected, treating RNAzol directly on the alive cells. Then the transcriptional activities of IL-6, 16, GM-CSF were measured by RT-PCR with electrophoresis. Results: In the Maekmundongcheongpye-eum study, the mRNA expression of IL-6 showed 48% transcriptional inhibitory effect compared to the control group in the $100{\;}{\mu}l/ml$ category (P<0.001). In the IL-16, there was 53% and 57% transcriptional inhibitory effect compared to the control group in the $20{\;}{\mu}l/ml$ and $100{\;}{\mu}l/ml$ categories (P<0.001). In the GM-CSF, there was no inhibitory effect. In the Liriopis Tuber study, the mRNA expression of IL-6 showed 43% transcriptional inhibitory effect compared to the control group in the $100{\;}{\mu}l/ml$ category (p<0.005). In the IL-16, 34% and 26% of transcriptional inhibitory effect was shown compared to the control group in the $20{\;}{\mu}l/ml$ and $100{\;}{\mu}l/ml$ categories, respectively (P<0.05). In the GM-CSF, there was no inhibitory effect. Conclusions: This study shows that Maekmundongcheongpye-eum and Liriopis Tuber have dose-dependent inhibitory effects on the mRNA expression of IL-6 and IL-16 in BEAS-2B cell lines, human epithelial cells. Advanced studies are required to investigate the mechanisms of inhibition by herbal medicine in the asthma model.

• Korean Journal of Food Science and Technology
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• v.22 no.2
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• pp.177-182
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• 1990

The changes in the partition coefficient of model proteins (lysozyme, myoglobin, conalbumin, bovine serum albumin) in an aqueous two·phase system formed by polyethylene glycol and dextran were examined in order to improve the capacity of counter current distribution (CCD) for the protein fractionation and concentration . The protein distribution pattern in CCD with 30 tubes varied with the pH (4.5, 5.5, 6.5, 9.0, 12.0) and KCl concentration (0mM, 50mM, 250mM, 500mM) of the system. From the mixture of model proteins, pure myoglobin was appeared at the upperphase of 14th tube having 50mM of KCl at pH 5.5 and the upper-phase of 13th tube having 250mM of KCl at pH 6.5. Similarly pure BSA was obtained at the 14th tube having KCl 250mM with pH 4.5, pure lysozyme at the 19th tube having 500mM of KCl at pH 4.5 and the upper-phase of 16th tube 50mM of KCl at pH 5.5.

• Journal of the Korean Geotechnical Society
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• v.34 no.4
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• pp.49-55
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• 2018

A pre-load of bracing was imposed to prevent the horizontal displacement on the strut of the braced wall adjacent to the building during the ground excavation. For this purpose, large scale model tests were conducted, without and with pre-load on braced wall. Adjacent building load was also imposed in different locations, that were 0 m, 1D, 2D on ground surface. In this study, model tests in 1:10 scale were performed in real construction sequences, and adjacent building was 12 m in width and the size of model test pit was 2 m in width, 6 m in height, and 4 m in length. As a result, it was found that the stability of the existing building adjacent to the braced wall within Rankine's active zone could be greatly enhanced when the horizontal displacement of the braced wall was reduced by applying a pre-load. which was larger than the designated axial force on the strut of the braced wall.

• Journal of Environmental Science International
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• v.7 no.6
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• pp.833-843
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• 1998

It is noted that the red tides and the oxygen-deficient water mass are extensively developed in Masan Bay during summer. The nutrients mass balance was calculated in Masan Bay, using the three-dimensional numerical hydrodynamic model and the material cycle model. The material cycle model was calibrated with the data obtained on the field of the study area in June 1993. The nutrients mass balance calculated by the combination of the residual currents and material cycle model results showed nutrients of surface and middle levels to be transported from the inner part to the outer part of Masan Bay, and nutrients of bottom level to be transported from outer part to inner part of Masan Bay. The uptake rate of DIN in the box A1(surface level of inner part) was found to be 337. 5mg/$m^3$ㆍday, the largest value in all 9 boxes and that of DIP was found to be 18.6mg/$m^3$ㆍday in box A1, and the regeneration rate of DIN was found to be 78.2mg/$m^3$ㆍday in the box A3(bottom level of inner part), and that of DIP was found to be 18.6mg/$m^3$ㆍday in box A1. The regenerations of DIN and DIP in the water column of the entire Bay were found to be 7.66ton/day and 760kg/day, respectively. And the releases of DIN and DIP from the sediments of the entire Bay were found to be 2.86ton/day and 634kg/day, respectively. The regeneration rate was 2.5 times as high as the release rate in DIN, and 1.2 times in DIP. The results of mass balance calculation showed not only the nutrients released from the sediments but the nutrients regenerated in water column to be important in the control and management of water quality in Masan Bay.

• Geomechanics and Engineering
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• v.36 no.5
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• pp.427-440
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• 2024

This study concentrates on the 301 comprehensive caving working face, notable for its considerable mining height. The roof model is established by integrating prior geological data and the latest borehole rock stratum's physical and mechanical parameters. This comprehensive approach enables the determination of lithology, thickness, and mechanical properties of the roof within 50 m of the primary mining coal seam. Utilizing the transfer rock beam theory and incorporating mining pressure monitoring data, the study delves into the geometric parameters of the direct roof, basic roof movement, and roof pressure during the initial mining process of the 301 comprehensive caving working face. The direct roof of the mining working face is stratified into upper and lower sections. The lower direct roof consists of 6.0 m thick coarse sandstone, while the upper direct roof comprises 9.2 m coarse sandstone, 2.6 m sandy mudstone, and 2.8 m medium sandstone. The basic roof stratum, totaling 22.1 m in thickness, includes layers such as silty sand, medium sandstone, sandy mudstone, and coal. The first pressure step of the basic roof is 61.6 m, with theoretical research indicating a maximum roof pressure of 1.62 MPa during periodic pressure. Extensive simulations and analyses of roof subsidence and advanced abutment pressure under varying working face lengths. Optimal roof control effect is observed when the mining face length falls within the range of 140 m-155 m. This study holds significance as it optimizes the working face length in thick coal seams, enhancing safety and efficiency in coal mining operations.

• Journal of the Korean Magnetics Society
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• v.21 no.1
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• pp.15-22
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• 2011

It is necessary to describe the hysteresis characteristics of magnetic material precisely for the analysis or design of system with ferromagnetic materials. Although Preisach model is regarded as the most accurate method to describe the hysteresis characteristics, it is not widely applied to the real systems because of some difficulties. The conventional Preisach model shows the numerical instabilities during the iterative computations because the density distribution obtained from the sets of M-H curves are strongly localized. To remove such numerical instabilities, M-B instead of M-H is adopted as an implementation variable in normal Preisach modeling. The two dimensional computations with hysteresis characteristics by using normal Preisach modeling are tested and the result showed that the modeling by using M-B variables showed better stabilities than M-H variables.

• Journal of Power Electronics
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• v.10 no.6
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• pp.739-748
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• 2010

The increased integration of fuel cells with power electronics, critical loads, and control systems has prompted recent interest in accurate electrical terminal models of the polymer electrolyte membrane (PEM) fuel cell. Advancement in computing technologies, particularly parallel computation techniques and various real-time simulation tools have allowed the prototyping of novel apparatus to be investigated in a virtual system under a wide range of realistic conditions repeatedly, safely, and economically. This paper builds upon both advancements and provides a means of optimized model construction boosting computation speeds for a fuel cell model on a real-time simulator which can be used in a power hardware-in-the-loop (PHIL) application. Significant improvement in computation time has been achieved. The effectiveness of the proposed model developed on Opal RT's RT-Lab Matlab/Simulink based real-time engineering simulator is verified using experimental results from a Ballard Nexa fuel cell system.

• Bulletin of the Korean Chemical Society
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• v.29 no.6
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• pp.1137-1140
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• 2008

M1 RNA, the catalytic subunit of Escherichia coli RNase P, is an essential ribozyme that processes the 5' leader sequence of tRNA precursors (ptRNAs). Using KS2003, an E. coli strain generating only low levels of M1 RNA, which showed growth defects, we examined whether M1 RNA is involved in polycistronic mRNA processing or degradation. Microarray analysis of total RNA from KS2003 revealed six polycistronic operon mRNAs (acpP-fabF, cysDNC, flgAMN, lepAB, phoPQ, and puuCBE) showing large differences in expression between the adjacent genes in the same mRNA transcript compared with the KS2001 wild type strain. Model substrates spanning an adjacent pair of genes for each polycistronic mRNA were tested for RNase P cleavage in vitro. Five model RNAs (cysNC, flgMN, lepAB, phoPQ, and puuBE) were cleaved by RNase P holoenzyme but not by M1 RNA alone. However, the cleavages occurred at non-ptRNA-like cleavage sites, with much less efficiency than the cleavage of ptRNA. Since cleavage products generated by RNase P from a polycistronic mRNA can have different in vivo stabilities, our results suggest that RNase P cleavage may lead to differential expression of each cistron.