• Journal of Integrative Natural Science
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• v.9 no.2
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• pp.128-135
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• 2016

5-hydroxytryptamine (serotonin) receptor ($5-HT_7R$) 7 is one of G-Protein coupled receptors, which is activated by the neurotransmitter Serotonin. After activation by serotonin, $5-HT_7$ activates the production of the intracellular signaling molecule cyclic AMP. $5-HT_7$ receptor has been found to be involved in the pathophysiology of various disorders. It is reported that $5-HT_7$ receptor antagonists can be used as antidepressant agents. In this study, we report the important structural and chemical parameters for 2-methoxyphenylpiperazinylakanamides as $5-HT_7R$ inhibitors. A 3D QSAR study based on comparative molecular field analysis (CoMFA) was performed. The best predictions were obtained for the best CoMFA model with $q^2$ of 0.594 with 6 components, $r^2$ of 0.986, Fisher value as 60.607, and an estimated standard error of 0.043. The predictive ability of the test set was 0.602. Results obtained the CoMFA models suggest that the data are well fitted and have high predictive ability. The contour maps are generated and studied. The contour analyses may serve as tool in the future for designing of novel and more potent $5-HT_7R$ derivatives.

• Journal of international Conference on Electrical Machines and Systems
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• v.3 no.4
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• pp.367-373
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• 2014

The most common current controller for the Switched Reluctance Motor (SRM) is the hysteresis controller. This method, however, suffers from such drawbacks as variable switching frequency, consequent audible noise and high current ripple. These disadvantages make this controlling method undesirable for many applications. The alternative solution is the PI controller. Since the fixed gain PI current controller can only be optimized for one operating point, and on the other hand, SR motor is highly nonlinear, PI controller gain should be adjusted according to incremental inductance. This paper presents a novel method for PI current controller gain adaptation which is simple and yields a good performance. The proposed controller has been implemented on a test bench using a eZdsp F28335 board. The performance of the current controller has been investigated in both simulation and experimental tests using a four-phase 8/6 4KW SRM drive system.

• ALGAE
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• v.31 no.2
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• pp.117-128
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• 2016

Cryptomonas curvata Ehrenberg is a photosynthetic freshwater flagellate and the type species of the genus Cryptomonas. We examined the flagellar apparatus of cryptomorphic C. curvata by transmission electron microscopy. The major components of the flagellar apparatus are the non-keeled rhizostyle (Rhs), striated fibrous root (SR), striated fiber-associated microtubular root (SRm), mitochondrion-associated lamella (ML), and two types of microtubular roots (3r and 2r). The non-keeled Rhs originate at the ventral basal body and consist of two types of microtubule bands extending together into the middle of the cell. The SR and SRm extend parallel to the left side of the cell. The ML originates from the ventral basal body and is a plate-like fibrous structure associated with mitochondria. The 3r extends from the dorsal basal body toward the dorsal anterior of the cell. The 2r originates between the two basal bodies and extends shortly to the left of the cell. The overall configuration of the flagellar apparatus is most similar to that previously reported for C. pyrenoidifera. These results demonstrate that the features of the flagellar apparatus are useful for distinguishing closely related species and inferring phylogenetic relationships among taxa.

• The Transactions of the Korean Institute of Power Electronics
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• v.21 no.1
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• pp.1-9
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• 2016

In this study, two types of switched reluctance motors (SRMs) with segmental rotors are presented in detail. The first is a 6/5 segmental rotor type, whereas the second is a 12/8 segmental rotor type. Both motor types have the same stator, rotor, and winding configurations. The stator is constructed with special stator poles, namely, exclusively designed exciting and auxiliary poles. The rotor is constructed from a series of discrete segments, each of which is embedded into the nonmagnetic isolator. The windings are only wound on the exciting poles, and no winding is wound on the auxiliary poles. Given these configurations, short flux paths and high flux-linkage utilization rate are achieved in the proposed motors, which may reduce the magnetomotive force requirement and increase the electrical utilization of a machine. To verify the effectiveness of the proposed motors, their characteristics, such as magnetic flux distribution, flux-linkage, torque, radial force, and efficiency, are analyzed and compared with those of a conventional 12/8 SRM. Meanwhile, two prototypes, one for each proposed segmental rotor type, are also designed and manufactured. Finally, the validity of the proposed motors is further verified by test results.

• Analytical Science and Technology
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• v.21 no.6
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• pp.502-509
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• 2008

An ID LC/MS (isotope dilution liquid chromatography/mass spectrometry) was used as a primary method for the quantitative analysis of cholesterol in human serum. The separation of cholesterol was carried out by Thermo ODS hypersil $C^{18}$ column. The mobile phase was 100% methanol, and flow rate was $0.3m{\ell}/min$. Cholesterol and cholesterol-$3,4-13C_2$ were monitored at m/z 369.4 and 371.3, which correspond to $[M-H_2O+H]^+$ respectively. In order to verify the measurement method, NIST SRM 909b was analyzed. The results agreed well with certified values within uncertainty. The four kinds of serum certified reference material were prepared and certified. The repeatabilities of measurement were ranged from 0.1 to 0.8% (RSD), which were relatively good. The reproducibility between independent measurement run was below 0.24% (RSD). The expanded uncertainty was about 1.43% within the 95% confidence interval.

• Analytical Science and Technology
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• v.29 no.4
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• pp.170-178
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• 2016

Accuracy and precision of ID methods for different spike isotopes of ⁷⁶Se, ⁷⁷Se, and ⁷⁸Se were compared for the analysis of Selenium using quadrupole ICP/MS equipped with Octopole reaction cell. From the analysis of Se inorganic standard solution, all of three spikes showed less than 1 % error and 1 % RSD for both short-term (a day) and long-term (several months) periods. They showed similar results with each other and ⁷⁸Se showed was a bit better than ⁷⁶Se and ⁷⁷Se. However, different spikes showed different results when NIST SRM 1568a and SRM 2967 were analyzed because of the several interferences on the m/z measured and calculated. Interferences due to the generation of SeH from ORC was considered as well as As and Br in matrix. The results showed similar accuracy and precisions against SRM 1568a, which has a simple background matrix, for all three spikes and the recovery rate was about 80% with steadiness. The %RSD was a bit higher than inorganic standard (1.8 %, 8.6 %, and 6.3 % for ⁷⁸Se, ⁷⁶Se and ⁷⁷Se, respectively) but low enough to conclude that this experiment is reliable. However, mussel tissue has a complex matrix showed inaccurate results in case of ⁷⁸Se isotope spike (over 100 % RSD). ⁷⁶Se and ⁷⁷Se showd relatively good results of around 98.6 % and 104.2 % recovery rate. The errors were less than 5 % but the precision was a bit higher value of 15 % RSD. This clearly shows that Br interferences are so large that a simple mathematical calibration is not enough for a complex-matrixed sample. In conclusion, all three spikes show similar results when matrix is simple. However, ⁷⁸Se should be avoided when large amount of Br exists in matrix. Either ⁷⁶Se or ⁷⁷Se would provide accurate results.

• Journal of Soil and Groundwater Environment
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• v.23 no.6
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• pp.73-81
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• 2018

Inductively coupled plasma-mass spectrometry (ICP-MS), one of the most commonly used instruments for metal analysis, was used to determine total uranium in soil. The method was named as "Modified ASTM C1345-96". When comparing with ASTM C1345-96, digestion time (2~3 days) was shorten to 7 hours and the treatment in furnace was eliminated. In analyses of 26 field soil samples, there was a significant difference in the average concentration of total uranium between modified ASTM C1345-96 and ASTM C1345-96 (F : 6.22 > Fc : 4.03, significance level : 0.05, n=26). The average concentration of modified ASTM C1345-96 was 1.8 times larger than that of ASTM C1345-96. In addition, modified ASTM C1345-96 was compared with other acid digestion methods for soil including ISO 11466, Modified ISO 11466, US EPA-3051, US EPA-3051A and US EPA-3052 using a certificated reference material (SRM 2711a, NIST) and field soil samples with different level of organic matter content (1.6%, 5.8%, 10.6%). Modified ASTM C1345-96 showed the best accuracy of 93.01% for SRM 2711a. Also, modified ASTM C1345-96 showed the higher extraction rates than other digestion methods by 11~45%.

• Journal of the Korea Organic Resources Recycling Association
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• v.10 no.2
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• pp.117-124
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• 2002

This study was carried out to investigate variation of heavy metal contents for feed materials during composting and to evaluate the effect of pre-treatment methods on heavy metal analysis. Dry ashing, $HNO_3-HClO_4$, aqua-regia, HCl reflux, $HNO_3-HClO_4-HF$, autoclaving methods of $HNO_3$, HCl, and $HNO_3(2+1)$ were used as pre-treatment for heavy metal analysis. In analyzing standard material SRM 2781, recovery efficiencies of pre-treatment methods were 50-60% for Cr and Zn, >100% for Ni, and 80-90% for Cd and Cu. Recovery efficiency of dry ashing for SRM 2781 was the lowest. In composting raw material, Cd concentration by autoclaving methods was 3 to 4 times higher than the other methods and recovery efficiency of dry ashing was also the lowest. During composting, Cd content was the highest in autoclaving. Cr and Cu concentrations were the lowest in dry ashing and aqua-regia, respectively. Variation coefficients of Pb and Zn between pre-treatment methods were generally low.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2000.04a
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• pp.12-12
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• 2000

우리 나라는 일본상공의 비행을 피하기 위하여 제주도와 남해안 근해로 발사장 선정이 국한되는 지정학적인 위치로 볼 때 발사장 선택에 제한이 없는 공중발사에 대한 가능성 연구가 필요한 시점에 있다. 본 연구는 우리 나라와 같은 분단 된 특수상황 그리고 지정학적 위치에서의 발사장을 고려한 우주 발사체 개발의 필요성에 따라 F-4에 장착 가능한 3단형 공중발사 로켓을 설계하고 1/3의 축소 모형을 제작하였다. 2kg의 payload를 갖는 발사체의 1단은 LRM ( Lox/kerosene )을 사용하였고 2, 3단은 SRM ( HTPB/AP/Al )을 사용하였으며 발사고도는 11-l2km 상공에서 F-4에 의해서 발사되고 31km지점에서 1단 분리가 이루어지며 62km지점에서 2단 분리와 nose fairing을 분리하게 된다. 전장은 6.85m 이며 전체 무게는 560.6kg 이고 전체 발사체 시스템의 CAD 도면은 아래 그림 1과 같이 주어져 있다. 그림 2에서는 F-4E phantom의 장착성을 검토해 본 결과 장착이 가능함을 알 수 있었으며 추진제 양의 감소로 크기를 대폭 줄일 수 있었다.

• Analytical Science and Technology
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• v.20 no.1
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• pp.33-40
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• 2007

This study centered on the quantitative analysis of about 27 trace elements including toxic ones using instrumental neutron activation analysis of fine ambient particulate matter in the third and fourth industrial complex area of Daejeon city, Korea. For analytical quality control, the certified reference material (NIST, the National Institute of Standards and Technology, U.S.A., SRM 2783, air particulate on filter media) was used. The errors relative to SRM values of Sb, Mn, V, Mg, Na, K, Ti, Co, Zn, and Sm fell below 5%, while those of Cr, Fe, Ba, Th, Ce, Al, and Cu were less than 10%. From the results of the quantitative analysis, the concentration of toxic metals such as As, Mn, Se, V, and Zn were $3.26{\pm}2.72$, $9.86{\pm}4.71$, $2.18{\pm}1.25$, $4.91{\pm}2.41$, $158{\pm}78ng/m^3$, respectively. And the results of factor analysis indicated that there are no more than six factors of sources of fine ambient particulate with statistical significance in the study area.