• Journal of Environmental Science International
• /
• v.24 no.1
• /
• pp.81-96
• /
• 2015

The characteristics of atmospheric dispersion of radioactive material (i.e. $^{137}Cs$) related to local wind patterns around the Kori nuclear power plant (KNPP) were studied using WRF/HYSPLIT model. The cluster analysis using observed winds from 28 weather stations during a year (2012) was performed in order to obtain representative local wind patterns. The cluster analysis identified eight local wind patterns (P1, P2, P3, P4-1, P4-2, P4-3, P4-4, P4-5) over the KNPP region. P1, P2 and P3 accounted for 14.5%, 27.0% and 14.5%, respectively. Both P1 and P2 are related to westerly/northwesterly synoptic flows in winter and P3 includes the Changma or typhoons days. The simulations of P1, P2 and P3 with high wind velocities and constant wind directions show that $^{137}Cs$ emitted from the KNPP during 0900~1400 LST (Local Standard Time) are dispersed to the east sea, southeast sea and southwestern inland, respectively. On the other hands, 5 sub-category of P4 have various local wind distributions under weak synoptic forcing and accounted for less than 10% of all. While the simulated $^{137}Cs$ for P4-2 is dispersed to southwest inland due to northeasterly flows, $^{137}Cs$ dispersed northward for the other patterns. The simulated average 137Cs concentrations of each local wind pattern are $564.1{\sim}1076.3Bqm^{-3}$. The highest average concentration appeared P4-4 due to dispersion in a narrow zone and weak wind environment. On the other hands, the lowest average concentration appeared P1 and P2 due to rapid dispersion to the sea. The simulated $^{137}Cs$ concentrations and dispersion locations of each local wind pattern are different according to the local wind conditions.

• Tuberculosis and Respiratory Diseases
• /
• v.73 no.1
• /
• pp.11-21
• /
• 2012

Background: While qualitative analysis of methylation has been reviewed, the quantitative analysis of methylation has rarely been studied. We evaluated the methylation status of CDKN2A, $RAR{\beta}$, and RASSF1A promoter regions in non-small cell lung carcinomas (NSCLCs) by using pyrosequencing. Then, we evaluated the association between methylation at the promoter regions of these tumor suppressor genes and the clinicopathological parameters of the NSCLCs. Methods: We collected tumor tissues from a total of 53 patients with NSCLCs and analyzed the methylation level of the CDKN2A, $RAR{\beta}$, and RASSF1A promoter regions by using pyrosequencing. In addition, we investigated the correlation between the hypermethylation of CDKN2A and the loss of $p16^{INK4A}$ immunoexpression. Results: Hypermethylation of CDKN2A, $RAR{\beta}$, and RASSF1A promoter regions were 16 (30.2%), 22 (41.5%), and 21 tumors (39.6%), respectively. The incidence of hypermethylation at the CDKN2A promoter in the tumors was higher in undifferentiated large cell carcinomas than in other subtypes (p=0.002). Hyperrmethylation of CDKN2A was significantly associated with $p16^{INK4A}$ immunoexpression loss (p=0.045). With regard to the clinicopathological characteristics of NSCLC, certain histopathological subtypes were found to be strongly associated with the loss of $p16^{INK4A}$ immunoexpression (p=0.016). Squamous cell carcinoma and undifferentiated large cell carcinoma showed $p16^{INK4A}$ immunoexpression loss more frequently. The Kaplan-Meier survival curves analysis showed that methylation level and patient survival were barely related to one another. Conclusion: We quantitatively analyzed the promoter methylation status by using pyrosequencing. We showed a significant correlation between CDKN2A hypermethylation and $p16^{INK4A}$ immunoexpression loss.

• Journal of the Computational Structural Engineering Institute of Korea
• /
• v.24 no.4
• /
• pp.449-455
• /
• 2011

Recently, international collaborative research which was organized at Bhabha Atomic Research Centre in India, was conducted to develop for pressure capacity and nonlinear behavior of PHWR 1/4 scale nuclear containment building between experimental test and numerical code. In this paper, a nonlinear finite element analysis was carried out in order to predict ultimate pressure capacity and nonlinear behavior of the 1/4 scale containment building. The 1/4 scale containment building is consisted of basemat, cylinder wall, dome and 4-buttress. For the finite element analysis, commercial program ABAQUS was used. Finite element models including concrete, rebar and tendon have been developed for assessment of ultimate pressure capacity and failure mode for nuclear containment building. From the analysis results, first crack of the concrete, the yielding of the rebar and ultimate capacity pressure occurred at $1.6P_d$(design pressure), $3.36P_d$ and $4.0P_d$, respectively.

• The Korean Journal of Nuclear Medicine Technology
• /
• v.13 no.3
• /
• pp.67-75
• /
• 2009

Purpose: As to the analytical method of data, the various programs in which it is used for the quantitative rating of the Tl-201 myocardial perfusion SPECT are reported that there is a difference. Therefore, the measured value error of the mutual program is expected to be generated even if the quantitative analysis is made against data of the same patient. Using quantitative index that able to represent myocardial perfusion defect level, we aimed to determine correlation among three myocardial perfusion analysis programs 4DM (4DMSPECT), QPS (Quantitative Perfusion SPECT), ECT (Emory Cardiac Toolbox) that be used generally in most departments of Nuclear Medicine. Materials and Methods: We analyzed the 145 patients who were examined by Tl-201 gated myocardial perfusion SPECT in department of nuclear medicine at Asan Mediacal Center from December 1th 2008 to February 14th 2008. We sorted as normal group and abnormal group. Normal group consist of 80 patients (Male/Female=38/42, age:$65.1{\pm}9.9$) who have low possibility of cardiovascular disease. And abnormal group consist of 65 patients (Male/Female=45/20, age:$63.0{\pm}8.7$) who were diagnosed cardiovascular disease with reversible perfusion defect or fixed perfusion defect through myocardial perfusion SPECT results. Using the 4DM, QPS, and ECT programs, the total defect extent (TDE) such as LAD, LCX, RCA and the summed stress score (SSS) have been analysed for their correlations and statistical comparison with the paried t-test for the quantitative indices analysed from each group. Results: The correlation of 4DM:QPS, QPS:ECT, ECT:4DM each group result from 145 patients is 0.84, 0.86, 0.82 at SSS, 0.87, 0.84, 0.87 at TDE, and both index showed good correlation. In paired t-test and Bland-Altman analysis results showed no statistically significant difference in the comparison of QPS:ECT at the mean SSS and TDE, 4DM:QPS, ECT:4DM comparative analysis results showed statistically significant difference at SSS and TDE index. The correlation of 4DM:QPS, QPS:ECT, ECT:4DM program results from abnormal group (65 patients) is 0.72, 0.72, 0.70 at SSS and 0.77, 0.70, 0.77 at TDE and TDE and SSS has a good correlation. In abnormal group, paired t-test and Bland-Altman analysis results showed no statistically significant difference at QPS:ECT SSS (p=0.89) and TDE (p=0.23) comparison, 4DM:QPS, ECT:4DM comparative analysis results showed statistically significant difference at SSS and TDE index (p<0.01). In normal group (80 patients), paired t-test and Bland-Altman analysis results showed no statistically significant difference at QPS:ECT SSS (p=0.95) and TDE (p=0.73) comparison. And 4DM:QPS, ECT:4DM comparative analysis results showed statistically significant difference at SSS and TDE index (p<0.01). Conclusions: The perfusion defect of the Tl-201 myocardial perfusion SPECT was analyzed in not only the patient in whom it has the cardiovascular disease but also the patient in whom the possibility of the cardiovascular disease is few. In the comparison of the all group research, the mean of the TDE and SSS, 4DM was lower than QPS and ECT progrms. Each program showed good correlation and the results showed statistically significant difference. However, in this way, it is determined to be compatible about the analysis value in which the large-scale side between the programs uses each program a difference in a clinical in the Bland-Altman analyzed result in spite of the good correlation and cannot use. but, this analyzed result will be able to be usefully used as the reference material for the clinical read and is expected.

• Analytical Science and Technology
• /
• v.17 no.3
• /
• pp.282-288
• /
• 2004

Inclusion selectivities of the cyanocadmate host complexes with ammonium oniums, $[Cd_x(CN)_{2x}][onium{\cdot}zG]$ (onium = $NMe_3Et^+$, $NMeEt{_3}^+$ and $NEt{_4}^+$, G = guest), have been investigated for $C_6H_6$ (B), PhMe (T), PhEt (E), ortho (O), meta (M), and para (P) isomers of $C_6H_4Me_2$ as the aromatic guest molecules. From the binary, ternary, quaternary and quinary mixed guests of B, T, E, O, M and P, the order of preference in the $NMe_3Et+$-host is $B{\gg}$T>P${\fallingdotseq}O{\fallingdotseq}M$ and E>O${\gg}P{\fallingdotseq}M$; in the $NMeEt{_3}^+$-host is T>B>P${\gg}O{\fallingdotseq}M$ and E>P${\gg}$M>O; in the $NEt{_4}^+$-host is $B{\gg}T{\fallingdotseq}O{\fallingdotseq}M{\fallingdotseq}P$. However, the $NEt{_4}^+$-host complexes of E, O, M and P mixed-guests were not obtained. These inclusion selectivities were compared to our previous results of the $NMe{_4}^+$-host; T>B>P${\gg}$M>O and E>P${\gg}$M>O.

• Journal of Microbiology and Biotechnology
• /
• v.16 no.11
• /
• pp.1740-1746
• /
• 2006

Enrichment techniques led to the isolation of a Pseudomonas sp. strain P2 from municipal waste-contaminated soil sample, which could utilize different isomers of a commercial mixture of 4-nonylphenol when grown in the presence of phenol. The isolate was identified as Pseudomonas sp., based on the morphological, nutritional, and biochemical characteristics and 16S rDNA sequence analysis. The ${\beta}$-ketoadipate pathway was found to be involved in the degradation of phenol by Pseudomonas sp. strain P2. Gas chromatography-mass spectrometric analysis of the culture media indicated degradation of various major isomers of 4-nonylphenol in the range of 29-50%. However, the selected ion monitoring mode of analysis of biodegraded products of 4-nonylphenol indicated the absence of any aromatic compounds other than those of the isomers of 4-nonylphenol. Moreover, Pseudomonas sp. strain P2 was incapable of utilizing various alkanes individually as sole carbon source, whereas the degradation of 4-nonylphenol was observed only when the test organism was induced with phenol, suggesting that the degradation of 4-nonylphenol was possibly initiated from the phenolic moiety of the molecule, but not from the alkyl side-chain.

• Journal of Korean Biological Nursing Science
• /
• v.24 no.4
• /
• pp.209-218
• /
• 2022

Purpose: This study aimed to investigate the relationships between the characteristics of nurses' work schedules, health outcomes, and work-life balance. Methods: This was a secondary data analysis that included 422 nurses in Korean hospitals. Descriptive analysis, independent sample t-test, one-way ANOVA, Pearson correlation analysis, and multiple linear regression analysis were used to identify the associated factors. Results: Multiple linear regression analysis showed that work-life balance was lower when atypical work was performed (β=-.14, p=.010). Nurses who did not work overtime showed a higher level of work-life balance than those who worked overtime infrequently (β=-.11, p=.002) or frequently (β=-.28, p<.001). The work-life balance level increased when nurses had better subjective health status (β=.16, p<.001) or higher sleep quality (β=.29, p<.001). It was verified that the work-life balance level was higher for single-person households than for households with two (β=-.18, p=.003), three to four (β=-.16, p=.022), or five or more (β=-.21, p<.001) persons. Conclusion: This study suggests that government and hospital organizations should provide high-quality care and consideration to nurses who do atypical or overtime work as well as their subjective health status and sleep quality. Further research should focus on the development of a policy that improves the work-life balance of nurses, especially for those who work during atypical hours.

• Information Systems Review
• /
• v.25 no.4
• /
• pp.205-231
• /
• 2023

The Information Security Management System (ISMS) is a protection procedure and process that keeps information assets confidential, flawless, and available at any time. ISMS-P in Korea and ISO/IEC 27001 overseas are the most representative ISMS certification systems. In this paper, in order to understand the relationship between ISMS certification and organizational characteristics, data were collected from Korea Internet & Security Agency (KISA), Ministry of Science and ICT, Information Security Disclosure System (ISDS), Financial Supervisory Service, Data Analysis, Retrieval and Transfer System (DART), and probit regression analysis was performed. In the probit analysis, the relationship with four independent variables was confirmed for three cases: ISMS-P acquisition, ISO/IEC 27001 acquisition, and both ISMS-P and ISO/IEC 27001 acquisition. As a result of the analysis, it was found that companies that acquired both ISMS-P and ISO/IEC 27001 had a positive correlation with the total number of employees and a negative correlation with business history. In addition, the improvement direction of the ISMS-P certification system and information security disclosure system could also be confirmed.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.8
• /
• pp.3691-3698
• /
• 2014

Background: Published studies on the association between the Ras Association Domain Family 1 isoform A (RASSF1A) Ala133Ser polymorphism and cancer susceptibility have yielded conflicting results. Thus, a meta-analysis was here performed to assess the possible association. Materials and Methods: All eligible case-control studies published up to November 2013 on the association between RASSF1A Ala133Ser polymorphism and cancer susceptibility were identified by searching PubMed, Web of Science, Science Direct and hand search. Bothfixed-effect and random-effect models were used to calculate pooled odds ratios (ORs) with 95% confidence intervals (CIs) by using the Comprehensive Meta-Analysis software version 2.2. Results: A total of 10 studies including 4,572 cancer cases and 4,320 controls were included in the meta-analysis. Overall, significantly increased cancer risk was associated with the variant Ser133 when all studies were pooled (Ser vs Ala: OR=1.51, 95% CI=1.08-2.12, $P_{heterogeneity}{\leq}0.001$; Ser/Ser+Ala/Ser vs Ala/Ala: OR=1.55, 95% CI=1.08-2.22, $P_{heterogeneity}{\leq}0.001$). Moreover, in subgroup analyses by cancer types, a significant association between RASSF1A Ala133Ser polymorphism and lung cancer risk was found (Ser vs Ala: OR=2.27, 95% CI=1.29-4.02, $P_{heterogeneity}$=0.61; Ser/Ser+Ala/Ser vs Ala/Ala: OR=2.42, 95% CI=1.33-4.42, $P_{heterogeneity}=0.75$). In addition, in subgroup analyses by ethnicity, it was found that the RASSF1A Ala133Ser polymorphism was associated with overall cancer risk in Asians (Ser vs Ala: OR=1.37, 95% CI=1.06-1.77, $P_{heterogeneity}=0.06$) and Caucasians (Ser/Ser+Ala/Ser vs Ala/Ala: OR=2.21, 95% CI=1.01-4.82, $P_{heterogeneity}{\leq}0.001$). Conclusions: This meta-analysis suggests, for the first time, that RASSF1A Ala133Ser polymorphism may contribute to cancer susceptibility, especially for lung cancer. Besides, additional well-designed studies with larger sample size focusing on different ethnicities and cancer types are needed to confirm these findings.

• Journal of Korean Society on Water Environment
• /
• v.29 no.6
• /
• pp.832-841
• /
• 2013

In recent years, eutrophication in the Paldang Lake has become one of the major environmental problems in Korea as it may threaten drinking water safety and human health. Thus it is important to understand the phenomena and predict the time and magnitude of algal blooms for applying adequate algal reduction measures. This study performed seasonal water quality assessment and chlorophyll-a prediction using Bayseian simple/multiple linear regression analysis. Bayseian regression analysis could be a useful tool to overcome limitations of conventional regression analysis. Also it can consider uncertainty in prediction by using posterior distribution. Generally, chlorophyll-a of a P2(Paldang Dam 2) site showed high concentration in spring and it was similar to that of P4(Paldang Dam 4) site. For the development of Bayseian model, we performed seasonal correlation. As a result, chlorophyll-a of a P2 site had a high correlation with P5(Paldang Dam 5) site in spring (r = 0.786, p<0.05) and with P4 in winter (r = 0.843, p<0.05). Based on the DIC (Deviance Information Criterion) value, critical explanatory variables of the best fitting Bayesian linear regression model were selected as a $PO_4-P$ (P2), Chlorophyll-a (P5) in spring, $NH_3-N$ (P2), Chlorophyll-a (P4), $NH_3-N$ (P4) in summer, DTP (P2), outflow (P2), TP (P3), TP (P4) fall, COD (P2), Chl-a (P4) and COD (P4) in winter. The results of chlorophyll-a prediction showed relatively high $R^2$ and low RMSE values in summer and winter.