• Biomolecules & Therapeutics
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• 제10권1호
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• pp.1-6
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• 2002

The particle size of medicinal materials is an Important physical property that affects the phar-maceutical behaviors such as dissolution, chemical stability, and bioavailability of solid dosage forms. The size reduction of raw medicinal powder is needed to formulate insoluble drugs or slightly soluble medicines and to improve the pharmaceutical properties such as the solubility, the pharmaceutical mixing, and the dispersion. The objective of the present study is to evaluate physiological activity of amorphous and nano-particle prep-arations of insoluble drug, ursodeoxycholic acid (UDCA), which were made by three types of fine grinding mills. The change of physical properties of ground UDCA was conformed by Mastersiger microplus and X-ray diffraction. We have investigated hepatoprotective effects of the nano-particle preparations of UDCA by plan-etary mill, vibration rod mill and jet mill in $CCI_4$-induced oxidatively injured mouse liver. The results showed that nano-particle preparations of UDCA all decreased reactive oxygen sepecies generation and lipid peroxi-dation in $CCI_4$-induced oxidative stress mice. Among them, nano-particle preparations by vibration rod mill and jet mill showed more significantly hepatoprotective effects compared to intact UDCA and planetary mill-ground UDCA. These results suggest that ground UDCA with vibration rod mill and jet mill shows a high amorphous state and the improved dissolution.

• 한국식품영양과학회지
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• 제38권8호
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• pp.1076-1083
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• 2009

국내 소규모 쌀 가공 산업현장에서 적용될 수 있는 쌀가루의 습식제분방법을 모색하고자 수침시간(3, 6, 9 및 12 hr)을 달리한 세 가지 제분방법에 의해 제조된 쌀가루의 이화학적 특성을 비교분석하였다. 사용된 제분방법은 roller mill, pin mill 그리고 roller & pin mills 등 세 가지이다. 모든 제분기에서 수침시간이 증가할수록 미세입도 분포율이 상승하였다. 쌀가루의 미세 정도는 roller mill의 쌀가루가 가장 거칠었고 roller & pin mills는 중간정도, pin mill의 쌀가루가 가장 미세하였다. 조단백질, 조지방, 조회분은 수침시간 증가에 따라 감소하였다. 조단백질 함량은 pin mill 9, 12시간 수침에서 각각 7.66%와 7.58%로 낮게 나타났다. 수침시간 증가에 따라 L값은 증가하였고, a, b값은 감소하였다. 손상전분은 수침초기 roller mill에서 낮았으나 수침시간이 증가하면서 pin mill이 낮아져 수침 12시간에는 roller mill과 유사하였다. 그러나 roller mill & pin mills는 모든 수침시간에서 유의적으로 높은 손상전분을 나타내었다. 아밀로오스 함량은 수침시간이 증가할수록 증가하였고, 미세입도 분포율이 높은 pin mill과 roller & pin mills에서 높았다. 물 결합 능력은 쌀가루가 미세하여질수록 높게 나타났고, 손상전분이 많은 roller & pin mills에서 가장 높게 나타났다. 용해도와 팽윤력은 수침시간 증가에 따라 사용한 제분기 모두에서 지속적으로 상승하였으며, 특히 pin mill에서 용해도와 팽윤력 모두 비교적 높은 값을 나타내었다. 또한 미세구조 관찰시 수침시간 증가에 따라 pin mill 사용 시 미세한 쌀가루의 분포를 나타내었다. 이러한 결과로부터 습식제분과정 중 쌀의 수침시간과 사용한 제분기에 따라 쌀가루의 이화학적 특성 변화가 많으며, 소규모 산업현장에서 손상전분이 낮은 미세한 쌀가루를 제조하려면 충분한 수침을 통한 pin mill의 사용이 가장 적합하리라 생각된다.

• Journal of Advanced Marine Engineering and Technology
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• 제31권6호
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• pp.753-760
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• 2007

For protection of the cylinder wall of the ball mill for grinding raw ore. the inner side of the cylinder is covered with rubber liner. The rubber is easily worn down because the rubber relatively soft compared with raw ore. So the rubber liner in the ball mill cylinder must be replaced almost every year and the cost for replacing rubber liner formidable. In this paper, for reducing or excluding the cost of replacing rubber liner the basalt liner is designed. The basalt materials are generally harder than raw ore and the basalt liner in the ball mill does not wear down and so it can be used almost permanently. The concave surfaces are made on the liner of the ball mill and the liner in the cylinder wall plays also the role of raising the steel balls mixed in the raw ore. The section profiles of the concave surface have an important effect on the performance of the ball mill. The deep concave grooves raise the steel balls to high levels and give the large potential energy to the steel balls impacting to the raw ore. But if the concave grooves are too deep. the steel balls raised too high by the concave grooves fly along the parabolic path and reach to the other side of cylinder wall and so the steel balls do not play the roles of grinding the raw ore. The forces acting to a steel ball in a concave groove of the cylinder liner are also analyzed in this paper. The formulas calculating the height and the impact point of the steel ball are introduced and presented. Based to these formulas, the optimum section profiles of the basalt liner are presented.

• 한국응용과학기술학회지
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• 제24권3호
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• pp.253-263
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• 2007

Three different weather-resistant coatings were fabricated with the various weight ratios of a mill-base silicone/acrylic resin to let-down silicone /acrylic resin at 2:8, 3:7, and 4:6 respectively. The prepared coatings were tested to investigate the effect of composition of weather-resistant coatings on the physical properties. The thermal stability, salt spray exposure, and weather-resistance were improved with the increased silicone content. It was concluded that the optimum retio of mill-base silicone/acrylic resin to let-down silicone/acrylic resin would be 2:8 and the coating with 30 wt% of silicone content would have high weather-resistance.

• 대한금속재료학회지
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• 제56권12호
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• pp.845-853
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• 2018

To understand the effect of microstructural factors (i.e., the size of ${\alpha}$ phase, equiaxed vs bimodal structure) on high cycle fatigue (HCF) and fatigue crack propagation (FCP) behaviors of mill-annealed Ti-6Al-4V (Ti64) alloy, three specimens of EQ (equiaxed)-8 (8 indicates the size of ${\alpha}$ grain), BM (bimodal)-8, and BM-16 were studied. The uniaxial HCF and FCP tests were conducted at an R ratio of 0.1 under sinusoidal fatigue loading. The microstructural influence (i.e., EQ vs BM) was not significant on the tensile properties of mill-annealed Ti64 alloy, and showed an increase in tensile strength and elongation with decreasing gauge thickness from 50 mm to 1.3 mm. The microstructure, on the other hand, affected the resistance to HCF substantially. It was found that the EQ structure in mill-annealed Ti64 has better resistance to HCF than the BM structure, as a result of different crack initiation mechanism. Unlike HCF behavior, the effect of microstructural features on the FCP behavior of mill-annealed Ti64 was not significant. Among the three specimens, BM-16 specimen showed the highest near-threshold ΔK value, probably because it had the greatest slip reversibility with large ${\alpha}$ grains. The effect of microstructural factors on the HCF and FCP behaviors of mill-annealed Ti64 alloy are discussed based on fractographic and micrographic observations.

• 제어로봇시스템학회논문지
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• 제15권6호
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• pp.634-640
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• 2009

The plate manufacturing processes are composed of the reheating furnace, finishing mill, cooling process and hot leveling. The finishing rolling mill (FM) as a reversing mill has produced the plate steel through multiple pass rolling. The automatic gauge control (AGC) is employed to maintain the thickness tolerance. The high grade products are forming greater parts of the manufacturing and customers are requiring strict thickness margin. For this reason, the advanced AGC method is required instead of the conventional AGC based on the PI control. To overcome the slow response performance of the conventional AGC and the thickness measurement delay, a fuzzy AGC based on the thickness deviation and its trend is proposed in this paper. An embedded controller with the fuzzy AGC has been developed and implemented at the plate mill in POSCO. The fuzzy AGC has dynamically controlled the roll gap in real time with the programmable logic controller (PLC). On line tests have been performed for the general and TMCP products. As the results, the thickness deviation range (maximum - minimum of the inner plate) is averagely from 0.3 to 0.1 mm over the full length. The fuzzy AGC has improved thickness deviation and completely satisfied customer needs.

• 제어로봇시스템학회논문지
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• 제6권1호
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• pp.98-103
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• 2000

This paper suggests a method to recognize the various defect patterns of a cold mill strip using a binary decision tree automatically constructed by a genetic algorithm(GA). In classifying complex patterns with high similarity like the defect patterns of a cold mill stirp, the selection of an optimal feature set and an appropriate recognizer is important to achieve high recognition rate. In this paper a GA is used to select a subset of the suitable features at each node in the binary decision tree. The feature subset with maximum fitness is chosen and the patterns are classified into two classes using a linear decision function. This process is repeated at each node until all the patterns are classified into individual classes. In this way, the classifier using the binary decision tree is constructed automatically. After constructing the binary decision tree, the final recognizer is accomplished by having neural network learning sits of standard patterns at each node. In this paper, the classifier using the binary decision tree is applied to the recognition of defect patterns of a cold mill strip, and the experimental results are given to demonstrate the usefulness of the proposed scheme.

• 한국식품과학회지
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• 제28권6호
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• pp.1078-1083
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• 1996

쌀보리를 정맥기를 사용하여 도정한 정맥에 대해 제분기의 종류를 달리하여 제분한 결과 보리가루는 입도 분포에서 차이를 나타내 Jet mill로 제분한 보리가루의 입자 크기가 가장 작았으며 그 다음으로 Pin mill과 Cyclotec sample mill에 의한 입자 크기가 작았고 Ball mill과 Fitz mill에 의한 보리가루가 가장 큰 것으로 나타났다. 보리가루는 입자크기가 작을수록 색이 밝고 전분 손상도가 높은 경향을 나타냈다. 보리가루의 표면구조는 크고 작은 전분 입자, 주름진 세포벽 물질 등으로 관찰되었으며 가루 입자의 형태 및 크기가 제분기의 종류에 따라 다소 차이를 나타냈다. 보리가루는 손상된 전분의 양이 많을수록 높은 수분흡수지수 및 보수력을 나타냈으며 수분용해도지수 역시 증가하는 경향을 보여주었다. 보리가루의 호화 특성을 측정한 결과 보리가루의 점도는 입자가 크게 분쇄된 Fitz mill에 의한 보리가루에서 가장 낮았으며 Pin mill과 Cyclotec mill에서 높게 나타났다. 아주 미세하게 분쇄된 Jet mill은 호화가 빨리 진행된 반면 점도의 상승은 크지 않아 지나친 전분의 손상은 점도를 떨어뜨리는 것으로 판단되었다.

• 한국공작기계학회논문집
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• 제16권6호
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• pp.1-8
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• 2007

The ultra-fine tungsten carbide(WC) powders have been actively used in the cemented carbides industry, because they have excellent mechanical properties such as high hardness, strength, and toughness. In this study, ultra-fine WC-Co alloys powders have been fabricated by thermochemical and thermomechanical process such as spray conversion process or high energy ball milling. The non-coated end-mill which is made of ultra-fine tungsten carbide is investigated by measuring cutting force, tool wear, tool life, and surface roughness profile according to cutting length. The machining test was conducted with high hardened workpiece and their performances are investigated in high speed cutting conditions. Also, the relationship between the machining characteristics and the Co contents are investigated under various high speed cutting conditions.

• 한국토양비료학회지
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• 제32권1호
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• pp.1-6
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• 1999

To find the latent effect of paper mill sludges (PMS) with and without alum, and alum paper mill sludge compost(PMSC) on aluminum toxicity of crops, the pH buffer capacity and the acidification resistance index (ARI) for PMSs and PMSC were investigated, comparing to upland soil. Buffer capacities of PMS with and without alum, and PMSC were significantly higher than $2.5cmol^+kg^{-1}$ of check soil as 137, 250, and $147cmol^+kg^{-1}$, respectively. Owing to such high buffer capacity of PMS and PMSC, they showed to be well-resisted to acidification.