• YAKHAK HOEJI
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• v.59 no.6
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• pp.266-269
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• 2015

Coccidiosis is induced by Toxoplasma gondii and Eimeria tenella and novel anticoccidial drugs have been requested. In this study, the anticoccidial effect of 3-(4-methoxybenzylaminomethylene)-1,3-dihydroindole-2-one (5-108) on T. gondii and E. tenella was evaluated. Novel synthetic derivative 5-108 showed 1.44 fold higher relative selectivity compared to pyrimethamine against T. gondii in vitro assay. In chicken study, compound 5-108 significantly decreased the number of oocytes of E. tenella in feces, obtained from E. tenella-infected chickens, by $33{\pm}2.64%$ and $23{\pm}3.60%$ (P<0.001) at $7^{th}$ day and $9^{th}$ day p.i.. Conclusively, compound 5-108 was effective against T. gondii and E. tenella.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 1998.04a
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• pp.280-281
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• 1998

이 글의 구성은 다음과 같다. 1. 소개 2. 한국의 활동 3. ISO 규격 제정단계 4. TC 108 22차 총회 내용 5. TC 108/SC 5 4차 분과위원회 내용

• KOREAN POULTRY JOURNAL
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• v.5 no.3 s.41
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• pp.108-108
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• 1973

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2000.06a
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• pp.218-221
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• 2000

1999년 5월 4일부터 5월 7일까지 덴마크 오덴스에서 개최되었던 18차 ISO TC108/SC2 (기계 차량 구조물의 기계 진동 충격의 측정 및 평가) 총회내용 및 결의사항과 최근 진행되고 있는 ISO TC108/SC2 산하 규격 제 개정 동향에 대하여 살펴본다.

• 월간낙농육우
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• v.37 no.5
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• pp.108-108
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• 2017

• Korean Architects
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• no.5 s.146
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• pp.108-108
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• 1981

• Korea Petroleum Association Journal
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• no.5 s.159
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• pp.108-108
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• 1994

• 베이커리
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• no.5 s.430
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• pp.108-108
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• 2004

• Korea Petroleum Association Journal
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• no.7 s.231
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• pp.108-108
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• 2002

• Bulletin of the Korean Chemical Society
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• v.26 no.3
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• pp.433-439
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• 2005

To gain further insight on the relationship between structure and functions of glutathione S-transferase (GST), the three tyrosine 108 mutants, Y108A, Y108F, and Y108W, of human GST P1-1 were expressed in Escherichia coli and purified to electrophoretic homogeneity by affinity chromatography on immobilized GSH. The substitution of Tyr 108 with alanine resulted in significant decrease of the GSH-conjugation activity and the GSH peroxidase activity, but approximately 63% increase of steroid isomerase activity toward ${\Delta}^5$–[androstene 3,17-dione. On the other hand, the substitution of Tyr 108 with phenylalanine resulted in decreases of $k_{cat}\;and\;k_{cat}/K_m{^{EPNP}}$ by 2 orders of magnitude, suggesting that Tyr 108 residue of hGSTP1-1 are considered to be important for the catalysis and the binding of the epoxide substrates. The substitution of Tyr 108 with tryptophan resulted in significant decreases of the specific activities toward EPNP, cumene hydroperoxide and ${\Delta}^5$–ndrostene 3,17-dione, but approximately 2-fold increase on the enzyme-catalyzed addition of GSH to DCNB. We conclude from these results that Tyr 108 in hGST P1-1 plays very different roles depending upon the nature of the electrophilic substrates.