• 한국발생생물학회지:발생과생식
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• 제7권1호
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• pp.41-48
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• 2003

본 연구는 생식주기 중의 흰쥐 자궁에서 발현되는 유전자들 중 adhesion수용체 유전자들의 발현이 프로게스테론(P$_4$)에 의하여 차별적으로 조절되는 실험을 하였다. 첫째 실험군은 난소절제 흰쥐와 배란기 흰쥐를 사용하였고(OVX/estrus), 둘째 실험군은 난소절제 흰쥐와 난소절제 후 P4를 주사한 흰쥐를 사용하였다(OVX/OVX+P$_4$). 적출한 자궁조직에서 total RNA를 추출, [$\alpha$$^{32}$P]-dATP로 probe를 제작한 후 Rat Atlas away 1.2 II(Clontech)을 이용하여 발현되는 유전자들을 선별하였으며, 그 중 adhesion 수용체 유전자들의 발현양상을 RT-PCR 방법으로 확인하였다. OVX/estrus 자궁의 유전자 발현을 비교한 경우, 전체 1176개의 유전자들 중 P4에 의해 발현이 증가되는 adhesion 수용체 유전자들은 embigin protein, activated leukocyte cell adhesion molecule, afadin, neuroligin 2, semaphorin Z, osteonectin 등 이었다. OVX/OVX+P$_4$자궁의 유전자 발현을 비교한 경우, P$_4$에 의해 발현이 증가되는 adhesion수용체 유전자들은 osteonectin, afadin, neuroligin 2, semaphorin Z 등 이었다. 그리고 afadin, neuroligin 2, semaphorin Z은 두 실험 군에 서 모두 유전자 발현이 증가되었다. 이러한 결과로 보아 이 유전자들은 P$_4$에 의하여 발현이 조절되어 배란 후 착상 준비에 관여할 것으로 추측된다.

• Journal of Gastric Cancer
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• 제14권4호
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• pp.252-258
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• 2014

Purpose: The macroscopic diagnosis of tumor invasion through the serosa during surgery is not always distinct in patients with gastric cancer. The prognostic impact of the difference between macroscopic findings and pathological diagnosis of serosal invasion is not fully elucidated and needs to be re-evaluated. Materials and Methods: A total of 370 patients with locally advanced pT2 to pT4a gastric cancer who underwent curative surgery were enrolled in this study. Among them, 155 patients with pT3 were divided into three groups according to the intraoperative macroscopic diagnosis of serosal invasion, as follows: serosa exposure (SE)(-) (no invasion, 72 patients), SE(${\pm}$) (ambiguous, 47 patients), and SE(+) (definite invasion, 36 patients), and the clinicopathological features, surgical outcomes, and disease-free survival (DFS) were analyzed. Results: A comparison of the 5-year DFS between pT3_SE(-) and pT2 groups and between pT3_SE(+) and pT4a groups revealed that the differences were not statistically significant. In addition, in a subgroup analysis of pT3 patients, the 5-year DFS was 75.1% in SE(-), 68.5% in SE(${\pm}$), and 39.4% in SE(+) patients (P<0.05). In a multivariate analysis to evaluate risk factors for tumor recurrence, macroscopic diagnosis (hazard ratio [HR], SE(-) : SE(${\pm}$) : SE(+)=1 : 1.01 : 2.45, P=0.019) and lymph node metastasis (HR, N0 : N1 : N2 : N3=1 : 1.45 : 2.20 : 9.82, P<0.001) were independent risk factors for recurrence. Conclusions: Gross inspection of serosal invasion by the surgeon had a strong impact on tumor recurrence in gastric cancer patients. Consequently, the gross appearance of serosal invasion should be considered as a factor for predicting patients' prognosis.

• 융합정보논문지
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• 제7권4호
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• pp.205-213
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• 2017

본 연구의 목적은 건강신념모델에 근거하여 대학생의 흡연에 영향을 미치는 융합적 요인을 분석하기 위하여 시행되었다. 연구 방법은 제주지역 417명의 대학생들을 대상으로 서술적 조사연구가 진행되었고 기술 통계 및 다중회귀 분석은 SPSS 19.0 프로그램을 사용하여 수행되었다. 연구 결과, 성별(t=-7.44, p<.001), 용돈 (t=-2.06, p=.040), 가족의 흡연 여부(t=4.43, p<.001), 친구의 흡연 여부(t=9.59, p<.001), 지각된 장애(t=0.87, p=.014), 행동의 계기(t=6.33, p<.001)는 흡연에 영향을 미치는 통계적으로 유의한 변수였다. 본 연구결과를 토대로 흡연과 관련된 건강 및 건강 관련 변수 중 대학생의 흡연을 예방하기 위한 예방적 및 치료적 접근 방법이 필요할 것으로 보인다.

• 대한방사선기술학회지:방사선기술과학
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• 제27권3호
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• pp.31-41
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• 2004

남,여 ADHD환자별 뇌혈류 상태를 비교분석하기 위하여 SPECT 영상을 획득하고, 유의수준에 따른 클러스터(cluster)의 분포변화와 혈류량 증가율과 감소율의 변화를 조사하였다. 남자 어린이 ADHD환자군 51명과 정상군 8명, 여자 어린이 ADHD환자군 13명과 정상군 4명에 대하여. Multi SPECT3 camera를 이용하여 $^{99m}Tc-ECD$를 정맥 주사후 30분에 영상을 획득하고, 뇌혈류 상태를 통계적 파라미터 지도작성법(SPM)으로 분석하였다. 정상 어린이군에 대한 남,여 환자군의 뇌혈류 증가와 감소부위의 분포를 통계적 유의수준 P<0.001부터 P<0.05 범위에서 나타내었다. 남자 어린이 ADHD환자군에서 유의수준 P<0.02에서부터 P<0.05까지 대상회전(post. cingurate gyrus)에서만 혈류가 증가되었다. 증가율의 변화는 유의수준에 영향을 받지 않았으며, 정상군보다 환자군은 평균 15.84%가 증가되었다. 여자의 경우, P<0.003에서 소뇌후엽 중앙상부, P<0.005에서 소뇌 중앙후엽과 좌측 대뇌변연엽(limbic lobe)에서 혈류증가 클러스터가 나타났다. P<0.009에서 P<0.01까지는 좌측대뇌 측두엽에서, P<0.02에서는 우측 대뇌측두엽과 좌측 대뇌 두정엽에서 혈류증가 클러스터가 나타났으며, 각 클러스터에서 평균 $24.68{\sim}31.25%$의 혈류증가율을 나타내었다. 남자 ADHD 질환군의 혈류 감소는 P<0.004에서 좌측의 대뇌 도이랑(Insula gyrus), P<0.005에서는 우측 대뇌 측두엽, P<0.007에서는 우측대뇌 전두엽, P<0.009에서 P<0.01까지는 좌측 대뇌전두엽 그리고 P<0.02에서는 대뇌전두엽 중앙이랑에서 혈류감소 클러스터가 나타났다. 혈류 감소율은 유의 수준에 의해 영향을 받지 않았으며 평균 $15.21{\sim}16.64%$의 감소율을 나타내었다. 여자어린이 ADHD환자에서는 P<0.001에서 좌측 대뇌렌즈핵(lentiform nucleus)에서만 감소되었으며, P<0.003에서는 좌우 대뇌렌즈핵에서 모두 감소되었고 P<0.005에서 P<0.01까지는 좌우의 렌즈핵 외 좌측 대뇌 측두엽이랑등 3개의 감소 클러스터가 나타났다. P<0.03에서는 좌측 대뇌두정엽과 전두엽에서 감소되었고, 평균 $30.57{\sim}30.84%$의 혈류감소율을 나타내었다. 혈류감소율은 유의수준의 변화에 영향을 받지 않았다. ADHD환자의 뇌혈류증가, 감소율이 남자보다 여자환자에서 2배 정도가 많았고, 혈류 증가와 감소클러스터분포의 차이가 있는 것으로 나타나, ADHD환자의 분석은 남, 여별로 구분하여야 할 필요가 있다고 판단된다.

• Journal of Trauma and Injury
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• 제34권1호
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• pp.21-30
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• 2021

Purpose: The purpose of this study was to determine the influence of seasons and weather on the volume of trauma patients in central Korea. Methods: The records of 4,665 patients treated at Chungbuk National Hospital Regional Trauma Center from January 2016 to December 2019 were retrospectively reviewed. Meteorological data including hourly temperature (℃), precipitation (mm), humidity (%), and wind speed (m/s) for each district were collected retrospectively. Statistical analysis was done using the independent t-test, one-way analysis of variance (ANOVA), and linear regression analysis. Results: Patients' average age was 53.66 years, with a significant difference between men (49.92 years) and women (60.48 years) (p<0.001). Rolling/slipping down was a prominent cause of injury in winter (28.4%, n=283), with statistical significance (p<0.001). Trauma occurred least frequently in winter (p=0.005). Linear regression analysis revealed an increasing number of patients as the temperature increased (p<0.05), the humidity increased (p<0.001), and the wind speed decreased (p<0.001). Precipitation did not affect patient volume (p=0.562). One-way ANOVA revealed a decreased incidence of trauma when the temperature exceeded 30℃ (p<0.001), and when the humidity was more than 75%, compared to 25-50% and 50-75%. Conclusions: At the regional trauma center of Chungbuk National University Hospital, in central Korea, the number of trauma patients was lowest in winter, and patient volume was affected by temperature, humidity, and wind speed.

• Clinical Nutrition Research
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• 제12권4호
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• pp.320-335
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• 2023

Literature showed that soluble fiber has beneficial effects on cardiometabolic risk factors and leptin and adiponectin serum levels. Our aim in this meta-analysis was to determine the effect of soluble fiber supplementation on leptin and adiponectin serum levels. A systematic search was conducted using PubMed, Scopus, and ISI Web of Science for eligible trials up to December 2021. A random-effects model was used to pool calculated effect sizes. Our analysis showed that soluble fiber supplementation did not significantly affect adiponectin (standardized mean difference [SMD], -0.49 Hedges's, 95% confidence interval [CI], -1.20, 0.21, p value = 0.167; I² = 95.4, p value < 0.001) and leptin (SMD, -0.8 Hedges's, 95% CI, -1.70, 0.08, p value = 0.076; I² = 94.6, p value < 0.001) concentrations in comparison with placebo. However, in the subgroup, soluble fiber supplementation had a significant improvement in leptin concentration in overweight and obese patients (SMD, -0.22 Hedges's, 95% CI, -0.43, -0.01, p value = 0.048) and a non-significant beneficial effect in adiponectin level in female (SMD, 0.29 Hedges's, 95% CI, -0.13, 0.71, p value = 0.183) and diabetic patients (SMD, 0.32 Hedges's, 95% CI, -0.67, 1.32, p value = 0.526). A non-linear association between soluble fiber dosage and adiponectin (p_{non-linearity} < 0.001) was observed. Soluble fiber supplementation could not change the circulatory leptin and adiponectin levels. However, beneficial effects were seen in overweight and obese leptin, and increases in adiponectin may also be observed in female and diabetic patients. Further studies are needed to confirm this results.

• 대한치과기공학회지
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• 제45권4호
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• pp.102-110
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• 2023

Purpose: This study aims to examine the influence of personality types on recovery resilience and college life adjustment among dental technology students. Methods: The study recruited 165 students in colleges in some areas using convenience sampling. Data were processed through reliability analysis, frequency analysis, descriptive statistics, and correlation analysis. Moreover, linear regression analysis was performed to confirm the influence. Results: The results confirmed that the motivation for selecting a department exerted an effect on adaptation to college life and satisfaction with majors (p<0.05). Additionally, the finding indicated that personality type partially influenced resilience and adaptation to college life among dental technology students (p<0.05). Finally, the results of regression analysis on adaptation to college life found that resilience and satisfaction with majors were significant predictors of adaptation to college life (p<0.05). Conclusion: To improve adaptation to college life, increasing resilience and satisfaction with majors is necessary.

• 한국표면공학회:학술대회논문집
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• 한국표면공학회 2017년도 춘계학술대회 논문집
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• pp.155-155
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• 2017

Surface modifications are commonly utilized to adjust the properties of the titanium and its alloy surface to the specific needs of the medical applications, but there are disadvantages such as poor osteoconductive properties and low adhesion of bone cell to implant surface. In order to improve these disadvantages, changes in surface properties have an important effect on osseointegration during implantation. In this paper we applied new technological method for improving a unique surface modification using the characteristic of an electrolytic Solution. Thus, in the electrolyte containing NaF in Na2SO4, TiO2 nanoporous was uniformly formed, and HAp nanoparticles were electrodeposited around the TiO2 nanopores, but in the electrolyte containing NH4F in (NH4)H2PO4, the coarse protrusions including HAp nano particles were regularly deposited onto the TiO2 barrier layer. The surface characteristics and the distributed elements and have been investigated by EDS analysis, and ultra-fine structure of surface are carried out using FE-SEM. To investigate the behavior of the anion, the analysis of chemical states was performed by XPS, and the narrow spectrums for Ti2P, Ca 2p, and P 2p seems to be almost similar depending on the characteristics of the electrolyte solution respectively. In addition, Ca 2p spectrum could be resolved into two peaks for Ca 2p3/2 and 2p1/2 at 347.4 and 351.3 eV, which are related to hydroxyapatite. And, the P peak can also be deconvoluted into two peaks for P1/2 and P3/2 levels with binding energy 134.2 and 133.4 eV, respectively. From the result of soaking test, the apatite morphologys were well-formed onto the modified surface according to the different conditions.

• Animal Systematics, Evolution and Diversity
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• 제13권2호
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• pp.73-81
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• 1997

한국산 조류 중 박새속(genus Parus)에 속하는 4종 Parus major wladiwostokensis (박새), P. ater amurensis(진박새), P. palustrius hellmayri(쇠박새) 및 P. varius varius(곤줄 박이)를 대상으로 이들의 계통적 유연관계를 구명하기 위하여 mtDNA분석을 실시하였다. 6 base를 인지하는 10개의 제한효소를 처리하여 얻어진 mtDNA의 크기는 16.6~17.0Kb였으며 Pst I과 Pvu II는 종간 차이가 뚜렷하였다. 각 종간의 절편양상을 비교하여 Parus속의 종 간 분화정도를 비교한 결과 P. m. wladiwostokensis와 P. a. amurensis의 유전적 근연관계 가 가장 가까웠고(p=0.073, F=0.294) P. a. amurensis와 P. v. varius는 비교적 현저한 유전 적 차이를 보였다.(p=0.119, F=0.143). Brown 등 (1979)의 공식을 이용하여 박새속 4종의 분 화시기를 추정한 결과 이들은 후기 선신세(Pliocene)와 초기 홍적세(Pleistocene) 사이에 분 화된 것으로 추정되었다.

• Bulletin of the Korean Chemical Society
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• 제18권4호
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• pp.374-379
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• 1997

The rate constants for the nucleophilic addition of thiophenol derivatives (p-OCH3, H, p-CH3, m-CH3, p-Br and p-NO2) to 4'-[N-(9-acridinyl)]-1'-(N-methanesulfonyl)-3'-methoxyquinonediimide (AMQD) were determined by ultraviolet spectrophotometer in water at 5 ℃, and rate equations which can be applied over a wide pH range were obtained. On the basis of pH-rate profile, Bronsted plot, adduct analysis, general base catalysis and substituent effect, a plausible mechanism of this addition reaction was proposed: Below pH 2.5, the reaction proceeded by the addition of thiophenol molecule to 6'-position of quinonoid after protonation at the acridinyl nitrogen. Above pH 6.2, the addition of sulfide anion to 6'-position of quinonoid was rate controlling. However, in the range of pH 3.0-6.0, these two reactions occured competively.