• Proceedings of the Korean Society of Developmental Biology Conference
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• 2003.10a
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• pp.104-104
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• 2003

As an effort to direct differentiation of human embryonic stem (hES, MB03) cells to dopamine-producing neuronal cells, Nurr1 was transfected using conventional transfection protocol into MB03 and examined the expression of tyrosine hydroylase (TH) after differentiation induced by retinoic acid (RA) and ascorbic acid (AA). Experimentally, cells were transfected with linearized Nurr1 cDNA in pcDNA3.1 (+)-hygovernight followed by selection in medium containing hygromycin-B (150 $\mu$/ml). Expression of Nurr1 mRNA was confirmed by RT-PCR and protein by immunocytochemistry in the drug resistant clones. In order to study the effect of Nurr1 protein on the differentiation pattern of ES cells, one of the positive clones (MBNr24) was allowed to form embryoid body (EB) for 2 days and were induced to differentiate for another 4 days using RA (1 $\mu M$) and AA (50 mM) (2-/4+ protocol) followed by selection in N2 medium for 10 or 20 days. After 10 days in N2 medium, cells immunoreactive to anti-GFAP, anti-TH, or anti-NF200 antibodies were 38.8%, 11%, and 20.5%, respectively. After 20 days in N2 medium, cells expressing GFAP, TH, or NF200 were 28%, 15% and 44.8%, respectively but approximately 9% of MB03 expressed TH protein when the cells were induced to differentiate using a similar prorocol, These results suggest that ectopic expression of Nurr1 enhances generation of TH+ cells as well as neuronal cells when hES cells were differentiated by 2-/4+ protocol.

• Electronics and Telecommunications Trends
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• v.30 no.1
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• pp.21-33
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• 2015

고성능 스마트기기의 보급과 모바일 사용자들의 고품질 컨텐츠 수요가 증가하면서 급증하는 모바일 데이터 트래픽을 수용하기 위해 소형셀을 통한 네트워크 용량 증대가 가장 현실적인 방안으로 고려되고 있다. 이와 더불어 차세대 이동통신 네트워크의 패러다임이 사용자가 인프라 영역 내에 위치해야 통신 및 서비스를 제공받던 인프라 중심에서, 통신 및 제반 서비스 환경이 사용자를 중심으로 구축되고 운영되는 사용자 중심으로 전환되면서 사용자를 따라 움직이는 이동 소형셀에 대한 관심이 고조되고 있다. 본고에서는 ETRI에서 개발 중인 5G(5th Generation) 이동셀 개념 및 주요 기술을 소개하고, 관련 3GPP 표준화 동향 및 국내외 기술개발 동향을 소개한다.

• Journal of Digital Convergence
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• v.15 no.10
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• pp.19-29
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• 2017

The purpose of this study was to identify the multidimensional factors that affect the satisfaction of life by type of baby boomer generation. The subjects of this study were 1,895 households who were born from 1955 to 1963 among the respondents in the Korea welfare panel (the 10th year). The baby boomer generation was classified into four types such as gender, income status, male and female as socioeconomic status. The male type IV (B=.074, t=1.992, p<.05), health status (B=.233, t=7.268, p<.001), household income (B=.174, t=4.476, p<.001), depression (B=-.182, t=-5.242, p<.001), self-esteem (B=.255, t=7.027, p<.001), trust (B=.064, t=2.036, p<.05), etc. were found to have a significant effect on the life satisfaction of the male baby boomer generation. The female type IV (B=.100, t=2.598, p<.05), health status (B=.239, t=6.790, p<.001) (P<.001), depression (B=-.181, t=-5.142, p<.001), and self-esteem (B=.320, t=8.600, p<.001), etc. were found to have a significant effect on the life satisfaction of the female baby boomer generation.

• Journal of the Korea Fashion and Costume Design Association
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• v.14 no.2
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• pp.199-214
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• 2012

$21^{st}$ century customer is voluntary actor, who has hegemony of communication based on digital surrounding. They are co-creator dismantling boundary between production and spending, and digital homonarrance of digital storyteller acting on the emotion. What is more, they prove the utility of 5 sense, value, experience, and story in market. 20th century Me generation is changing into We generation, who overcomes a sense of alienation and aim at smart life style for harmonious symbiosis with earth environments. Customer cultural trends are as follow as that 1) personalization of taste and experience, 2) spreading and sharing about personal use and experience, 3) consumption centered the value, 4) retreat and healthcare, 5) counter trend comes into the reaction about the forceful major trend. Contemporary customer changes essence of the life on the ground of emotion, symbol, image, and value not a commodity, function, and logos, and demands into change about direction of business to mostly enterprises. Customer's need and desire are on the increase as various emotion and value. Therefore, change of customer cultural trend is barometers for the growth and development of new fashion industry in $21^{st}$ century.

• Journal of the korean academy of Pediatric Dentistry
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• v.31 no.1
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• pp.26-33
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• 2004

Self-etching priming bonding system was recently developed in order to simplify the clinical skills & save chair time after continuous improvements on dentin bonding agents. To test the magnitude of microleakage of a new "self-etching priming bonding agent" using sound premolar 4th, 5th, 6th generation dentin bonding agent was applied. Measure the magnitude of infiltration to the gap of enamel-restoration interface and dentin-restoration interface. After bonding of composite resin to sample surfaces according to the manufactures direction and 500 times thermocycling on dwell time 30 second, and microleakage was measured by the ratio of the depth to the axial wall and the magnitude of infiltration. Afterward analyzed by ANOVA test. The result were as follows ; 1. Enamel groups showed lesser microleakage (Group I, II, III, IV) than dentin groups(Group V, VI, VII, VIII). (p<0.05) 2. There are no statical differences among the dentin groups, in enamel groups, group IV showed more microleakage than group I, II, III. (p<0.05). For a clinical acceptance, better enamel marginal adaptation is required.

• Journal of environmental and Sanitary engineering
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• v.15 no.3
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• pp.15-23
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• 2000

This study's purpose is the investigating the created liquid post-acid fermentation of usability of denitrification as exterior carbon sources by loading capacity of Organic matters. The time of acid fermentation of food waste, the slower loading capacity of organic matter, the faster decomposition fate, but the density of generation $VFA_S$ was weak and, $SBOD_5$ : ST-N rate and $SBOD_5/SCOD_{Cr}$ rate was low. Between TS and VS, VS was decreased to 6th day rast, and then was decreased slowly. Two days after stating the experiments, $SCOD_{Cr}$, $SBOD_5$, STOC and $VFA_S$ was decreased or increased slowly, and then increased fast. And after showing the highest density, it was tended to decreased fast. About 5 days after, because about 5 days later $CH_4$ bacteria activity due to the accumulation of $VFA_S$ was limited, $CH_4$ density was weak. When highest density in the acquisition of VFA, $R_1$ was $10,120mg/{\ell}$, $R_2$ was $11,380mg/{\ell}$, $R_3$was $13,720mg/{\ell}$. So $R_3$ only cut was highest generation. At the time of $SBOD_5$ with the highest density, at $SBOD_5$ : ST-N ratio, $R_1$ was 243:1, $R_2$ was 278:1, $R_3$ was 293:1. All of these were high $SBOD_5$ : ST-N ratios. And $R_3$ was the highest. After studying $SBOD_5$ : ST-N ratio and $SBCD_5/SCOD_{Cr}$ ratio, as a carbon source of biological denitrification it was profitable composition ratio.

• Journal of Sericultural and Entomological Science
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• v.8
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• pp.51-62
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• 1968

This study was carried out to investigate the life cycle and the damage of Tricholyga sorbillans Wiedmann to silkworms(Bombyx mori L.). The results are summarized as follows. 1. This insect has 5 or 6 generations per year in Suwon area. 2. The egg, larval, and pupal stage are about 2, 8 and 18 days respectively. 3. The weather conditions considerably affect the life cycle, that is, the 3 rd generation is the shortest of all, lasting for 21 days and l4 hours, and the 5th generation is the longest for about 40 days. 4. The larvae come out of silkworm bodies, burrowing into the ground 3.5cm to 10.5cm in depth before changing into the pupae. 5. This insect does not overwinter as pupa, but seems to do as larva, parasiting on the field insects. 6. The damage of Tricholyga sorbillans Wiedmann to silkworm was 27.9％, it is so high that the silk worms could not be reared outside without a reasonable control method. 7. When the full-grown silkworm is parasited by one egg of these insects, there is not only enough possibility of spinning. but also without any effects of their larvae on the cocoon quality. 8. The damage of Tricholyga sorbillans Wiedmann throughout the country covers 6.36％ in spring, 4.09％ in fall, and 5.25％ yearly mean.

• Advances in biomechanics and applications
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• v.1 no.3
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• pp.187-210
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• 2014

With the goal of increasing the survivorship of the prosthesis and anticipating primary stability problems of new prosthetic implants, finite element evaluation of the micromotion, at an early stage of the development, is mandatory. This allows assessing and optimizing different designs without manufacturing prostheses. This study aimed at investigating, using finite element analysis (FEA), the difference in the prediction of the primary stability of cementless hip prostheses implanted into a $Sawbones^{(R)}$ 4th generation, using the manufacturer's mechanical properties and using mechanical properties close to that of human bone provided by the literature (39 papers). FEA was carried out on the composite $Sawbones^{(R)}$ implanted with a straight taper femoral stem subjected to a loading condition simulating normal walking. Our results show that micromotion increases with a reduction of the bone material properties and decreases with the augmentation of the bone material properties at the stem-bone interface. Indeed, a decrease of the cancellous Young modulus from 155MPa to 50MPa increased the average micromotion from $29{\mu}m$ up to $41{\mu}m$ (+42%), whereas an increase of the cancellous Young modulus from 155MPa to 1000MPa decreased the average micromotion from $29{\mu}m$ to $5{\mu}m$ (-83%). A decrease of cortical Young modulus from 16.7GPa to 9GPa increase the average global micromotion from $29{\mu}m$ to $35{\mu}m$ (+33%), whereas an increase of the cortical Young modulus from 16.7GPa to 21GPa decreased the average global micromotion from $29{\mu}m$ to $27{\mu}m$ (-7%). It can also be seen that the material properties of the cancellous structure had a greater influence on the micromotion than the material properties of the cortical structure. The present study shows that micromotion predicted at the stem-bone interface with material properties of the $Sawbones^{(R)}$ 4th generation is close to that predicted with mechanical properties of human femur.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.55 no.5
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• pp.549-556
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• 2022

The aim of this study was to evaluate the genetic parameters of growth traits for improvement breeding in olive flounder Paralichthys olivaceus at the 8^th generation of selective breeding in April 2021. Growth traits such as total length, body weight and condition factor at 11 months of age were measured for 7,508 individuals with confirmed paternity. Data were analyzed using the restricted maximum likelihood method applied to a multiple traits animal model. The effects of sex and family were significantly different across traits (P<0.05). The heritability values of total length, body weight and condition factor were estimated to be high as 0.479, 0.457, and 0.466, respectively. Correlation analysis between phenotypic and breeding values, indicated that the selection accuracy was 75.9-85.2% for all traits. To increase the selection accuracy for parent fish selection, the sex and pedigree characteristics that affect each trait should be considered. Moreover, further improvement of multiple traits can be achieved if the correlation between each trait is appropriately considered.

• World Technopolis Review
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• v.7 no.1
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• pp.2-14
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• 2018

Nowadays, we are standing in front of the $4^{th}$ Industrial Revolution that is featured by a great range of new and advanced technologies that influences all the domains of economies and industries. The great question that this revolution raises is how it can lead to a future that reflects the peoples' common objectives and values on how these advanced technologies can affect the life and transform the economic, social, cultural, and human environment. It is commonly agreed that to be adapted to these changes and needs and shape a society with competitive economies with highly-skilled individuals, we need to encourage innovation, entrepreneurship, new knowledge generation and exchange and true and effective collaboration and communication. In this complex scene, education seems to have a central and critical role on finding new ways of developing expertise and innovation within the existing knowledge procedures, with more and better cooperation between the key players. This paper argues the concepts, opportunities and challenges that are related to the learning ecosystem towards the needs raised by the $4^{th}$ Industrial Revolution. The education is discussed as catalyst but also as carrier of innovation and innovation practices and the basis of a relevant framework is presented that takes into account all the aspects, domains and key players of educational world and interacting domains. Having introduced the ideas of innovation, collaboration and technology advancement in this environment, this paper also presents a real case of practice, focusing on how more than 5.000 schools around Europe succeeded the last four (4) years to implement innovation activities in a collaborative way and under a unique but also flexible pedagogical innovation framework.