• 한국환경과학회지
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• 제24권1호
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• pp.81-96
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• 2015

The characteristics of atmospheric dispersion of radioactive material (i.e. $^{137}Cs$) related to local wind patterns around the Kori nuclear power plant (KNPP) were studied using WRF/HYSPLIT model. The cluster analysis using observed winds from 28 weather stations during a year (2012) was performed in order to obtain representative local wind patterns. The cluster analysis identified eight local wind patterns (P1, P2, P3, P4-1, P4-2, P4-3, P4-4, P4-5) over the KNPP region. P1, P2 and P3 accounted for 14.5%, 27.0% and 14.5%, respectively. Both P1 and P2 are related to westerly/northwesterly synoptic flows in winter and P3 includes the Changma or typhoons days. The simulations of P1, P2 and P3 with high wind velocities and constant wind directions show that $^{137}Cs$ emitted from the KNPP during 0900~1400 LST (Local Standard Time) are dispersed to the east sea, southeast sea and southwestern inland, respectively. On the other hands, 5 sub-category of P4 have various local wind distributions under weak synoptic forcing and accounted for less than 10% of all. While the simulated $^{137}Cs$ for P4-2 is dispersed to southwest inland due to northeasterly flows, $^{137}Cs$ dispersed northward for the other patterns. The simulated average 137Cs concentrations of each local wind pattern are $564.1{\sim}1076.3Bqm^{-3}$. The highest average concentration appeared P4-4 due to dispersion in a narrow zone and weak wind environment. On the other hands, the lowest average concentration appeared P1 and P2 due to rapid dispersion to the sea. The simulated $^{137}Cs$ concentrations and dispersion locations of each local wind pattern are different according to the local wind conditions.

• Tuberculosis and Respiratory Diseases
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• 제73권1호
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• pp.11-21
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• 2012

Background: While qualitative analysis of methylation has been reviewed, the quantitative analysis of methylation has rarely been studied. We evaluated the methylation status of CDKN2A, $RAR{\beta}$, and RASSF1A promoter regions in non-small cell lung carcinomas (NSCLCs) by using pyrosequencing. Then, we evaluated the association between methylation at the promoter regions of these tumor suppressor genes and the clinicopathological parameters of the NSCLCs. Methods: We collected tumor tissues from a total of 53 patients with NSCLCs and analyzed the methylation level of the CDKN2A, $RAR{\beta}$, and RASSF1A promoter regions by using pyrosequencing. In addition, we investigated the correlation between the hypermethylation of CDKN2A and the loss of $p16^{INK4A}$ immunoexpression. Results: Hypermethylation of CDKN2A, $RAR{\beta}$, and RASSF1A promoter regions were 16 (30.2%), 22 (41.5%), and 21 tumors (39.6%), respectively. The incidence of hypermethylation at the CDKN2A promoter in the tumors was higher in undifferentiated large cell carcinomas than in other subtypes (p=0.002). Hyperrmethylation of CDKN2A was significantly associated with $p16^{INK4A}$ immunoexpression loss (p=0.045). With regard to the clinicopathological characteristics of NSCLC, certain histopathological subtypes were found to be strongly associated with the loss of $p16^{INK4A}$ immunoexpression (p=0.016). Squamous cell carcinoma and undifferentiated large cell carcinoma showed $p16^{INK4A}$ immunoexpression loss more frequently. The Kaplan-Meier survival curves analysis showed that methylation level and patient survival were barely related to one another. Conclusion: We quantitatively analyzed the promoter methylation status by using pyrosequencing. We showed a significant correlation between CDKN2A hypermethylation and $p16^{INK4A}$ immunoexpression loss.

• 한국전산구조공학회논문집
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• 제24권4호
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• pp.449-455
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• 2011

최근 가압중수형 원전 격납건물의 내압능력 및 비선형 거동에 관한 실증실험과 해석코드에 대한 검증을 위하여 인도의 BARC 주관으로 가압중수형 격납건물 1/4 축소모델을 건설하였고, 내압성능평가를 위한 국제공동연구가 수행되었다. 이 논문은 가압중수형 1/4 축소모델 격납건물에 대한 내압성능과 비선형 거동을 예측하기 위하여 유한요소해석을 수행하였고 그 결과를 도출하였다. 대상 격납건물은 기초매트와 원통형 벽체 및 돔으로 구성되어 있고, 수평 텐던의 정착을 위하여 4개의 부벽(buttress)을 가지고 있다. 유한요소해석을 위하여 ABAQUS를 이용하였고 콘크리트, 철근 및 텐던에 대한 유한요소 모델을 작성하여 극한내압해석을 수행하였다. 유한요소해석결과 콘크리트의 초기 균열은 $1.6P_d$(design pressure)에서 발생하였고, 철근의 항복은 $3.36P_d$ 그리고 극한내압능력은 $4.0P_d$ 수준으로 나타났다.

• 핵의학기술
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• 제13권3호
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• pp.67-75
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• 2009

목적 : Tl-201 심근관류 SPECT의 정량적 평가를 위해 사용되는 다양한 프로그램은 자료의 분석 방법에 있어서 각각 차이가 있는 것으로 보고되고 있다. 따라서 동일한 환자의 자료를 대상으로 정량적 분석을 하여도 프로그램 상호간의 측정치 오차가 발생할 것으로 예상된다. 그 중 심근의 관류결손 정도를 표현할 수 있는 정량적 지표를 이용하여 현재 각 병원에서 가장 일반적으로 사용하고 있는 심근관류분석 프로그램 QPS (Quantitative Perfusion SPECT)와 4DM (4DMSPECT) 그리고 ECT (Emory Cardiac Toolbox)의 분석값을 이용하여 프로그램 상호간의 연관성을 알아보고자 한다. 실험재료 및 방법 : 2008년 12월 1일 부터 2009년 2월 14까지 서울아산병원 핵의학과에서 Tl-201을 이용하여 게이트 심근관류 SPECT를 시행한 환자 145명을 대상으로 하였다. 이들 중 심혈관 질환의 가능성이 비교적 적다고 판단된 정상군 80(남/여=38/42, $65.1{\pm}9.9$세)명과 게이트 심근관류 SPECT의 판독결과를 통해 가역성 관류결손이나 고정 관류결손 등 심혈관 질환의 판정을 받은 비정상군 65(남/여=45/20, $63.0{\pm}8.7$세)명을 선별하였다. QPS와 4DM 그리고 ECT 프로그램을 이용하여 각각의 군에서 분석된 정량적 지표인 LAD, LCX, RCA 영역에서의 관류결손 범위율의 합(Total Defect Extent, TDE)과 부하기 관류점수합(Summed Stress Score, SSS)을 이용하여 상관관계 분석과 차이분석(paired t-test, Bland-Altman)을 이용하여 통계 결과를 비교 분석하였다. 결과 : 연구 대상 145명의 4DM:QPS, QPS:ECT, ECT:4DM 프로그램의 상관 계수는 SSS에서 각각 0.84, 0.86, 0.82이었고, TDE에서 각각 0.87, 0.84, 0.87로 SSS와 TDE 모두 높은 상관관계가 있었다. paired t-test 분석 결과에서는 QPS:ECT만 SSS (p=0.92)와 TDE (p=0.33) 모두 통계적으로 유의한 차이가 없었고, 4DM:QPS, ECT:4DM은 SSS와 TDE 모두 통계적으로 유의한 차이가 있었다(p<0.01). 비정상군 65명의 4DM/QPS, QPS/ECT, ECT/4DM 프로그램의 상관 계수는 SSS에서 각각 0.72, 0.72, 0.70이었고, TDE에서 각각 0.77, 0.70, 0.77로 SSS와 TDE 모두 높은 상관관계가 있었다. 비정상군 역시 paired t-test 분석 결과 QPS:ECT만 SSS (p=0.89)와 TDE (p=0.23) 모두 통계적으로 유의한 차이가 없었고, 4DM : QPS, ECT:4DM은 SSS와 TDE 모두 통계적으로 유의한 차이가 있었다(p<0.01). 정상군 80명의 분석 결과에서도 QPS : ECT만 SSS (p=0.95)와 TDE (p=0.73) 모두 통계적으로 유의한 차이가 없을 뿐, 4DM:QPS, ECT:4DM은 SSS와 TDE 모두 통계적으로 유의한 차이가 있었다(p<0.01). 결론 : 심혈관 질환을 가진 환자뿐 아니라 심혈관 질환의 가능성이 적은 환자에서도 Tl-201 심근 관류 SPECT의 관류 결손을 분석한 결과, 4DM은 QPS와 ECT 프로그램에 비해 SSS와 TDE 모두 낮게 분석되는 경향을 보였지만 프로그램 상호간에는 좋은 상관관계가 있다는 것을 확인 할 수 있었다. 하지만 이와 같이 좋은 상관관계에도 불구하고 Bland-Altman 분석 결과에서 프로그램간의 큰 변이 차이 때문에 임상에서 각각의 프로그램을 이용한 분석값을 서로 호환하여 사용할 수는 없을 것으로 판단된다. 그렇지만 이러한 분석결과는 임상적인 판독을 위한 참고 자료로서 유용하게 이용될 수 있을 것이라 기대된다.

• 분석과학
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• 제17권3호
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• pp.282-288
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• 2004

Inclusion selectivities of the cyanocadmate host complexes with ammonium oniums, $[Cd_x(CN)_{2x}][onium{\cdot}zG]$ (onium = $NMe_3Et^+$, $NMeEt{_3}^+$ and $NEt{_4}^+$, G = guest), have been investigated for $C_6H_6$ (B), PhMe (T), PhEt (E), ortho (O), meta (M), and para (P) isomers of $C_6H_4Me_2$ as the aromatic guest molecules. From the binary, ternary, quaternary and quinary mixed guests of B, T, E, O, M and P, the order of preference in the $NMe_3Et+$-host is $B{\gg}$T>P${\fallingdotseq}O{\fallingdotseq}M$ and E>O${\gg}P{\fallingdotseq}M$; in the $NMeEt{_3}^+$-host is T>B>P${\gg}O{\fallingdotseq}M$ and E>P${\gg}$M>O; in the $NEt{_4}^+$-host is $B{\gg}T{\fallingdotseq}O{\fallingdotseq}M{\fallingdotseq}P$. However, the $NEt{_4}^+$-host complexes of E, O, M and P mixed-guests were not obtained. These inclusion selectivities were compared to our previous results of the $NMe{_4}^+$-host; T>B>P${\gg}$M>O and E>P${\gg}$M>O.

• Journal of Microbiology and Biotechnology
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• 제16권11호
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• pp.1740-1746
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• 2006

Enrichment techniques led to the isolation of a Pseudomonas sp. strain P2 from municipal waste-contaminated soil sample, which could utilize different isomers of a commercial mixture of 4-nonylphenol when grown in the presence of phenol. The isolate was identified as Pseudomonas sp., based on the morphological, nutritional, and biochemical characteristics and 16S rDNA sequence analysis. The ${\beta}$-ketoadipate pathway was found to be involved in the degradation of phenol by Pseudomonas sp. strain P2. Gas chromatography-mass spectrometric analysis of the culture media indicated degradation of various major isomers of 4-nonylphenol in the range of 29-50%. However, the selected ion monitoring mode of analysis of biodegraded products of 4-nonylphenol indicated the absence of any aromatic compounds other than those of the isomers of 4-nonylphenol. Moreover, Pseudomonas sp. strain P2 was incapable of utilizing various alkanes individually as sole carbon source, whereas the degradation of 4-nonylphenol was observed only when the test organism was induced with phenol, suggesting that the degradation of 4-nonylphenol was possibly initiated from the phenolic moiety of the molecule, but not from the alkyl side-chain.

• Journal of Korean Biological Nursing Science
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• 제24권4호
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• pp.209-218
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• 2022

Purpose: This study aimed to investigate the relationships between the characteristics of nurses' work schedules, health outcomes, and work-life balance. Methods: This was a secondary data analysis that included 422 nurses in Korean hospitals. Descriptive analysis, independent sample t-test, one-way ANOVA, Pearson correlation analysis, and multiple linear regression analysis were used to identify the associated factors. Results: Multiple linear regression analysis showed that work-life balance was lower when atypical work was performed (β=-.14, p=.010). Nurses who did not work overtime showed a higher level of work-life balance than those who worked overtime infrequently (β=-.11, p=.002) or frequently (β=-.28, p<.001). The work-life balance level increased when nurses had better subjective health status (β=.16, p<.001) or higher sleep quality (β=.29, p<.001). It was verified that the work-life balance level was higher for single-person households than for households with two (β=-.18, p=.003), three to four (β=-.16, p=.022), or five or more (β=-.21, p<.001) persons. Conclusion: This study suggests that government and hospital organizations should provide high-quality care and consideration to nurses who do atypical or overtime work as well as their subjective health status and sleep quality. Further research should focus on the development of a policy that improves the work-life balance of nurses, especially for those who work during atypical hours.

• 경영정보학연구
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• 제25권4호
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• pp.205-231
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• 2023

정보보호 관리체계(Information Security Management System, ISMS)는 정보 자산의 기밀을 유지하고 결함이 없게 하며 언제든 사용할 수 있게 하는 보호 절차와 과정이고, 국내의 ISMS-P와 국외의 ISO/IEC 27001이 가장 대표적인 ISMS 인증제도이다. 본 논문에서는 ISMS 인증과 조직의 특성과의 관계를 파악하기 위해서 한국인터넷진흥원(KISA), 과학기술정보통신부 전자공시시스템(ISDS), 금융감독원 전자공시시스템(DART)로부터 데이터를 수집하고, Probit 회귀 분석을 실시하였다. Probit 분석 시 ISMS-P 취득여부, ISO/IEC 27001 취득여부, ISMS-P와 ISO/IEC 27001 모두 취득여부의 세 가지 경우에 대해 독립변수 4개와의 관련성을 확인하였다. 분석 결과, ISMS-P, ISO/IEC 27001 모두 취득한 기업은 총 임직원 수와는 양의 상관관계, 업력과는 음의 상관관계가 있음을 알 수 있었다. 이외에도 ISMS-P 인증제도와 정보보호 공시제도의 개선방향에 대해서도 확인할 수 있었다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권8호
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• pp.3691-3698
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• 2014

Background: Published studies on the association between the Ras Association Domain Family 1 isoform A (RASSF1A) Ala133Ser polymorphism and cancer susceptibility have yielded conflicting results. Thus, a meta-analysis was here performed to assess the possible association. Materials and Methods: All eligible case-control studies published up to November 2013 on the association between RASSF1A Ala133Ser polymorphism and cancer susceptibility were identified by searching PubMed, Web of Science, Science Direct and hand search. Bothfixed-effect and random-effect models were used to calculate pooled odds ratios (ORs) with 95% confidence intervals (CIs) by using the Comprehensive Meta-Analysis software version 2.2. Results: A total of 10 studies including 4,572 cancer cases and 4,320 controls were included in the meta-analysis. Overall, significantly increased cancer risk was associated with the variant Ser133 when all studies were pooled (Ser vs Ala: OR=1.51, 95% CI=1.08-2.12, $P_{heterogeneity}{\leq}0.001$; Ser/Ser+Ala/Ser vs Ala/Ala: OR=1.55, 95% CI=1.08-2.22, $P_{heterogeneity}{\leq}0.001$). Moreover, in subgroup analyses by cancer types, a significant association between RASSF1A Ala133Ser polymorphism and lung cancer risk was found (Ser vs Ala: OR=2.27, 95% CI=1.29-4.02, $P_{heterogeneity}$=0.61; Ser/Ser+Ala/Ser vs Ala/Ala: OR=2.42, 95% CI=1.33-4.42, $P_{heterogeneity}=0.75$). In addition, in subgroup analyses by ethnicity, it was found that the RASSF1A Ala133Ser polymorphism was associated with overall cancer risk in Asians (Ser vs Ala: OR=1.37, 95% CI=1.06-1.77, $P_{heterogeneity}=0.06$) and Caucasians (Ser/Ser+Ala/Ser vs Ala/Ala: OR=2.21, 95% CI=1.01-4.82, $P_{heterogeneity}{\leq}0.001$). Conclusions: This meta-analysis suggests, for the first time, that RASSF1A Ala133Ser polymorphism may contribute to cancer susceptibility, especially for lung cancer. Besides, additional well-designed studies with larger sample size focusing on different ethnicities and cancer types are needed to confirm these findings.

• 한국물환경학회지
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• 제29권6호
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• pp.832-841
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• 2013

In recent years, eutrophication in the Paldang Lake has become one of the major environmental problems in Korea as it may threaten drinking water safety and human health. Thus it is important to understand the phenomena and predict the time and magnitude of algal blooms for applying adequate algal reduction measures. This study performed seasonal water quality assessment and chlorophyll-a prediction using Bayseian simple/multiple linear regression analysis. Bayseian regression analysis could be a useful tool to overcome limitations of conventional regression analysis. Also it can consider uncertainty in prediction by using posterior distribution. Generally, chlorophyll-a of a P2(Paldang Dam 2) site showed high concentration in spring and it was similar to that of P4(Paldang Dam 4) site. For the development of Bayseian model, we performed seasonal correlation. As a result, chlorophyll-a of a P2 site had a high correlation with P5(Paldang Dam 5) site in spring (r = 0.786, p<0.05) and with P4 in winter (r = 0.843, p<0.05). Based on the DIC (Deviance Information Criterion) value, critical explanatory variables of the best fitting Bayesian linear regression model were selected as a $PO_4-P$ (P2), Chlorophyll-a (P5) in spring, $NH_3-N$ (P2), Chlorophyll-a (P4), $NH_3-N$ (P4) in summer, DTP (P2), outflow (P2), TP (P3), TP (P4) fall, COD (P2), Chl-a (P4) and COD (P4) in winter. The results of chlorophyll-a prediction showed relatively high $R^2$ and low RMSE values in summer and winter.