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Coronary Artery Bypass Surgery with Radial Artery -Early Results (요골동맥을 이용한 관상동맥우회술 -조기성적)

  • 나찬영;이영탁;박국양;이해영;김욱성;박?현;홍민수;심재천;권오춘
    • Journal of Chest Surgery
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    • v.30 no.3
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    • pp.275-281
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    • 1997
  • The radial artery as a graft for myocardial revascularization was introduced by Carpentier in the early 1970s. Mid-term results were unfortunately discoura ing, and the clinical experience with this graft was interrupted. At the end of the 1980s, these authors reproposed the same arterial conduit with more satisfying results, because of improved technique and pharmacological management of the graft. Between October 1994 and July 1995, 36 patients underwent myocardial revascularization with a radial artery graft in Seiong General Hospital. Left internal mammary artery was concomitantly used as a pedicled Vift in 34 patients. Fifteen patients (42%) had a complete arterial waft revascularization. A total of 12) distal anastomoses were performed (average 3.4 per patient), including 36 left internal mammary artery wafts (two sequential in 2 patients), and 23 saphenous vein grafts. The remaining 64 distal anastomoses were perFormed with radial artery grafts (mean 1.8 per patient). The radial arteries were anastomosed to the circumflex (n=38), diagonal (n= 18), right coronary(n=G), and left anterior descending coronary artery(n=2). The percent ge of radial artery graft anastomoses (64) to the total anastomoses(123) was 52%. The radial artery was used as a single graft in 10 patients, as a sequential graft in 25 patients, and two grafts in 1 patient. Twenty patients underwent associated procedures coronary endarterectomy (14), coronary artery patch angioplasty (4), mitral valve repair (1), and repair of ventricular septal rupture (1). One patient died of low cardiac output syndrome and the others had no perioperative myocardial infarction. There are no ischemic and functional complications in the arm or hand aftcr removal of the radial artery. Only 1 patient required reexploration of the am, for the hematoma evacuation, and 2 patients complained transient thumb dysesthesia of the side of the havested arm. This dysesthesia improved within one month. Postoperative angiovaphic controls were obtained in 11 patients(31%) postoperative 79 to 210 days (mean 126 days). The patency rate were as follows : left internal mammary artery (100%), saphcnous vein (100%), and radial artery(95%). We concluded that the radial artery is useful alternative graft, but long term clinical and angiographic studies are required to derterminc whether wider application is warranted.

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Antioxidant Activities and Cytoprotective Effects of Lonicera japonica Thunb. Extract and Fraction against Oxidative Stress (인동덩굴 추출물과 분획물의 항산화 활성 및 산화적 스트레스에 대한 세포 보호 효과)

  • Lee, Ye Seul;Yun, Mid Eum;Lee, Yun Ju;Park, Young Min;Lee, Sang Lae;Park, Soo Nam
    • Microbiology and Biotechnology Letters
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    • v.46 no.1
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    • pp.18-28
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    • 2018
  • In this study, the antioxidant activities and cytoprotective effects against oxidative stress of Lonicera japonica Thunb. 50% ethanol extract and ethyl acetate fraction were investigated. Using the 1,1-diphenyl-2-picrylhydrazyl assay, the free radical scavenging activity (FSC50) of L. japonica Thunb. 50% ethanol extract and ethyl acetate fraction was determined as 152.00 and $77.25{\mu}g/ml$, respectively. To measure the reactive oxygen species (ROS) scavenging activity, the total antioxidant capacity (OSC50) was determined by using a luminol-dependent chemiluminescence assay. The antioxidant activity of the ethyl acetate fraction ($0.33{\mu}g/ml$) was approximately four times stronger than that of the 50% ethanol extract ($1.12{\mu}g/ml$). The protective effect against $^1O_2$-induced cellular damage of human erythrocytes (${\tau}_{50}$) was 46.0 min at $10{\mu}g/ml$ of the 50% ethanol extract and 52.3 min at $1{\mu}g/ml$ of the ethyl acetate fraction. We also investigated the cytoprotective effects against oxidative stress induced by $H_2O_2$ and the intracellular ROS scavenging activity in response to UVB irradiation and found that the extract and fraction protected human skin cells from damage and reduced ROS. These results confirmed that L. japonica Thunb. was a valuable plant-derived natural antioxidant with potential for development as an antioxidative functional ingredient.

A Rapid Analysis of 226Ra in Raw Materials and By-Products Using Gamma-ray Spectrometry (감마분광분석을 이용한 원료물질 및 공정부산물 중 226Ra 신속분석방법)

  • Lim, Chung-Sup;Chung, Kun-Ho;Kim, Chang-Jong;Ji, Young-Yong
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.15 no.1
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    • pp.35-44
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    • 2017
  • A gamma-ray peak of $^{226}Ra$ (186.2 keV) overlaps with one of $^{235}U$ (185.7 keV) in a gamma-ray spectrometry system. Though reference peaks of $^{235}U$ can be used to correct the peak interference of $^{235}U$ in the analysis of $^{226}Ra$, this requires a complicated calculation process and a high limit of quantitation. On the other hand, evaluating $^{226}Ra$ using the correction constant in the overlapped peak can make a rapid measurement of $^{226}Ra$ without the complicated calculation process as well as overcome the disadvantage in the indirect measurement of $^{214}Bi$, which means the confinement of $^{222}Rn$ gas in a sample container and a time period to recover the secular equilibrium. About 93 samples with 6 species for raw-materials and by-products were prepared to evaluate the activity of $^{226}Ra$ using the correction constant. The results were compared with the activity of $^{214}Bi$, which means the indirect measurement of $^{226}Ra$, to validate the method of the direct measurement of $^{226}Ra$ using the correction constant. The difference between the direct and indirect measurement of $^{226}Ra$ was generally below about ${\pm}20%$. However, in the case of the phospho gypsum, a large error of about 50% was found in the comparison results, which indicates the disequilibrium between $^{238}U$ and $^{226}Ra$ in the materials. Application results of the contribution ratio of $^{226}Ra$ were below about ${\pm}10%$. The direct measurement of $^{226}Ra$ using the correction constant can be an effective method for its rapid measurement of raw materials and by-products because the activity of $^{226}Ra$ can be produced with a simple calculation without the consideration of the integrity of a sample container and the time period to recover the secular equilibrium.

The Differentiation of the Cholinergic Nerve Cells at the Meynert Basal Nucleus of the Basal Forebrains in the Growth Period of Rat (흰쥐 전뇌 기저부 Meynert기저핵에서 출생 후 발육기간에 따른 콜린성 신경세포의 분화)

  • Hahm, Young-Ok;Kim, Soo-Jin
    • Applied Microscopy
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    • v.31 no.4
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    • pp.355-365
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    • 2001
  • This study was performed to investigate the distribution and differentiation on the immunoreacted cells of the ChAT (choline acetyltransferase) at the Meynert basal nucleus of the forebrains in the growth periods of rat, using the immunohistochemistric method. According to the cell shape and the ratio of long axis vs short axis of cell soma, the ChAT antibody reacted nerve cells in the Meynert basal nucleus of the rats were classified into six types. In the adult rats, the FD (frequency distributions) of round, oval and elongated cells were maximum. The FD of these types were shown to be progressively decreased during the postnatal development. In addition, the FD of elongated nerve cells in were observed in the adult rats respectively. This was thought to be the same phenomenon as those in the round and oval cells . The total mean volume of ChAT antibody reacted cell somata was lowest in the PND (postnatal days) 7 rats and was highest in the PND 21 rats. But, those were decreased to the adult. These results suggest that ChAT antibody reacted nerve cells grow up to PND 21 and then, differentiate into the various types by neurites outgrowing. On the electron micrography, the adult rat forebrain cells were obtained to be well developed ribosomes, polysomes , rough endoplasmic reticula and mitochondria. The immunreactivities were observed in ribosomes, polysomes, rough endoplasmic reticula and outer membrane of mitochondria. Golgi complexes were poorly developed and not showed jmmunreactivity. The ribosomes , polysomes and endoplasmic reticula are considered to be closely related to the inter cellular localization and biosynthesis of the ChAT but not Golgi complex. According to the results in the present study, it is considered that the ChAT-immunoreacted nerve cells in the Meynert basal nucleus of the rat forebrains are differentiated throughout the postnatal development with following processes of changes; 1) the cholinergic nerve cells develop postnatally 2) cell soma volumes gradually increase during the early postnatal days 3) and then, cells differentiate into the various types by projecting the neurites to the appropriate area after PND 21.

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글로벌 아트페어(Global Art Fair) 비평적 읽기

  • Sim, Sang-Yong
    • The Journal of Art Theory & Practice
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    • no.6
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    • pp.51-76
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    • 2008
  • Nous obserbons dans le champs de l'art aujourd' hui, le changement radical provoquant $\'{e}$tant donn$\'{e}$ que le pouvoir du march$\'{e}$ de l'art s'augmente de plus en plus. C'est pour cela que le champ du discours de l'art n'est actuellement plus form$\'{e}$ par des notions esth$\`{e}$tiques artistiques, mais par celles qui sont r$\'{e}$serv$\'{e}$es au domaine de l'$\'{e}$conomie et du march$\'{e}$. Il n'est plus significatif de croire la valeur esth$\`{e}$tique de l'oeuvre d'art, puisque l'esth$\`{e}$tique elle-m$\^{e}$me ne fonctionne plus. Par contre, le syst$\`{e}$me de donner le prix $\`{a}$ l'oeuvre d'art fonctionne rigoureusement. En plus, cette situation s'aggrave $\'{e}$tant donn$\'{e}$ que la mondialisation du march$\'{e}$ de l'art s'installe avec rapidit$\'{e}$. Malgr$\'{e}$ la mondialisation de l'art, des gens qui habitent par exemple $\`{a}$ S$\'{e}$oul ne peuvent pas s' approcher facilement de ce qui se passe $\`{a}$ New York, le vrai centre de l'art contemporain. Dans cette situation, le champ de discours de l'art n'a pas d'autre solution de se r$\'{e}$tr$\'{e}$cir remaquablement et le sujet de discussion sur le grand art est remplac$\'{e}$ par celui du success de l'art. Cette recherche est arriv$\'{e}$e $\`{a}$ remarquer que le syst$\`{e}$me du foire internationale de l'art fonctionne comme une locomotive dans le march$\'{e}$ de l'art qui est le vrai dominateur de l'art contemporain. Aujourd'hui les grands clients du monde de l'art et les jeunes sp$\'{e}$ctateurs, les clients de l'avenir s'assemblent autour de quelques foires internationales r$\'{e}$put$\'{e}$s qui ont de l'autorit$\'{e}$. C'est ainsi que l'achat et la vante de l'oeuvres d'art est suffisamment mondialis$\'{e}$ et que le syst$\`{e}$me local du march$\'{e}$ est d$\'{e}$rang$\'{e}$ et s'$\'{e}$ffondr$\'{e}$gravement. Malgr$\'{e}$ la diff$\'{e}$rence significative, la majorit$\'{e}$ des galeries d'art lacaux s'oblige de suivre $\`{a}$ la suite du style du foire internationale de l'art. C'est la raison pour laquelle que cette recherche se fait une id$\'{e}$e nette que la prosp$\'{e}$rit$\'{e}$ actuelle du march$\'{e}$ de l'art n'est que la situation $\'{e}$conomique ou financi$\`{e}$re. A ce stade de la r$\'{e}$flexion, cette recherche arrivera $\`{a}$ poser une question primordiale ci-dessous: "Si l'art qu'on $\`{a}$ l'intention de proclamer ne serai plus possible de faire r$\'{e}$fl$\'{e}$chir sur la libert$\'{e}$ et la solidarit$\'{e}$ humain, la dignit$\'{e}$ de l'homme, cet art n'est plus autre chose que l'insignifiance. Au lieu de parcourir divers ph$\'{e}$nom$\`{e}$ne du march$\'{e}$ de l'art aujourd'hui, cette recherche fixera son attention sur la r$\'{e}$alit$\'{e}$ du foire internationales de l'art. Dans ce context, cette recherche sera compos$\'{e}$e par trois chapitres donc le premi$\`{e}$re essayera de r$\'{e}$pondre $\'{a}$ la question de son influence extraodinairement puissante. Le deuxi$\`{e}$me chapitre essayera d'analiser la r$\'{e}$alit$\'{e}$ et la source du pouvoir du foire internationale de l'art. Nous essayeront au troisi$\`{e}$me chapitre de configurer le point de vue critique qui permettra de bien comprendre notre sujet.

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Effects of Opuntia ficus-indica Complexes B(OCB) on Blood Glucose and Lipid Metabolism in Streptozotocin-induced Diabetic Rats (손바닥선인장 복합물이 당뇨 쥐의 혈당 및 지질대사에 미치는 영향)

  • Yoon, Jin-A;Son, Yong-Suk
    • The Korean Journal of Food And Nutrition
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    • v.22 no.1
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    • pp.48-56
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    • 2009
  • This study was conducted to examine the effects of Opuntia ficus-indica complexes(OCB) on the intake of water and food, body weight, blood glucose levels, glucose tolerance and lipid metabolism in streptozotocin(STZ)-induced diabetic rats. Thirty-two male Sprague-Dawley rats were assigned to four different groups; non-diabetic control(NC), diabetic control (DC), diabetic OCB of 2%(OCB-2), and diabetic OCB of 5%(OCB-5). The animals were fed on each experimental diet for 3 weeks. The DC, OCB-2 and OCB-5 groups showed a higher intake of water and food than the NC group. The fasting blood glucose levels were 100 $ mg/d{\ell}$ and 416 $ mg/d{\ell}$ for the NC and DC groups, respectively. The OCB-5 group presented a significantly low fasting glucose level of 21%(P<0.05), while OCB-2 group had a decrease of 13% compared to the DC group. As for the results of the glucose tolerance test, the highest blood glucose level was observed for all the groups at 30 minutes after the glucose injections as well as higher plasma insulin levels in the OCB-5 group. Plasma total cholesterol, triglyceride, non-esterified fatty acids(NEFA) and LDL-cholesterol concentrations were also lower in the OCB-2 and OCB-5 groups. The experimental diet did not affect the HDL-cholesterol levels. The overall results suggest that the higher intake of food by the OCB-2 and OCB-5 groups improved the blood glucose levels and lipid metabolism in STZ-induced diabetic rats.

Writing and Sijo in new media culture age (새로운 매체문화시대의 글쓰기와 시조)

  • Jung Ki-chul
    • Sijohaknonchong
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    • v.22
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    • pp.27-55
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    • 2005
  • Visual media are taken the highest position in modem society, Modern poems also have been changed into visual poems, This aspect is the result of considering only individual talents ignoring traditions. Now, new Sigo should be concentrated on the mythological and historical voice from true nature and the body of human being, That is. ut should be converted into an ecological world view resolutely and restored a form of expression granted specific characteristics of our language. Advantages the computer media have brought. that is. equality freedom. human rights. harmony. pro-environmental value. can be maximized by positively accepting an ecological world view of Sijo which had included daily lives and spirits of the nation. Moreover. these all changes of new Sijo have to be established and recreated in the traditional expressions of Sijo. Aesthetic value of Sijo should be found in the expression forms such as phonetic harmony, rules of versification, rhythm, and etc. Then, we can overcome modern society's pathological phenomena such as severance, separation, dissolution, estrangement, psychiatric syndrome and etc. which visual media superiority brought. At the same time. it will cure ills of modern poems, Sijo and writing epochally and can establish true happiness and development.

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The Effect of Feeding Whole-crop Barley Silage and Grass Hay on Productivity and Economic Efficiency in Elk (Cervus canadensis) (청보리 사일리지 및 목건초 급여가 엘크 사슴의 생산성 및 경제성에 미치는 영향)

  • Kim, Sang Woo;Suh, Sang Won;Kim, Dong Hoon;Kim, Jae Hwan;Kim, Young Sin;Kim, Kwan Woo;Yoon, Sei Hyung
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.33 no.1
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    • pp.52-57
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    • 2013
  • This study was conducted to determine the effect of dietary whole-crop barley silage on the daily feed intake, daily weight gain, velvet antler yield and economic efficacy in elk during growth. A total of 21 elk (average BW 303 kg, 5 years old) were allotted randomly to three treatments. The three treatments were T1 (hay diet), T2 (whole-crop barley silage), and T3 (50% hay + 50% whole-crop barley silage). The average daily weight gain of T3 was higher than the others throughout the entire experimental period. The average daily feed intake of elk in decreasing order was as follows; T1>T3>T2. The velvet antler yield was higher in T3 group (8,585 g) compared with T1 (8,037 g) and T2 (7,713 g). However, there were no significant differences in the average daily feed intake, average daily weight gain, or velvet antler yield (p>0.05). In economic efficacy, T3 was gained about 29~43% more value than T1 or T2. In conclusion, the mixed feeding of 50% hay and 50% whole-crop barley silage was more effective than feeding hay of barley alone, in terms of average daily weight gain, velvet antler yield, and economic efficacy in elk.

Antioxidant and Cellular Protective Effects against Oxidative Stress of Calendula officinalis Flowers Extracts in Human Skin Cells (사람피부세포에서 카렌둘라 꽃 추출물의 항산화 및 산화적 스트레스에 대한 세포보호효과)

  • Xuan, Song Hua;Kim, Ga Yoon;Yu, Ji Yeon;Kim, Jee Won;Yang, Ye Rim;Jeon, Young Hee;Jeong, Yoon Ju;Kim, A Rang;Park, Soo Nam
    • Applied Chemistry for Engineering
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    • v.27 no.6
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    • pp.620-626
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    • 2016
  • In this study, we investigated the total phenolic and flavonoid contents, antioxidant activity and cellular protective effects against oxidative stress on human skin cells in 50% ethanol extract and its fractions of Calendula officinalis (C. officinalis) flowers. We measured the antioxidant effects of 50% ethanol extract and its fractions of C. officinalis flowers on the free radical scavenging activity ($FSC_{50}$), the reactive oxygen species (ROS) scavenging activities ($OSC_{50}$) and the inhibition of intracellular ROS generation in human skin cells. These results showed that the antioxidant effect of the ethyl acetate and aglycone fraction was more than the 50% ethanol extract of C. officinalis flowers. We also investigated the cellular protective activity and the results showed that treatment of the ethyl acetate fraction ($0.05-3.13{\mu}g/mL$) protects human skin cells in a concentration-dependent manner when the skin cell damages were induced by treating them with $H_2O_2$. In addition, the aglycone fraction ($1.56-3.13{\mu}g/mL$) shows cellular protective effects on the UV-induced cell damages in a dose-dependent manner. These results suggest that the fractions of C. officinalis flowers can function as a natural antioxidant agent of cosmetics in human skin cells exposed to oxidative stress by ROS scavenging effects.

Exploration and Development of the Taebaek Orebody in the Yeonwha Pb-Zn Mine (연화광산(蓮花鑛山)의 태백광체탐사(太白鑛體探査)와 개발현황(開發現況))

  • Je, Young-Kun;Lee, Eun-Jae
    • Economic and Environmental Geology
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    • v.20 no.4
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    • pp.273-288
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    • 1987
  • 연화(蓮花) 연(鉛) 아연광산(亞鉛鑛山)은 광체(鑛體)의 분포(分布)에 따라 본산지구(本山地區), 동점지구(銅店地區) 및 태백지구(太白地區)로 구분할 수 있다. 태백지구(太白地區)에 대한 본격적인 탐광(探鑛)이 시작되기 전인 1981년 당시, 약 25년 동안 채광작업(採鑛作業)이 진행되어 온 본산지역(本山地域)은 주종광체(主宗鑛體)인 월암(月岩) 및 남산광체(南山鑛體)가 -600m level에서 하한(下限)이 드러남에 따라 광량(鑛量)이 크게 소진(消盡)된 상태였으며, 동점지성(銅店地城)은 상하(上下)의 광황변화(鑛況變化)는 크지 않으나 광체(鑛體)의 규모(規模)가 비교적 작아, 조업(操業)의 안정(安定)을 위해서는 신광화대(新鑛化帶)의 개발(開發)이 시급(時急)한 과제(課題)로 대두되었다. 이에 따라 평천(平川), 태백(太白), 동점역(銅店驛), 방터골, 삼방산광화대(三芳山鑛化帶) 등 연화(蓮花) 전역(全域)에 걸쳐 모암(母岩)의 분포(分布), 지질구조(地質構造), 광징(鑛徵) 등을 검토한 결과 탐광대상(探鑛對象)에서 제외되어 왔던 태백지구(太白地區)가 다음과 같은 점에서 유망(有望)한 탐사후보지(探査候補地)로 부각되었다. 첫째, 지표(地表)에서는 풍촌석회암층(豊村石灰岩層)이 분포(分布)되지 않으나 지질구조(地質構造)를 검토한 결과 -300m level 하부(下部)에서는 이의 전층(全層)이 분포(分布)할 것으로 예상되며, 둘째, 두무동층(斗務洞層) 및 동점규암층내(銅店珪岩層內)에서 발견된 광징(鑛徵)들이 하부(下部)의 풍촌석회암내(豊村石灰岩內)로 연장(延長)되면 부광부(富鑛部)를 이룰 것으로 기대되고, 셋째, 지층(地層)의 경사(傾斜)가 $50^{\circ}$ 이상(以上)인 점, 석영반암(石英斑岩)이 분포(分布)하는 점 등은 광상배태(鑛床胚胎)에 양호(良好)한 조건(條件)이고, 넷째, 본산지구(本山地區)의 월곡(月谷), 월암(月岩), 남산(南山)등 주종광화대(主宗鑛化帶)의 연장부(延長部)인 점, 다섯째, 중앙견갱(中央堅坑)으로부터 약 2km 거리로 탐사단계(探査段階)에 별도의 신규투자(新規投資) 없이 굴진(掘進)이 가능하다는 개발조건상(開發條件上)의 이점(利點)이 있었다. 이에 따라 태백지구(太白地區)에 대한 지표정사(地表精査), 물리탐사(物理探査) 및 지화탐(地化探)을 실시하고, 20여년간 축적된 연화광산(蓮花鑛山)의 지질(地質), 광상자료(鑛床資料)를 정리(整理), 그 특성(特性)을 태백지구(太白地區) 탐사(探査)의 가설(假說)로 적용하여 시추계획(試錐計劃)을 수립, 1982년 구조시추(構造試錐)를 실시한 결과 지질구조(地質構造), 풍촌석회암층(豊村石灰岩層)의 분포(分布) 등이 거의 예상했던 대로 밝혀졌으며 태백(太白) 1호광체(號鑛體)의 일단(一端)이 확인되기에 이르렀다. 1983년(年) 7월(月) 본산지구(本山地區) -600m level에서 태백(太白) 크로스 탐광굴진(探鑛掘進)이 착수되었으며, 1985년에 마침내 갱내(坑內)에서 태백(太白) 1호(號), 2호(號) 광체(鑛體)가 착광(着鑛)되었다. -600m level에서의 태백(太白) 1호광체(號鑛體)의 규모(規模)는 연장(延長) 300m, 평균맥폭(平均脈幅) 8.5m이며, 품위(品位)는 Pb 4.5%, Zn 4.5%, Ag 109g/t이다. 태백광화대(太白鑛化帶)의 지질학적(地質學的) 예상광량(豫想鑛量)은 1,000만(萬)t 이상(以上)이 될 것으로 추정(推定)되며, 현재 -480m level에서 -720m level에 이르기까지 5개 level에서 가행(稼行)되고 있다. 현재 level에서 태백(太白) 1호(號) 광체(鑛體)는 풍촌석회암층(豊村石灰岩層) 및 화절층(花折層)을 모암(母岩)으로 하여 맥상광상(脈狀鑛床)으로 생산(生産)되며, 맥석광물(脈石鑛物)은 능망간석, Mn-방해석(方解石), 방해석(方解石), 석영(石英) 등이고 광석광물(鑛石鑛物)은 섬아연석(閃亞鉛石), 방연석(方鉛石), 황철석(黃鐵石), 자유철석(磁硫鐵石), 유비광석(硫砒鑛石), 황동석(黃銅石), 사면동석(四面銅石), 엘렉트럼 등이다. 태백지구(太自地區)는 광상(鑛床)의 산출상태(産出狀態) 및 지질(地質), 광상학적(鑛床學的) 환경(環境)이 본산지구(本山地區)와 거의 동일(同一)함이 밝혀지고 있다. 태백지구(太白地區)에서는 현재 태백(太白) 1호(號), 2호(號), 3호(號), 5호(號) 및 절골 1호(號), 2호(號) 등 6개 광화대(鑛化帶)에 대한 탐광(探鑛)이 진행되고 있다.

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