• Tuberculosis and Respiratory Diseases
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• v.45 no.4
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• pp.861-869
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• 1998

Backgrounds: The injury of a tissue results in the infalmmation, and the imflammed tissue is replaced by the normal parenchymal cells during the process of repair. But, constitutional or repetitive damage of a tissue causes the deposition of collagen resulting in the loss of its function. These lesions are found in the lung of patients with idiopathic pulmonary fibrosis, complicated fibrosis after diffuse alveolar damage (DAD) and inorganic dust-induced lung fibrosis. The tissue from lungs of patients undergoing episodes of active and/or end-stage pulmonary fibrosis shows the accumulation of inflammatory cells, such as mononuclear cells, neutrophils, mast cells and eosinophils, and fibroblast hyperplasia. In this regard, it appears that the inflammation triggers fibroblast activation and proliferation with enhanced matrix synthesis, stimulated by inflammatory mediators such as interleukin-1 (IL-1) and/or tumor necrosis factor (TNF). It has been well known that TGF-$\beta$ enhance the proliferation of fibroblasts and the production of collagen and fibronectin, and inhibit the degradation of collagen. In this regard, It is likely that TGF-$\beta$ undergoes important roles in the pathogenesis of pulmonary fibrosis. Nevertheless, this single cytokine is not the sole regulator of the pulmonary fibrotic response. It is likely that the balance of many cytokines including TGF-$\beta$, IL-1, IL-6 and TNF-$\alpha$ regulates the pathogenesis of pulmonary fibrosis. In this study, we investigate the interaction of TGF-$\beta$, IL-1$\beta$, IL-6 and TNF-$\alpha$ and their effect on the proliferation of fibroblasts. Methods: We used a human fibroblast cell line, MRC-5 (ATCC). The culture of MRC-5 was confirmed by immunofluorecent staining. First, we determined the concentration of serum in cuture medium, in which the proliferation of MRC-5 is supressed but the survival of MRC-5 is retained. Second, we measured optical density after staining the cytokine-stimulated cells with 0.5% naphthol blue black in order to detect the effect of cytokines on the proliferation of MRC-5. Result: In the medium containing 0.5% fetal calf serum, the proliferation of MRC-5 increased by 50%, and it was maintained for 6 days. IL-1$\beta$, TNF-$\alpha$ and IL-6 induced the proliferation of MRC-5 by 45%, 160% and 120%, respectively. IL-1$\beta$ and TNF-$\alpha$ enhanced TGF-$\beta$-induced proliferation of MRC-5 by 64% and 159%, but IL-6 did not affect the TGF-$\beta$-induced proliferation. And lNF-$\alpha$-induced proliferation of MRC-5 was reduced by IL-1$\beta$ in 50%. TGF-$\beta$, TNF-$\alpha$ and both induced the proliferation of MRC-5 to 89%, 135% and 222%, respectively. Conclusions: TNF-$\alpha$, TGF-$\beta$ and IL-1$\beta$, in the order of the effectiveness, showed the induction of MRC-5 proliferation of MRC-5. TNF-$\alpha$ and IL-1$\beta$ enhance the TGF-$\beta$-induced proliferation of MRC-5, but IL-6 did not have any effect TNF-$\alpha$-induced proliferation of MRC-5 is diminished by IL-1, and TNF-$\alpha$ and TGF-$\beta$ showed a additive effect.

• Proceedings of the KIEE Conference
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• 1999.07f
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• pp.2698-2700
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• 1999

The MRC minimizes a parasitic oscillation using the resonant tank circuit absorbed parasitic reactances existing in a converter circuit. So the converter is capable of operating at a high switching and also reducing the losses. But the resonant voltage stress across a resonant switch is 4-5 times a input voltage. This high voltage stress increases the conduction loss in MOSFET. In this paper, the CM forward MRC with synchronous rectifier and AT forward MRC are compared about efficiency and semiconductor stress. For analysis, we have built a 50W CM forward MRC and a 50W AT forward MRC. in which the input voltage is 48V, output voltage is 5V, each other. The measured voltage stress is about 170V of 2.9 times the input voltage in the AT Forward MRC, about 106V of 1.8 times the input voltage in CM forward MRC, and the efficiency is 81.05% in AT Forward MRC, 83.61% in CM forward MRC.

• Journal of radiological science and technology
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• v.34 no.4
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• pp.333-339
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• 2011

The purpose of this study is to compare DNA repair characteristics of normal fibroblast cell (MRC-5) and neuroblastoma cell (SK-N-SH) induced by proton beam. Cells were irradiated with 2Gy, 5Gy and 8Gy proton beam. The rate of DNA rejoining was measured by alkaline version of the comet assay. After a repair time, tail moment was measured again. The tail moment of MRC-5 was lower than SK-N-SH. However, after 8Gy of exposure, the tail moment of MRC-5 was measured as 50.320223.17155 which represents dangerous level of DNA damage. The cells were repaired practically within 25 hours after 2 and 5Gy of exposure while they were not fully recovered after 8Gy of exposure. Especially, tail moment of MRC-5 after 25 hours was 18.15364.42849. In the distal declining edge of SOBP, the RBE value is increased by high LET. The RBE differences of SOBP in high-dose were greater than low-dose. After the high-dose exposure, MRC-5 of normal fibroblast cell could lead to lasting DNA damage as shown in this study. In conclusion, we has to pay special attention when the region of the treatment volume is close to sensitive tissues.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.4A
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• pp.302-308
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• 2009

In this paper, two receive diversity combining techniques are proposed for single-carrier Sequency division multiple access (SC-FDMA)-based cooperative relay systems when DFT spreading sizes for mobile station (MS) and relay station (RS) are different. A simplified-MRC (5-MRC) technique performs diversity combining in the time domain using the estimated channel weight and initial values obtained by SC-FDMA signal detection. An interference rejection-MRC (IR-MRC) technique performs diversity combining in the frequency domain by adjusting DFT spreading size in the receiver. It is shown by computer simulation that the proposed receive diversity combining techniques achieve a significant performance gain over the conventional MRC technique with zero forcing (ZF) detector.

• The Korean Journal of Physiology and Pharmacology
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• v.9 no.5
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• pp.255-262
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• 2005

Striatum is involved in the control of movement and habitual memory. It receives glutamatergic input from wide area of the cerebral cortex as well as an extensive serotonergic (5-hydroxytryptamine, 5-HT) input from the raphe nuclei. In our study, the effects of 5-HT on synaptic transmission were studied in the rat corticostriatal brain slice using in vitro whole-cell recording technique. 5-HT inhibited the amplitude as well as frequency of spontaneous excitatory postsynaptic currents (sEPSC) significantly, and neither ${\gamma}-aminobutyric$ acid (GABA)A receptor antagonist bicuculline (BIC), nor $N-methyl-_{D}-aspartate$ (NMDA) receptor antagonist, $_{DL}-2-amino-5-phosphonovaleric$ acid (AP-V) could block the effect of 5-HT. In the presence non-NMDA receptor antagonist, 2,3-dioxo-6-nitro-1,2,3,4-tetrahydrobenxo[f] quinoxaline-7-sulfonamide (NBQX), the inhibitory effect of 5-HT was blocked. We also figured out that 5-HT change the channel kinetics of the sEPSC. There was a significant increase in the rise time during the 5-HT application. Our results suggest that 5-HT has an effect on both pre- and postsynaptic site with decreasing neurotransmitter release probability of glutamate and decreasing the sensitivity to glutamate by increasing the rise time of non-NMDA receptor mediated synaptic transmission in the corticostriatal synapses.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.7 no.3
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• pp.355-362
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• 2003

In this paper, we analyzed the DS/CDMA System with Hybrid SC/MRC diversity, as a method to achieve a good performance by reducing the complexity of system, when PLL gain value was revised a phase gulf among branches to make perfect coherent receive signal. The channel is a multipath Nakagami-m fading channel, we consider user(K), processor gain(N), number of paths(Lp) in DS/CDMA system with hybrid SC/MRC diversity. We found that PLL gain values exist to make perfect coherent receive signal. We verified that DS/CDMA system with Hybrid SC/MRC diversity can improve performance when the proper PLL gain values is used in the system. As a result, we verified that the upper limit of PLL gain value is 5dB to make perfect coherent receive signal in the DS/CDMA system with hybrid SC/MRC diversity.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.25 no.3A
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• pp.391-398
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• 2000

In this paper, MRC(Maximum Ratio Combine) diversity, (23, 12) Golay code, (7, 5) Reed-Solomon code, and (3, 1) majority selection code are employed to improve the performance of DS/CDMA BRSK in Nakagami fading channel. and MRC diversity combined with other coding techniques is suggested, with which, the performance of DS/CDMA BRSK is compared and analyzed. Also, system required Eb/N0 to meet BER=10-5 for multi user data communication is obtained according to each techniques. From the results, when each techniques is employed to DS/CDMA BRSK system. coding employed system shows better performance than diversity employed system. Especially, Golay code shows better performance than oter codes. also MRC diversity is employed, the number of multiple access user to meet data communication requirement of BER=10-5 can accomodate up to 8 users. and when each code is employed, Golay code, majority selection code, and Reed-Solomon code shows the capacity of 14, 12, and 10 user respectively. But MRC diversity combined with coding techniques can reduce restriction of multiple access user. However, it is desirable these combined technique are employed according to service types and requirements provided.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2000.05a
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• pp.183-187
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• 2000

In this paper, the performance of DS-CDMA system and FH-CDMA system has been comparision analyzed in a channel environment which is characterized by Multi-User environment and Rayleigh fading environment. The techniques of improvement of the performance has been comperision analysis evaluated when adopting MRC diversity techniques. In same condition, We are analyzed the BER(Bit Error Rate) as increase Use's number due to comparing performance of two systems by Same communication band(300KHz), jamming signal(JSR) 10∼20dB, user data-rate 300bps. In the result, the performance of DS and FH systems in multiuser and Rayleigh fading environment is improved performance when adopting MRC diversity techniques. Especially DS system has been improved performance about 9.5 times than FH system when adopting MRC diversity techniques.

• YAKHAK HOEJI
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• v.26 no.4
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• pp.197-208
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• 1982

In this study attemps were made to obtain evidence as to the action of Mori Radicis Cortex on the renal' function of anesthetized mongrel dogs. 1. A light brown powder isolated from Mori Radicis Cortex (MRC) by a slight modification of Tanemura's method, when given intravenously in doses ranging 0.5 to 5.0mg/kg, elicited diuresis with the increase of positive water clearance and amounts of $Na^{+}$ and $K^{+}$ excreted in the urine. At this time the glomerular filtration rate, renal plasma flow and osmolar clearance were not observed to have any significant changes. This diuresis was augmented in process of time and its maximum effect was exhibited about 30 minutes after administration of MRC. 2. The MRC, when administered into a intra carotid artery, responded promptly with diuresis and natriuresis at a level too small to effect renal functions when administered intravenously. In this experiment the patterns of changes of renal function were the patterns of changes of renal function were the same as those of the above intravenously administered experiment. 3. When infused directly into a renal artery, the MRC exhibited little effect on either kidney. 4. During water diuresis, the MRC did not elicit diuretic action or significant changes in renal functions. The above observations suggest that the diuresis of MRC is brought about by the inhibition of the release of antidiuretic hormone with the mechanism facilitating the excretion of $Na^{+/}$ and $K^{+}$ in urine.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.9 no.3
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• pp.317-329
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• 1998

In this paper, we have analyzed the packet error probability of DS/CDMA-Trellis Coded QPSK modulation signal with MRC(Maximum Ratio Combining) diversity reception in Rician fading, multi-user interferences and multipath channel. And then we have evaluated the performance and capacity of DS/CDMA-Trellis Coded QPSK system using the MRC diversity reception as a function of direct power to indirect power ratio ($K_R$), the number of diversity branch(M), the number of multi-user(U), PN chip rate(PN), the number of multipath channel($L_P$), and packet length(PL). From the results, we know that the coding gain of DS/CDMA-Trellis Coded QPSK system with 2 branch MRC diversity is about 6 dB against uncoded DS/CDMA BPSK system with 2 branch MRC diversity in Rician fading ($K_R=6dB), 5 multi-user interferences, and 3 multipath channel. And, we know that coded QPSK signal designed for the AWGN channel also perform well on a Rician fading channel with MRC diversity reception. Consequently, we expected that proposed system structure is reliable to the wireless data communication system in Rician fading, multi-user interferences, and multipath channel.