• Title/Summary/Keyword: 4WS

Search Result 284, Processing Time 0.023 seconds

In Vitro and in Vivo Antifungal Activities of 6-[(N-4-bromophenyl)amino]-7-chloro-5,8-quinolinediones

  • Ryu, Chung-Kyu;Kim, Dong-Hyun;Kwon, Sang-Mee;Jung, Sung-Hee;Kim, Sung-Hee
    • Archives of Pharmacal Research
    • /
    • v.20 no.6
    • /
    • pp.586-589
    • /
    • 1997
  • Antifungal activities of 6-[(N-4-bromophenyl)amino]-7-chloro-5,8-quinolinedione (RCK7) were tested. The MIC values of RCK7 were determined for antifungal suceptibility, in vitro against Aspergillus niger, Cryptococcus neoformans and Trichophyton mentagrophyte by standard agar streak method. In vitro, RCK7 showed more potent antifungal activity than fluconazole and ketoconazole. Also, RCK7 was tested for in vivo antifungal activity in the treatment of systemic infection with Candida albicans in normal mice. The therapeutic potential of RCK7 had been assessed by evaluating their survival rate against systemic infections compared with that of ketoconazole. $ED_{50}$ of intraperitoneally administered RCK7 ws $2.05{\pm}0.30mg/kg$ but that of ketoconazole was $8.00{\pm}0.73 mg/kg$, respectively. When RCK7 was administered intravenously at the $ED_{50}$(2.05 mg/kg). the colony counts of Candida albicans in the liver after 7 days and 14 days were reduced as likely as ketoconazole at the $ED_{50}(8.00 mg/kg)$, and the better survival rates than ketoconazole's were achieved after 14 days. The results suggest that RCK7 may be a potent antifungal agent.

  • PDF

The Standing Crops and Soil-borne Microfungal Flora of Phyllostachys reticulata in Korea (한국산(韓國産) 왕대나무의 현존량(現存量)과 토양(土壤) 미세균류상(微細菌類相))

  • Kim, Kwan-Soo
    • The Korean Journal of Mycology
    • /
    • v.7 no.2
    • /
    • pp.91-116
    • /
    • 1979
  • This paper is to investigate the standing crops and microfungal flora in soil in Phyllostachys reticulata forests in both the Yesan area (A) and the Kwangsan area (B). The stand density of the bamboo revealed 17,250 shoots per ha in area A, and in area B 14,780 shoots which were 16.1% less in number than area A. In respect to the environmental factors between the two areas, the mean temperature during the growth period was $1.5{\sim}2^{\circ}C$ higher in area B than in area A, soil tempeature also was $1{\sim}2^{\circ}C$ higher in area B, and the total quantities of nitrogen, phosphoric acid and organic compounds contained in the soil of area B were also slightly higher than those of area A. In area B the quantities of dried leaf matter, humus, and vegetation in the bamboo forest were also larger than in area A. In addition, five more species of microfungi which playa role in the decomposition of the various organic materials in the bamboo forests were identified in area B: Mortierella elongata, Mucor circinelloides, Aspergillus japonicus, Penicillium waksmani and Trichoderma lignorum. The atmospheric temperature in the inner portions of the bamboo forests was lower than the outside temperature, but the humidity was higher. The rates of relative illuminance were measured in area A at 4.19%, and in area B at 2.7%. These values revealed that the photosynthetic acitivity in the lower part of the bamboo was lost but it was considered that lower illuminance increased the microfungal activities in the vicinity of the surface soil. Since the productive structure of the bamboo showed that the maximum amount of photosynthesis was located in the upper portion of the bamboo in area B, it was considered to be an effective structure in maintaining the high productivity of the bamboo. The allometric relation between $D^2H$ and dry weight of stems(Ws), branches(Wb) and leaves(Wl) of the bamboo in area A were appoximated by log Ws=0.5262 log $D^2H$+1.9546; log Wb=0.6288 log $D^2H$+1.5723; log Wl=0.5181 log $D^2H$+1.8732, and those of the bamboo in area B were approximated by log Ws=0.5433 log $D^2H$+1.8610; log Wb=0.1630 log $D^2H$+2.3475; log Wl=0.4509 log $D^2H$+2.0041. From the above, the standing crops in area A were measured thus: Ws was 1,128. 83kg; Wb, 689.05kg; Wl, 926.69kg and Wl, 2,744.57kg per 10a. In area B, Ws was 1,206. 66kg; Wb, 679.92kg; Wl, 1,112.51kg and Wt, 2.999kg per l0a. Significant differences from the result of t-test were for $D^2H$ Ws, Wl and Wt between areas A and B. But no significant difference was found for Wb. In order to record as completely as possible the microfungal flora of the areas, every possible means was tried, and 158 strains of fungi were isolated, and of these, the microfungi of 55 species were identified. The dominant species were Trichoderma viride, Penicillium janthinellum, P. commune, Aspergillus oryzae, A. niger, A. gigantus, A. fumigatus, Mortierella ramaniana, var. anguliFPora, Mucor hiemalis and Zygorhynchus moelleri. According to the above results, it was revealed that optimum soil, the increases of soil materials, more species of soil microfungi, and the atmospheric temperature during the growth period have made the bamboo flourish and bring more species and larger quantities of vegetation in the bamboo forests. The correlation between the standing crops and environmental factors in the bamboo forest is considered to be a complicated relationship of all the factors, but the stand density is thought to be the most important factor involved.

  • PDF

Development and Management of an Ontology and Registries for Sharing Metadata about Business Process Specifications under SOA (서비스 지향 아키텍쳐 하에서 비즈니스 프로세스 명세에 관한 메타 데이터를 공유하기 위한 온톨로지와 등록저장소의 개발 및 관리 방안)

  • Kim, Hyoung-Do;Kim, Jong-Woo
    • The Journal of the Korea Contents Association
    • /
    • v.7 no.11
    • /
    • pp.9-22
    • /
    • 2007
  • While standardization and its applications for registering and sharing information resources about B2B transactions such as business documents are relatively well developed, it is not easy to register and share business process resources because there are many ways to define complex business processes using different specification(definition) languages. In practice, there are several competing business process specification languages applicable under service-oriented architecture (SOA) such as ebXML BPSS, WS-BPEL, BPMN and so on. A systematic way has to be prepared to register/share diverse and heterogeneous specifications represented using those languages. This paper demonstrates the usefulness of sharing B2B business processes by prototyping a business process registry called ebRR4BP. First of all, we designed a metadata ontology to support the registration of diverse B2B business processes. To implement the proposed metadata ontology using ebXML registries, a mapping scheme to ebXML Registry Information Model is also suggested. The ontology and mapping scheme will be a foundation for supporting common interchange of business process metadata among B2B resistries.

Using an ABS Controller and Rear Wheel Controller for Stability Improvement of a Vehicle (ABS 제어 및 후륜조향 제어기를 이용한 차량 안정성 개선에 관한 연구)

  • Song, Jeong-Hoon;Boo, Kwang-Suck;Lee, Jong-Il
    • Transactions of the Korean Society of Mechanical Engineers A
    • /
    • v.28 no.8 s.227
    • /
    • pp.1125-1134
    • /
    • 2004
  • This paper presents a mathematical model which is about the dynamics of not only a two wheel steering vehicle but a four wheel steering vehicle. A sliding mode ABS control strategy and PID rear wheel control logic are developed to improve the brake and cornering performances, and enhance the stability during emergency maneuvers. The performances of the controllers are evaluated under the various driving road conditions and driving situations. The numerical study shows that the proposed full car model is sufficient to accurately predict the vehicle response. The proposed ABS controller reduces the stopping distance and increases the vehicle stability. The results also prove that the ABS controller can be employed to a four wheel steering vehicle and improves its performance. The four wheel steering vehicle with PID rear wheel controller shows increase of stability when a vehicle speed is high and sharp cornering maneuver when a vehicle speed is low compared to that of a two wheel steer vehicle.

Studies on the Serum total Activities and Isoenzyme Patterns of CPK in non-human Primates Reared in Korea (國內飼育 원숭이의 血淸 CPK의 總活性値와 isoenzyme에 관한 硏究)

  • 윤상보;김덕환;서지민;신남식;현병화;박배근;송희종
    • Journal of Veterinary Clinics
    • /
    • v.18 no.4
    • /
    • pp.390-396
    • /
    • 2001
  • CKP isoenzymes have a high level of efficaciousness as diagnostic and prognostic aids in various diseases. There is not any report on the total activity of CPK of non-human primates, let alone CPK isoenzyme patterns, in Korea. In this study, total activities and isoenzyme patterns of CPK were measured to obtain their reference values in domestically reared common marmosets, crab-eating macaques and Japanese macaques. We observed remarkable different values of serum total CPK from the primates used in this experiment. Serum CPK activities of Japanese macaques and crab-eating macaques were 275.8$\pm$158.1 IU/l and 396.7$\pm$697.4 IU/l, respectively, whereas those of common marmosets showed much higher value of 618.8$\pm$1,117.6 IU/l. In all common marmosets and crab-eating macaques, only CPK$_3$ ws observed. In five out of eight Japanese macaques, CPK$_3$ was the sole fraction but two animals showed CPK$_1$ and CPK$_3$ isoenzymes, and the remaining one had CPK$_2$ and CPK$_3$ fractions. There were some discrepancies in the pattern and ratio of isoenzyme fractions in Japanese macaques. In conclusion, values such as CPK and CPK isoenzyme patterns of investigated for the first time form non-human primates reared in Korea, could be reference values for the optimal diagnosis and therapy diseases of the corresponding animal species.

  • PDF

Effect of Splenectomy on the Blood Picture according to Gestation Periods in Rats (비장적출이 임신 rat의 혈액상에 미치는 영향)

  • 정원철;오석두;성환후;정진관;윤창현;이병오
    • Korean Journal of Animal Reproduction
    • /
    • v.18 no.3
    • /
    • pp.157-165
    • /
    • 1994
  • This experiment was examined the effect of splenectomy on the hematology in pregnant wistar rat. Only animals that had been shown regular 4-day estrous cycles for more than two cycles were used. The day after mating with the same male animal ws designated Day 0 of pregnancy. Spleen was removed from Day 0(early), 6(middle) and 13(late) of pregnant rat, respectively. Blood sample was collected at Day 1, 7, 14 and 21 of the pregnancy. 1. RBC was increased significantly(P<0.05) to the progress of pregnancy in control rat. The late splenectomized rats were decreased significantly(P<0.05) at Day 21 of pregnancy than control rats. 2. Hb was increased significantly (P<0.05) at 21th day of pregnancy in late splenectomized groups than others group. 3. In the late splenectomized rats, Ht was decreased significant (P<0.05) due to the progress of pregnancy and decreased significantly (P<0.05) at Day 21 of pregnancy in all splenectomized groups. 4. WBC was increased significantly (P<0.05) at Day 1 of pregnancy in splenectomized groups compared with control. 5. In differential leukocyte rate, the Basophils and Monocytes was not significantly changed. Neutrophils was increased significantly(P<0.05) at Day 14 and 21 than Day 1 and 7 of pregnancy in control. Lymphocytes was decreased significantly(P<0.05) in control due to progress of pregnancy. Neutrophils was increased and Lymphocytes was decreased significantly(P<0.05) in splenectomized groups compared with control.

  • PDF

Effect of Splenectomy on the Blood Component and Reproductive Performance accordingto Gestation in Rats (비장적출이 임신 rat의 혈액성분 및 번식력에 미치는 영향)

  • 정원철;오석두;성환후;정진관;윤창현;이병오
    • Korean Journal of Animal Reproduction
    • /
    • v.18 no.3
    • /
    • pp.167-174
    • /
    • 1994
  • This experiment was undertaken to investigate the effect of splenectomy on the hematology and maintenance of pregnant rats. Those animals that had shown regular 4 or 5 day estrous cycles for more than two cycles were used. The day after mating ws designated Day 0 of pregnancy. Spleen was removed from Day 0(early), 6(middle) and 13(late) of pregnant rat, respectively. Blood was collected on Day 1, 7, 14 and 21 of the pregnancy. 1. The total serum protein was increased significantly (P<0.05) to the progress of pregnancy in control rat. All rats that splenectomized groups were decreased significantly(P<0.05) at Day 21 of pregnancy than control rats. 2. Albumin was not significantly changed. 3. Globulin was decreased significantly(P<0.05) between contol and middle treatment at Day 7, 14 of pregnancy. 4. Glucose was increased for the due to the pregress of pregnancy. It was no significance differences among the each groups. 5. Rate of abortion was increased in groups of early and middle of splenectomy compared with control. 6. Period of pregnancy was delayed in middle and late splenectomized gruops companed with control. 7. Litter size was lowed significantly (P<0.05) in early and middle splenectomized groups compared with control.

  • PDF

Simplified Methodology to Generate 2D/3D Object in 4D system for Civil Engineering Projects (토목시설물 4D구현을 위한 2D/3D 객체 생성 간편화 기법)

  • Lee Syeung-Youl;Lee Yong-Soo;Kim Chang-Hak;Kang Leen-Seok
    • Proceedings of the Korean Institute Of Construction Engineering and Management
    • /
    • autumn
    • /
    • pp.585-588
    • /
    • 2003
  • This study attempts to develop a skeleton model to link construction schedule and 3D object for drawings in 4D system. Generally, the construction schedule and 3D object can be linked in 4D system by imported files which are made in specific S/Ws such as CAD S/W and scheduling S/W. Those methods have a difficulties for operating 4D data because extra work needs to link 4D data for each activity. This study develops a 4D model which the 4D data can be self-generated within the system. The suggested model can reduce the initial input data for new project by integrating schedule and 3D object in 4D system.

  • PDF

Improvement of Water Quality Using Ultra Filtration System in Artificial Seed Production of Olive Flounder, Paralichthys olivaceus (넙치 인공종묘생산에 있어 막분리 여과 시스템을 이용한 수질환경의 개선)

  • Jung Gwan Sik;Ann Chang Bum;Oh Myung Joo;Ji Seung Cheol;Yoo Jin Hyung
    • Korean Journal of Fisheries and Aquatic Sciences
    • /
    • v.35 no.6
    • /
    • pp.639-643
    • /
    • 2002
  • Water quality, bacterial phase and fish growth rate were analyzed in the process of artificial seed production of flounder (Paralichtys oliraceus) larvae to investigate the water quality in rearing tank using Ultra Filtration System (UES). Sand Filtration System (SFS) and Ultra Filtration System (Ins) were set up in the experimental group. For the analysis of water quality, pH, salinity, DO, SS, COD, $NH_{4}^{+},\;NO_{2}^{-},\;NO^-,\;DIN$ (dissolved inorganic nitrogen) and DU (dissolved inorganic phosphate) were measured. There was no data difference between SFS group and UES group in most analysis items, but the UEs group showed low salinity and low 55 values, such that salinity was $33.5\%_{\circ}$ in SES group and $30.2\%_{\circ}$ in WS group and 55 was 15.5 mL/L in SES group and 7.0 mL/L for UPS group. For changes in bacterial phase and TBC (Total Bacterial Counts), in SES group, 6$\times$10^{5}CFU/mL in seawater decreased to the ratio of about 116, and TBC, Genus Vibrio and bacteria in the Genus Acinetobacter and Genus Micrococcus sharply increased after nine days, while stable bacterial phase was maintained low in UES group during the experiment except for Genus Ajteromonas. In the growth of the larvae, fish length was 17.0 mm (SGR 14.0) in the SES group and 18.8 mm (SGR 14.3) in the UFS group. It is concluded that when water is supplied for artificial seed production with WS, stabilization of water quality condition and inhibition of bacterial multiplication are possible. When production environment becomes stable, stable growth of fish becomes possible by reduction of environmental stress.

Effect of acupuncture at TE4, SP3 and TE4+SP3 in hyperglycemia rats induced by streptozotocin (태백 ${\cdot}$ 양지 자침이 streptozocin에 의해 유발된 고혈당 백서에 미치는 영향)

  • Na, Chang-Su;Youn, Dae-Hwan;Cho, Myung-Rae;Lee, Kang-Ouk
    • Korean Journal of Acupuncture
    • /
    • v.24 no.1
    • /
    • pp.95-111
    • /
    • 2007
  • Objectives : This research ws performed to investigate the effect of manual acupuncture at TE4, SP3 and TE4+SP3 on body weight, blood glucose, BUN, creatinine, lipid metabolism, liver function and morphological change of hepatic tissue in hyperglycemia rats. Methods : Experimenal groups were divided into hyperglycemia group(Control group), hyperglycemia and acupuncture therapy group at SP3, hyperglycemia and acupuncture therapy group at TE4, hyperglycemia and acupuncture therapy group at TE4+SP3 , once per 2 days during 5 weeks. Results : Body weight was decreased significantly in TE4 group of fifth week compared with Control group. Blood glucose was decreased significantly in SP3 group compared with control group. Creatinine was decreased significantly in TE4 and TE4+SP3 group compared with control group. Total cholesterol was decreased significantly in TE4+SP3 group compared with control group. Triglyceride was decreased significantly in TE4 gorup compared with control group. In the morphological change of hepatic cell, TE4 and SP3 group were showed he rough endoplasmic reticulum forms aggregates of parallel, flattened cisternae scattered randomly throughout the cytoplasm compared with control gruop. Conclusions : Acupuncture at TE4 can manage hyperglycemia by controlling body weight, and lipid metabolism in hyperglycemia rats induced by streptozotocin.

  • PDF