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http://dx.doi.org/10.17480/psk.2015.59.6.266

Anticoccidial Effect of 3-(4-Methoxybenzylaminomethylene)-1,3-dihydroindole-2-one(5-108)  

Yeo, Seon-Ju (Zoonosis Research Center, Department of Infection Biology, School of Medicine, Wonkwang University)
Kim, Hak Sung (College of Pharmacy, Wonkwang University)
Kim, Suk (College of Veterinary Medicine, Gyeongsang National University)
Lee, Kee-In (Bio-Organic Science Division, Korea Research Institute of Chemical Technology)
Park, Hyun (Zoonosis Research Center, Department of Infection Biology, School of Medicine, Wonkwang University)
Publication Information
YAKHAK HOEJI / v.59, no.6, 2015 , pp. 266-269 More about this Journal
Abstract
Coccidiosis is induced by Toxoplasma gondii and Eimeria tenella and novel anticoccidial drugs have been requested. In this study, the anticoccidial effect of 3-(4-methoxybenzylaminomethylene)-1,3-dihydroindole-2-one (5-108) on T. gondii and E. tenella was evaluated. Novel synthetic derivative 5-108 showed 1.44 fold higher relative selectivity compared to pyrimethamine against T. gondii in vitro assay. In chicken study, compound 5-108 significantly decreased the number of oocytes of E. tenella in feces, obtained from E. tenella-infected chickens, by $33{\pm}2.64%$ and $23{\pm}3.60%$ (P<0.001) at $7^{th}$ day and $9^{th}$ day p.i.. Conclusively, compound 5-108 was effective against T. gondii and E. tenella.
Keywords
Toxoplasma gondii; Eimeria tenella; anticoccidial effect; selectivity; 5-108;
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